Compound

L-isoleucine

An essential branched-chain aliphatic amino acid found in many proteins. It is an isomer of leucine. It is important in hemoglobin synthesis and regulation of blood sugar and energy levels.

Definition from MeSH (D007532), National Library of Medicine, read 2026-09-23. NLM revises MeSH; this copy may not reflect its current record.

CHEBI:17191ChEBI

Open in the graph

Studied for

6 endpoints · 6 findings · 5 papers

Peak postprandial blood glucoselowersEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.
Postprandial blood glucose area under the curvelowersEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.
Alanine aminotransferaselowersEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.
Fat massraisesEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.
MTORraisesEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.

All 6 endpoints, with the quotes

Structure

The L-enantiomer of isoleucine.

2D depiction · 3D model shown

Loading the model…

A generated conformer of L-isoleucine — one low-energy arrangement PubChem computed, not a measured structure. Hydrogens are not drawn; the formula counts them.

Class: Organic compound
Formula: C6H13NO2
Mass: 131.175 g/mol
Charge: 0
InChIKey: AGPKZVBTJJNPAG-WHFBIAKZSA-N
SMILES: CC[C@H](C)[C@H](N)C(=O)O
Look it up: ChEBI PubChem By InChIKey

Identity from ChEBI, geometry from PubChem. Not evidence.

What the evidence says

How to read these marks

6 findings · 6 endpoints · 5 papers · by evidence strength

Heavier lines are better evidence, and a line with a gap in the middle is an inference rather than a reported result. Two lines arriving at one endpoint are two findings of it, marked ×2. How evidence strength is computed.

What moved

6 findings

Decreases postprandial blood glucose area under the curve
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding
“Compared with the control, isoleucine-10g reduced the blood glucose AUC and peak blood glucose (P < 0.01), whereas effects of isoleucine-5g were NS.”
Quoted verbatim from Intragastric administration of leucine or isoleucine lowers the blood glucose response to a mixed-nutrient drink by different mechanisms in healthy, lean volunteers..
Study

crossover
Dose

10 g isoleucine, single intragastric infusion, 15 min before a mixed-nutrient drink
Population

healthy, lean subjects; isoleucine 10 g intragastric dose (isoleucine 5 g dose was not significant)
Intragastric administration of leucine or isoleucine lowers the blood glucose response to a mixed-nutrient drink by different mechanisms in healthy, lean volunteers.2017PMID:27655440Permalink
Decreases peak postprandial blood glucose
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding
“Compared with the control, isoleucine-10g reduced the blood glucose AUC and peak blood glucose (P < 0.01), whereas effects of isoleucine-5g were NS.”
Quoted verbatim from Intragastric administration of leucine or isoleucine lowers the blood glucose response to a mixed-nutrient drink by different mechanisms in healthy, lean volunteers..
Study

crossover
Dose

10 g isoleucine, single intragastric infusion, 15 min before a mixed-nutrient drink
Population

healthy, lean subjects; isoleucine 10 g intragastric dose (isoleucine 5 g dose was not significant)
Intragastric administration of leucine or isoleucine lowers the blood glucose response to a mixed-nutrient drink by different mechanisms in healthy, lean volunteers.2017PMID:27655440Permalink
Decreases alanine aminotransferase
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding
“Isoleucine had a more pronounced lowering effect and significantly decreased ALT and CK18‐M30.”
Quoted verbatim from Intervention with isoleucine or valine corrects hyperinsulinemia and reduces intrahepatic diacylglycerols, liver steatosis, and inflammation in Ldlr-/-.Leiden mice with manifest obesity-associated NASH..
Study

animal · not in humans
Participants

15
Duration

3 months
Dose

3% (w/w) isoleucine added to fast-food diet for 12 weeks
Population

Male Ldlr-/-.Leiden mice with fast-food-diet-induced obesity and NASH, 12-week dietary isoleucine (3% w/w) supplementation after a 26-week fast-food-diet run-in
Intervention with isoleucine or valine corrects hyperinsulinemia and reduces intrahepatic diacylglycerols, liver steatosis, and inflammation in Ldlr-/-.Leiden mice with manifest obesity-associated NASH.2022PMID:35830259Permalink
Decreases triglycerides
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding
“The results showed that adding Leu, Ile and their combination in drinking water significantly decreased relative white adipose tissue (WAT) weight and serum triglycerides, low-density lipoprotein, free fatty acid, and insulin compared with the HFD control.”
Quoted verbatim from Leucine and isoleucine have similar effects on reducing lipid accumulation, improving insulin sensitivity and increasing the browning of WAT in high-fat diet-induced obese mice..
Study

animal · not in humans
Dose

isoleucine in drinking water
Population

already obese mice induced by high-fat diet; Ile given in drinking water, compared with HFD control (Ile arm separate from Leu and Leu+Ile arms)
Leucine and isoleucine have similar effects on reducing lipid accumulation, improving insulin sensitivity and increasing the browning of WAT in high-fat diet-induced obese mice.2020PMID:32104819Permalink
Increases fat mass
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding
“The results showed that Ile significantly increased both muscle and fat mass, as well as causing insulin resistance and meanwhile upregulating the levels of key adipogenic and myogenic proteins.”
Quoted verbatim from Isoleucine increases muscle mass through promoting myogenesis and intramyocellular fat deposition..
Study

animal · not in humans
Dose

high-fat diet with 25 g L-1 Ile
Population

wild male C57BL/6J mice on a high-fat diet with or without isoleucine (32 mice, two groups)
Isoleucine increases muscle mass through promoting myogenesis and intramyocellular fat deposition.2021PMID:33289736Permalink
Activates MTOR
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding
“Supplementation of L-isoleucine increased mTOR, S6K1, and rpS6 phosphorylation (P < 0.05).”
Quoted verbatim from Isoleucine and leucine independently regulate mTOR signaling and protein synthesis in MAC-T cells and bovine mammary tissue slices..
Study

in vitro · not in humans
Population

bovine mammary epithelial MAC-T cells, essential amino acid-depleted media supplemented with L-isoleucine
Isoleucine and leucine independently regulate mTOR signaling and protein synthesis in MAC-T cells and bovine mammary tissue slices.2012PMID:22298573Permalink

What it touches on the way

Mechanistic reach

20 entities

20 entities reached.

0 reported hops20 assembled from the scaffold

Show the remaining 8

What the reference databases state

Statements

94 statements

94 statements · 2 reference databases · Subject: L-isoleucine · Sources: Human-GEM, Rhea

Order

(S)-3-methyl-2-oxopentanoate is converted to L-isoleucineCompoundRhea RHEA:61232Inferred only
L-isoleucine is converted to (S)-3-methyl-2-oxopentanoateCompoundRhea RHEA:24801Inferred only
L-isoleucine is converted to (S)-3-methyl-2-oxopentanoateCompoundRhea RHEA:32959Inferred only
L-isoleucine is converted to (S)-3-methyl-2-oxopentanoateCompoundRhea RHEA:61232Inferred only
(S)-3-methyl-2-oxopentanoate is converted to L-isoleucineCompoundRhea RHEA:32959Inferred only
L-isoleucine is converted to 3-methyl-2-oxovaleric acidCompoundHuman-GEM MAR03777Inferred only
L-isoleucine is converted to 3-methyl-2-oxovaleric acidCompoundHuman-GEM MAR03778Inferred only
L-isoleucine is a substrate of ACE2ProteinHuman-GEM MAR02641Inferred only
L-isoleucine is a substrate of ACE2ProteinHuman-GEM MAR02639Inferred only
L-isoleucine is a substrate of BCAT1ProteinRhea RHEA:24801Inferred only
L-isoleucine is a substrate of BCAT1ProteinHuman-GEM MAR03777Inferred only
L-isoleucine is a substrate of BCAT2ProteinHuman-GEM MAR03778Inferred only

Show the remaining 82

L-isoleucine is a substrate of BCAT2ProteinRhea RHEA:24801Inferred only
L-isoleucine is a substrate of IARS1ProteinRhea RHEA:11060Inferred only
L-isoleucine is a substrate of IARS1ProteinHuman-GEM MAR05140Inferred only
L-isoleucine is a substrate of IARS2ProteinRhea RHEA:11060Inferred only
L-isoleucine is transported by CLTRNProteinHuman-GEM MAR09891Inferred only
L-isoleucine is transported by SLC36A1ProteinHuman-GEM MAR05092Inferred only
L-isoleucine is transported by SLC36A1ProteinHuman-GEM MAR05065Inferred only
L-isoleucine is transported by SLC3A1ProteinHuman-GEM MAR05954Inferred only
L-isoleucine is transported by SLC3A1ProteinHuman-GEM MAR05986Inferred only
L-isoleucine is transported by SLC3A1ProteinHuman-GEM MAR05922Inferred only
L-isoleucine is transported by SLC3A1ProteinHuman-GEM MAR05970Inferred only
L-isoleucine is transported by SLC3A1ProteinHuman-GEM MAR05938Inferred only
L-isoleucine is transported by SLC3A2ProteinHuman-GEM MAR05092Inferred only
L-isoleucine is transported by SLC43A1ProteinHuman-GEM MAR05092Inferred only
L-isoleucine is transported by SLC43A1ProteinRhea RHEA:70943Inferred only
L-isoleucine is transported by SLC43A2ProteinHuman-GEM MAR05092Inferred only
L-isoleucine is transported by SLC43A2ProteinRhea RHEA:70943Inferred only
L-isoleucine is transported by SLC6A14ProteinHuman-GEM MAR09594Inferred only
L-isoleucine is transported by SLC6A14ProteinRhea RHEA:71299Inferred only
L-isoleucine is transported by SLC6A15ProteinRhea RHEA:29275Inferred only
L-isoleucine is transported by SLC6A15ProteinHuman-GEM MAR05316Inferred only
L-isoleucine is transported by SLC6A18ProteinHuman-GEM MAR09891Inferred only
L-isoleucine is transported by SLC6A19ProteinRhea RHEA:29275Inferred only
L-isoleucine is transported by SLC6A19ProteinHuman-GEM MAR05316Inferred only
L-isoleucine is transported by SLC7A5ProteinRhea RHEA:70943Inferred only
L-isoleucine is transported by SLC7A5ProteinHuman-GEM MAR05646Inferred only
L-isoleucine is transported by SLC7A5ProteinHuman-GEM MAR05661Inferred only
L-isoleucine is transported by SLC7A5ProteinHuman-GEM MAR05676Inferred only
L-isoleucine is transported by SLC7A5ProteinHuman-GEM MAR05092Inferred only
L-isoleucine is transported by SLC7A5ProteinHuman-GEM MAR05472Inferred only
L-isoleucine is transported by SLC7A5ProteinHuman-GEM MAR05486Inferred only
L-isoleucine is transported by SLC7A5ProteinHuman-GEM MAR05499Inferred only
L-isoleucine is transported by SLC7A5ProteinHuman-GEM MAR05549Inferred only
L-isoleucine is transported by SLC7A5ProteinHuman-GEM MAR05511Inferred only
L-isoleucine is transported by SLC7A5ProteinHuman-GEM MAR05522Inferred only
L-isoleucine is transported by SLC7A5ProteinHuman-GEM MAR05532Inferred only
L-isoleucine is transported by SLC7A5ProteinHuman-GEM MAR05541Inferred only
L-isoleucine is transported by SLC7A5ProteinHuman-GEM MAR05556Inferred only
L-isoleucine is transported by SLC7A5ProteinHuman-GEM MAR05562Inferred only
L-isoleucine is transported by SLC7A5ProteinHuman-GEM MAR05567Inferred only
L-isoleucine is transported by SLC7A5ProteinHuman-GEM MAR05571Inferred only
L-isoleucine is transported by SLC7A5ProteinHuman-GEM MAR05574Inferred only
L-isoleucine is transported by SLC7A5ProteinHuman-GEM MAR05576Inferred only
L-isoleucine is transported by SLC7A5ProteinHuman-GEM MAR05577Inferred only
L-isoleucine is transported by SLC7A5ProteinHuman-GEM MAR05601Inferred only
L-isoleucine is transported by SLC7A5ProteinHuman-GEM MAR05616Inferred only
L-isoleucine is transported by SLC7A5ProteinHuman-GEM MAR05631Inferred only
L-isoleucine is transported by SLC7A6ProteinHuman-GEM MAR05905Inferred only
L-isoleucine is transported by SLC7A6ProteinHuman-GEM MAR05601Inferred only
L-isoleucine is transported by SLC7A6ProteinHuman-GEM MAR05631Inferred only
L-isoleucine is transported by SLC7A6ProteinHuman-GEM MAR05646Inferred only
L-isoleucine is transported by SLC7A6ProteinHuman-GEM MAR05661Inferred only
L-isoleucine is transported by SLC7A6ProteinHuman-GEM MAR05676Inferred only
L-isoleucine is transported by SLC7A6ProteinHuman-GEM MAR05691Inferred only
L-isoleucine is transported by SLC7A6ProteinHuman-GEM MAR05706Inferred only
L-isoleucine is transported by SLC7A6ProteinHuman-GEM MAR05721Inferred only
L-isoleucine is transported by SLC7A6ProteinHuman-GEM MAR05736Inferred only
L-isoleucine is transported by SLC7A6ProteinHuman-GEM MAR05781Inferred only
L-isoleucine is transported by SLC7A6ProteinHuman-GEM MAR05796Inferred only
L-isoleucine is transported by SLC7A6ProteinHuman-GEM MAR05812Inferred only
L-isoleucine is transported by SLC7A6ProteinHuman-GEM MAR05814Inferred only
L-isoleucine is transported by SLC7A6ProteinHuman-GEM MAR05817Inferred only
L-isoleucine is transported by SLC7A6ProteinHuman-GEM MAR05819Inferred only
L-isoleucine is transported by SLC7A6ProteinHuman-GEM MAR05820Inferred only
L-isoleucine is transported by SLC7A6ProteinHuman-GEM MAR05823Inferred only
L-isoleucine is transported by SLC7A6ProteinHuman-GEM MAR05902Inferred only
L-isoleucine is transported by SLC7A6ProteinHuman-GEM MAR05903Inferred only
L-isoleucine is transported by SLC7A6ProteinHuman-GEM MAR05904Inferred only
L-isoleucine is transported by SLC7A6ProteinHuman-GEM MAR05906Inferred only
L-isoleucine is transported by SLC7A6ProteinHuman-GEM MAR05922Inferred only
L-isoleucine is transported by SLC7A6ProteinHuman-GEM MAR05938Inferred only
L-isoleucine is transported by SLC7A6ProteinHuman-GEM MAR05954Inferred only
L-isoleucine is transported by SLC7A6ProteinHuman-GEM MAR05970Inferred only
L-isoleucine is transported by SLC7A6ProteinHuman-GEM MAR05986Inferred only
L-isoleucine is transported by SLC7A7ProteinHuman-GEM MAR05092Inferred only
L-isoleucine is transported by SLC7A8ProteinRhea RHEA:71011Inferred only
L-isoleucine is transported by SLC7A8ProteinHuman-GEM MAR05092Inferred only
L-isoleucine is transported by SLC7A9ProteinHuman-GEM MAR05938Inferred only
L-isoleucine is transported by SLC7A9ProteinHuman-GEM MAR05986Inferred only
L-isoleucine is transported by SLC7A9ProteinHuman-GEM MAR05922Inferred only
L-isoleucine is transported by SLC7A9ProteinHuman-GEM MAR05954Inferred only
L-isoleucine is transported by SLC7A9ProteinHuman-GEM MAR05970Inferred only

Reactions

150 reactions

L-alanine+L-arginine+L-asparagine+L-aspartate+CHEBI:1307929+a cholesterol ester+a cardiolipin+MAM01602c+L-cysteine+MAM01721n+MAM01722n+L-glutamate(1-)+L-glutamine+glycine+CHEBI:15971+L-isoleucine+L-leucine+MAM02392c+CHEBI:18019+L-methionine+L-phenylalanine+phosphatidic acid+1-phosphatidyl-1D-myo-inositol+CHEBI:17203+MAM02847c+L-seryl residue+a sphingomyelin+CHEBI:16857+L-tryptophan+CHEBI:17895+L-valine+MAM03161cMAM03970c
Reaction pageBlockedBalance undeterminablecytosol, endoplasmic reticulum, nucleus
Human-GEM MAR00021CC BY 4.0Reference data
L-isoleucineL-isoleucine
Reaction pageReversibleBalancedEC 1.1.1.42cytosol, mitochondrial matrix
Human-GEM MAR01464CC BY 4.0Reference data
MAM01387e+waterMAM01386e+L-isoleucine
Catalysed by ACE2
Reaction pageReversibleBalancedEC 3.4.17.23extracellular space
Human-GEM MAR02639CC BY 4.0Reference data
water+MAM02563eL-isoleucine+MAM02562e
Catalysed by ACE2
Reaction pageReversibleBalancedEC 3.1.6.2extracellular space
Human-GEM MAR02641CC BY 4.0Reference data
2-oxoglutarate(2-)+L-isoleucine3-methyl-2-oxovaleric acid+L-glutamate(1-)
Catalysed by BCAT1
Reaction pageLeft to rightBalancedEC 2.6.1.42cytosol
Human-GEM MAR03777CC BY 4.0Reference data
2-oxoglutarate(2-)+L-isoleucine3-methyl-2-oxovaleric acid+L-glutamate(1-)
Catalysed by BCAT2
Reaction pageLeft to rightBalancedEC 2.6.1.42mitochondrial matrix
Human-GEM MAR03778CC BY 4.0Reference data
0.505626L-alanine+0.35926L-arginine+0.279425L-asparagine+0.352607L-aspartate+20.704451ATP+0.020401CHEBI:1307929+0.011658a cardiolipin+0.039036CHEBI:17677+0.046571L-cysteine+0.013183CHEBI:16284+0.009442dCTP+0.009898CHEBI:16497+0.013091dTTP+0.275194D-glucopyranose 6-phosphate+0.385872L-glutamate(1-)+0.325996L-glutamine+0.538891glycine+0.036117GTP+20.650823water+0.126406CHEBI:15971+0.286078L-isoleucine+0.545544L-leucine+0.592114CHEBI:18019+0.153018L-methionine+0.1544631,2-diacyl-sn-glycero-3-phosphocholine(1+)+0.055374phosphatidylethanolamine+0.002914MAM02715c+0.259466L-phenylalanine+0.0233151-phosphatidyl-1D-myo-inositol+0.412484CHEBI:17203+0.005829phosphatidyl-L-serine+0.392525L-seryl residue+0.017486a sphingomyelin+0.31269CHEBI:16857+0.013306L-tryptophan+0.159671CHEBI:17895+0.053446UTP+0.352607L-valine20.650823ADP+20.650823proton+20.650823phosphate(3-)+MAM03970c
Reaction pageBlockedBalance undeterminablecytosol, nucleus
Human-GEM MAR04413CC BY 4.0Reference data
L-isoleucineL-isoleucine
Transported by SLC36A1
Reaction pageLeft to rightBalancedlysosome, cytosol
Human-GEM MAR05065CC BY 4.0Reference data
L-isoleucineL-isoleucine
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC36A1 or SLC43A1 or SLC7A7 or SLC43A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05092CC BY 4.0Reference data
proton+L-isoleucineproton+L-isoleucine
Reaction pageLeft to rightBalancedmitochondrial intermembrane space, cytosol, mitochondrial matrix
Human-GEM MAR05107CC BY 4.0Reference data
ATP+L-isoleucine+MAM03072cAMP+Ile-tRNA(Ile)+diphosphate(3-)
Catalysed by IARS1
Reaction pageLeft to rightBalance undeterminableEC 6.1.1.5cytosol
Human-GEM MAR05140CC BY 4.0Reference data
MAM01308c+608ATP+1216water608ADP+63L-alanine+27L-arginine+17L-asparagine+36L-aspartate+35L-cysteine+62L-glutamate(1-)+20L-glutamine+13glycine+619proton+16CHEBI:15971+9L-isoleucine+64L-leucine+60CHEBI:18019+7L-methionine+35L-phenylalanine+608phosphate(3-)+24CHEBI:17203+28L-seryl residue+29CHEBI:16857+2L-tryptophan+19CHEBI:17895+43L-valine
Catalysed by ALB
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR05258CC BY 4.0Reference data

Show the remaining 138

On the label

Labelled products

732 products

Source: NIH DSLD · Ingredient: L-isoleucine · 732 products · Declared amount per serving: 2.86–3,454 mg (537 products)

715 labels state an amount17 do not

Order

1 Up NutritionBCAA's Glutamine & Collagen Candy Watermelon1,000 mgper 15 Gram(s)DSLD:64636
1 Up NutritionBCAA's Glutamine & Collagen Pineapple1,000 mgper 15 Gram(s)DSLD:64634
1 Up NutritionBCAA's Glutamine & Collagen Raspberry Lemonade1,000 mgper 15 Gram(s)DSLD:64635
1 Up NutritionBCAA's Glutamine & L-Carnitine Candy Watermelon1,600 mgper 15 Gram(s)DSLD:64714
1 Up NutritionBCAA's Glutamine & L-Carnitine Pineapple1,600 mgper 15 Gram(s)DSLD:64637
1 Up NutritionBCAA's Glutamine & L-Carnitine Raspberry Lemonade1,600 mgper 15 Gram(s)DSLD:64638
1st PhormAnabolic Bridge608 mgper 8 Capsule(s)DSLD:242704
1st PhormBCAA Apple Juice2,000 mgper 11 Gram(s)DSLD:242705
1st PhormBCAA Blue Raspberry2,000 mgper 11 Gram(s)DSLD:242713
1st PhormBCAA Green Apple2,000 mgper 11 Gram(s)DSLD:242719
1st PhormBCAA Lemonade2,000 mgper 11 Gram(s)DSLD:242722
1st PhormBCAA Pineapple Mango2,000 mgper 11.3 Gram(s)DSLD:242723

