Compound
kynurenate
A broad-spectrum excitatory amino acid antagonist used as a research tool.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C10H6NO3
- Mass
- 188.162 g/mol
- Charge
- -1
- InChIKey
- HCZHHEIFKROPDY-UHFFFAOYSA-M
- SMILES
- O=C([O-])c1cc(O)c2ccccc2n1
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
2 entities
2 entities reached.
0 reported hops2 assembled from the scaffold
What the reference databases state
Statements
7 statements
7 statements · 2 reference databases · Subject: kynurenate · Sources: Human-GEM, Rhea
- L-kynurenine is converted to kynurenateCompoundHuman-GEM MAR02765Inferred only
- L-kynurenine is converted to kynurenateCompoundHuman-GEM MAR04222Inferred only
- L-kynurenine is converted to kynurenateCompoundRhea RHEA:65560Inferred only
- kynurenate is transported by SLC22A6ProteinRhea RHEA:75999Inferred only
- kynurenate is transported by SLC22A6ProteinHuman-GEM MAR09576Inferred only
- kynurenate is transported by SLC22A8ProteinRhea RHEA:76087Inferred only
- kynurenate is transported by SLC22A8ProteinHuman-GEM MAR09576Inferred only
Reactions
24 reactions
2-oxoglutarate(2-)+L-kynureninekynurenate+L-glutamate(1-)+water
Reaction pageLeft to rightBalancedEC 2.6.1.7mitochondrial matrix
Human-GEM MAR02765CC BY 4.0Reference data
2-oxoglutarate(2-)+L-kynureninekynurenate+L-glutamate(1-)+water
Reaction pageLeft to rightBalancedEC 2.6.1.7cytosol
Human-GEM MAR04222CC BY 4.0Reference data
kynurenate+2-oxoglutarate(2-)kynurenate+2-oxoglutarate(2-)
Transported by SLC22A8 or SLC22A6
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR09576CC BY 4.0Reference data
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR09589CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR09855CC BY 4.0Reference data
kynurenate+AH2+dioxygenCHEBI:58015+A
Reaction pageDirection not assertedBalanced
Rhea RHEA:11968CC BY 4.0Reference data
CHEBI:19775+A+waterkynurenate+AH2
Reaction pageDirection not assertedBalanced
Rhea RHEA:16697CC BY 4.0Reference data
CHEBI:58147kynurenate+water
Reaction pageDirection not assertedBalanced
Rhea RHEA:42452CC BY 4.0Reference data
L-kynurenine+2-oxoglutarate(2-)kynurenate+L-glutamate(1-)+water
Catalysed by GOT2 or KYAT1 or KYAT3 or AADAT
Reaction pageLeft to rightBalanced
Rhea RHEA:65560CC BY 4.0Reference data
L-kynurenine+glyoxylatekynurenate+glycine+water
Reaction pageLeft to rightBalanced
Rhea RHEA:65896CC BY 4.0Reference data
L-kynurenine+pyruvatekynurenate+L-alanine+water
Reaction pageDirection not assertedBalanced
Rhea RHEA:65916CC BY 4.0Reference data
2-oxobutanoate+L-kynurenine(2S)-2-aminobutanoate+kynurenate+water
Catalysed by AADAT
Reaction pageLeft to rightBalanced
Rhea RHEA:66044CC BY 4.0Reference data
Where it reaches
1 system, 1 region, 1 tissue, 1 transporter route — routes, not measurements: transporters known to carry kynurenate are expressed there, and no source reports it arriving.
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Other names
1 name
Resolves to: kynurenate
- Systematic name
- 4-hydroxyquinoline-2-carboxylate