Endpoint
Beck Depression Inventory (BDI) total score
CAT:outcome/bdi-total-scorereported in points (0-63)1 finding from 1 compound
What moved it
How to read these marks1 finding · 1 compound · 1 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| escitalopram | no effect | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
Every finding here is a null result.
Measured, no effect detected
1 finding
escitalopram — no detected effect on
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“There were no statistically significant differences between the groups: the mean difference for change in BDI-II severity was − 3.1 (95% confidence interval (CI) -8.66 to 2.53, p = 0.28) for nortriptyline vs. placebo and − 0.7 (95% CI -6.11 to 4.70, p = 0.80) for escitalopram vs. placebo (Supplementary Table 3).”
Quoted verbatim from Placebo-controlled three-armed pilot trial of Escitalopram or Nortriptyline for depressive symptoms in Parkinson's disease (ADepT-PD).. - Study
- RCT
- Duration
- 8 weeks
- Dose
- target 20 mg/day in patients aged 65 or under, 10 mg/day in patients over 65 or with hepatic impairment, titrated from 5 mg in two-weekly steps
- Population
- People with Parkinson's disease and depressive symptoms (BDI-II 14 or above) in a three-arm pilot trial of escitalopram, nortriptyline or placebo; change from baseline to 8 weeks, escitalopram versus placebo
Effect -0.7 mean difference, 95% CI -6.11 to 4.7
Placebo-controlled three-armed pilot trial of Escitalopram or Nortriptyline for depressive symptoms in Parkinson's disease (ADepT-PD).2026PMID:42101650Permalink
How it is measured
Total score on the self-report Beck Depression Inventory (BDI or BDI-II), summed across its items into a single continuous depression-severity score.
Measured, not recorded
- Subject
- beck depression inventory (bdi) total score
- Measurements
- 1 measurement
- Recorded as a finding
- No
Show what was measured
Beck Depression Inventory (BDI) total score
no effect, p = 0.978
Not recorded as a finding: The sentence reporting the result refers to 'the groups' and never names melatonin, so it is not self-supporting as a claim.
BDI: Depression scores were stable throughout the study, with no significant differences between the groups at any time point (p = 0.978) and no significant time × group interaction.
PMID:42770942 · one of two readings recorded this
Sources cited
1 paper
- Subject
- beck depression inventory (bdi) total score
- Findings
- 1
- Papers
- 1