Show the remaining 720

1st PhormIntra-Formance Lemon Lime1,000 mgper 31.8 Gram(s)DSLD:242858
1st PhormIntra-Formance Orange1,000 mgper 31.8 Gram(s)DSLD:242859
21st CenturyDaily Amino Acid63 mgper 1 Tablet(s)DSLD:258438
6AM RunFinishLine Lemon Lime1,000 mgper 6.5 Gram(s)DSLD:337316
6AM RunFinishLine Watermelon1,000 mgper 6.5 Gram(s)DSLD:337317
Absorb HealthBCAA 2:1:1375 mgper 1.5 Gram(s)DSLD:215652
AdvocareCatalyst225 mgper 3 Capsule(s)DSLD:60518
AdvoCareBioCharge500 mgper 4.35 Gram(s)DSLD:206881
AdvoCareBioCharge Peach & Mixed Berry500 mgper 1 Stick Pack(s)DSLD:318407
AdvoCareCatalyst225 mgper 3 Capsule(s)DSLD:265036
AdvoCarePost-Workout Recovery Chocolate 100 mgper 2 Ounce(s)DSLD:296897
AdvoCarePost-Workout Recovery Vanilla100 mgper 60 Gram(s)DSLD:296898
AjinomotoFusi-BCAA Fruit Punch Flavor1,250 mgper 8.83 Gram(s)DSLD:81433
AjinomotoFusi-BCAA Lemon Flavor1,250 mgper 8.31 Gram(s)DSLD:81437
AjinomotoFusi-BCAA Pure & Unflavored1.25 Gram(s)per 5 Gram(s)DSLD:81375
AjinomotoFusi-BCAA Pure & Unflavored1.25 Gram(s)per 5 Gram(s)DSLD:81409
Alani NuBCAA BerryVegan InstAminos1.25 Gram(s)per 7.9 Gram(s)DSLD:247871
Allergy Research GroupAmino Acid Neurotransmitter Formula185 mgper 4 Gram(s)DSLD:54247
Allergy Research GroupSteady On45 mgper 20 Gram(s)DSLD:54474
Allergy Research GroupSteady On45 mgper 20 Gram(s)DSLD:54482
Allergy Research GroupTake Heart II Without Hormones35 mgper 20 Gram(s)DSLD:54484
Allergy Research GroupTake Heart II Without Hormones35 mgper 20 Gram(s)DSLD:54477
Amazing MusclePre Rise Fruit Punch1 Gram(s)per 21 Gram(s)DSLD:251083
American MetabolixWarpath Fruit Punch250 mgper 1 Scoop(s)DSLD:199563
ANSI Pro-SeriesBCAA 1000L-Isoleucine Note: (usp) (Free Form)100 mgper 2 Capsule(s)DSLD:21003
ANSI Pro-SeriesBCAA 2200L-Isoleucine Note: (usp) (Free Form)220 mgper 4 Capsule(s)DSLD:21005
ANSI Pro-SeriesInstantized BCAA 12400 Blue RaspberryL-Isoleucine Note: (usp) (Free Form)620 mgper 11.5 Gram(s)DSLD:21008
ANSI Pro-SeriesInstantized BCAA 12400 Fruit PunchL-Isoleucine Note: (usp) (Free Form)620 mgper 11.5 Gram(s)DSLD:21010
ANSI Pro-SeriesInstantized BCAA 12400 GrapeL-Isoleucine Note: (usp) (Free Form)620 mgper 11.5 Gram(s)DSLD:21012
ANSI Pro-SeriesInstantized BCAA 12400 WatermelonL-Isoleucine Note: (usp) (Free Form)620 mgper 11.5 Gram(s)DSLD:21013
Apollon NutritionChainsaw Blue Bomb1,250 mgper 12 Gram(s)DSLD:215752
Apollon NutritionEnigma Passion Fruit1,200 mgper 21.6 Gram(s)DSLD:215758
Apollon NutritionEnigma Pineapple1,200 mgper 22 Gram(s)DSLD:235587
Approved ScienceBCAA 2:1:1 +BioPerine600 mgper 1 Tablet(s)DSLD:319724
ATP ScienceVegan Essential Aminos Cola750 mgper 6 Gram(s)DSLD:241753
ATP ScienceVegan Essential Aminos Raspberry750 mgper 6 Gram(s)DSLD:241760
BELDT LabsRebaar750 mgper 3 Tablet(s)DSLD:237023
BELDT LabsRebaar750 mgper 3 Tablet(s)DSLD:331479
Best NaturalsBCAA 3200 mg800 mgper 4 Capsule(s)DSLD:269289
Best NaturalsBCAA 3200 mg800 mgper 4 Capsule(s)DSLD:270350
Best NaturalsBCAA Pure PowderFree-Form1,300 mgper 5.2 Gram(s)DSLD:269247
Beverly InternationalDensity500 mgper 5 Tablet(s)DSLD:332818
Beverly InternationalGlutamine Select Black Cherry750 mgper 9.2 Gram(s)DSLD:332832
Beverly InternationalGlutamine Select Wild Berry750 mgper 9.4 Gram(s)DSLD:332833
Beverly InternationalMuscle Mass1,000 mgper 5 Tablet(s)DSLD:332837
Beverly InternationalMuscularity835 mgper 2 Capsule(s)DSLD:332851
BiochemH Hydro Recovery Coconut FlavorVegan L-Isoleucine250 mgper 4.9 Gram(s)DSLD:183896
BiolayneCarbon Recover Blueberry Pomegranate2 Gram(s)per 14.9 Gram(s)DSLD:202622
BiolayneCarbon Recover Sour Apple2 Gram(s)per 15.65 Gram(s)DSLD:202625
BiosteelAdvanced Recovery Formula Vanilla3,108 mgper 36 Gram(s)DSLD:30899
BioSteelAdvanced Recovery Formula Chocolate3,108 mgper 36 Gram(s)DSLD:30953
BioSteelBioSteel Hydration Mix Mixed Berry Flavor544 mgper 7 Gram(s)DSLD:273699
BioSteelBioSteel Hydration Mix Rainbow Twist Flavor544 mgper 7 Gram(s)DSLD:273703
BioSteelBioSteel Hydration Mix White Freeze Flavor544 mgper 7 Gram(s)DSLD:271048
BioSteelBioSteel Sports Hydration Mix Blue Raspberry536 mgper 0.24 ozDSLD:273737
BioSteelBioSteel Sports Hydration Mix Lemon-Lime536 mgper 0.24 ozDSLD:273736
BioSteelBioSteel Sports Hydration Mix Mixed Berry536 mgper 0.24 ozDSLD:271055
BioSteelBioSteel Sports Hydration Mix Orange536 mgper 0.24 ozDSLD:273726
BioSteelBioSteel Sports Hydration Mixed Berry536 mgper 0.24 ozDSLD:273727
BioSteelWhey Protein Isolate Chocolate2,899 mgper 32 Gram(s)DSLD:30990
BioSteelWhey Protein Isolate Vanilla2,899 mgper 32 Gram(s)DSLD:30993
Biotics Research CorporationAmino Sport89 mgper 3 Capsule(s)DSLD:21470
BioTrustBCAA Matrix75 mgper 4 Veggie Capsule(s)DSLD:64579
BIOVEABCAA800 mgper 8 Vegetarian Capsule(s)DSLD:248957
BIOVEABCAA250 mgper 2 Capsule(s)DSLD:45523
BIOVEA Natural FoodsSilk Brown Rice Protein1,050 mgper 4 TbspDSLD:65970
Blackstone LabsBCAA Resurgence Kiwi Strawberry1.25 Gram(s)per 7 Gram(s)DSLD:219494
Blackstone LabsBCAA Resurgence Orange1.25 Gram(s)per 7 Gram(s)DSLD:219524
Blackstone LabsBCAA Resurgence Pina Colada1 Gram(s)per 11 Gram(s)DSLD:204827
Body AttackBCAA 6000 mg + L-Glutamine 6000 mg1,500 mgper 5 Capsule(s)DSLD:329538
Body AttackExtreme Instant EAA Blackberry FlavourBranched chain amino acid1,229 mgper 14 Gram(s)DSLD:329555
Body AttackExtreme Instant EAA Cherry FlavourBranched chain amino acid1,229 mgper 14 Gram(s)DSLD:334227
Body AttackExtreme Instant EAA Ice Tea Lemon FlavourBranched chain amino acid1,229 mgper 14 Gram(s)DSLD:334229
Body AttackExtreme Instant EAA Watermelon FlavourBranched chain amino acid1,229 mgper 14 Gram(s)DSLD:334233
Body Attack Sports Nutrition100% Whey Protein ApfelstrudelBCAA, Amino Acid Profile6.12 Gram(s)per 30 Gram(s)DSLD:329523
Body Attack Sports NutritionExtreme Instant BCAA Mojito Flavour2,500 mgper 13 Gram(s)DSLD:335171
Body Attack Sports NutritionPower Protein 90 Apricot-Maracuya Flavouradded substances0.15 Gram(s)per 30 Gram(s)DSLD:337737
Body Attack Sports NutritionPower Protein 90 Banana Flavouradded substances0.15 Gram(s)per 30 Gram(s)DSLD:337738
Body Attack Sports NutritionPower Protein 90 Blueberry-Yoghurt Creamadded substances0.25 Gram(s)per 30 Gram(s)DSLD:334252
Body Attack Sports NutritionPower Protein 90 Coconut Creamadded substances0.15 Gram(s)per 30 Gram(s)DSLD:334253
Body FortressBCAA 2200500 mgper 4 Softgel(s)DSLD:19307
Body FortressBCAA Tri-Amino Complex250 mgper 2 Softgel(s)DSLD:21343
Body KitchenHydrolyzed Protein Collagen Decadent Chocolate0.28 Gram(s)per 22 Gram(s)DSLD:241118
Bodybuilding.com Foundation SeriesBCAA Powder1.25 Gram(s)per 5 Gram(s)DSLD:199880
Bodybuilding.com Platinum SeriesAMP'D Recovery Blue Raspberry750 mgper 7.6 Gram(s)DSLD:175305
Bodybuilding.com Platinum SeriesAMP'D Recovery Orange Mango750 mgper 7.3 Gram(s)DSLD:175311
Bodybuilding.com Platinum SeriesAMP'D Recovery Watermelon750 mgper 7.8 Gram(s)DSLD:175314
Bodybuilding.com Platinum SeriesPost Protocol Black Cherry2 Gram(s)per 23 Gram(s)DSLD:64288
Bodybuilding.com Platinum SeriesPost Protocol Fruit Punch2 Gram(s)per 22 Gram(s)DSLD:64287
Bodybuilding.com SignatureAmino Plus Energy Blueberry Lemonade1 Gram(s)per 10 Gram(s)DSLD:202969
Bodybuilding.com SignatureAmino Plus Energy Tropical Pineapple1 Gram(s)per 11 Gram(s)DSLD:203201
Bodybuilding.com SignatureAmino Plus Energy Watermelon Lime1 Gram(s)per 10 Gram(s)DSLD:203202
Bodybuilding.com SignatureBCAA Blue Raspberry1 Gram(s)per 7.4 Gram(s)DSLD:199994
Bodybuilding.com SignatureBCAA Blueberry Lemonade1 Gram(s)per 8 Gram(s)DSLD:203204
Bodybuilding.com SignatureBCAA Cherry Limeade1 Gram(s)per 7.4 Gram(s)DSLD:199996
Bodybuilding.com SignatureBCAA Fruit Punch1 Gram(s)per 7.1 Gram(s)DSLD:200053
Bodybuilding.com SignatureBCAA Tropical Pineapple1 Gram(s)per 8 Gram(s)DSLD:203205
Bodybuilding.com SignatureBCAA Watermelon Lime1 Gram(s)per 8 Gram(s)DSLD:200054
BodyLogixNatural BCAA Green Applefermented from vegan sources1,250 mgper 8.2 Gram(s)DSLD:314859
BodyTechBCAAL-Isoleucine Note: free form amino acid600 mgper 3 Capsule(s)DSLD:204648
BodyTechBCAAL-Isoleucine Note: free form amino acid600 mgper 3 Capsule(s)DSLD:245180
BodyTechBCAAL-Isoleucine Note: free form amino acid600 mgper 3 Capsule(s)DSLD:64693
BodyTechBCAA + Glutamine UnflavoredL-Isoleucine Note: free form amino acid1 Gram(s)per 6.9 Gram(s)DSLD:183485
BodyTechBCAA + Glutamine UnflavoredL-Isoleucine Note: free form amino acid1 Gram(s)per 6.9 Gram(s)DSLD:183487
BodyTechBCAA UnflavoredL-Isoleucine Note: free form amino acid1.25 Gram(s)per 5 Gram(s)DSLD:64732
BodyTechCritical Aminos XT Blue Ice Pop625 mgper 7.8 Gram(s)DSLD:184597
BodyTechCritical Aminos XT Fruit Punch625 mgper 10 Gram(s)DSLD:183762
BodyTechCritical Aminos XT Grape625 mgper 7.1 Gram(s)DSLD:183639
BodyTechCritical Aminos XT Pineapple625 mgper 7.4 Gram(s)DSLD:183663
BodyTechCritical Aminos XT Sweet Tea625 mgper 7.3 Gram(s)DSLD:184033
BodyTechCritical Aminos XT Watermelon625 mgper 10.1 Gram(s)DSLD:184323
BodyTechInstantized BCAA Fruit Punch1.25 Gram(s)per 7.3 Gram(s)DSLD:184319
BodyTechInstantized BCAA UnflavoredL-Isoleucine Note: free form amino acid1.25 Gram(s)per 5.6 Gram(s)DSLD:245230
BodyTech EliteUltimate BCAA Fruit Punch1,750 mgper 15.5 Gram(s)DSLD:204853
BodyTech EliteUltimate BCAA Grape1,750 mgper 15.6 Gram(s)DSLD:204862
BodyTech EliteUltimate BCAA Strawberry Kiwi1,750 mgper 15.6 Gram(s)DSLD:204916
BodyTech EliteUltimate BCAA Watermelon Candy1,750 mgper 15.6 Gram(s)DSLD:204855
BodyTech EliteUltimate EAA Fruit Punch1,500 mgper 14.7 Gram(s)DSLD:208824
BodyTech EliteUltimate EAA Grape1,500 mgper 15 Gram(s)DSLD:208744
BPI SportsBulk Muscle Chocolate Peanut ButterL-Isoleucine Note: naturally occurring from protein1.4 Gram(s)per 168 Gram(s)DSLD:43309
BPI SportsBulk Muscle Cookies and CreamL-Isoleucine Note: from protein complex matrix1.75 Gram(s)per 165 Gram(s)DSLD:41630
BPI SportsBulk Muscle Cookies and CreamL-Isoleucine Note: naturally occurring from protein1.4 Gram(s)per 168 Gram(s)DSLD:43304
BPI SportsBulk Muscle Whipped VanillaL-Isoleucine Note: naturally occurring from protein1.4 Gram(s)per 165 Gram(s)DSLD:43310
Bricker LabsAmino Supreme132 mgper 5 Tablet(s)DSLD:3182
BronsonAmino Acid ComplexIsoleucine Note: Essential Amino Acids55 mgper 1 Tablet(s)DSLD:8461
Bronson LaboratoriesAll Insurance Vitamin Powder40 mgper 8.76 Gram(s)DSLD:25265
Bucked UpOriginal BCAA 2:1:1 Apple Jacked1,500 mgper 10.67 Gram(s)DSLD:269121
Bucked UpRacked Branched Chain Amino Acids Grape1,000 mgper 10.84 Gram(s)DSLD:269524
BulkSupplements.comBCAA 2:1:1440 mgper 2000 mgDSLD:252404
BulkSupplements.comBCAA 2:1:1375 mgper 3 Vegetarian Capsule(s)DSLD:252414
BulkSupplements.comBCAA 2:1:1440 mgper 4 Capsule(s)DSLD:253383
BulkSupplements.comBCAA 2:1:1440 mgper 2000 mgDSLD:253390
BulkSupplements.comBCAA 2:1:1440 mgper 4 Capsule(s)DSLD:253409
BulkSupplements.comBCAA 2:1:1375 mgper 3 Capsule(s)DSLD:253425
BulkSupplements.comBCAA 2:1:1500 mgper 4 Capsule(s)DSLD:295062
BulkSupplements.comBCAA 2:1:1500 mgper 2000 mgDSLD:295063
BulkSupplements.comBCAA 2:1:1500 mgper 2000 mgDSLD:295065
BulkSupplements.comBCAA 2:1:1500 mgper 2000 mgDSLD:295066
BulkSupplements.comBCAA 2:1:11,500 mgper 6000 mgDSLD:310663
BulkSupplements.comBCAA 2:1:11,500 mgper 6000 mgDSLD:310962
BulkSupplements.comBCAA 2:1:11,500 mgper 6000 mgDSLD:310963
BulkSupplements.comBCAA 2:1:11,500 mgper 6000 mgDSLD:310964
BulkSupplements.comBCAA 2:1:1500 mgper 4 Capsule(s)DSLD:310965
BulkSupplements.comBCAA 2:1:1500 mgper 4 Capsule(s)DSLD:310966
BulkSupplements.comBCAA 2:1:1 1000 mg250 mgper 2 Capsule(s)DSLD:310664
BulkSupplements.comBCAA 3:1:2250 mgper 1500 mgDSLD:252409
BulkSupplements.comBCAA 3:1:2250 mgper 1500 mgDSLD:253415
BulkSupplements.comBCAA 3:1:2250 mgper 1500 mgDSLD:253419
BulkSupplements.comBCAA 3:1:2250 mgper 1500 mgDSLD:253423
BulkSupplements.comBCAA 3:1:2250 mgper 1500 mgDSLD:310967
BulkSupplements.comBCAA 3:1:2250 mgper 1500 mgDSLD:310968
BulkSupplements.comBCAA 3:1:2250 mgper 1500 mgDSLD:310969
BulkSupplements.comBCAA 3:1:2250 mgper 1500 mgDSLD:310970
BulkSupplements.comBCAA 3:1:2 Powder 1500 mg250 mgper 1500 mgDSLD:330319
BulkSupplements.comBCAA 3:1:2 Powder 1500 mg250 mgper 1500 mgDSLD:330320
BulkSupplements.comBCAA 3:1:2 Powder 1500 mg250 mgper 1500 mgDSLD:330321
BulkSupplements.comL-Isoleucine1,000 mgper 1000 mgDSLD:252779
BulkSupplements.comL-Isoleucine1,000 mgper 1000 mgDSLD:254536
BulkSupplements.comL-Isoleucine1,000 mgper 1000 mgDSLD:254538
BulkSupplements.comL-Isoleucine1,000 mgper 1000 mgDSLD:254529
BulkSupplements.comL-Isoleucine1,000 mgper 1000 mgDSLD:312173
BulkSupplements.comL-Isoleucine1,000 mgper 1000 mgDSLD:312174
BulkSupplements.comL-Isoleucine1,000 mgper 1000 mgDSLD:312175
BulkSupplements.comL-Isoleucine1,000 mgper 1000 mgDSLD:312176
California Academy of HealthWhey Protein Gold Isolate Plus Natural Chocolate Flavor1,458 mgper 44 Gram(s)DSLD:191162
California Academy of HealthWhey Protein Gold Isolate Plus Natural Vanilla Flavor1,668 mgper 6 TbspDSLD:197375
California Gold Nutrition SPORTBCAA fermented1.25 Gram(s)per 5 Gram(s)DSLD:299579
CellucorCOR-Performance B-BCAA Lemon-Lime1.25 gper 11.4 Gram(s)DSLD:18927
CellucorCOR-Performance B-BCAA Lemon-Lime1.25 Gram(s)per 9 Gram(s)DSLD:82876
CellucorCOR-Performance B-BCAA Tropical Punch1.25 gper 11.3 Gram(s)DSLD:18929
CellucorCOR-Performance B-BCAA Tropical Punch1.25 Gram(s)per 9 Gram(s)DSLD:82880
CellucorCOR-Performance B-BCAA Watermelon1.25 gper 11.5 Gram(s)DSLD:18928
CellucorCOR-Performance B-BCAA Watermelon1.25 Gram(s)per 9 Gram(s)DSLD:82881
CellucorCOR-Performance BCAA 2:1:1 Cherry Limeade1.5 Gram(s)per 8.5 Gram(s)DSLD:82885
CellucorCOR-Performance BCAA 2:1:1 Cherry Limeade1.5 Gram(s)per 8.5 Gram(s)DSLD:82886
CellucorCOR-Performance BCAA 2:1:1 Icy Blue Razz1.5 Gram(s)per 8.5 Gram(s)DSLD:82882
CellucorCor-Performance Beta-BCAA1.25 gper 11.4 Gram(s)DSLD:18971
Clean MachineClean BCAA Fruit Punch1,000 mgper 7.2 Gram(s)DSLD:307873
Clean MachineClean BCAA Lemonade1,000 mgper 7.4 Gram(s)DSLD:307874
Clean MachineClean BCAA Watermelon1,000 mgper 7.6 Gram(s)DSLD:307875
Combat NutraBattle Buddy Fruit Punch1,000 mgper 6.5 Gram(s)DSLD:249643
Country LifeIron Tek Hydro Recovery Coconut flavorL-Isoleucine Note: vegan250 mgper 4.9 Gram(s)DSLD:79109
Country LifeIron Tek Hydro Recovery Coconut FlavorL-Isoleucine Note: vegan250 mgper 4.9 Gram(s)DSLD:79099
Country LifeMax-Amino Caps with Vitamin B6L-Isoleucine Note: free form amino acid130 mgper 4 Capsule(s)DSLD:208012
Country LifeMax-Amino Caps with Vitamin B6L-Isoleucine Note: free form amino acid130 mgper 4 Capsule(s)DSLD:208016
CrazyBulkD-Bal300 mgper 3 Capsule(s)DSLD:255127
Creative BiosciencePure BCAA Unflavored1,000 mgper 5.2 Gram(s)DSLD:79179
CymbiotikaPure Hydration Lemon Citrus75 mgper 8 Gram(s)DSLD:304740
CymbiotikaPure Hydration Lychee75 mgper 8 Gram(s)DSLD:304739
CymbiotikaPure Hydration Watermelon75 mgper 8 Gram(s)DSLD:304293
D.Bal.MaxD.Bal.Max100 mgper 3 Capsule(s)DSLD:268023
DaVinci LaboratoriesAmino 217.5 mgper 1 Capsule(s)DSLD:322151
DCFree-Form AminosL-Isoleucine Note: (Essential Amino Acid) (Branched Chain Amino Acid)18 mgper 1 Tablet(s)DSLD:245133
Designs for HealthAmino Acid Synergy270 mgper 4 Capsule(s)DSLD:22323
Do VitaminsBCAAL-Isoleucine (Alt. Name: AjiPure)525 mgper 1 Capsule(s)DSLD:269487
Do VitaminsBCAA Powder UnflavoredAjiPure1,250 mgper 5 Gram(s)DSLD:269497
Do VitaminsPostPump UnflavoredL-Isoleucine (Alt. Name: AjiPure)750 mgper 7.75 Gram(s)DSLD:269521
Do VitaminsPurePump LemonAjiPure250 mgper 4.48 Gram(s)DSLD:269537
Do VitaminsPurePump UnflavoredAjiPure250 mgper 3.8 Gram(s)DSLD:269534
Double Wood SupplementsEssential Amino Acids115 mgper 3 Capsule(s)DSLD:241772
Douglas LaboratoriesAmino Gram ForteL-Isoleucine Note: One of 10 essential Amino Acids.59 mgper 1 Tablet(s)DSLD:57724
Douglas LaboratoriesBranched Chain Amino Acid150 mgper 1 Capsule(s)DSLD:5380
Douglas LaboratoriesBranched Chain Amino Acids150 mgper 1 Capsule(s)DSLD:8825
Douglas LaboratoriesL-Isoleucine 500 mg500 mgper 1 Capsule(s)DSLD:9242
Douglas LaboratoriesPro-Shake 19 Natural Vanilla Protein Powder403 mgper 15 Gram(s)DSLD:9404
Douglas LaboratoriesUltra Anabolic82 mgper 1 Capsule(s)DSLD:8361
Douglas LaboratoriesUltra Protein Plus Natural Vanilla Bean Flavor830 mgper 31.6 Gram(s)DSLD:30694
Dr. Clark Research Association Dr. Clark ZentrumBranch Chained Amino Acids 500 mg750 mgper 6 Capsule(s)DSLD:223141
Dr. Clark Research Association Dr. Clark ZentrumEssential Amino Acids 500 mg348 mgper 6 Capsule(s)DSLD:223131
Dr. Rico PerezAmino Complex24 mgper 1 Capsule(s)DSLD:321008
Drucker LabsintraMAX 2.0 Peach Mango Flavoramount not statedper 1 fl. Oz.DSLD:236722
DymatizeBCAAs Blue Raspberry1.2 Gram(s)per 9 Gram(s)DSLD:83002
DymatizeBCAAs Cherry Limeade1.2 Gram(s)per 9 Gram(s)DSLD:83005
DymatizeBCAAs Watermelon1.2 Gram(s)per 9 Gram(s)DSLD:83009
Dymatize NutritionBCAA Complex 5050 Branched Chain Amino Acids Pink Lemonade1.26 Gram(s)per 9 Gram(s)DSLD:53042
EAEnhanced EAA + Blood Orange2,000 mgper 7.6 Gram(s)DSLD:321428
EA EnhancedAnabolic IV Tropical2,000 mgper 7.6 Gram(s)DSLD:223079
Enriching GiftsAmino Acids22 mgper 2 Capsule(s)DSLD:228176
EquatePost Workout Fruit Punch1.2 Gram(s)per 7.8 Gram(s)DSLD:272969
EquipPure Pre Blackberry Lemon425 mgper 19.2 Gram(s)DSLD:332846
Everyday DoseMushroom Coffee+71 mgper 7 Gram(s)DSLD:315153
Everyday DoseMushroom Matcha+76 mgper 7 Gram(s)DSLD:317537
Evlution NutritionBCAA 1000250 mgper 2 Capsule(s)DSLD:326366
Evlution NutritionBCAA 5000 Cherry Limeade1,250 mgper 8.3 Gram(s)DSLD:302086
Evlution NutritionBCAA 5000 Fruit Punch1,250 mgper 8.1 Gram(s)DSLD:326367
Evlution NutritionBCAA 5000 Furious Grape1,250 mgper 8.6 Gram(s)DSLD:326368
Evlution NutritionBCAA 5000 Lemon Lime1,250 mgper 8.6 Gram(s)DSLD:302087
Evlution NutritionBCAA 5000 Unflavored1,250 mgper 5 Gram(s)DSLD:302062
Evlution NutritionBCAA 5000 Unflavored1,250 mgper 5 Gram(s)DSLD:326369
Evlution NutritionBCAA50001,250 mgper 8 Capsule(s)DSLD:302061
Evlution NutritionBCAA5000 Blue Raz1,250 mgper 8 Gram(s)DSLD:302085
Evlution NutritionLeanBCAA Fruit Punch1,250 mgper 7.9 Gram(s)DSLD:302122
EvogenAmino K.E.M.750 mgper 5 Tablet(s)DSLD:300193
Fahrenheit NutritionEndurance BCAA Plus1.8 gper 13.5 Gram(s)DSLD:19244
FINAFLEXEAA Psycho Peach1,250 mgper 13.4 Gram(s)DSLD:333668
FitLinePROSHAPE (Amino)11.62%400 mgper 6 Capsule(s)DSLD:321599
FN Formutech NutritionEndurance BCAA+ Melon1.8 Gram(s)per 14.47 Gram(s)DSLD:261044
FN Formutech NutritionEndurance BCAA+ Orange1.8 Gram(s)per 14.47 Gram(s)DSLD:261045
FN Formutech NutritionEndurance BCAA+ Sweet Tea1.8 Gram(s)per 15 Gram(s)DSLD:259061
FoodScience of VermontAmino Max 217.5 mgper 1 Capsule(s)DSLD:74925
G GainfulGainful Pre-Workout Sour Watermelon500 mgper 10 Gram(s)DSLD:252036
G6 SportsMass Pro ChocolateL-Isoleucine3,379 mgper 219 Gram(s)DSLD:269036
G6 SportsMass Pro High Protein Mass Gainer ChocolateL-Isoleucine3,379 mgper 219 Gram(s)DSLD:267987
G6 SportsMass Pro High Protein Mass Gainer VanillaL-Isoleucine3,454 mgper 43.8 Gram(s)DSLD:269280
G6 SportsMass Pro VanillaL-Isoleucine3,454 mgper 219 Gram(s)DSLD:269038
