Compound
glycochenodeoxycholic acid
A bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic.
What it touches on the way
Mechanistic reach
8 entities
8 entities reached.
0 reported hops8 assembled from the scaffold
- ABCC3ProteinUNIPROT:O15438transported byInferred only33 paths30 endpoints
- SULT2A1ProteinUNIPROT:Q06520metabolized byInferred only24 paths24 endpoints
- ABCC4ProteinUNIPROT:O15439transported byInferred only10 paths10 endpoints
- SLC51BProteinUNIPROT:Q86UW2transported byInferred only9 paths9 endpoints
- SLC51AProteinUNIPROT:Q86UW1transported byInferred only5 paths5 endpoints
- ABCB11ProteinUNIPROT:O95342transported byInferred only4 paths3 endpoints
- SLC10A2ProteinUNIPROT:Q12908transported byInferred only2 paths2 endpoints
- SLC10A1ProteinUNIPROT:Q14973transported byInferred only2 paths2 endpoints
What the reference databases state
Statements
8 statements
8 statements · 1 reference database · Subject: glycochenodeoxycholic acid · Sources: Human-GEM
- glycochenodeoxycholic acid is metabolised by SULT2A1ProteinHuman-GEM MAR12239Inferred only
- glycochenodeoxycholic acid is transported by ABCB11ProteinHuman-GEM MAR01874Inferred only
- glycochenodeoxycholic acid is transported by ABCC3ProteinHuman-GEM MAR01874Inferred only
- glycochenodeoxycholic acid is transported by ABCC4ProteinHuman-GEM MAR01874Inferred only
- glycochenodeoxycholic acid is transported by SLC10A1ProteinHuman-GEM MAR01867Inferred only
- glycochenodeoxycholic acid is transported by SLC10A2ProteinHuman-GEM MAR01867Inferred only
- glycochenodeoxycholic acid is transported by SLC51AProteinHuman-GEM MAR01874Inferred only
- glycochenodeoxycholic acid is transported by SLC51BProteinHuman-GEM MAR01874Inferred only
Reactions
10 reactions
glycine+MAM03548xCHEBI:1146900+glycochenodeoxycholic acid
Catalysed by BAAT
Reaction pageLeft to rightBalancedEC 2.3.1.65GO:0005777
Human-GEM MAR00084CC BY 4.0Reference data
CHEBI:28701+glycineCHEBI:1146900+glycochenodeoxycholic acid
Catalysed by BAAT
Reaction pageLeft to rightBalancedEC 2.3.1.65GO:0005777
Human-GEM MAR00085CC BY 4.0Reference data
glycochenodeoxycholic acidglycochenodeoxycholic acid
Reaction pageReversibleBalancedEC 1.14.19.1GO:0005615, GO:0005829
Human-GEM MAR00219CC BY 4.0Reference data
glycochenodeoxycholic acidglycochenodeoxycholic acid
Reaction pageReversibleBalancedEC 1.14.19.1GO:0005777, GO:0005829
Human-GEM MAR00220CC BY 4.0Reference data
CHEBI:28701+glycineCHEBI:1146900+glycochenodeoxycholic acid
Catalysed by BAAT
Reaction pageLeft to rightBalancedEC 2.3.1.65GO:0005829
Human-GEM MAR01722CC BY 4.0Reference data
glycochenodeoxycholic acid+MAM02357cglycochenodeoxycholic acid+MAM02357e
Reaction pageReversibleBalance undeterminableGO:0005829, GO:0005615
Human-GEM MAR01859CC BY 4.0Reference data
glycochenodeoxycholic acid+2sodium(1+)glycochenodeoxycholic acid+2sodium(1+)
Transported by SLC10A1 or SLC10A2
Reaction pageLeft to rightBalancedGO:0005615, GO:0005829
Human-GEM MAR01867CC BY 4.0Reference data
ATP+glycochenodeoxycholic acid+waterADP+glycochenodeoxycholic acid+proton+phosphate(3-)
Transported by ABCB11 or ABCC3 or ABCC4 or SLC51A or SLC51B
Reaction pageLeft to rightBalancedGO:0005829, GO:0005615
Human-GEM MAR01874CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableGO:0005615
Human-GEM MAR09283CC BY 4.0Reference data
glycochenodeoxycholic acid+3'-phospho-5'-adenylyl sulfateproton+adenosine 3',5'-bismonophosphate+MAM03588c
Catalysed by SULT2A1
Reaction pageLeft to rightBalancedEC 2.8.2.14GO:0005829
Human-GEM MAR12239CC BY 4.0Reference data
Where it reaches
8 systems, 17 regions, 38 tissues, 57 transporter routes — routes, not measurements: transporters known to carry glycochenodeoxycholic acid are expressed there, and no source reports it arriving.
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Other names
10 names
Resolves to: glycochenodeoxycholic acid
- Also called
- chenodeoxycholylglycineChenodeoxyglycocholatechenodeoxyglycocholic acidGCDCAglycine chenodeoxycholateGlycochenodeoxycholate
- Systematic name
- [(3alpha,7alpha-dihydroxy-24-oxo-5beta-cholan-24-yl)amino]acetic acid[(3α,7α-dihydroxy-24-oxo-5β-cholan-24-yl)amino]acetic acidN-(3alpha,7alpha-dihydroxy-5beta-cholan-24-oyl)glycineN-(3α,7α-dihydroxy-5β-cholan-24-oyl)glycine