Compound
17alpha-hydroxyprogesterone
No description recorded for this entry yet. Everything this graph holds about 17alpha-hydroxyprogesterone is below.
Structure
- Class
- Organic compound
- Formula
- C21H30O3
- Mass
- 330.468 g/mol
- Charge
- 0
- InChIKey
- DBPWSSGDRRHUNT-CEGNMAFCSA-N
- SMILES
- [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(C)=O
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence — none of it carries a grade.
What it touches on the way
A finding says 17alpha-hydroxyprogesterone moved an endpoint. This is the biology in between: the proteins and reactions it runs through to get there. It is where to look for the two things a list of findings cannot answer — why a result might happen, and what else acts on the same machinery.
10 of these are proteins with a page of their own, and that is the door: a protein page says what else it carries, which is how one compound leads to the next.
Mechanistic reach
10 entities
10 entities reached, most connected first. Hub metabolites are excluded, so this is not a claim that the compound touches everything.
0 reported hops10 assembled from the scaffold
- CYP17A1ProteinUNIPROT:P05093metabolized byInferred only198 paths22 endpoints
- CYP21A2ProteinUNIPROT:P08686metabolized byInferred only63 paths21 endpoints
- HSD3B1ProteinUNIPROT:P14060substrate ofInferred only54 paths18 endpoints
- HSD3B2ProteinUNIPROT:P26439substrate ofInferred only54 paths18 endpoints
- AKR1C1ProteinUNIPROT:Q04828substrate ofInferred only46 paths23 endpoints
- AKR1C3ProteinUNIPROT:P42330substrate ofInferred only31 paths31 endpoints
- CYP11B2ProteinUNIPROT:P19099metabolized byInferred only23 paths23 endpoints
- CYP11B1ProteinUNIPROT:P15538metabolized byInferred only20 paths20 endpoints
- CYP46A1ProteinUNIPROT:Q9Y6A2metabolized byInferred only16 paths16 endpoints
- ABCB1ProteinUNIPROT:P08183transported byInferred only12 paths11 endpoints
What the reference databases state
The section above shows paths a projection assembled. This is the reference layer itself, one step from 17alpha-hydroxyprogesterone: what the cleared databases state it reacts with, is carried by, is converted to and takes part in, whether or not a projection has walked it yet.
Regulatory determinations
Published numbers and scores, transcribed from the body that issued them. A determination is not a finding and is not graded; it is the number, who set it, and the document it came from.
LiverTox likelihood score ALiverTox
LiverTox Likelihood Score A — well known, well described and well reported to cause liver injury. Chapter: "Cyproterone". Source: LiverTox Master List (NBK571102).
The document·Public Domain (NLM/NIH)·Transcribed, not graded
Statements
29 statements
29 statements in 2 reference databases name 17alpha-hydroxyprogesterone — Human-GEM, Rhea. Press a relation to see only its rows; every count is the rows behind it.
- 17alpha-hydroxyprogesterone is converted to (17R,20S)-17,20-dihydroxypregn-4-en-3-oneCompoundRhea RHEA:15853Inferred only
- (17R,20S)-17,20-dihydroxypregn-4-en-3-one is converted to 17alpha-hydroxyprogesteroneCompoundRhea RHEA:15853Inferred only
- (17R,20S)-17,20-dihydroxypregn-4-en-3-one is converted to 17alpha-hydroxyprogesteroneCompoundRhea RHEA:15857Inferred only
- 17alpha-hydroxyprogesterone is converted to (17R,20S)-17,20-dihydroxypregn-4-en-3-oneCompoundRhea RHEA:15857Inferred only
- 17alpha-hydroxyprogesterone is metabolised by CYP11B1ProteinHuman-GEM MAR01989Inferred only
- 17alpha-hydroxyprogesterone is metabolised by CYP11B2ProteinHuman-GEM MAR01989Inferred only
- 17alpha-hydroxyprogesterone is metabolised by CYP17A1ProteinRhea RHEA:14753Inferred only
- 17alpha-hydroxyprogesterone is metabolised by CYP17A1ProteinRhea RHEA:46308Inferred only
- 17alpha-hydroxyprogesterone is metabolised by CYP17A1ProteinRhea RHEA:53216Inferred only
- 17alpha-hydroxyprogesterone is metabolised by CYP17A1ProteinHuman-GEM MAR07937Inferred only
- 17alpha-hydroxyprogesterone is metabolised by CYP17A1ProteinHuman-GEM MAR07938Inferred only
- 17alpha-hydroxyprogesterone is metabolised by CYP17A1ProteinHuman-GEM MAR01981Inferred only
Show the remaining 17
- 17alpha-hydroxyprogesterone is metabolised by CYP17A1ProteinHuman-GEM MAR01985Inferred only
- 17alpha-hydroxyprogesterone is metabolised by CYP17A1ProteinHuman-GEM MAR01987Inferred only
- 17alpha-hydroxyprogesterone is metabolised by CYP17A1ProteinHuman-GEM MAR02723Inferred only
- 17alpha-hydroxyprogesterone is metabolised by CYP21A2ProteinHuman-GEM MAR01988Inferred only
- 17alpha-hydroxyprogesterone is metabolised by CYP21A2ProteinHuman-GEM MAR07928Inferred only
- 17alpha-hydroxyprogesterone is metabolised by CYP21A2ProteinRhea RHEA:50308Inferred only
- 17alpha-hydroxyprogesterone is metabolised by CYP46A1ProteinRhea RHEA:46308Inferred only
- 17alpha-hydroxyprogesterone is a substrate of AKR1C1ProteinRhea RHEA:15857Inferred only
- 17alpha-hydroxyprogesterone is a substrate of AKR1C1ProteinRhea RHEA:15853Inferred only
- 17alpha-hydroxyprogesterone is a substrate of AKR1C3ProteinHuman-GEM MAR10072Inferred only
- 17alpha-hydroxyprogesterone is a substrate of HSD3B1ProteinHuman-GEM MAR01983Inferred only
- 17alpha-hydroxyprogesterone is a substrate of HSD3B1ProteinHuman-GEM MAR07973Inferred only
- 17alpha-hydroxyprogesterone is a substrate of HSD3B1ProteinHuman-GEM MAR07939Inferred only
- 17alpha-hydroxyprogesterone is a substrate of HSD3B2ProteinHuman-GEM MAR07973Inferred only
- 17alpha-hydroxyprogesterone is a substrate of HSD3B2ProteinHuman-GEM MAR07939Inferred only
- 17alpha-hydroxyprogesterone is a substrate of HSD3B2ProteinHuman-GEM MAR01983Inferred only
- 17alpha-hydroxyprogesterone is transported by ABCB1ProteinHuman-GEM MAR11770Inferred only
Where it reaches
3 systems, 6 regions, 11 tissues, 11 transporter routes.
Loading the model…
Other names
9 names
Every name this graph resolves to 17alpha-hydroxyprogesterone. Searching any of them lands here.
- Also called
- 17-Hydroxypregn-4-en-3,20-dione17-hydroxyprogesterone17alpha-Hydroxy-4-pregnene-3,20-dione17alpha-Hydroxy-progesteronedelta(4)-Pregnene-17alpha-ol-3,20-dionehydroxyprogesteronePregn-4-ene-3,20-dione-17-olST 21:3;O3
- Systematic name
- 17-hydroxypregn-4-ene-3,20-dione