G6 SportsReplenish Orange Mangofrom natural and artificial sources1,478 mgper 55.3 Gram(s)DSLD:269005
Garden of LifeRaw Organic Fit Chocolate FlavorEssential Amino Acids, branched Chain Amino Acids1,340 mgper 45.5 Gram(s)DSLD:297638
Gaspari NutritionBCAA 60001,000 mgper 6 Tablet(s)DSLD:228168
Gaspari NutritionBCAA 60001,000 mgper 6 Tablet(s)DSLD:80189
GAT SportJetMASS Strawberry Lemonade250 mgper 23.6 Gram(s)DSLD:276597
GenesaTotal Amino SolutionL-Isoleucine · Isoleucine (Form: as L-Isoleucine)90 mgper 3 Vegi-Capsule(s)DSLD:205996
GNC AMP Advanced Muscle PerformanceMega Men Sport MultivitaminL-Isoleucine50 mgper 2 Mocha Brown Timed-Release Caplet(s)DSLD:312637
GNC AMP Advanced Muscle PerformanceMega Men Sport Multivitamin50 mgper 2 Mocha Brown Caplet(s)DSLD:312702
GNC AMP Advanced Muscle PerformanceMega Men Sport Multivitamin50 mgper 2 Mocha Brown Caplet(s)DSLD:317645
GNC AMP Advanced Muscle PerformanceWheybolic Chocolate FudgeL-Isoleucine, Micronized · Isoleucine (Form: from Whey Protein isolate, hydrolyzed Whey Protein, micronized L-Isoleucine)2.5 Gram(s)per 62.5 Gram(s)DSLD:220074
GNC AMP Advanced Muscle PerformanceWheybolic Chocolate FudgeL-Isoleucine, Micronized · Isoleucine (Form: from Whey Protein isolate, hydrolyzed Whey Protein, micronized L-Isoleucine)2.5 Gram(s)per 62.5 Gram(s)DSLD:243050
GNC AMP Advanced Muscle PerformanceWheybolic Classic VanillaL-Isoleucine, Micronized · L-Isoleucine (Form: from Whey Protein Isolate, hydrolyzed Whey Protein, micronized L-Isoleucine)1.25 Gram(s)per 61.5 Gram(s)DSLD:228524
GNC Beyond RawmTOR Matrix200 mgper 2 White Capsule(s)DSLD:63771
GNC Beyond RawPrecision Amino Crisp Apple2 Gram(s)per 20.6 Gram(s)DSLD:330844
GNC Beyond RawPrecision Amino Gummy Worm2 Gram(s)per 21.83 Gram(s)DSLD:327389
GNC Beyond RawPrecision Amino Peach Mango Tea2 Gram(s)per 21.43 Gram(s)DSLD:330845
GNC Mega MenSport Multivitamin50 mgper 2 Caplet(s)DSLD:334082
GNC Mega MenSport Multivitamin50 mgper 2 Caplet(s)DSLD:334083
GNC MilestonesMuscle Function Complex175 mgper 2 White Capsule(s)DSLD:65755
GNC Pro PerformanceAmino Complex 4400700 mgper 8 Capsule(s)DSLD:2715
GNC Pro PerformanceBCAA 1800630 mgper 6 Capsule(s)DSLD:74854
GNC Pro PerformanceBCAA 1800 mg630 mgper 6 Capsule(s)DSLD:309076
GNC Pro PerformanceBCAA 1800 mg630 mgper 6 Capsule(s)DSLD:315320
GNC Pro PerformanceBCAA Complex Chew Tropical Punch350 mgper 2 Chew(s)DSLD:74828
GNC Pro PerformanceBCAA Unflavored1,000 mgper 5.3 Gram(s)DSLD:78476
GNC Pro PerformanceHybrid Creatine Complex Fruit Punch250 mgper 48.17 Gram(s)DSLD:25606
GNC Pro PerformanceHybrid Creatine Complex Unflavored250 mgper 48.64 Gram(s)DSLD:27358
GNC Pro PerformanceNighttime Restore50 mgper 2 White Capsule(s)DSLD:30570
GNC Pro PerformanceRapidDrive BCAA 5000 Fruit Punch1,000 mgper 7 Gram(s)DSLD:66893
GNC Pro PerformanceRapidDrive BCAA 5000 Unflavored1,000 mgper 5.3 Gram(s)DSLD:2719
GNC Pro PerformanceRapidDrive Post-Workout Amino Complex Fruit Punch1,800 mgper 17 Gram(s)DSLD:2723
GNC Pro PerformanceRapidDrive Pre-Workout Amino Complex Fruit Punch1,000 mgper 15.5 Gram(s)DSLD:2722
GNC Pro PerformanceUltra Amino Complex Fruit Punch1,200 mgper 14.07 Gram(s)DSLD:16385
GNC Pro PerformanceUltra Amino Complex Fruit Punch1.2 Gram(s)per 14.07 Gram(s)DSLD:207201
GNC Pro PerformanceUltra Amino Complex Watermelon1,200 mgper 13.98 Gram(s)DSLD:25704
GNC Pro PerformanceXR Series BCAA Advanced XR Berry Fusion2 Gram(s)per 10.6 Gram(s)DSLD:74587
GNC Pro Performance AMPAmplified Endurance Booster Blue Raspberry125 mgper 60 Gram(s)DSLD:18529
GNC Pro Performance AMPAmplified Endurance Booster Blue Raspberry125 mgper 60 Gram(s)DSLD:5862
GNC Pro Performance AMPAmplified Endurance Booster Orange125 mgper 61 Gram(s)DSLD:5864
GNC Pro Performance AMPAmplified Push Blue RaspberryL-Isoleucine · Isoleucine (Form: as L-Isoleucine, Whey Protein isolate)1.5 Gram(s)per 16.25 Gram(s)DSLD:48182
GNC Pro Performance AMPMuscle Function Formula50 mgper 2 Capsule(s)DSLD:45115
GNC Pro Performance AMPWomen's Advanced Protein Chocolate CupcakeWhey Protein Concentrate · Isoleucine (Form: as Whey Protein concentrate, Whey Protein isolate)850 mgper 26.5 Gram(s)DSLD:70292
GNC Pro Performance AMPWomen's Advanced Protein Cinnamon BunWhey Protein Concentrate · Isoleucine (Form: as Whey Protein concentrate, Whey Protein isolate)850 mgper 25.3 Gram(s)DSLD:69507
GNC Pro Performance AMPWomen's Advanced Protein Vanilla Ice CreamWhey Protein Concentrate · Isoleucine (Form: as Whey Protein concentrate, Whey Protein isolate)850 mgper 26.5 Gram(s)DSLD:74605
GNC Women'sAdvanced Collagen Formula8 mgper 1 Capsule(s)DSLD:79168
Gorilla MindGorilla Mode EAAS Jungle Juice2,000 mgper 14.1 Gram(s)DSLD:301117
Gorilla MindGorilla Mode EAAS Lemon Lime2,000 mgper 14.1 Gram(s)DSLD:274368
GPS Genesis Pure SportsPro-Arginine250 mgper 1 Level Scoop(s)DSLD:70413
Great Lakes Gelatin Co.Collagen Hydrolysate Apple + Cucumber FlavoredIsoleucine Note: Essential amino acids144 mgper 13 Gram(s)DSLD:230087
GymFloOvercome Candy Tart2.5 Gram(s)per 31.5 Gram(s)DSLD:208721
Hard RhinoBCAA 2:1:1 1200 mg300 mgper 2 Capsule(s)DSLD:71752
Hard RhinoBCAA 2:1:1 3000 mg750 mgper 5 Capsule(s)DSLD:71750
Hard RhinoInstantized BCAA 2:1:11,250 mgper 5 Gram(s)DSLD:71762
Hard RhinoInstantized BCAA 2:1:11,250 mgper 5 Gram(s)DSLD:71754
Hard RhinoInstantized BCAA 2:1:11,250 mgper 5 Gram(s)DSLD:71860
Hard RhinoInstantized BCAA 2:1:1 Blue Raspberry1,250 mgper 6.56 Gram(s)DSLD:71759
Hard RhinoInstantized BCAA 2:1:1 Blue Raspberry1,250 mgper 6.56 Gram(s)DSLD:71763
Hard RhinoInstantized BCAA 2:1:1 Fruit Punch1,250 mgper 6.285 Gram(s)DSLD:71760
Hard RhinoInstantized BCAA 2:1:1 Fruit Punch1,250 mgper 6.285 Gram(s)DSLD:71764
HARD RHINOPure BCAA 2:1:1 Instant Grade Powder1,250 mgper 10 Gram(s)DSLD:34279
Healthy 'N FitAnabolic Amino BCAA1,346 mgper 3 Caplet(s)DSLD:262210
Highland LaboratoriesMuscle Dynamics50 mgper 11 Gram(s)DSLD:80034
Hollywood SuppsBranched Chain-Amino CapsulesL-Isoleucine Note: free form800 mgper 4 Capsule(s)DSLD:199730
HTLTWhey Protein Vanilla Peanut Butter1,458 mgper 32 Gram(s)DSLD:265454
IMSOALPHAAlpha Carb Fruit Punch1,000 mgper 33 Gram(s)DSLD:216984
IMSOALPHABCAA Grape1,000 mgper 6.5 Gram(s)DSLD:256162
IMSOALPHABCAA Lemon Lime1,000 mgper 6.5 Gram(s)DSLD:256180
IMSOALPHABCAA Watermelon1,000 mgper 6.5 Gram(s)DSLD:256183
Infinite LabsBCAA750 mgper 6 Capsule(s)DSLD:42412
Integrative TherapeuticsMercury Detox200 mgper 2 Capsule(s)DSLD:77926
InterActive NutritionBCAA Muscle Guard676 mgper 4 Capsule(s)DSLD:2438
Irwin NaturalsTriple Shredder Body-Shaper250 mgper 3 Liquid Soft-Gel(s)DSLD:239454
Irwin NaturalsTriple Shredder Body-Shaper100 mgper 3 Liquid Softgel(s)DSLD:292098
Jacked Factory Essential SeriesBCAA 6000 mg Fruit Punch1,500 mgper 8.5 Gram(s)DSLD:257522
Jacked Factory Essential SeriesBCAA 6000 mg Unflavored1,500 mgper 6 Gram(s)DSLD:261411
JayLab ProBCAA400 mgper 2 Capsule(s)DSLD:221025
JJJ DistributorsKH-623.83 mgper 6 Tablet(s)DSLD:26749
Julian BakeryPegan Thin Seed Protein 20 g Triple Chocolatebranched chain amino acid, essential amino acids1,000 mgper 44 Gram(s)DSLD:296710
JYMPre JYM Cherry Limeade1.5 Gram(s)per 26.5 Gram(s)DSLD:207898
JYMPre JYM Orange Mango1.5 Gram(s)per 26.5 Gram(s)DSLD:207840
JYMPre JYM Raspberry Lemonade1.5 Gram(s)per 26.5 Gram(s)DSLD:207893
JYMPre JYM Raspberry Lemonade1.5 Gram(s)per 26.5 Gram(s)DSLD:207901
JYM Supplement ScienceBCAAs Grape Candy1.5 Gram(s)per 9 Gram(s)DSLD:286241
JYM Supplement ScienceBCAAs Green Apple1.5 Gram(s)per 9 Gram(s)DSLD:287322
JYM Supplement SciencePost JYM BCAAs+ Recovery Matrix Blue Arctic Freeze1.2 Gram(s)per 21 Gram(s)DSLD:216080
JYM Supplement SciencePost JYM BCAAs+ Recovery Matrix Fruit Punch1.2 Gram(s)per 21 Gram(s)DSLD:334773
JYM Supplement SciencePost JYM BCAAs+ Recovery Matrix Rainbow Sherbet1.2 Gram(s)per 19 Gram(s)DSLD:334774
JYM Supplement SciencePre JYM Black Cherry1.5 Gram(s)per 26 Gram(s)DSLD:286244
JYM Supplement SciencePre JYM Cherry Limeade1.5 Gram(s)per 13 Gram(s)DSLD:334771
JYM Supplement SciencePre JYM Grape Candy1.5 Gram(s)per 25 Gram(s)DSLD:286245
JYM Supplement SciencePre JYM High-Performance Pre-Workout Rainbow Sherbet1.5 Gram(s)per 27 Gram(s)DSLD:286247
JYM Supplement SciencePre JYM Natural Island Punch1.5 Gram(s)per 26 Gram(s)DSLD:252280
JYM Supplement SciencePre JYM Natural Island Punch1.5 Gram(s)per 26 Gram(s)DSLD:74216
JYM Supplement SciencePre JYM Pineapple Strawberry1.5 Gram(s)per 13 Gram(s)DSLD:217574
JYM Supplement SciencePre JYM Pineapple Strawberry1.5 Gram(s)per 26 Gram(s)DSLD:286246
JYM Supplement SciencePre JYM Pink Lemonade1.5 Gram(s)per 12.5 Gram(s)DSLD:217569
JYM Supplement SciencePre JYM Pink Lemonade1.5 Gram(s)per 12.5 Gram(s)DSLD:335180
JYM Supplement SciencePre JYM Rainbow Sherbet1.5 Gram(s)per 13.5 Gram(s)DSLD:217595
JYM Supplement SciencePre JYM Refreshing Melon1.5 Gram(s)per 13 Gram(s)DSLD:217815
JYM Supplement SciencePre JYM Refreshing Melon1.5 Gram(s)per 26 Gram(s)DSLD:252281
JYM Supplement SciencePre JYM Strawberry Kiwi1.5 Gram(s)per 13 Gram(s)DSLD:217814
JYM Supplement SciencePre JYM Strawberry Kiwi1.5 Gram(s)per 13 Gram(s)DSLD:286248
JYM Supplement SciencePre JYM Tangerine1.5 Gram(s)per 25 Gram(s)DSLD:286249
JYM Supplement SciencePre JYM Tangerine1.5 Gram(s)per 25 Gram(s)DSLD:312646
KagedBCAA 2:1:1 Unflavoredfermented1.25 Gram(s)per 5.5 Gram(s)DSLD:298709
Kaged MuscleBCAA 2:1:1 UnflavoredL-Isoleucine Note: fermented1.25 Gram(s)per 5.5 Gram(s)DSLD:202108
Kaged MuscleBCAA 2:1:1 UnflavoredL-Isoleucine Note: fermented1.25 Gram(s)per 5.5 Gram(s)DSLD:202136
KionAminos550 mgper 7 Capsule(s)DSLD:307219
KirkmanAmino Support Powder240 mgper 1 tspDSLD:23882
Klean AthleteKlean BCAA + Peak ATP Orange Flavor1 Gram(s)per 8.6 Gram(s)DSLD:293246
Lake Avenue NutritionBranched-Chain Amino AcidsFree-form650 mgper 4 Veggie Capsule(s)DSLD:272298
Lake Avenue NutritionInstantized BCAA Unflavored1.25 Gram(s)per 5.3 Gram(s)DSLD:272385
Lake Avenue NutritionInstantized BCAA Unflavored1.25 Gram(s)per 5 Gram(s)DSLD:319371
Leading Edge HealthGenFX2.86 mgper 1 Capsule(s)DSLD:336110
Leading Edge HealthHyperGH 14x160 mgper 2 Tablet(s)DSLD:339437
Lee Haney's Nutritional Support SystemsCompetitive MassWhey Protein1,356 mgper 65 Gram(s)DSLD:12990
Life ExtensionBranched Chain Amino Acids (Free Form)600 mgper 4 Capsule(s)DSLD:231773
Life ExtensionBranched Chain Amino Acids (Free Form)600 mgper 4 Capsule(s)DSLD:328302
Lifestyle Fitness & NutritionBCAA Force Branched Chain Amino Acids400 mgper 2 Capsule(s)DSLD:16965
LiveGoodEssential Aminos Delicious Fruit Punch Flavor450 mgper 10.14 Gram(s)DSLD:339347
MacroLife NaturalsMacroMeal Ultimate ChocolateEssential amino acids653 mgper 45 Gram(s)DSLD:295312
MacroLife NaturalsMacroMeal Ultimate Chocolateessential amino acids1,306 mgper 22.5 Gram(s)DSLD:295313
MacroLife NaturalsMacroMeal Ultimate Chocolate Protein PowderAmino acids, essential amino acidsamount not statedper 45 Gram(s)DSLD:288254
MacroLife NaturalsMacroMeal Ultimate Chocolate Protein PowderAmino acids, essential amino acidsamount not statedper 22.5 Gram(s)DSLD:293340
MacroLife NaturalsMacroMeal Ultimate Chocolate Protein Powderessential amino acidsamount not statedper 22.5 Gram(s)DSLD:293341
MacroLife NaturalsMacroMeal Ultimate Chocolate Protein PowderAmino acids, essential amino acidsamount not statedper 22.5 Gram(s)DSLD:293342
MacroLife NaturalsMacroMeal Ultimate VanillaAmino acids, essential amino acidsamount not statedper 40 Gram(s)DSLD:292749
MacroLife NaturalsMacroMeal Ultimate Vanilla Protein PowderAmino acids, essential amino acidsamount not statedper 40 Gram(s)DSLD:288255
MacroLife NaturalsMacroMeal Ultimate Vanilla Protein PowderAmino acids, essential amino acidsamount not statedper 41 Gram(s)DSLD:288256
MacroLife NaturalsMacroMeal Ultimate Vanilla Protein PowderAmino acids, essential amino acids1,455 mgper 40 Gram(s)DSLD:292747
MacroLife NaturalsMacroMeal Ultimate Vanilla Protein PowderAmino acids, essential amino acidsamount not statedper 40 Gram(s)DSLD:292748
MacroLife NaturalsMacroMeal Ultimate Vanilla Protein PowderAmino acids, essential amino acidsamount not statedper 41 Gram(s)DSLD:292755
MacroLife NaturalsMacroMeal Ultimate Vanilla Protein PowderAmino acids, essential amino acids1,275 mgper 41 Gram(s)DSLD:292756
MacroLife NaturalsMacroMeal Ultimate Vanilla Protein PowderAmino acids, essential amino acidsamount not statedper 41 Gram(s)DSLD:292757
Market AmericaTorch After-Burn Recovery Drink Creamy Vanilla Flavor250 mgper 43 Gram(s)DSLD:6204
Martin Avenue PharmacyAmino Acids Formula59 mgper 1 Tablet(s)DSLD:18766
Max Effort MusclePre Workout Raspberry Punch250 mgper 12.2 Gram(s)DSLD:240233
MBi NutraceuticalsBio-Aminos166 mgper 2 Capsule(s)DSLD:231378
MET-RxBCAA 2200500 mgper 4 Softgel(s)DSLD:73342
MET-RxBCAA 5000 Blue RaspberryL-Isoleucine Note: 1.25 g1,250 mgper 6.5 Gram(s)DSLD:63881
MET-RxBCAA 5000 UnflavoredL-Isoleucine Note: 1.25 g1,250 mgper 5 Gram(s)DSLD:66278
MET-RxBCAA 5000 WatermelonL-Isoleucine Note: 1.25 g1,250 mgper 6.5 Gram(s)DSLD:64039
MET-RxTimed-Release BCAA 1800400 mgper 2 Caplet(s)DSLD:34121
Metabolic MaintenanceBCAA+ Branched Chain Amino Acids100 mgper 1 Capsule(s)DSLD:24739
MetagenicsBCAAs Orange Mango Flavor1.5 Gram(s)per 7.3 Gram(s)DSLD:295631
MHP Maximum Human PerformanceBCAA 3300550 mgper 4 Tablet(s)DSLD:5717
MillecorAminos Watermelon1,000 mgper 6.5 Gram(s)DSLD:317781
MM Sports NutritionEnduroMAX Natural Lemon Lime Flavor500 mgper 61.7 Gram(s)DSLD:38180
MN Morphogen NutritionVegagen Almond BlissInstAminos · vegan fermented250 mgper 37.5 Gram(s)DSLD:261249
MN Morphogen NutritionVegagen SnickerdoodleInstAminos · vegan fermented250 mgper 38.1 Gram(s)DSLD:261251
MontiffAll- Basic 677 Milligramsamount not statedper 1 Capsule(s)DSLD:42000
MontiffSuper-Sportsamount not statedper 1 Capsule(s)DSLD:237087
MontiffSuper-Sports 750 Milligramsamount not statedper 1 Capsule(s)DSLD:293563
MontiffSuper-Sports 750 Milligramsamount not statedper 1 Capsule(s)DSLD:42099
Moss NutritionAminoSelect320 mgper 1 Capsule(s)DSLD:306480
MRMBCAA+G Green Apple1,000 mgper 6.5 Gram(s)DSLD:178962
MRMBCAA+G RELOAD LemonadeL-Isoleucine Note: fermented1,500 mgper 13.8 Gram(s)DSLD:178976
MRM NutritionBCAA+G 1000 Green Apple Flavoredfermented1,000 mgper 6.5 Gram(s)DSLD:305015
MRM NutritionBCAA+G 1000 Lemonade Flavoredfermented1,000 mgper 6.5 Gram(s)DSLD:319058
MRM NutritionBCAA+G 6,000Fermented1,000 mgper 6 Capsule(s)DSLD:319059
MRM NutritionBCAA+G Lemonade FlavoredFermented1,000 mgper 6.5 Gram(s)DSLD:305017
MRM NutritionBCAA+G RELOAD Island Fusion FlavoredFermented1,000 mgper 12.5 Gram(s)DSLD:319060
MRM NutritionBCAA+G RELOAD Lemonade FlavoredFermented1,000 mgper 12.5 Gram(s)DSLD:319061
MRM NutritionRELOAD BCAA+G Watermelon FlavoredFermented1,000 mgper 12.5 Gram(s)DSLD:319062
MRM NutritionRELOAD BCAA+G Watermelon FlavoredFermented1,000 mgper 12.5 Gram(s)DSLD:319063
Mt. CapraCaproteinIsoleucine Note: Essential amino acids340 mgper 10 Gram(s)DSLD:4743
Mt. CapraDouble Bonded Protein Chocolate1,127 mgper 33.5 Gram(s)DSLD:19314
MTN OPSBCAA Strawberry Dragonfruitamount not statedper 12 Gram(s)DSLD:277540
Muscle FeastAll Natural BCAA 4:1:1 Mango Peachvegan925 mgper 6.6 Gram(s)DSLD:262852
Muscle FeastBCAA 4:1:1 Blue Ice Pop Flavorvegan833 mgper 8.3 Gram(s)DSLD:261355
Muscle FeastBCAA 4:1:1 Green Apple Flavorvegan833 mgper 8.3 Gram(s)DSLD:262851
Muscle FeastBCAA 4:1:1 Tangerine Flavorvegan833 mgper 8.3 Gram(s)DSLD:262853
Muscle FeastBCAA 4:1:1 Unflavoredvegan907 mgper 5.5 Gram(s)DSLD:262854
Muscle FeastBCAA 4:1:1 Watermelon Flavorvegan833 mgper 8.3 Gram(s)DSLD:262855
Musclegen Performance NutritionBCAA Watermelon1,000 mgper 6.5 Gram(s)DSLD:249692
MusclePharmBCAA 3:1:21,000 mgper 6 Capsule(s)DSLD:3713
MusclePharmBCAA 3:1:21,000 mgper 8 Capsule(s)DSLD:82242
MusclePharmBCAA 3:1:2 Blue Raspberry1,000 mgper 7.16 Gram(s)DSLD:38871
MusclePharmBCAA 3:1:2 Watermelon1,000 mgper 7.16 Gram(s)DSLD:38879
MusclePharm MP EssentialsBCAA1 Gram(s)per 8 Capsule(s)DSLD:265419
MusclePharm MP EssentialsBCAA Blue Raspberry1 Gram(s)per 7.5 Gram(s)DSLD:265420
MusclePharm MP EssentialsBCAA Blue Raspberry1 Gram(s)per 7.5 Gram(s)DSLD:267244
MusclePharm MP EssentialsBCAA Fruit Punch1 Gram(s)per 8.6 Gram(s)DSLD:265421
MusclePharm MP EssentialsBCAA Fruit Punch1 Gram(s)per 8.6 Gram(s)DSLD:267253
MusclePharm MP EssentialsBCAA Grape1 Gram(s)per 7.86 Gram(s)DSLD:265422
MusclePharm MP EssentialsBCAA Grape1 Gram(s)per 7.86 Gram(s)DSLD:267254
MusclePharm MP EssentialsBCAA Lemon Lime1 Gram(s)per 7.8 Gram(s)DSLD:265423
MusclePharm MP EssentialsBCAA Lemon Lime1 Gram(s)per 7.8 Gram(s)DSLD:267270
MusclePharm MP EssentialsBCAA Orange Mango1 Gram(s)per 7.5 Gram(s)DSLD:265424
MusclePharm MP EssentialsBCAA Unflavored1 Gram(s)per 6.5 Gram(s)DSLD:265425
MusclePharm MP EssentialsBCAA Watermelon1 Gram(s)per 7.2 Gram(s)DSLD:265426
MuscleTech100% Mass Gainer Chocolate Fudge BrownieL-Isoleucine · L-Isoleucine (Form: as Whey Protein, L-Isoleucine)3.3 Gram(s)per 359 Gram(s)DSLD:255834
MuscleTechMass Tech Cookies and CreamCalcium Caseinate4.5 Gram(s)per 230 Gram(s)DSLD:267879
MusclTech100% Mass Gainer Vanilla MilkshakeL-Isoleucine3.4 Gram(s)per 357 Gram(s)DSLD:267861
MyologyBCAA 2200500 mgper 4 Softgel(s)DSLD:286452
Nature's SunshineFree Amino Acids56 mgper 2 Tablet(s)DSLD:255231
Natures CraftBCAA750 mgper 3 Tablet(s)DSLD:256244
NewtonEverettAminoForce24 mgper 1 Capsule(s)DSLD:292148
NewtonEverettBCAA Plus Branched Chain Amino Acid Grape1,750 mgper 12 Gram(s)DSLD:34731
NewtonEverettWhey Protein Chocolate100 mgper 28 Gram(s)DSLD:82693
NewtonEverettWhey Protein Natural Vanilla Flavor100 mgper 21.5 Gram(s)DSLD:34730
NOW SportsAmino-9 Essentials333 mgper 3 Tablet(s)DSLD:12882
NOW SportsAmino-9 Essentials333 mgper 3 Tablet(s)DSLD:12883
NOW SportsAmino-9 Essentials Powder442 mgper 5.6 Gram(s)DSLD:314237
NOW SportsBranched Chain Amino AcidsL-Isoleucine Note: free-form650 mgper 4 Capsule(s)DSLD:210321
NOW SportsBranched-Chain Amino Acid PowderL-Isoleucine Note: (free-form) (1,100 mg)1.1 Gram(s)per 2 tspDSLD:210371
NOW SportsBranched-Chain Amino Acid PowderL-Isoleucine Note: (free-form) (1,100 mg)1.1 Gram(s)per 5.2 Gram(s)DSLD:314250
NOW SportsBranched-Chain Amino AcidsL-Isoleucine Note: free-form650 mgper 4 Capsule(s)DSLD:210353
NOW SportsBranched-Chain Amino AcidsL-Isoleucine Note: free-form650 mgper 4 Capsule(s)DSLD:210320
NOW SportsElectro Endurance Natural Orange FlavorL-Isoleucine Note: free-form250 mgper 45 Gram(s)DSLD:205226
NOW SportsElectro Endurance Orange FlavorL-Isoleucine Note: free-form250 mgper 45 Gram(s)DSLD:13117
NutivaOrganic MCT Protein Chocolate Flavored1 Gram(s)per 10 Gram(s)DSLD:251283
NutivaOrganic MCT Protein Vanilla Flavored1 Gram(s)per 39 Gram(s)DSLD:250822
NutraBio100% Pure L-Isoleucine2,000 mgper 2 Gram(s)DSLD:50934
NutraBioBCAA 2500L-Isoleucine Note: (naturally fermented) (vegan)625 mgper 5 Vegetable Capsule(s)DSLD:213014
NutraBioBCAA 2500L-Isoleucine Note: (naturally fermented) (vegan)625 mgper 5 Vegetable Capsule(s)DSLD:213019
NutraBioBCAA 2500fermented625 mgper 5 Vegetable Capsule(s)DSLD:329338
NutraBioBCAA 2500 500 mg625 mgper 5 Capsule(s)DSLD:248384
NutraBioBCAA 5000 Blue RaspberryL-Isoleucine Note: fermented - vegan1.25 Gram(s)per 7.4 Gram(s)DSLD:248586
NutraBioBCAA 5000 Dragonfruit CandyL-Isoleucine Note: fermented - vegan1.25 Gram(s)per 7.75 Gram(s)DSLD:248599
NutraBioBCAA 5000 Dragonfruit Candyfermented - vegan1.25 Gram(s)per 7.75 Gram(s)DSLD:329341
NutraBioBCAA 5000 Grape1,250 mgper 6.24 Gram(s)DSLD:174976
NutraBioBCAA 5000 GrapeL-Isoleucine Note: (naturally fermented) (vegan)1.25 Gram(s)per 6.24 Gram(s)DSLD:80001
NutraBioBCAA 5000 Grape Berry Crushfermented, vegan1.25 Gram(s)per 7.74 Gram(s)DSLD:309313
NutraBioBCAA 5000 Kiwi Strawberry1.25 Gram(s)per 6.69 Gram(s)DSLD:248195
NutraBioBCAA 5000 Kiwi Strawberryfermented1,250 mgper 6.69 Gram(s)DSLD:329342
NutraBioBCAA 5000 Lemon LimeL-Isoleucine Note: (naturally fermented) (vegan)1.25 Gram(s)per 6.19 Gram(s)DSLD:79991
NutraBioBCAA 5000 Lemonadefermented1,250 mgper 6.97 Gram(s)DSLD:329343
NutraBioBCAA 5000 Passion FruitL-Isoleucine Note: (naturally fermented) (vegan)1.25 Gram(s)per 6.36 Gram(s)DSLD:79970
NutraBioBCAA 5000 Pina ColadaL-Isoleucine Note: (naturally fermented) (vegan)1.25 Gram(s)per 6.62 Gram(s)DSLD:79958
NutraBioBCAA 5000 Raw Unflavored1.25 Gram(s)per 5 Gram(s)DSLD:248197
NutraBioBCAA 5000 Raw Unflavoredfermented1,250 mgper 5 Gram(s)DSLD:329344
NutraBioBCAA 5000 Strawberry Lemon BombL-Isoleucine Note: fermented - vegan1.25 Gram(s)per 7.96 Gram(s)DSLD:248615
NutraBioBCAA 5000 Strawberry Lemonade1,250 mgper 7.54 Gram(s)DSLD:309311
NutraBioBCAA 5000 Sun TeaL-Isoleucine Note: (naturally fermented) (vegan)1.25 Gram(s)per 6.92 Gram(s)DSLD:248391
NutraBioBCAA 5000 Tropical Fruit PunchL-Isoleucine Note: (naturally fermented) (vegan)1.25 Gram(s)per 6.44 Gram(s)DSLD:79975
NutraBioBCAA 5000 Watermelon1.25 Gram(s)per 6.33 Gram(s)DSLD:248200
NutraBio NaturalsBCAA 5000 Lemonade1.25 Gram(s)per 6.97 Gram(s)DSLD:248196
NutraKey Health Performance BCAA358 mgper 3 Capsule(s)DSLD:287384
NutraOneAminoOne Strawberry Pineapple1,250 mgper 7.5 Gram(s)DSLD:304925
Nutrex ResearchAmino Drive Black Bruisin' Berry1,500 mgper 14 Gram(s)DSLD:29971
Nutrex ResearchAmino Drive Black Gashin' Grape1,500 mgper 14.2 Gram(s)DSLD:29973
Nutrex ResearchAmino Drive Black Malicious Melon1,500 mgper 13.7 Gram(s)DSLD:29975
Nutrex ResearchAmino Drive Fruit Punch1.5 Gram(s)per 13.6 Gram(s)DSLD:52840
Nutrex ResearchAmino Drive Green Apple1.5 Gram(s)per 14.5 Gram(s)DSLD:52841
Nutrex Research Black SeriesAmino Drive Blackberry Lemonade1.25 Gram(s)per 8 Gram(s)DSLD:176153
Nutrex Research Black SeriesAmino Drive Peach Pineapple1.25 Gram(s)per 8.1 Gram(s)DSLD:176156
Nutrex Research Black SeriesAmino Drive Strawberry Kiwi1.25 Gram(s)per 8.7 Gram(s)DSLD:176162
Nutrex Research Black SeriesAmino Drive Wild Cherry Citrus1.25 Gram(s)per 8.6 Gram(s)DSLD:176155
Nutrex Research Black SeriesBCAA Drive1.25 Gram(s)per 5 Tablet(s)DSLD:176182
Nutri-WestCore Level Zinc40 mgper 1 Tablet(s)DSLD:27758
NutriCologySuper Immuno Complex69 mgper 1 Packet(s)DSLD:183928
NutricostL-Isoleucine 2,000 mg2,000 mgper 1 Capsule(s)DSLD:269674
NutricostL-Isoleucine 2,000 mg2,000 mgper 1 Capsule(s)DSLD:306320
ON Optimum NutritionBCAA 1000250 mgper 2 Capsule(s)DSLD:319464
ON Optimum NutritionBCAA 1000 Caps 1,000 mg250 mgper 2 Capsule(s)DSLD:29073
ON Optimum NutritionBCAA 5000 Powder Unflavored1.25 Gram(s)per 11.5 Gram(s)DSLD:57619
ON Optimum NutritionInstantized BCAA 5000 Powder1.25 gper 5.75 Gram(s)DSLD:17615
ON Optimum NutritionInstantized BCAA 5000 Powder Fruit Punch1.25 Gram(s)per 9.5 Gram(s)DSLD:218736
ON Optimum NutritionInstantized BCAA 5000 Powder Orange1.25 gper 9.5 Gram(s)DSLD:17594
ON Optimum NutritionMega-Size BCAA 1000 Caps250 mgper 2 Capsule(s)DSLD:29075
ON Optimum NutritionPre-Load Creatine Complex Fruit Punch500 mgper 1 Scoop(s)DSLD:13927
Optimum NutritionBCAA 1000 Caps250 mgper 2 Capsule(s)DSLD:58706
Optimum NutritionMega-Size BCAA 1000 Caps250 mgper 2 Capsule(s)DSLD:258965
Optimum NutritionMega-Size BCAA 1000 Caps250 mgper 2 Capsule(s)DSLD:308429
Parrillo PerformanceUltimate Amino Formula110 mgper 2 Capsule(s)DSLD:322532
Power BlendzRecovery156 mgper 6.5 Gram(s)DSLD:263917
Power BlendzStrength156 mgper 6 Gram(s)DSLD:263919
Power Blendz NutritionBCAA Pro Formula750 mgper 3 Tablet(s)DSLD:263643
Power Blendz NutritionBCAA Pro Formula750 mgper 3 Tablet(s)DSLD:318654
Precision EngineeredAmino 1000L-Isoleucine Note: essential amino acids21 mgper 2 Caplet(s)DSLD:2461
Precision EngineeredBCAA 2200500 mgper 4 Softgel(s)DSLD:21340
Precision EngineeredBCAA PowderL-Isoleucine Note: 1.25 g1,250 mgper 5 Gram(s)DSLD:21204
Precision EngineeredBCAA Powder Lemon-LimeL-Isoleucine Note: 1.25 g1,250 mgper 6 Gram(s)DSLD:18166
Precision EngineeredBCAA Powder WatermelonL-Isoleucine Note: 1.25 g1,250 mgper 6.4 Gram(s)DSLD:21348
Precision EngineeredLiquid Aminos Wild Cherry FlavorL-Isoleucine Note: essential amino acids186 mgper 2 TbspDSLD:21045
Precision EngineeredTimed Release BCAA 900 mg400 mgper 2 Caplet(s)DSLD:21342
Premium CertifiedBCAA 2:1:1 with BioPerine600 mgper 2 Tablet(s)DSLD:308051
Priority One Nutritional SupplementsAdrenal Focus20 mgper 1 Capsule(s)DSLD:277334
ProCapsEssential Amino Proteinessential amino acids, branched chain amino acids150 mgper 4 Capsule(s)DSLD:331548
Progressive Professional from Progressive LaboratoriesAdreno Chelate10 mgper 1 Capsule(s)DSLD:261324
Progressive Professional from Progressive LaboratoriesAmino Blend71 mgper 3 Capsule(s)DSLD:261202
Promuscle ProductsAmino 8:1:1+L-Glutamine Blue Raz Flavour6.8 Gram(s)per 1 Scoop(s)DSLD:211366
Propello LifeRejuvenating Non-GMO Aminos Cherries & Vanilla1.25 Gram(s)per 10.7 Gram(s)DSLD:69562
PS ProSuppsHydroBCAA Blue Razz1.75 Gram(s)per 13.6 Gram(s)DSLD:47730
PS ProSuppsHydroBCAA LemonLime1.75 Gram(s)per 13.3 Gram(s)DSLD:47732
PS ProSuppsHydroBCAA Pineapple1.75 Gram(s)per 13.5 Gram(s)DSLD:47733
PS ProSuppsHydroBCAA Pineapple1.75 Gram(s)per 13.5 Gram(s)DSLD:47771
PureBCAA375 mgper 3 Capsule(s)DSLD:248623
Pure EncapsulationsAmino RepleteL-Isoleucine Note: free-form200 mgper 9 Gram(s)DSLD:184274
Pure EncapsulationsAmino Repletefree-form200 mgper 4 Gram(s)DSLD:293886
Pure EncapsulationsAmino-NRL-Isoleucine Note: free-form117 mgper 3 Capsule(s)DSLD:245985
Pure EncapsulationsAmino-NRFree-form117 mgper 3 Capsule(s)DSLD:293887
Pure EncapsulationsEssential Aminos79 mgper 1 Capsule(s)DSLD:261613
Pure PowerEAA + BCAA Orange1,500 mgper 11.6 Gram(s)DSLD:327158
Puritan's PrideEssential Aminos Complexfree form75 mgper 1 Vegetable Capsule(s)DSLD:318139
RackedBCAA Blood Raz1,000 mgper 9.61 Gram(s)DSLD:229055
RackedBCAA Peach Mango1,000 mgper 9.72 Gram(s)DSLD:229056
RackedBCAA Pina Colada1,000 mgper 9.27 Gram(s)DSLD:229057
RackedBCAA Watermelon1,000 mgper 9.63 Gram(s)DSLD:229058
Reaction NutritionBCAA 2:1:1500 mgper 3 Capsule(s)DSLD:19582
Redcon1Grunt Blood Orange15.8 Gram(s)per 9.5 Gram(s)DSLD:269167
Redcon1Grunt Cherry Lime15.8 Gram(s)per 9.5 Gram(s)DSLD:269116
Redcon1Grunt Pineapple Banana1.5 Gram(s)per 9.5 Gram(s)DSLD:269166
Redcon1Grunt Tiger's Blood1.5 Gram(s)per 9.5 Gram(s)DSLD:236985
Revolution Nutrition Pro SeriesBCAA Splash Blue Raspberry900 mgper 5.5 Gram(s)DSLD:232598
Ryno PowerRecoveryBranched-Chain Amino Acids300 mgper 3 Capsule(s)DSLD:255753
ScivationXTEND Lemon Lime Sour1,750 mgper 12.8 Gram(s)DSLD:13369
Scivation XTENDElite Island Punch Flavor1,750 mgper 19.5 Gram(s)DSLD:82434
Scivation XTENDElite Sour Gummy Flavor1,750 mgper 19.8 Gram(s)DSLD:82438
Seeking HealthOptimal Amino Blend36 mgper 1 Capsule(s)DSLD:210883
ShredzBCAA + Glutamine Fruit Punch800 mgper 9.86 Gram(s)DSLD:36649
Signature Supplements9 Essential Amino Acids97 mgper 2 Capsule(s)DSLD:338587
Six Star Pro NutritionAmino Max Fruit Punch1,000 mgper 8 Gram(s)DSLD:62848
SolgarBCAA Plus Branched Chain Amino AcidsL-Isoleucine Note: free form360 mgper 2 Vegetable Capsule(s)DSLD:71680
SomaLifeYouth Formula400 mgper 6 Capsule(s)DSLD:16517
SomaLife InternationalgHP Sport400 mgper 6 Capsule(s)DSLD:16512
Source NaturalsBCAA450 mgper 3 Capsule(s)DSLD:209439
Source NaturalsBCAA450 mgper 3 Capsule(s)DSLD:210778
Source NaturalsBCAA450 mgper 3 Capsule(s)DSLD:214428
SP Standard ProcessSP Detox Balance850 mgper 37 Gram(s)DSLD:340373
SteelADABolic Candy Bliss1.75 Gram(s)per 37 Gram(s)DSLD:277714
SteelBCAA + EAA1.25 Gram(s)per 10 Gram(s)DSLD:266712
SteelVeg-Pro Vanilla Cream Pie714 mgper 1 Scoop(s)DSLD:218137
STI Presents G6 SportsReplenish Candy Watermelon1,478 mgper 55.3 Gram(s)DSLD:327606
STI Presents G6 SportsReplenish Fruit Punch1,478 mgper 55.3 Gram(s)DSLD:323692
STI Presents G6 SportsReplenish Mixed Berry1,478 mgper 55.3 Gram(s)DSLD:327607
SuperSmartBCAA's2,500 mgper 2 Scoop(s)DSLD:285311
SwansonBCAA513 mgper 3 Capsule(s)DSLD:308485
SyntraxAmino-Tor Blue Raspberry1,500 mgper 11 Gram(s)DSLD:228545
SyntraxAmino-Tor Juicy Watermelon1,500 mgper 11 Gram(s)DSLD:228547
SyntraxAmino-Tor Orange Citrus1,500 mgper 11 Gram(s)DSLD:228550
SyntraxAmino-Tor Pink Lemonade1,500 mgper 11 Gram(s)DSLD:228551
SyntraxAmino-Tor Strawberry Kiwi1,500 mgper 11 Gram(s)DSLD:228552
SyntraxAmino-Tor Tangy Mango1,500 mgper 11 Gram(s)DSLD:228553
SyntraxMatrix 1.0 Milk ChocolateIsoleucine Note: (Branched-Chain Amino Acid) (Essential Amino Acid)5.8 Gram(s)per 31 Gram(s)DSLD:228586
SyntraxMatrix Amino Blue Raspberry500 mgper 12 Gram(s)DSLD:228556
SyntraxMatrix Amino Juicy Watermelon500 mgper 12 Gram(s)DSLD:228560
SyntraxMatrix Amino Orange Citrus500 mgper 12 Gram(s)DSLD:228563
SyntraxMatrix Amino Pink Lemonade500 mgper 12 Gram(s)DSLD:228570
SyntraxMatrix Amino Strawberry Kiwi500 mgper 12 Gram(s)DSLD:228571
SyntraxMatrix Amino Tangy Mango500 mgper 12 Gram(s)DSLD:228572
Systemic FormulasAccell Therapeutic405 mgper 30 Gram(s)DSLD:22284
Systemic FormulaseNRG LQ Quantum Cellular ATP Energyamount not statedper 0.5 Dropper(s)DSLD:22506
Tapout Sports NutritionRecover Post Workout12.5 mgper 66 Gram(s)DSLD:2126
Taylor MD FormulationsAmino Restore Natural Choclate Flavor1.64 Gram(s)per 15 Gram(s)DSLD:263101
Ten PerformancePro BCAA1.25 Gram(s)per 6 Gram(s)DSLD:287117
The Genius BrandGenius BCAA Power OrangeVegan1.25 Gram(s)per 13.8 Gram(s)DSLD:263173
The Vitamin ShoppeCritical Aminos XT Strawberry Lemonade625 mgper 10.1 Gram(s)DSLD:183879
ThorneAmino Complex Berry Flavored625 mgper 7.6 Gram(s)DSLD:328818
ThorneAmino Complex Berry Flavored625 mgper 7.6 Gram(s)DSLD:337851
ThorneAmino Complex Lemon Flavored625 mgper 7.7 Gram(s)DSLD:323098
ThorneAmino Complex Lemon Flavored625 mgper 7.7 Gram(s)DSLD:336309
ThorneSynaQuell625 mgper 7.8 Gram(s)DSLD:337875
TN Trusted NutrientsBCAA 2200 mg500 mgper 4 Softgel(s)DSLD:70276
tnvitaminsBCAA 2000 mg500 mgper 4 Tablet(s)DSLD:217696
Tokkyo NutritionBCAA Stack Watermelon1,750 mgper 12.5 Gram(s)DSLD:180485
TriVitaLeanology ChocolateIsoleucine Note: Essential Amino Acids (amount in 30.3g of powder)714 mgper 30.3 Gram(s)DSLD:33082
True AthleteBCAA Powder 4:1:1 Ratio1 Gram(s)per 6.7 Gram(s)DSLD:207946
True AthleteEndurance and Recovery Fruit Punch1,250 mgper 12.2 Gram(s)DSLD:221237
True AthleteEndurance and Recovery Grape1,250 mgper 12 Gram(s)DSLD:213890
True AthleteEndurance and Recovery Grape1,250 mgper 12 Gram(s)DSLD:221536
True AthleteFermented BCAA 4:1:11,000 mgper 6.7 Gram(s)DSLD:221519
True AthleteNatural Recovery Mixed Berry1,250 mgper 10.25 Gram(s)DSLD:217915
TruehopeAminopowerplusIsoleucine Hydrochloride · Isoleucine (Form: as L-isoleucine hydrochloride)149 mgper 4 Veggie Capsule(s)DSLD:32348
Twinlab100% Whey Protein Fuel Chocolate Surge1,610 mgper 35 Gram(s)DSLD:4265
Twinlab100% Whey Protein Fuel Strawberry Smash1,610 mgper 34 Gram(s)DSLD:3623
Twinlab100% Whey Protein Fuel Vanilla Slam1,610 mgper 33 Gram(s)DSLD:3624
TwinlabAmino Fuel 1000331 mgper 4 Tablet(s)DSLD:3625
TwinlabAmino Fuel 1000331 mgper 4 Tablet(s)DSLD:73907
Ultimate Nutrition100% Crystalline BCAA 500 mgUSP300 mgper 3 Capsule(s)DSLD:293445
UniversalAmino 1000L-Isoleucine · Isoleucine (Form: as L-Isoleucine)247 mgper 5 Capsule(s)DSLD:64048
UniversalAmino 1900350 mgper 4 Tablet(s)DSLD:246059
UniversalAmino 1900350 mgper 4 Tablet(s)DSLD:274619
UniversalAmino 1900365 mgper 4 Tablet(s)DSLD:64049
UniversalAmino 2250216 mgper 2 Tablet(s)DSLD:37728
UniversalAmino 2250216 mgper 2 Tablet(s)DSLD:64054
UniversalAmino 2250216 mgper 2 Tablet(s)DSLD:64059
UniversalAmino 2700378 mgper 3 Tablet(s)DSLD:37770
UniversalAmino 2700378 mgper 3 Tablet(s)DSLD:65618
UniversalAtomic 7 'Lectric Lemon Lime2 Gram(s)per 13.1 Gram(s)DSLD:64099
UniversalAtomic 7 'Lectric Lemon Lime2 Gram(s)per 13.1 Gram(s)DSLD:64122
UniversalAtomic 7 Black Cherry Bomb2 Gram(s)per 12.9 Gram(s)DSLD:64095
UniversalAtomic 7 Black Cherry Bomb2 Gram(s)per 12.9 Gram(s)DSLD:64119
UniversalAtomic 7 Groovy Grape2 Gram(s)per 13.71 Gram(s)DSLD:64097
UniversalAtomic 7 Groovy Grape2 Gram(s)per 13.71 Gram(s)DSLD:64126
UniversalAtomic 7 Rockin' Razz Lemonade2 Gram(s)per 13.41 Gram(s)DSLD:37789
UniversalAtomic 7 Rockin' Razz Lemonade2 Gram(s)per 13.41 Gram(s)DSLD:64128
UniversalAtomic 7 Way Out Watermelon2 Gram(s)per 12.78 Gram(s)DSLD:64102
UniversalAtomic 7 Way Out Watermelon2 Gram(s)per 12.78 Gram(s)DSLD:64113
UniversalBCAA 2000L-Isoleucine · Isoleucine (Form: as L-Isoleucine)135 mgper 2 Capsule(s)DSLD:64131
UniversalBCAA ProL-Isoleucine250 mgper 2 Capsule(s)DSLD:275307
UniversalBCAA PROL-Isoleucine · Isoleucine (Form: as L-Isoleucine)250 mgper 2 Capsule(s)DSLD:246198
UniversalBCAA Stack Grape Splash1.25 Gram(s)per 10 Gram(s)DSLD:64183
UniversalBCAA Stack Lemon Lime1.25 Gram(s)per 9.2 Gram(s)DSLD:37889
UniversalBCAA Stack Lemon Lime1.25 Gram(s)per 9.2 Gram(s)DSLD:64187
UniversalBCAA Stack Orange Splash1.25 Gram(s)per 9.34 Gram(s)DSLD:64178
UniversalBCAA Stack Orange Splash1.25 Gram(s)per 9.34 Gram(s)DSLD:64190
UniversalUniversal Amino 2700350 mgper 3 Tablet(s)DSLD:247363
UniversalUniversal BCAA Stack Grape Splash1.25 Gram(s)per 10 Gram(s)DSLD:65619
Universal NutritionUniversal Amino 2700350 mgper 3 Tablet(s)DSLD:274726
ViMulti Beautiful MeBCAA Amino Essentials750 mgper 3 Tablet(s)DSLD:230844
Vital NutrientsBranched Chain AminosUSP270 mgper 3 Vegetarian Capsule(s)DSLD:304957
VitalBulkStamina Kit10 mcgper 1 PackDSLD:258765
VMI SportsAminogex Ultra Miami Vice1,750 mgper 17.2 Gram(s)DSLD:257498
VMI SportsAminogex Ultra Red Fruit Candy1,750 mgper 17.2 Gram(s)DSLD:257499
VMI SportsAminogex Ultra Tropical Mango1,750 mgper 17.2 Gram(s)DSLD:257500
VMI SportsAminogex Ultra Watermelon1,750 mgper 17.2 Gram(s)DSLD:257497
VPXCREmTOR1,000 mgper 6 Gram(s)DSLD:51508
VPXCREmTOR Watermelon1,000 mgper 7.6 Gram(s)DSLD:39470
VPXCREmTOR Watermelon1,000 mgper 7.6 Gram(s)DSLD:51510
VPXCREmTOR Wild Grape1,000 mgper 7.1 Gram(s)DSLD:51505
Wonder LabsAmino Acid ComplexL-Isoleucine Note: (Essential Amino Acid) (Branched Chain Amino Acid)18 mgper 1 Tablet(s)DSLD:214914
Wonder LabsAmino Acid Complex(Essential Amino Acid) (Branched Chain Amino Acid)18 mgper 1 Tablet(s)DSLD:260733
Worldwide NutritionBCAA Mango Colada1,250 mgper 14.1 Gram(s)DSLD:287532
Worldwide NutritionBCAA Watermelon1,250 mgper 14.1 Gram(s)DSLD:287533
XTENDElite Citrus Passionfruit1,750 mgper 18 Gram(s)DSLD:228992
XTENDElite Citrus Passionfruit1,750 mgper 18 Gram(s)DSLD:229004
XTENDElite Fraserade1,750 mgper 18.5 Gram(s)DSLD:229746
XTENDElite Island Punch Fusion1,750 mgper 18 Gram(s)DSLD:228941
XTENDElite Island Punch Fusion1,750 mgper 18 Gram(s)DSLD:228998
XTENDElite Pre Mango Madness1,750 mgper 13.5 Gram(s)DSLD:249085
XTENDElite Pre Strawberry Kiwi Splash1,750 mgper 13.5 Gram(s)DSLD:229868
XTENDElite Pre Watermelon Explosion1,750 mgper 13.5 Gram(s)DSLD:229876
XTENDElite Sour Gummy Flavor1,750 mgper 18 Gram(s)DSLD:228986
XTENDElite Sour Gummy Flavor1,750 mgper 18 Gram(s)DSLD:229001
XTENDEnergy Blue Raspberry Ice1,750 mgper 11.6 Gram(s)DSLD:229086
XTENDEnergy Knockout Fruit Punch1,750 mgper 11.6 Gram(s)DSLD:229014
XTENDEnergy Mango Madness1,750 mgper 11.6 Gram(s)DSLD:229082
XTENDKeto Energy Knockout Fruit Punch1,750 mgper 17 Gram(s)DSLD:229220
XTENDKeto Energy Ultra Frost1,750 mgper 16.5 Gram(s)DSLD:229745
XTENDKeto Orange Mango1,750 mgper 16.6 Gram(s)DSLD:229156
XTENDKeto Strawberry Kiwi Splash1,750 mgper 17.2 Gram(s)DSLD:229201
XTENDRipped Blueberry Lemonade1,750 mgper 16.5 Gram(s)DSLD:228723
XTENDRipped Strawberry Kiwi Splash1,750 mgper 16.5 Gram(s)DSLD:228782
XTENDRipped Watermelon Lime1,750 mgper 16.5 Gram(s)DSLD:228772
XTENDSport Blue Raspberry Ice1,750 mgper 11.5 Gram(s)DSLD:261338
XTENDSport Strawberry Kiwi Splash1,750 mgper 11.5 Gram(s)DSLD:292456
XTENDThe Original Black Cherry1,750 mgper 13.5 Gram(s)DSLD:240942
XTENDThe Original Blue Raspberry Ice1,750 mgper 14 Gram(s)DSLD:228580
XTENDThe Original Blue Raspberry Ice1,750 mgper 14 Gram(s)DSLD:229101
XTENDThe Original Blue Raspberry Ice1,750 mgper 14 Gram(s)DSLD:254294
XTENDThe Original Blue Raspberry Ice1,750 mgper 14 Gram(s)DSLD:292457
XTENDThe Original Blueberry Lemonade1,750 mgper 14.7 Gram(s)DSLD:295112
XTENDThe Original Freedom Ice1,750 mgper 14 Gram(s)DSLD:295113
XTENDThe Original Glacial Grape1,750 mgper 13.5 Gram(s)DSLD:228587
XTENDThe Original Glacial Grape1,750 mgper 13.5 Gram(s)DSLD:295110
XTENDThe Original Italian Blood Orange1,750 mgper 14.5 Gram(s)DSLD:244190
XTENDThe Original Italian Blood Orange1,750 mgper 14.5 Gram(s)DSLD:292458
XTENDThe Original Knockout Fruit Punch1,750 mgper 13.5 Gram(s)DSLD:228681
XTENDThe Original Knockout Fruit Punch1,750 mgper 13.5 Gram(s)DSLD:278240
XTENDThe Original Lemon-Lime Squeeze1,750 mgper 14 Gram(s)DSLD:295111
XTENDThe Original Lemon-Lime Squeeze1,750 mgper 14 Gram(s)DSLD:296441
XTENDThe Original Mango Madness1,750 mgper 14 Gram(s)DSLD:229150
XTENDThe Original Mango Madness1,750 mgper 14 Gram(s)DSLD:295114
XTENDThe Original Mango Madness1,750 mgper 14 Gram(s)DSLD:295115
XTENDThe Original Smash Apple1,750 mgper 14 Gram(s)DSLD:228709
XTENDThe Original Smash Apple1,750 mgper 14 Gram(s)DSLD:292459
XTENDThe Original Strawberry Kiwi Splash1,750 mgper 14 Gram(s)DSLD:228712
XTENDThe Original Strawberry Kiwi Splash1,750 mgper 14 Gram(s)DSLD:229145
XTENDThe Original Strawberry Kiwi Splash1,750 mgper 14 Gram(s)DSLD:292461
XTENDThe Original Strawberry Kiwi Splash1,750 mgper 14.7 Gram(s)DSLD:295116
XTENDThe Original Tropic Thunder1,750 mgper 14 Gram(s)DSLD:228719
XTENDThe Original Tropic Thunder1,750 mgper 14 Gram(s)DSLD:292460
XTENDThe Original Watermelon Explosion1,750 mgper 13 Gram(s)DSLD:228538
XTENDThe Original Watermelon Explosion1,750 mgper 13 Gram(s)DSLD:229114
XTENDThe Original Watermelon Explosion1,750 mgper 13 Gram(s)DSLD:292462
XTENDXTEND Blue Raspberry Ice1,750 mgper 16.9 Fluid Ounce(s)DSLD:229752
XTENDXTEND Kiwi Berry Blast1,750 mgper 1 Can(s)DSLD:321645
XTENDXTEND Mango Madness1,750 mgper 16.9 Fluid Ounce(s)DSLD:229758
XYMOGENOptiCleanse Plus Rice Original1,257 mgper 53 Gram(s)DSLD:6563
XYMOGENOptiCleanse Plus Rice Raspberry Lemonade250 mgper 60 Gram(s)DSLD:6562
XYMOGENXymoBolX Natural Lemon Flavor414 mgper 6.8 Gram(s)DSLD:335572
ZHOUBCAA 2:1:1 2500 mg625 mgper 4 Vegetable Capsule(s)DSLD:250042
ZHOUMuscle BCAA Tropical Punch2,500 mgper 11 Gram(s)DSLD:313669

Label record: NIH Office of Dietary Supplements · CC0

Registered, and not reported

Source: ClinicalTrials.gov
Intervention: L-isoleucine
Status: Completed, terminated or suspended
Results posted: No

Trials without posted results

27 trials

27 registered trials without posted results · Overdue (FDAAA 801): 25

25 past the window2 within it, or no actual date

Order

NCT04603443completed2025-09-30US federal agencypast the reporting window
NCT05682339completed2024-06-24a university or hospitalpast the reporting window
NCT06125730completed2024-02-10industrypast the reporting window
NCT06088550completed2022-06-30a university or hospitalpast the reporting window
NCT05152849completed2022-06-21industrypast the reporting window
NCT04201418completed2022-05-24industrypast the reporting window
NCT03539809completed2021-08-15a university or hospitalpast the reporting window
NCT04969536completed2021-02-23a university or hospitalpast the reporting window
NCT05143398completed2020-10-15a university or hospitalpast the reporting window
NCT02780219completed2020-03-06a university or hospitalpast the reporting window
NCT04461236completed2020-03-02a university or hospitalpast the reporting window
NCT06801951completed2020-02-27a university or hospitalpast the reporting window

Show the remaining 15

NCT03339232completed2019-06-17a university or hospitalpast the reporting window
NCT03017768completed2017-03-24a university or hospitalpast the reporting window
NCT02634164completed2016-07a university or hospitalpast the reporting window
NCT02697305completed2015-05a university or hospitalpast the reporting window
NCT03784495completed2014-12-31a university or hospitalpast the reporting window
NCT02110602completed2014-08a university or hospitalpast the reporting window
NCT01350427completed2013-02a university or hospitalpast the reporting window
NCT01305018suspendedexpected 2012-01a university or hospital
NCT01529281completed2011-09a university or hospitalpast the reporting window
NCT01885429completed2011-05a university or hospitalpast the reporting window
NCT01211717completed2011-03a university or hospitalpast the reporting window
NCT01215396completed2010-10a university or hospitalpast the reporting window
NCT01034228completed2008-06a university or hospitalpast the reporting window
NCT00955500completed2008-01a university or hospitalpast the reporting window
NCT00799630completedno completion dateindustry

Where it reaches

10 systems, 24 regions, 65 tissues, 108 transporter routes — routes, not measurements: transporters known to carry L-isoleucine are expressed there, and no source reports it arriving.

Loading the model…

Nervous

Endocrine

Respiratory

Cardiovascular

Digestive

Urinary

Reproductive

Blood and immune

Musculoskeletal

Skin and adipose

Papers screened

658 papers

Compound: L-isoleucine
Screened: 658
Admitted: 4
Discarded: 605
Not read: 49
Showing: 200 of 658

The whole record

Produced a finding4 papers

PMID:222985732026-10-11
PMID:321048192026-10-11
PMID:332897362026-10-11
PMID:358302592026-09-29

Discarded: the wrong intervention544 papers

PMID:12535503cited by PMID:23382495; not about the subject it would be filed under2026-10-15
PMID:12540390cited by PMID:23382495; not about the subject it would be filed under2026-10-15
PMID:15266549cited by PMID:23382495; not about the subject it would be filed under2026-10-15
PMID:17707755cited by PMID:23382495; not about the subject it would be filed under2026-10-15
PMID:18086944cited by PMID:23382495; not about the subject it would be filed under2026-10-15
PMID:18528405cited by PMID:23382495; not about the subject it would be filed under2026-10-15
PMID:18551027cited by PMID:23382495; not about the subject it would be filed under2026-10-15
PMID:18562172cited by PMID:23382495; not about the subject it would be filed under2026-10-15
PMID:18816584cited by PMID:23382495; not about the subject it would be filed under2026-10-15
PMID:19064533cited by PMID:23382495; not about the subject it would be filed under2026-10-15
PMID:19109662cited by PMID:23382495; not about the subject it would be filed under2026-10-15
PMID:19247842cited by PMID:23382495; not about the subject it would be filed under2026-10-15

and 532 more.

Discarded: not retrievable31 papers

PMID:14676222no PMID parsed, abstract under 200 characters, or no record returned by efetch2026-10-15
PMID:17562668no PMID parsed, abstract under 200 characters, or no record returned by efetch2026-10-15
PMID:17715411no PMID parsed, abstract under 200 characters, or no record returned by efetch2026-10-15
PMID:18809808no PMID parsed, abstract under 200 characters, or no record returned by efetch2026-10-15
PMID:9202117no PMID parsed, abstract under 200 characters, or no record returned by efetch2026-10-13
PMID:6076279no PMID parsed, abstract under 200 characters, or no record returned by efetch2026-10-12
PMID:23817082no PMID parsed, abstract under 200 characters, or no record returned by efetch2026-10-10
PMID:10639873no PMID parsed, abstract under 200 characters, or no record returned by efetch2026-10-08
PMID:11493102no PMID parsed, abstract under 200 characters, or no record returned by efetch2026-10-08
PMID:18385500no PMID parsed, abstract under 200 characters, or no record returned by efetch2026-10-08
PMID:19171846no PMID parsed, abstract under 200 characters, or no record returned by efetch2026-09-29
PMID:34489606no PMID parsed, abstract under 200 characters, or no record returned by efetch2026-09-29

and 19 more.

Discarded: an endpoint this vocabulary does not hold16 papers

PMID:11058160no claim extracted — no_outcome_node — measured: epithelial beta-defensin expression, transcriptional induction | epithelial beta-defensin expression (transcriptional induction)2026-10-11
PMID:22969433no claim extracted — no_outcome_node — measured: bacterial virulence gene (prfA) expression induction | bacterial virulence gene (prfA) expression under isoleucine limitation2026-10-11
PMID:26891318no claim extracted — no_outcome_node — measured: endogenous glucose production, tracer-based whole body glucose kinetics, euglycemic pancreatic clamp | endogenous glucose production, tracer-based whole-body glucose kinetics during pancreatic clamp2026-10-11
PMID:37658490no claim extracted — no_outcome_node — measured: cognitive function by behavioral testing in mice; neuroinflammation markers, brain insulin signalling, gut microbiota composition | cognitive function by behavioral testing in mice; gut microbiota composition; brain neuroinflammation2026-10-11
PMID:8929440no claim extracted — no_outcome_node — measured: methylmalonyl-CoA mutase mRNA induction in cultured astrocytes | methylmalonyl-CoA mutase mRNA expression, Northern blot2026-10-11
PMID:35360198no claim extracted — no_outcome_node — measured: relative proliferation rate of MAC-T bovine mammary epithelial cells exposed to isoleucine (CCK-8 assay, OD ratio test/control) | cultured mammary epithelial cell proliferation rate/viability under isoleucine dosing (CCK-8 assay), non-monotonic dose-response2026-09-29

and 10 more.

Discarded: another reason, stated per paper8 papers

PMID:38305939no claim extracted — cause not determined (one pass only) — measured: nicotine resistance / survival time following nicotine exposure after isoleucine-dropout pre-treatment (Cox proportional-hazards survival analysis)2026-09-29

and 7 more.

Discarded: no comparator3 papers

and 3 more.

Discarded: no extractable result3 papers

and 3 more.

Not read yet49 papers

PMID:122698022026-10-09
PMID:187044842026-10-09
PMID:221898902026-09-29
PMID:225405212026-09-29
PMID:288753372026-09-29
PMID:320698722026-09-29
PMID:346877392026-09-29
PMID:413715492026-09-29
PMID:419283002026-09-29
PMID:419485562026-09-29
PMID:422063702026-09-29
PMID:88818002026-09-29

and 37 more.

Measured, not recorded

Compound: L-isoleucine
Endpoints measured: 256 endpoints
Recorded as a finding: No

Show what was measured

epithelial beta-defensin expression induced by l-isoleucine and analogs
increases
Not recorded as a finding: this platform holds no node for the endpoint
Here we show that a class of small molecules, including l-isoleucine and several of its analogs, can specifically induce epithelial beta-defensin expression.
PMID:11058160 · both readings recorded this
epithelial beta-defensin expression
increases
Here we show that a class of small molecules, including l-isoleucine and several of its analogs, can specifically induce epithelial beta-defensin expression
PMID:11058160 · one of two readings recorded this
NF-kappaB/rel activation
increases
This induction is transcriptional in nature and involves activation of the NF-kappaB/rel family of trans-activating factors
PMID:11058160 · one of two readings recorded this
lung cancer risk by CYP1A1 genotype
no effect
Overall, we found no association between CYP1A1 genotype and lung cancer risk.
PMID:11396202 · one of two readings recorded this
smoking-lung cancer association modified by CYP1A1 genotype
no effect
CYP1A1 genotype did not modify the effect of smoking on lung cancer risk.
PMID:11396202 · one of two readings recorded this
amino acid labelling from labelled HCO3- and acetate
increases
Mixed rumen micro-organisms, maintained in continuous culture readily incorporated labelled HCO3- and acetate into amino acids
PMID:1212197 · one of two readings recorded this
amino acid labelling from labelled propionate
increases
Labelled propionate, in contrast, was utilized only for isoleucine biosynthesis, but failed to label other amino acids to any significant extent
PMID:1212197 · one of two readings recorded this
hepatic and muscle protein synthesis (phenylalanine net balance, multicatheterization with stable-isotope tracers) during a simulated upper GI bleed in cirrhosis
increases, positive net balance of phenylalanine across liver and muscle
Not recorded as a finding: this platform holds no node for the endpoint
Isoleucine infusion during the bleed resulted in a positive net balance of phenylalanine across liver and muscle, whereas renal and portal drained viscera protein kinetics were unaffected.
PMID:17326149 · one of two readings recorded this
hepatic and muscle protein synthesis (phenylalanine net balance)
increases, positive net balance of phenylalanine across liver and muscle
Isoleucine infusion during the bleed resulted in a positive net balance of phenylalanine across liver and muscle, whereas renal and portal drained viscera protein kinetics were unaffected.
PMID:17326149 · one of two readings recorded this
hepatic and muscle protein synthesis, quantified as net organ balance of phenylalanine across liver and muscle by multicatheterization technique with stable-isotope tracers
increases
Not recorded as a finding: a node exists but the paper states a different instrument or population
Isoleucine infusion during the bleed resulted in a positive net balance of phenylalanine across liver and muscle, whereas renal and portal drained viscera protein kinetics were unaffected.
PMID:17326149 · one of two readings recorded this
hypoisoleucinemia (plasma isoleucine concentration)
increases
This simulated bleed resulted in hypoisoleucinemia that was attenuated by isoleucine infusion.
PMID:17326149 · one of two readings recorded this
Net balance of phenylalanine across liver and muscle, by multicatheterization and infusion of stable isotope tracers (L-[ring-2H5]phenylalanine, L-[ring-2H4]tyrosine, L-[ring-2H2]tyrosine), as a marker of organ protein kinetics
increases
Not recorded as a finding: a node exists but the paper states a different instrument or population
Isoleucine infusion during the bleed resulted in a positive net balance of phenylalanine across liver and muscle, whereas renal and portal drained viscera protein kinetics were unaffected.
PMID:17326149 · one of two readings recorded this
renal and portal drained viscera protein kinetics
no effect
Isoleucine infusion during the bleed resulted in a positive net balance of phenylalanine across liver and muscle, whereas renal and portal drained viscera protein kinetics were unaffected.
PMID:17326149 · one of two readings recorded this
leucine oxidation (13C-tracer, fasted state)
no effect
Leucine oxidation was similar for all diet groups in the fasted state.
PMID:1858704 · one of two readings recorded this
leucine oxidation (13C-tracer, fed state)
no effect
During the fed state, leucine oxidation was not affected by the Val:Ile pattern.
PMID:1858704 · one of two readings recorded this
leucine oxidation by continuous intravenous L-[1-13C]leucine tracer infusion, fasted and fed states, across diets varying valine and isoleucine intake
no effect
Not recorded as a finding: this platform holds no node for the endpoint
During the fed state, leucine oxidation was not affected by the Val:Ile pattern.
PMID:1858704 · one of two readings recorded this
Leucine oxidation in the fasted and fed states, by continuous intravenous L-[1-13C]leucine infusion together with dietary [2H3]leucine tracer
no effect
Not recorded as a finding: this platform holds no node for the endpoint
During the fed state, leucine oxidation was not affected by the Val:Ile pattern.
PMID:1858704 · one of two readings recorded this
leucine oxidation, isotopically derived from continuous L-[1-13C]leucine infusion, at varying dietary valine and isoleucine intakes
no effect
Not recorded as a finding: this platform holds no node for the endpoint
During the fed state, leucine oxidation was not affected by the Val:Ile pattern.
PMID:1858704 · one of two readings recorded this
fasting serum homocysteine, change from week 12 to week 22
no effect
In phase 2 of the study, there were no significant changes from week 12 to week 22 in fasting serum homocysteine in any of the groups (Table 3), nor were there any significant between-group differences in these changes.
PMID:18591315 · one of two readings recorded this
daily stool output, measured by weight in grams
decreases, p = 0.03
Not recorded as a finding: this platform holds no node for the endpoint
With respect to stool output, we noted a trend in reduced output in children receiving ORS supplemented with L-isoleucine on day 1, which continued on day 2 and became statistically significant (p=0.03) on day 3 (Table 2).
PMID:21766553 · one of two readings recorded this
daily stool output, weight in grams
decreases, -265 g (-509, -20), day 3, p = 0.035, n = 50
With respect to stool output, we noted a trend in reduced output in children receiving ORS supplemented with L-isoleucine on day 1, which continued on day 2 and became statistically significant (p=0.03) on day 3 (Table 2).
PMID:21766553 · one of two readings recorded this
duration of diarrhoea, hours
no effect, n = 50
We did not observe a reduction in the duration of diarrhoea in children receiving L-isoleucine-supplemented ORS (Table 2).
PMID:21766553 · one of two readings recorded this
ORS intake volume, mL
decreases, -154 mL (-288, -18), day 1, p = 0.04, n = 50
Also, we observed a trend in reductions in the volume of ORS intake in the L-isoleucine group compared to the control group, although statistical significance (p=0.04) was only observed on day 1.
PMID:21766553 · one of two readings recorded this
stool beta-defensin 2 and 3 concentration
no effect, p = 0.51, n = 50
Two-way ANOVA showed a significant difference (p=0.02) between days but not between treatment groups (p=0.51).
PMID:21766553 · one of two readings recorded this
Time to completion of a sustained-attention task with mental processing (Attention Diagnostic Method), and performance on the Continuous Performance Test, in adolescents and young adults with phenylketonuria
decreases
Not recorded as a finding: the intervention held more than the compound
Time to completion of a test that required substantial attention with mental processing (Attention Diagnostic Method) was faster during the valine, isoleucine, and leucine periods than during the control mixture periods.
PMID:2184659 · one of two readings recorded this
time to completion of the Attention Diagnostic Method, an attention/mental-processing test, in adolescents and young adults with phenylketonuria
increases
Not recorded as a finding: the intervention held more than the compound
Time to completion of a test that required substantial attention with mental processing (Attention Diagnostic Method) was faster during the valine, isoleucine, and leucine periods than during the control mixture periods.
PMID:2184659 · one of two readings recorded this
correlation of FSR with eIF2α phosphorylation
decreases, p = 0.01
positively correlated (R = 0.64, P < 0.01) with phosphorylation of mTOR and negatively correlated (R = -0.42, P = 0.01) with phosphorylation of eIF2α
PMID:22298573 · one of two readings recorded this
correlation of FSR with mTOR phosphorylation
increases, p = 0.01
positively correlated (R = 0.64, P < 0.01) with phosphorylation of mTOR and negatively correlated (R = -0.42, P = 0.01) with phosphorylation of eIF2α
PMID:22298573 · one of two readings recorded this
eIF2α (Ser51) phosphorylation
decreases, p = 0.04
phosphorylation was reduced in response to provision of all EAA (P < 0.04)
PMID:22298573 · one of two readings recorded this
eukaryotic elongation factor 2 (Thr56) phosphorylation
decreases, p = 0.05
Supplementation of L-leucine to media depleted of EAA increased mTOR and rpS6 and decreased eukaryotic elongation factor 2 (Thr56) phosphorylation (P < 0.05) in MAC-T cells
PMID:22298573 · one of two readings recorded this
fractional protein synthesis rate (FSR)
decreases, p = 0.01
FSR declined when L-isoleucine (P = 0.01), L-leucine (P = 0.01), L-methionine (P = 0.02), or L-threonine (P = 0.07) was depleted in media
PMID:22298573 · one of two readings recorded this
fractional protein synthesis rate (FSR)
decreases, p = 0.01
FSR declined when L-isoleucine (P = 0.01), L-leucine (P = 0.01), L-methionine (P = 0.02), or L-threonine (P = 0.07) was depleted in media
PMID:22298573 · one of two readings recorded this
fractional protein synthesis rate (FSR)
decreases, p = 0.02
FSR declined when L-isoleucine (P = 0.01), L-leucine (P = 0.01), L-methionine (P = 0.02), or L-threonine (P = 0.07) was depleted in media
PMID:22298573 · one of two readings recorded this
fractional protein synthesis rate (FSR)
decreases, p = 0.07
FSR declined when L-isoleucine (P = 0.01), L-leucine (P = 0.01), L-methionine (P = 0.02), or L-threonine (P = 0.07) was depleted in media
PMID:22298573 · one of two readings recorded this
fractional protein synthesis rate in bovine mammary cells and tissue slices, isoleucine depletion
decreases, p = 0.01
Not recorded as a finding: no outcome node for in vitro fractional protein synthesis rate; muscle-protein-fractional-synthetic-rate is human muscle biopsy tracer incorporation
FSR declined when L-isoleucine (P = 0.01), L-leucine (P = 0.01), L-methionine (P = 0.02), or L-threonine (P = 0.07) was depleted in media and was positively correlated (R = 0.64, P < 0.01) with phosphorylation of mTOR and negatively correlated (R = -0.42, P = 0.01) with phosphorylation of eIF2α.
PMID:22298573 · one of two readings recorded this
mTOR phosphorylation
decreases, p = 0.05
Phosphorylation of mTOR and rpS6 kinase 1 (S6K1; Thr389) decreased (P < 0.05) in the absence of L-isoleucine, L-leucine, or all EAA in lactogenic mammary tissue slices
PMID:22298573 · one of two readings recorded this
mTOR phosphorylation
increases, p = 0.05
Supplementation of L-isoleucine increased mTOR, S6K1, and rpS6 phosphorylation (P < 0.05)
PMID:22298573 · one of two readings recorded this
mTOR phosphorylation
increases, p = 0.05
Supplementation of L-leucine to media depleted of EAA increased mTOR and rpS6 and decreased eukaryotic elongation factor 2 (Thr56) phosphorylation (P < 0.05) in MAC-T cells
PMID:22298573 · one of two readings recorded this
mTOR (Ser2448) phosphorylation
decreases, p = 0.05
Omission of L-arginine, L-isoleucine, L-leucine, or all EAA reduced (P < 0.05) mammalian target of rapamycin (mTOR; Ser2448) and ribosomal protein S6 (rpS6; Ser235/236) phosphorylation in MAC-T cells
PMID:22298573 · one of two readings recorded this
rpS6 phosphorylation
increases, p = 0.05
Supplementation of L-isoleucine increased mTOR, S6K1, and rpS6 phosphorylation (P < 0.05)
PMID:22298573 · one of two readings recorded this
rpS6 phosphorylation
increases, p = 0.05
Supplementation of L-leucine to media depleted of EAA increased mTOR and rpS6 and decreased eukaryotic elongation factor 2 (Thr56) phosphorylation (P < 0.05) in MAC-T cells
PMID:22298573 · one of two readings recorded this
rpS6 (Ser235/236) phosphorylation
decreases, p = 0.05
Omission of L-arginine, L-isoleucine, L-leucine, or all EAA reduced (P < 0.05) mammalian target of rapamycin (mTOR; Ser2448) and ribosomal protein S6 (rpS6; Ser235/236) phosphorylation in MAC-T cells
PMID:22298573 · one of two readings recorded this
S6K1 phosphorylation
increases, p = 0.05
Supplementation of L-isoleucine increased mTOR, S6K1, and rpS6 phosphorylation (P < 0.05)
PMID:22298573 · one of two readings recorded this
S6K1 phosphorylation
decreases, p = 0.01
Omission of L-tryptophan also reduced S6K1 phosphorylation (P = 0.01)
PMID:22298573 · one of two readings recorded this
S6K1 (Thr389) phosphorylation
decreases, p = 0.05
Phosphorylation of mTOR and rpS6 kinase 1 (S6K1; Thr389) decreased (P < 0.05) in the absence of L-isoleucine, L-leucine, or all EAA in lactogenic mammary tissue slices
PMID:22298573 · one of two readings recorded this
ambulatory blood pressure monitoring parameters
no effect
No significant change in predictors during the study of ambulatory blood pressure measurement (ABPM) parameters was observed.
PMID:22574612 · one of two readings recorded this
office diastolic blood pressure
decreases, -2.35 mm Hg
When compared with the baseline, office systolic blood pressure (SBP) (-3.42 mm Hg, P < .001) and diastolic blood pressure (DBP) (-2.35 mm Hg, P < .001) significantly decreased, in the LTP-treated patients only.
PMID:22574612 · one of two readings recorded this
office systolic blood pressure
decreases, -3.42 mm Hg
When compared with the baseline, office systolic blood pressure (SBP) (-3.42 mm Hg, P < .001) and diastolic blood pressure (DBP) (-2.35 mm Hg, P < .001) significantly decreased, in the LTP-treated patients only.
PMID:22574612 · one of two readings recorded this
induction of the master virulence activator gene prfA and PrfA-regulated genes in Listeria monocytogenes under limiting BCAA (primarily isoleucine) concentrations
increases
Not recorded as a finding: this platform holds no node for the endpoint
Here we show that limiting BCAA concentrations, primarily isoleucine, results in robust induction of the master virulence activator gene, prfA, and the PrfA-regulated genes.
PMID:22969433 · one of two readings recorded this
induction of the virulence activator gene prfA and PrfA-regulated genes in Listeria monocytogenes under limiting branched-chain amino acid (primarily isoleucine) concentrations
increases
Not recorded as a finding: this platform holds no node for the endpoint
Here we show that limiting BCAA concentrations, primarily isoleucine, results in robust induction of the master virulence activator gene, prfA, and the PrfA-regulated genes.
PMID:22969433 · one of two readings recorded this
intracellular replication requirement for de novo BCAA synthesis
unclear
Intracellular replication requires de novo synthesis of histidine, arginine, purine, and branch chain amino acids (BCAAs), as well as catabolism of L-rhamnose and glycerol
PMID:22969433 · one of two readings recorded this
prfA and PrfA-regulated gene induction under limiting BCAA (primarily isoleucine)
increases
Here we show that limiting BCAA concentrations, primarily isoleucine, results in robust induction of the master virulence activator gene, prfA, and the PrfA-regulated genes
PMID:22969433 · one of two readings recorded this
prfA induction response dependence on CodY
increases
This response was specific and required the nutrient responsive regulator CodY, which is known to bind isoleucine
PMID:22969433 · one of two readings recorded this
office diastolic blood pressure, change from baseline to endpoint
decreases, -0.59 mm Hg (95% CI, -1.18 to -0.01), p = 0.047
The decrease in DBP was marginal (–0.59mm Hg (95% CI, –1.18 to –0.01)) but significant (P = 0.047)(SDC Table 3).
PMID:23382495 · one of two readings recorded this
office systolic blood pressure, change from baseline to endpoint, pooled mean difference vs placebo
decreases, -1.28 mm Hg (95% CI, -2.09 to -0.48), p = 0.0017, n = 1277
Not recorded as a finding: the trial gave a chemically different species
The results of the primary meta-analysis done with the random-effect model showed a statistically significantly greater effect of IPP/VPP over placebo on SBP in European patients, of a magnitude of –1.28mm Hg (95% CI, –2.09 to –0.48, P = 0.0017).
PMID:23382495 · one of two readings recorded this
office systolic blood pressure, change from baseline to endpoint
decreases, -1.28 mm Hg (95% CI, -2.09 to -0.48), p = 0.0017, n = 1277
The results of the primary meta-analysis done with the random-effect model showed a statistically significantly greater effect of IPP/VPP over placebo on SBP in European patients, of a magnitude of –1.28mm Hg (95% CI, –2.09 to –0.48, P = 0.0017).
PMID:23382495 · one of two readings recorded this
angiotensin II AT2 receptor binding affinity (Ki)
increases, Ki = 8.5 µM, compound 17 over 12-times more potent than lead compound 2
The introduction of large, hydrophobic substituents was shown to be beneficial and the most active compound (17, Ki=8.5 μM) was over 12-times more potent than the lead compound 2.
PMID:24388688 · one of two readings recorded this
binding affinity (Ki) for the angiotensin II AT2 receptor (AT2R)
increases, compound 17, Ki=8.5 µM, over 12-times more potent than lead compound 2
The introduction of large, hydrophobic substituents was shown to be beneficial and the most active compound (17, Ki=8.5 μM) was over 12-times more potent than the lead compound 2.
PMID:24388688 · one of two readings recorded this
binding affinity (Ki) of C-terminally modified isoleucine-derived analogues for the angiotensin II AT2 receptor (AT2R)
increases, compound 17, Ki=8.5 µM, over 12-times more potent than lead compound 2
Not recorded as a finding: the trial gave a chemically different species
The introduction of large, hydrophobic substituents was shown to be beneficial and the most active compound (17, Ki=8.5 μM) was over 12-times more potent than the lead compound 2.
PMID:24388688 · one of two readings recorded this
facial Eczema Severity Score (ESS), a 4-point clinician-scored composite of erythema, induration, excoriation and lichenification
decreases, 1.0 vs. 2.6, p = 0.0001
Not recorded as a finding: this platform holds no node for the endpoint
At week 6, facial ESS in pro-AMP cream was significantly lower than the control group (1.0 vs. 2.6; p = 0.0001).
PMID:24750568 · one of two readings recorded this
Facial Eczema Severity Score (ESS)
decreases, 1.0 vs. 2.6, p = 0.0001, n = 107
At week 6, facial ESS in pro-AMP cream was significantly lower than the control group (1.0 vs. 2.6; p = 0.0001).
PMID:24750568 · one of two readings recorded this
Investigator's Global Assessment (IGA) score
decreases, 0.6 vs. 1.2, p = 0.0003, n = 107
IGA score at week 6 was lower in pro-AMP cream group in comparison with control group (0.6 vs. 1.2; p = 0.0003) (Fig. b).
PMID:24750568 · one of two readings recorded this
tolerability score
no effect, 2.8 vs. 2.9, n = 107
Both products were well tolerated with a tolerability score of 2.8 in pro-amp cream group and 2.9 in the control group (NS).
PMID:24750568 · one of two readings recorded this
treatment success (IGA score of 0 or 1) percentage
increases, 88% vs. 58%, p = 0.009, n = 107
Treatment success (IGA score ≤1) percentage at week 6 was 88% in pro-AMP group and 58% in the control group (p = 0.009; Fisher's exact test) with a number needed to treat of 3.3 in favor of pro-AMP group.
PMID:24750568 · one of two readings recorded this
fasting insulin and HOMA-IR by PNPLA3 rs738409 genotype
decreases, HOMA-IR β = -0.39; 95% CI -0.64, -0.14
At the end of the trial, fasting insulin and homeostasis model assessment of insulin resistance (HOMA-IR) values were significantly lower and liver enzymes significantly higher in PNPLA3 G-allele carriers.
PMID:25646328 · one of two readings recorded this
liver enzymes (AST, ALT, GGT) by PNPLA3 rs738409 genotype
increases, AST β = 2.60; ALT β = 3.70; GGT β = 3.70
At the end of the trial, fasting insulin and homeostasis model assessment of insulin resistance (HOMA-IR) values were significantly lower and liver enzymes significantly higher in PNPLA3 G-allele carriers.
PMID:25646328 · one of two readings recorded this
office diastolic blood pressure, change from baseline to final endpoint
decreases, -2.58 mm Hg (95% CI, -3.44 to -1.72)
The estimate of the effect of IPP/VPP on DBP was smaller but significant [-2.58 mmHg (95% CI, -3.44 to -1.72), P<0.0001] (S1 Fig).
PMID:26536628 · one of two readings recorded this
blood glucose and endogenous (hepatic) glucose production during intrahypothalamic isoleucine infusion, whole body glucose kinetics under basal conditions and euglycemic pancreatic clamps in rats
decreases
Not recorded as a finding: this platform holds no node for the endpoint
The results showed that both isoleucine and valine individually lowered blood glucose by decreasing liver glucose production.
PMID:26891318 · one of two readings recorded this
blood glucose and liver glucose production (endogenous glucose production) in rats after intrahypothalamic isoleucine infusion, whole body glucose kinetics under euglycemic pancreatic clamps
decreases
Not recorded as a finding: this platform holds no node for the endpoint
The results showed that both isoleucine and valine individually lowered blood glucose by decreasing liver glucose production.
PMID:26891318 · one of two readings recorded this
blood glucose
decreases
The results showed that both isoleucine and valine individually lowered blood glucose by decreasing liver glucose production
PMID:26891318 · one of two readings recorded this
blood glucose
decreases
The results showed that both isoleucine and valine individually lowered blood glucose by decreasing liver glucose production
PMID:26891318 · one of two readings recorded this
central leucine action on glucose metabolism
decreases
Furthermore, the action of the BCAA leucine was markedly attenuated by HFD feeding
PMID:26891318 · one of two readings recorded this
liver glucose production
decreases
The results showed that both isoleucine and valine individually lowered blood glucose by decreasing liver glucose production
PMID:26891318 · one of two readings recorded this
liver glucose production
decreases
The results showed that both isoleucine and valine individually lowered blood glucose by decreasing liver glucose production
PMID:26891318 · one of two readings recorded this
blood glucose AUC and peak blood glucose
decreases
Compared with the control, isoleucine-10g reduced the blood glucose AUC and peak blood glucose (P < 0.01), whereas effects of isoleucine-5g were NS.
PMID:27655440 · one of two readings recorded this
gastric emptying, 13C-acetate breath test
decreases
Isoleucine-10g, but not isoleucine-5g, slowed gastric emptying (P < 0.05), but gastric emptying was not correlated with the blood glucose AUC.
PMID:27655440 · one of two readings recorded this
plasma insulin, C-peptide, glucagon, GLP-1, GIP (isoleucine loads)
no effect
Not recorded as a finding: Sentence refers back to 'neither load' rather than naming isoleucine in this sentence; agentless reference to the prior isoleucine-dose sentence, not self-supporting on its own.
Neither load affected insulin, C-peptide, glucagon, GLP-1, or GIP.
PMID:27655440 · one of two readings recorded this
plasma insulin, C-peptide, glucagon, GLP-1, GIP
no effect
Neither load affected insulin, C-peptide, glucagon, GLP-1, or GIP.
PMID:27655440 · one of two readings recorded this
subsequent energy intake, buffet-style meal
no effect
Isoleucine did not affect energy intake.
PMID:27655440 · one of two readings recorded this
subsequent energy intake, cold buffet-style meal
no effect
Not recorded as a finding: No matching outcome node exists for post-dose ad-libitum energy intake.
Isoleucine did not affect energy intake.
PMID:27655440 · one of two readings recorded this
positions of isoleucine residues in the N-terminal region of spike polypeptide S2
unclear
The residues identified and their positions relative to the N-terminus of S2 were: serine, 13; valine, 6, 12; leucine, none in the first 20 residues; isoleucine, 2, 19
PMID:3010595 · one of two readings recorded this
expression of genes involved in WAT browning and beige selective markers
increases
the genes involved in the browning of WAT and beige selective markers were upregulated by dietary supplementation with Leu, Ile and their combination
PMID:32104819 · one of two readings recorded this
hepatic steatosis
decreases
Insulin sensitivity and hepatic steatosis impaired by HFD were alleviated after Leu or Ile supplementation
PMID:32104819 · one of two readings recorded this
insulin sensitivity impaired by HFD
increases
Insulin sensitivity and hepatic steatosis impaired by HFD were alleviated after Leu or Ile supplementation
PMID:32104819 · one of two readings recorded this
ratio of Firmicutes-to-Bacteroidetes
decreases
the ratio of Firmicutes-to-Bacteroidetes was decreased after Leu or Ile treatment
PMID:32104819 · one of two readings recorded this
relative white adipose tissue (WAT) weight
decreases
adding Leu, Ile and their combination in drinking water significantly decreased relative white adipose tissue (WAT) weight and serum triglycerides, low-density lipoprotein, free fatty acid, and insulin compared with the HFD control
PMID:32104819 · one of two readings recorded this
relative white adipose tissue weight, mice
decreases
Not recorded as a finding: fat-mass node names adipose mass by DXA or a recorded method; relative WAT weight is a dissected depot weight relative to body weight, not mapped
The results showed that adding Leu, Ile and their combination in drinking water significantly decreased relative white adipose tissue (WAT) weight and serum triglycerides, low-density lipoprotein, free fatty acid, and insulin compared with the HFD control.
PMID:32104819 · one of two readings recorded this
serum free fatty acid
decreases
adding Leu, Ile and their combination in drinking water significantly decreased relative white adipose tissue (WAT) weight and serum triglycerides, low-density lipoprotein, free fatty acid, and insulin compared with the HFD control
PMID:32104819 · one of two readings recorded this
serum insulin
decreases
adding Leu, Ile and their combination in drinking water significantly decreased relative white adipose tissue (WAT) weight and serum triglycerides, low-density lipoprotein, free fatty acid, and insulin compared with the HFD control
PMID:32104819 · one of two readings recorded this
serum low-density lipoprotein in HFD mice, assay not stated
decreases
Not recorded as a finding: mouse LDL sentence is the same grouped-arm sentence; LDL node requires cholesterol-based measurement and 'low-density lipoprotein' was not stated as LDL cholesterol
The results showed that adding Leu, Ile and their combination in drinking water significantly decreased relative white adipose tissue (WAT) weight and serum triglycerides, low-density lipoprotein, free fatty acid, and insulin compared with the HFD control.
PMID:32104819 · one of two readings recorded this
serum low-density lipoprotein
decreases
adding Leu, Ile and their combination in drinking water significantly decreased relative white adipose tissue (WAT) weight and serum triglycerides, low-density lipoprotein, free fatty acid, and insulin compared with the HFD control
PMID:32104819 · one of two readings recorded this
serum triglycerides
decreases
adding Leu, Ile and their combination in drinking water significantly decreased relative white adipose tissue (WAT) weight and serum triglycerides, low-density lipoprotein, free fatty acid, and insulin compared with the HFD control
PMID:32104819 · one of two readings recorded this
13C-labeling incorporation into isoleucine from propionate
increases, ~30% labeled isoleucine, rising to ~60% with formate
Surprisingly, we found that even within a WT strain, the addition of labeled propionate resulted in 30% labeled isoleucine, suggesting that the KBFL route operates naturally if propionate is present in the medium.
PMID:32831171 · one of two readings recorded this
growth without isoleucine supplementation (isoleucine auxotrophy rescue)
increases
We found that the Δ5 strain could grow anaerobically when propionate and formate were added to the medium instead of isoleucine (red line in Figure 8A).
PMID:32831171 · one of two readings recorded this
PTP1B and CDC25B enzyme inhibitory potency (IC50) of 5-aryl-furan derivatives bearing an isoleucine-derived rhodanine moiety
decreases, 5g: PTP1B IC50 = 2.66 ± 0.16 µM; CDC25B IC50 = 0.25 ± 0.02 µM
Not recorded as a finding: the trial gave a chemically different species
Among the compounds studied, 5g was found to have the best PTP1B inhibitory potency (IC50 = 2.66 ± 0.16 µM) and the best cell division cycle 25 homolog B (CDC25B) inhibitory potency (IC50 = 0.25 ± 0.02 µM).
PMID:33268007 · one of two readings recorded this
PTP1B inhibitory potency (IC50)
decreases, 5g IC50 = 2.66 ± 0.16 µM (best PTP1B inhibitor of the series)
Among the compounds studied, 5g was found to have the best PTP1B inhibitory potency (IC50 = 2.66 ± 0.16 µM) and the best cell division cycle 25 homolog B (CDC25B) inhibitory potency (IC50 = 0.25 ± 0.02 µM).
PMID:33268007 · one of two readings recorded this
PTP1B inhibitory potency (IC50)
increases, IC50 = 2.66 ± 0.16 µM (compound 5g)
Among the compounds studied, 5g was found to have the best PTP1B inhibitory potency and the best cell division cycle 25 homolog B (CDC25B) inhibitory potency.
PMID:33268007 · one of two readings recorded this
ATGL protein level
decreases
whereas the protein levels of adipose triglyceride lipase (ATGL) and lipoprotein lipase (LPL) were downregulated
PMID:33289736 · one of two readings recorded this
FAS protein level
increases
Compared with the control, the protein levels of myosin heavy chain (MyHC), myoblast determination protein 1 (MyoD), myogenin (MyoG), peroxisome proliferator-activated receptor gamma (PPARg) and fatty acid synthase (FAS) were upregulated in the Ile group
PMID:33289736 · one of two readings recorded this
insulin resistance
increases
Ile significantly increased both muscle and fat mass, as well as causing insulin resistance and meanwhile upregulating the levels of key adipogenic and myogenic proteins
PMID:33289736 · one of two readings recorded this
LPL protein level
decreases
whereas the protein levels of adipose triglyceride lipase (ATGL) and lipoprotein lipase (LPL) were downregulated
PMID:33289736 · one of two readings recorded this
mitochondrial damage (vacuolation, swelling, cristae fracture) in gastrocnemius and tibialis anterior
increases
Ile damaged the mitochondrial function by vacuolation, swelling and cristae fracture in the gastrocnemius (GAS) and tibialis anterior (TA) with downregulation of mitochondrial function-related genes
PMID:33289736 · one of two readings recorded this
mitochondrial function-related gene expression
decreases
Ile damaged the mitochondrial function by vacuolation, swelling and cristae fracture in the gastrocnemius (GAS) and tibialis anterior (TA) with downregulation of mitochondrial function-related genes
PMID:33289736 · one of two readings recorded this
muscle mass and fat mass
increases
Ile significantly increased both muscle and fat mass, as well as causing insulin resistance and meanwhile upregulating the levels of key adipogenic and myogenic proteins
PMID:33289736 · one of two readings recorded this
muscle mass in mice, method not stated
increases
Not recorded as a finding: lean-mass node is fat-free soft tissue mass by DXA; muscle mass with unstated method is a different construct
The results showed that Ile significantly increased both muscle and fat mass, as well as causing insulin resistance and meanwhile upregulating the levels of key adipogenic and myogenic proteins.
PMID:33289736 · both readings recorded this
MyHC protein level
increases
Compared with the control, the protein levels of myosin heavy chain (MyHC), myoblast determination protein 1 (MyoD), myogenin (MyoG), peroxisome proliferator-activated receptor gamma (PPARg) and fatty acid synthase (FAS) were upregulated in the Ile group
PMID:33289736 · one of two readings recorded this
MyoD protein level
increases
Compared with the control, the protein levels of myosin heavy chain (MyHC), myoblast determination protein 1 (MyoD), myogenin (MyoG), peroxisome proliferator-activated receptor gamma (PPARg) and fatty acid synthase (FAS) were upregulated in the Ile group
PMID:33289736 · one of two readings recorded this
MyoG protein level
increases
Compared with the control, the protein levels of myosin heavy chain (MyHC), myoblast determination protein 1 (MyoD), myogenin (MyoG), peroxisome proliferator-activated receptor gamma (PPARg) and fatty acid synthase (FAS) were upregulated in the Ile group
PMID:33289736 · one of two readings recorded this
myogenesis and lipid droplet accumulation in myotubes
increases
Ile promoted myogenesis and more lipid droplet accumulation in myotubes
PMID:33289736 · one of two readings recorded this
PPARg protein level
increases
Compared with the control, the protein levels of myosin heavy chain (MyHC), myoblast determination protein 1 (MyoD), myogenin (MyoG), peroxisome proliferator-activated receptor gamma (PPARg) and fatty acid synthase (FAS) were upregulated in the Ile group
PMID:33289736 · one of two readings recorded this
gastric emptying
no effect
Not recorded as a finding: Sentence refers to 'neither amino acid' rather than naming isoleucine specifically, and no gastric-emptying instrument is stated in the supplied text; not anchored as an isoleucine-specific claim.
Neither amino acid affected gastric emptying or plasma glucose (peak (mmol/L): control: 12.0 ± 0.5; leucine: 12.5 ± 0.7; isoleucine: 12.0 ± 0.6).
PMID:33310174 · one of two readings recorded this
peak plasma glucose, mmol/L
no effect, peak (mmol/L): control: 12.0 ± 0.5; isoleucine: 12.0 ± 0.6
Not recorded as a finding: Sentence refers to 'neither amino acid' rather than naming isoleucine specifically; not self-supporting for an isoleucine-only claim despite matching the peak-postprandial-glucose node.
Neither amino acid affected gastric emptying or plasma glucose (peak (mmol/L): control: 12.0 ± 0.5; leucine: 12.5 ± 0.7; isoleucine: 12.0 ± 0.6).
PMID:33310174 · one of two readings recorded this
plasma glucagon, before and after drink
increases, peak (pg/mL): control 62±5, isoleucine 69±6, p = 0.031
Isoleucine stimulated (P < 0.05), and leucine tended to stimulate (P = 0.078), glucagon before the drink, and isoleucine stimulated glucagon post-drink (P = 0.031; peak (pg/mL): control: 62 ± 5; leucine: 70 ± 9; isoleucine: 69 ± 6).
PMID:33310174 · one of two readings recorded this
plasma insulin, peak (mU/L)
increases, peak (mU/L): control 70±15, isoleucine 74±15
Leucine and isoleucine stimulated insulin, both before and after the drink (all P < 0.05; peak (mU/L): control: 70 ± 15; leucine: 88 ± 17; isoleucine: 74 ± 15).
PMID:33310174 · one of two readings recorded this
histone lysine propionylation (Kpr) at specific sites
increases
Increasing label incorporation was observed in H2AK5pr, H4K16pr and H3K23pr, but not in H2K14pr, in cells incubated in 13C6-isoleucine, demonstrating the direct contribution of propionate acyl-chains with all three carbons from isoleucine into histone Kpr marks.
PMID:34856123 · one of two readings recorded this
histone propionylation
increases
Not recorded as a finding: Histone propionylation is a chromatin modification, not a protein-activity mechanism predicate or a listed clinical/physiological outcome node.
Using isotope tracing, we identified the branched chain amino acid isoleucine as a major metabolic source of nuclear propionyl-CoA and histone propionylation, thus revealing a new mechanism of crosstalk between metabolism and the epigenome.
PMID:34856123 · one of two readings recorded this
isoleucine contribution to cellular propionyl-CoA pool
increases, ~30-50% of propionyl-CoA pool
Strikingly, isoleucine labeling into propionyl-CoA M3 contributed ∼30 – 50% of the propionyl-CoA pool across three cancer cell lines in the absence of propionate.
PMID:34856123 · one of two readings recorded this
nuclear propionyl-CoA abundance, isoleucine/valine deprivation
decreases, 4-5 fold decrease after 24 h
Nuclear acyl-CoA analysis revealed a substantial (4–5 fold) decrease in propionyl-CoA after 24 h of deprivation of these amino acids.
PMID:34856123 · one of two readings recorded this
claudin-1, occludin, ZO-1 mRNA expression (barrier function genes) in H2O2-challenged MAC-T cells
increases
Additionally, combined leucine and isoleucine significantly increased (p < 0.05) the mRNA expression levels of claudin-1, occludin, and ZO-1.
PMID:35360198 · one of two readings recorded this
IL-6 and IL-1β concentration in MAC-T cell supernatant (ELISA)
decreases
Compared to the H1L1I group, IL-6 significantly decreased (p < 0.05) by 48.24% in the H1L2I, H2L1I, and H2L1.5I groups, while 1 L-1 β significantly decreased (p < 0.05) in the H1L2I group by 65.64% (Figures and (b)).
PMID:35360198 · one of two readings recorded this
IL-6, IL-1β, TNF-α, IL-10 in H2O2-challenged MAC-T cells
decreases, IL-6 decreased 48.24% in combined-treatment groups
Compared to the H1L1I group, IL-6 significantly decreased (p < 0.05) by 48.24% in the H1L2I, H2L1I, and H2L1.5I groups, while 1 L-1 β significantly decreased (p < 0.05) in the H1L2I group by 65.64% (Figures and (b)).
PMID:35360198 · one of two readings recorded this
malondialdehyde (MDA) and total oxidant status (TOS) in MAC-T cells
decreases
TOS and MDA in the H1L2I, H2L1I, and H2L1.5I groups were significantly lower (p < 0.05) than the H1L1I group (Figures and).
PMID:35360198 · one of two readings recorded this
occludin and claudin-1 mRNA expression (RT-qPCR)
increases
When compared to the H1L1I group, leucine significantly increased (p < 0.05) the mRNA expression levels of claudin-1 and occludin and isoleucine significantly increased (p < 0.05) the mRNA expression level of occludin (p < 0.05).
PMID:35360198 · one of two readings recorded this
relative proliferation rate of MAC-T bovine mammary epithelial cells exposed to isoleucine (CCK-8 assay, OD ratio test/control)
decreases, 0.77 ± 0.02 (6 h) and 0.60 ± 0.08 (48 h) at 1.260 mmol/L isoleucine
Not recorded as a finding: this platform holds no node for the endpoint
After stabilizing from 0.420 to 0.840 mmol/L isoleucine, the relative proliferation rate significantly decreased (p < 0.05) to 0.77 ± 0.02 after 6 h and 0.60 ± 0.08 after 48 h under 1.260 mmol/L isoleucine.
PMID:35360198 · one of two readings recorded this
relative proliferation rate of MAC-T cells (CCK-8 assay)
decreases, 0.77 ± 0.02 (6 h) and 0.60 ± 0.08 (48 h) at 1.260 mmol/L isoleucine
After stabilizing from 0.420 to 0.840 mmol/L isoleucine, the relative proliferation rate significantly decreased (p < 0.05) to 0.77 ± 0.02 after 6 h and 0.60 ± 0.08 after 48 h under 1.260 mmol/L isoleucine.
PMID:35360198 · both readings recorded this
total antioxidant status (TAS) in MAC-T cells
increases
However, TAS significantly increased (p < 0.05) in the H1L2I and H2L1I groups by 46.15% and 38.46%, respectively, but not in the H2L1.5I group.
PMID:35360198 · one of two readings recorded this
total antioxidant status (TAS), total oxidant status (TOS), TOS/TAS ratio, malondialdehyde (MDA) in H2O2-challenged MAC-T cells
increases
Compared to the H1L1I group, the relative proliferation rate significantly increased (p < 0.05) in the H1L2I, H2L1I, and H2L1.5I groups by 23.08%, 34.62%, and 24.36%, respectively.
PMID:35360198 · one of two readings recorded this
flower pedicel abscission rate, SlHB15A knockout vs wild-type
increases
Knocking out SlHB15A using clustered regularly interspaced short palindromic repeats-associated protein 9 technology significantly accelerated abscission.
PMID:35522030 · one of two readings recorded this
flower pedicel abscission rate, SlHB15A overexpression
decreases
In contrast, overexpression of microRNA166-resistant SlHB15A (mSlHB15A) delayed abscission.
PMID:35522030 · one of two readings recorded this
fasting blood glucose
Not recorded as a finding: node exists (fasting-blood-glucose) but the isoleucine-specific direction is only reachable by inference from 'reversal reached significance', not stated in words within a self-supporting sentence
Fasting glucose was lower in the FFD group compared to chow, and valine reversed this FFD effect non‐significantly whereas this reversal reached significance in the isoleucine group (Table 1).
PMID:35830259 · one of two readings recorded this
fat mass
no effect
Not recorded as a finding: outcome node fat-mass requires the measurement method (DXA or a stated alternative), which the text supplied does not name
Valine or isoleucine did not affect these endpoint readouts.
PMID:35830259 · one of two readings recorded this
body weight, fat mass and lean mass (% of body weight)
no effect
Not recorded as a finding: combined statement across three endpoints named in the preceding sentence; recorded as a single null finding rather than split without a per-endpoint sentence
Valine or isoleucine did not affect these endpoint readouts.
PMID:35830259 · one of two readings recorded this
body weight, fat mass, lean mass
no effect
Valine or isoleucine did not affect these endpoint readouts.
PMID:35830259 · one of two readings recorded this
body weight
no effect
Not recorded as a finding: outcome node body-mass requires stated scale conditions (time of day, fasted/fed) not given in the text supplied
Valine or isoleucine did not affect these endpoint readouts.
PMID:35830259 · one of two readings recorded this
fasted plasma apolipoprotein B (ApoB) concentration
decreases
Not recorded as a finding: no outcome node for ApoB
Indeed, fasted plasma ApoB mainly present on (V)LDL particles was significantly increased with FFD, while valine did not affect ApoB concentrations and isoleucine significantly lowered ApoB (Table 1).
PMID:35830259 · one of two readings recorded this
fasting blood glucose (5-h fast)
increases
Fasting glucose was lower in the FFD group compared to chow, and valine reversed this FFD effect non‐significantly whereas this reversal reached significance in the isoleucine group (Table 1).
PMID:35830259 · one of two readings recorded this
fasting blood glucose concentration (5-h fasted, tail vein)
increases
Not recorded as a finding: the fasting-blood-glucose node requires an overnight fast; mice were fasted only 5 hours before sampling — endpoint near-miss
Fasting glucose was lower in the FFD group compared to chow, and valine reversed this FFD effect non‐significantly whereas this reversal reached significance in the isoleucine group (Table 1).
PMID:35830259 · one of two readings recorded this
fasting plasma insulin concentration
decreases
Not recorded as a finding: no outcome node for raw fasting insulin (only HOMA-IR is listed, and it was not computed)
Valine and Isoleucine significantly reduced fasting insulin concentrations compared to FFD, indicative of a BCAA‐induced improvement in insulin resistance.
PMID:35830259 · both readings recorded this
fasting plasma insulin
decreases
Valine and Isoleucine significantly reduced fasting insulin concentrations compared to FFD, indicative of a BCAA‐induced improvement in insulin resistance.
PMID:35830259 · both readings recorded this
fecal fatty acid excretion (gas chromatography with flame ionization detection)
no effect
Not recorded as a finding: no outcome node for fecal fatty acid excretion
Valine and isoleucine did not affect the excretion of fecal fatty acids showing comparable values (27.8 and 19.8 μmol/mouse/day, respectively).
PMID:35830259 · one of two readings recorded this
fecal fatty acid excretion
no effect
Valine and isoleucine did not affect the excretion of fecal fatty acids showing comparable values (27.8 and 19.8 μmol/mouse/day, respectively).
PMID:35830259 · both readings recorded this
gut permeability (plasma FD4 after oral gavage)
no effect
Gut permeability, assessed by analysis of orally administered FD4 and subsequent uptake in plasma, was non‐significantly elevated with FFD relative to chow, and not affected by either of the BCAAs (Table 1).
PMID:35830259 · one of two readings recorded this
gut permeability, plasma FITC-dextran (FD4) after oral administration
no effect
Not recorded as a finding: no outcome node for this gut-permeability marker
Gut permeability, assessed by analysis of orally administered FD4 and subsequent uptake in plasma, was non‐significantly elevated with FFD relative to chow, and not affected by either of the BCAAs (Table 1).
PMID:35830259 · one of two readings recorded this
hepatic 4-hydroxynonenal (4-HNE) immunoreactivity (lipid peroxidation marker)
decreases
This FFD‐induced increase was significantly suppressed with both valine and isoleucine.
PMID:35830259 · one of two readings recorded this
hepatic 4-hydroxynonenal (4-HNE) positive immunoreactive structures per mm2 (immunohistochemistry)
decreases
Not recorded as a finding: no outcome node for this lipid-peroxidation marker
This FFD‐induced increase was significantly suppressed with both valine and isoleucine.
PMID:35830259 · one of two readings recorded this
hepatic 4-hydroxynonenal (4-HNE)-positive immunoreactivity (IHC)
decreases
This FFD‐induced increase was significantly suppressed with both valine and isoleucine.
PMID:35830259 · one of two readings recorded this
hepatic chemokine protein expression (MCP-1/CCL2, KC/CXCL1, MIP-2/CXCL2), multiplex immunoassay
decreases
Not recorded as a finding: no outcome node for these hepatic chemokines
Isoleucine but not valine significantly attenuated the expression of the pro‐inflammatory chemokines MCP1/CCL2, KC/CXCL1, and MIP‐2/CXCL2.
PMID:35830259 · one of two readings recorded this
hepatic chemokines MCP-1/CCL2, KC/CXCL1, MIP-2/CXCL2 (multiplex immunoassay)
decreases
Isoleucine but not valine significantly attenuated the expression of the pro‐inflammatory chemokines MCP1/CCL2, KC/CXCL1, and MIP‐2/CXCL2.
PMID:35830259 · one of two readings recorded this
hepatic inflammatory aggregate count per mm2 (H&E histology)
decreases, 51%
Not recorded as a finding: no outcome node for this histological measure
Valine suppressed the number of inflammatory aggregates by 36% and isoleucine even by 51%.
PMID:35830259 · one of two readings recorded this
hepatic inflammatory aggregate count per mm2
decreases, 51%
Not recorded as a finding: no outcome node for histological hepatic inflammatory aggregate count exists in the supplied list
Valine suppressed the number of inflammatory aggregates by 36% and isoleucine even by 51%.
PMID:35830259 · one of two readings recorded this
hepatic inflammatory aggregates per mm2 (H&E)
decreases, 51%
Valine suppressed the number of inflammatory aggregates by 36% and isoleucine even by 51%.
PMID:35830259 · one of two readings recorded this
hepatic macrovesicular and microvesicular steatosis (% liver section affected)
decreases
The decrease in microvesicular steatosis was even more pronounced, with marked reductions by 61% (valine) and 71% (isoleucine) relative to FFD.
PMID:35830259 · one of two readings recorded this
hepatic macrovesicular and microvesicular steatosis (% liver section, H&E)
decreases
The decrease in microvesicular steatosis was even more pronounced, with marked reductions by 61% (valine) and 71% (isoleucine) relative to FFD.
PMID:35830259 · one of two readings recorded this
hepatic macrovesicular steatosis (% liver section affected)
decreases, 24%
Not recorded as a finding: no outcome node for histological liver steatosis exists in the supplied list
Macrovesicular steatosis was decreased by 28% with valine and by 24% with isoleucine.
PMID:35830259 · one of two readings recorded this
hepatic macrovesicular steatosis, percentage of liver cross-section (H&E histology)
decreases, 24%
Not recorded as a finding: no outcome node for hepatic steatosis percentage
Macrovesicular steatosis was decreased by 28% with valine and by 24% with isoleucine.
PMID:35830259 · one of two readings recorded this
hepatic microvesicular steatosis, percentage of liver cross-section (H&E histology)
decreases, 71% (isoleucine)
Not recorded as a finding: no outcome node for hepatic steatosis percentage
The decrease in microvesicular steatosis was even more pronounced, with marked reductions by 61% (valine) and 71% (isoleucine) relative to FFD.
PMID:35830259 · one of two readings recorded this
hepatocellular hypertrophy (% liver section)
decreases, 60%
Hepatocellular hypertrophy was lowered by 47% and 60% with valine and isoleucine, respectively.
PMID:35830259 · one of two readings recorded this
hepatocellular hypertrophy, percentage of liver section with enlarged hepatocytes
decreases, 60%
Not recorded as a finding: no outcome node for this histological measure
Hepatocellular hypertrophy was lowered by 47% and 60% with valine and isoleucine, respectively.
PMID:35830259 · one of two readings recorded this
intrahepatic diacylglycerol (DAG) concentration, fluorometric enzymatic assay
decreases
Not recorded as a finding: no outcome node for hepatic diacylglycerol
The FFD‐induced accumulation was significantly suppressed by both valine and isoleucine, providing a mechanistic rationale for the significant reduction of hyperinsulinemia observed with both BCAAs.
PMID:35830259 · one of two readings recorded this
intrahepatic diacylglycerol (DAG) content
decreases
The FFD‐induced accumulation was significantly suppressed by both valine and isoleucine, providing a mechanistic rationale for the significant reduction of hyperinsulinemia observed with both BCAAs.
PMID:35830259 · both readings recorded this
intrahepatic pro-inflammatory chemokines MCP1/CCL2, KC/CXCL1, MIP-2/CXCL2
decreases
Isoleucine but not valine significantly attenuated the expression of the pro‐inflammatory chemokines MCP1/CCL2, KC/CXCL1, and MIP‐2/CXCL2.
PMID:35830259 · one of two readings recorded this
lean mass
no effect
Not recorded as a finding: outcome node lean-mass requires the measurement method (DXA or a stated alternative), which the text supplied does not name
Valine or isoleucine did not affect these endpoint readouts.
PMID:35830259 · one of two readings recorded this
plasma apolipoprotein B (ApoB)
decreases
Indeed, fasted plasma ApoB mainly present on (V)LDL particles was significantly increased with FFD, while valine did not affect ApoB concentrations and isoleucine significantly lowered ApoB (Table 1).
PMID:35830259 · one of two readings recorded this
plasma cholesterol and triglycerides
FFD feeding induced hyperlipidemia with pronounced increases in plasma cholesterol and TGs, which were non‐significantly lowered by valine and isoleucine.
PMID:35830259 · one of two readings recorded this
plasma total cholesterol and triglycerides (fasting)
Not recorded as a finding: sentence lumps valine and isoleucine together and states the change was non-significant with no isolated estimate for isoleucine
FFD feeding induced hyperlipidemia with pronounced increases in plasma cholesterol and TGs, which were non‐significantly lowered by valine and isoleucine.
PMID:35830259 · one of two readings recorded this
plasma total cholesterol and triglycerides
FFD feeding induced hyperlipidemia with pronounced increases in plasma cholesterol and TGs, which were non‐significantly lowered by valine and isoleucine.
PMID:35830259 · one of two readings recorded this
serum alanine aminotransferase (ALT)
decreases
Isoleucine had a more pronounced lowering effect and significantly decreased ALT and CK18‐M30.
PMID:35830259 · both readings recorded this
serum CK18-M30 (cytokeratin-18 fragment, hepatocyte apoptosis marker)
decreases
Not recorded as a finding: no outcome node for CK18-M30 exists in the supplied list
Isoleucine had a more pronounced lowering effect and significantly decreased ALT and CK18‐M30.
PMID:35830259 · one of two readings recorded this
serum CK18-M30 (cytokeratin-18 fragment M30) concentration
decreases
Not recorded as a finding: no outcome node exists for this hepatocyte-death marker
Isoleucine had a more pronounced lowering effect and significantly decreased ALT and CK18‐M30.
PMID:35830259 · one of two readings recorded this
serum CK18-M30 (cytokeratin-18 fragment M30)
decreases
Isoleucine had a more pronounced lowering effect and significantly decreased ALT and CK18‐M30.
PMID:35830259 · one of two readings recorded this
serum CK18-M30 (hepatocyte apoptosis marker)
decreases
Isoleucine had a more pronounced lowering effect and significantly decreased ALT and CK18‐M30.
PMID:35830259 · one of two readings recorded this
bovine oocyte nuclear maturation to metaphase II (MII) and post-fertilisation zygote/blastocyst development
increases, M1+glutamine+proline+isoleucine gave maturation comparable to TCM199 (57.4% vs 67%); fertilisation medium with the same three amino acids increased the proportion of zygotes but not blastocyst development rate
Addition of glutamine, proline and isoleucine to fertilisation medium also increased the proportion of zygotes but did not increase blastocyst development rates.
PMID:36842262 · one of two readings recorded this
proportion of zygotes with two pronuclei / blastocyst development rate after fertilisation
Addition of glutamine, proline and isoleucine to fertilisation medium also increased the proportion of zygotes but did not increase blastocyst development rates.
PMID:36842262 · one of two readings recorded this
viability of oocytes matured in the simplified glutamine/proline/isoleucine medium, versus TCM199
no effect
Viability of oocytes matured in this simplified medium was equal to those matured in TCM199 since the same proportion of zygotes with 2 pronuclei were observed following fertilisation in medium containing no amino acids.
PMID:36842262 · one of two readings recorded this
surface exposure and contribution to transmembrane hydropathy of leucine versus isoleucine residues in class A GPCRs
Leu side chains more exposed at the protein surface than Ile side chains; Leu content tunes transmembrane domain hydropathy
We found that Leu side chains are generally more exposed at the protein surface than Ile side chains.
PMID:37497770 · one of two readings recorded this
transmembrane-domain hydropathy tuning by leucine versus isoleucine residue content in class A GPCRs
Leu content decreases the variation in hydropathy between receptors and correlates with the non-Leu receptor hydropathy.
PMID:37497770 · one of two readings recorded this
brain insulin resistance
decreases
isoleucine restriction significantly improves insulin resistance in the brain as well as synaptic plasticity impairment
PMID:37658490 · one of two readings recorded this
HFD-induced cognitive dysfunction (behavioral testing)
decreases
Feeding for 11 weeks with behavioral testing, which shows that isoleucine restriction attenuates HFD-induced cognitive dysfunction
PMID:37658490 · one of two readings recorded this
HFD-induced neuronal damage and microglia activation (staining)
decreases
As observed by staining, isoleucine restriction inhibits HFD-induced neuronal damage and microglia activation
PMID:37658490 · one of two readings recorded this
lipopolysaccharide (LPS) level
decreases
isoleucine restriction significantly increases the relative abundance of gut microbiota, decreases the proportion of Proteobacteria, and reduces the levels of lipopolysaccharide (LPS) in serum and brain
PMID:37658490 · one of two readings recorded this
proinflammatory cytokine gene and protein expression
decreases
Isoleucine restriction reduces protein expression of TLR4/MyD88/NF-κB signaling pathway and inhibits upregulation of proinflammatory cytokine genes and protein expression in mice brain
PMID:37658490 · one of two readings recorded this
proportion of Proteobacteria
decreases
isoleucine restriction significantly increases the relative abundance of gut microbiota, decreases the proportion of Proteobacteria, and reduces the levels of lipopolysaccharide (LPS) in serum and brain
PMID:37658490 · one of two readings recorded this
relative abundance of gut microbiota
increases
isoleucine restriction significantly increases the relative abundance of gut microbiota, decreases the proportion of Proteobacteria, and reduces the levels of lipopolysaccharide (LPS) in serum and brain
PMID:37658490 · one of two readings recorded this
synaptic plasticity impairment
decreases
isoleucine restriction significantly improves insulin resistance in the brain as well as synaptic plasticity impairment
PMID:37658490 · one of two readings recorded this
TLR4/MyD88/NF-κB signaling pathway protein expression
decreases
Isoleucine restriction reduces protein expression of TLR4/MyD88/NF-κB signaling pathway and inhibits upregulation of proinflammatory cytokine genes and protein expression in mice brain
PMID:37658490 · one of two readings recorded this
ATP content and global protein synthesis
increases
Not recorded as a finding: No outcome node exists for cellular ATP content or global protein synthesis rate in cultured myotubes.
Consistently, low ATP content and impaired global protein synthesis (high energy requiring cellular process) during hyperammonemia are reversed by Ile in murine myotubes and hiPSCM.
PMID:37871767 · one of two readings recorded this
cellular ATP content
increases
Consistent with reversal of mitochondrial oxidative responses, lower myotube ATP content during hyperammonemia is reversed by Ile supplementation at 6h and 24h, but Ile increased ATP content in UnT myotubes only at 24h.
PMID:37871767 · one of two readings recorded this
global protein synthesis, puromycin incorporation
increases
Leu and Ile treatment for 24h increase global protein synthesis as compared to UnT and Valtreated cells as measured by puromycin incorporation.
PMID:37871767 · one of two readings recorded this
maximal and reserve mitochondrial respiratory capacity
increases
Lower maximum respiration and reserve respiratory capacity, critical components of mitochondrial oxidation during the increased ATP demand resulting from hyperammonemia, are also reversed by Ile at 24h in intact myotubes.
PMID:37871767 · one of two readings recorded this
maximum respiratory capacity
increases
Not recorded as a finding: No outcome node in the closed list corresponds to mitochondrial maximal respiratory capacity in cultured myotubes; a mechanism_claims entry was extracted from the same sentence for complex I function instead.
Ile reverses hyperammonemia-induced reduction in the maximum respiratory capacity, complex I, II, and III functions in early passage murine myotubes and hiPSCM.
PMID:37871767 · one of two readings recorded this
myotube diameter (sarcopenic phenotype)
increases
Lower myotube diameter during hyperammonemia was reversed by Ile at both 6h and 24h.
PMID:37871767 · one of two readings recorded this
myotube maximal mitochondrial respiratory capacity and reserve respiratory capacity, high-resolution respirometry (Oroboros)
increases
Not recorded as a finding: this platform holds no node for the endpoint
Lower maximum respiration and reserve respiratory capacity, critical components of mitochondrial oxidation during the increased ATP demand resulting from hyperammonemia, are also reversed by Ile at 24h in intact myotubes.
PMID:37871767 · one of two readings recorded this
senescence-associated beta-galactosidase activity, senescent myotubes
no effect
However, in senescent myotubes, Ile did not alter SAMP markers (including senescence-associated β-galactosidase activity).
PMID:37871767 · one of two readings recorded this
body weight and adiposity, young mice
decreases
Overall, a Low Ile diet reduced adiposity in both sexes, while a Low AA diet did not reduce adiposity in either sex and S1A – B).
PMID:37939658 · one of two readings recorded this
energy expenditure
increases
Male mice fed a Low Ile diet had drastically increased energy expenditure as assessed via indirect calorimetry; the effect was particularly prominent during the "active" dark phase, when Low AA fed mice also had significantly upregulated energy expenditure.
PMID:37939658 · one of two readings recorded this
frailty and lifespan of genetically heterogeneous male and female UM-HET3 mice under dietary isoleucine restriction (IleR)
increases
Not recorded as a finding: no estimate is reported anywhere
IleR reduces frailty and extends the lifespan of male and female mice, but to a greater degree in males.
PMID:37939658 · one of two readings recorded this
frailty index score, aged mice
decreases
In summary, a Low Ile diet improves healthspan and reduces frailty in both male and female mice, and robustly extends median and maximum lifespan in males.
PMID:37939658 · one of two readings recorded this
glucose tolerance test, young mice
increases
Overall, we found that a Low Ile diet was able to reduce weight gain and improve glycemic control in young HET3 mice and was more effective at promoting metabolic health than reducing all AAs.
PMID:37939658 · one of two readings recorded this
Lifespan of genetically heterogeneous UM-HET3 mice under dietary isoleucine restriction (IleR) versus control diet
increases
Not recorded as a finding: the comparison was against another active treatment
IleR reduces frailty and extends the lifespan of male and female mice, but to a greater degree in males.
PMID:37939658 · one of two readings recorded this
serum isoleucine concentration across an oral glucose tolerance test (0, 30, 60, 120, 180 minutes) and its association with diabetes/prediabetes risk by generalized estimating equation
Not recorded as a finding: the compound is what was measured, not what was given
Isoleucine levels differed between the NGT and NDM groups and between the NGT and IGR groups.
PMID:38214112 · one of two readings recorded this

The whole record — 256 rows

Sources cited

5 papers

Subject: L-isoleucine
Findings: 6
Papers: 5

Other names

7 names

Resolves to: L-isoleucine

Also called: (2S,3S)-2-amino-3-methylpentanoic acid2-Amino-3-methylvaleric acid2S-Amino-3S-methylpentanoic acidalpha-amino-beta-methylvaleric acidIleISOLEUCINEα-amino-β-methylvaleric acid