Compound
oxaloacetate
A dicarboxylic acid ketone that is an important metabolic intermediate of the citric acid cycle. It can be converted to aspartic acid by aspartate transaminase.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C4H2O5
- Mass
- 130.055 g/mol
- Charge
- -2
- InChIKey
- KHPXUQMNIQBQEV-UHFFFAOYSA-L
- SMILES
- O=C([O-])CC(=O)C(=O)[O-]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
15 entities
15 entities reached.
0 reported hops15 assembled from the scaffold
- PCK1ProteinUNIPROT:P35558substrate ofInferred only84 paths42 endpoints
- GOT2ProteinUNIPROT:P00505substrate ofInferred only68 paths34 endpoints
- MDH2ProteinUNIPROT:P40926substrate ofInferred only52 paths26 endpoints
- CSProteinUNIPROT:O75390substrate ofInferred only48 paths24 endpoints
- UCP2ProteinUNIPROT:P55851transported byInferred only47 paths47 endpoints
- MDH1ProteinUNIPROT:P40925substrate ofInferred only46 paths23 endpoints
- PCK2ProteinUNIPROT:Q16822substrate ofInferred only26 paths13 endpoints
- GOT1ProteinUNIPROT:P17174substrate ofInferred only24 paths24 endpoints
- SLC25A11ProteinUNIPROT:Q02978transported byInferred only22 paths22 endpoints
- ME1ProteinUNIPROT:P48163substrate ofInferred only20 paths20 endpoints
- AGXT2ProteinUNIPROT:Q9BYV1substrate ofInferred only16 paths8 endpoints
- PHGDHProteinUNIPROT:O43175substrate ofInferred only14 paths14 endpoints
What the reference databases state
Statements
77 statements
77 statements · 2 reference databases · Subject: oxaloacetate · Sources: Human-GEM, Rhea
- (2R,3R)-tartrate is converted to oxaloacetateCompoundRhea RHEA:15413Inferred only
- oxaloacetate is converted to (2R,3R)-tartrateCompoundRhea RHEA:15413Inferred only
- (S,S)-tartrate is converted to oxaloacetateCompoundRhea RHEA:18289Inferred only
- oxaloacetate is converted to (S,S)-tartrateCompoundRhea RHEA:18289Inferred only
- (S)-malate is converted to oxaloacetateCompoundHuman-GEM MAR08981Inferred only
- oxaloacetate is converted to (S)-malateCompoundRhea RHEA:10824Inferred only
- (S)-malate is converted to oxaloacetateCompoundRhea RHEA:21432Inferred only
- (S)-malate is converted to oxaloacetateCompoundHuman-GEM MAR04139Inferred only
- (S)-malate is converted to oxaloacetateCompoundHuman-GEM MAR04141Inferred only
- oxaloacetate is converted to (S)-malateCompoundHuman-GEM MAR08981Inferred only
- oxaloacetate is converted to (S)-malateCompoundHuman-GEM MAR04141Inferred only
- oxaloacetate is converted to (S)-malateCompoundHuman-GEM MAR04139Inferred only
Show the remaining 65
- oxaloacetate is converted to (S)-malateCompoundRhea RHEA:21432Inferred only
- (S)-malate is converted to oxaloacetateCompoundRhea RHEA:10824Inferred only
- 2-oxosuccinamate is converted to oxaloacetateCompoundRhea RHEA:59412Inferred only
- oxaloacetate is converted to citric acidCompoundRhea RHEA:16845Inferred only
- citric acid is converted to oxaloacetateCompoundRhea RHEA:21160Inferred only
- citric acid is converted to oxaloacetateCompoundRhea RHEA:16845Inferred only
- D-aspartate is converted to oxaloacetateCompoundRhea RHEA:12512Inferred only
- oxaloacetate is converted to D-aspartateCompoundRhea RHEA:76819Inferred only
- D-aspartate is converted to oxaloacetateCompoundRhea RHEA:76819Inferred only
- D-aspartic acid is converted to oxaloacetateCompoundHuman-GEM MAR07641Inferred only
- enol-oxaloacetate is converted to oxaloacetateCompoundRhea RHEA:16021Inferred only
- oxaloacetate is converted to L-aspartateCompoundRhea RHEA:11788Inferred only
- oxaloacetate is converted to L-aspartateCompoundRhea RHEA:11784Inferred only
- oxaloacetate is converted to L-aspartateCompoundRhea RHEA:19025Inferred only
- oxaloacetate is converted to L-aspartateCompoundHuman-GEM MAR03829Inferred only
- oxaloacetate is converted to L-aspartateCompoundHuman-GEM MAR03827Inferred only
- L-aspartate is converted to oxaloacetateCompoundHuman-GEM MAR03827Inferred only
- L-aspartate is converted to oxaloacetateCompoundHuman-GEM MAR03829Inferred only
- L-aspartate is converted to oxaloacetateCompoundRhea RHEA:11784Inferred only
- L-aspartate is converted to oxaloacetateCompoundRhea RHEA:11788Inferred only
- L-aspartate is converted to oxaloacetateCompoundRhea RHEA:19025Inferred only
- L-aspartate is converted to oxaloacetateCompoundRhea RHEA:21824Inferred only
- oxaloacetate is converted to phosphoenolpyruvateCompoundRhea RHEA:18617Inferred only
- oxaloacetate is converted to phosphoenolpyruvateCompoundRhea RHEA:10388Inferred only
- phosphoenolpyruvate is converted to oxaloacetateCompoundRhea RHEA:22356Inferred only
- phosphoenolpyruvate is converted to oxaloacetateCompoundRhea RHEA:18617Inferred only
- phosphoenolpyruvate is converted to oxaloacetateCompoundRhea RHEA:10388Inferred only
- oxaloacetate is converted to phosphoenolpyruvateCompoundRhea RHEA:28370Inferred only
- oxaloacetate is converted to phosphoenolpyruvateCompoundRhea RHEA:22356Inferred only
- phosphoenolpyruvate is converted to oxaloacetateCompoundRhea RHEA:28370Inferred only
- oxaloacetate is converted to phosphoenolpyruvic acidCompoundHuman-GEM MAR04101Inferred only
- oxaloacetate is converted to phosphoenolpyruvic acidCompoundHuman-GEM MAR04103Inferred only
- pyruvate is converted to oxaloacetateCompoundRhea RHEA:20844Inferred only
- oxaloacetate is converted to pyruvateCompoundRhea RHEA:57724Inferred only
- oxaloacetate is converted to pyruvateCompoundHuman-GEM MAR20110Inferred only
- pyruvate is converted to oxaloacetateCompoundRhea RHEA:57724Inferred only
- oxaloacetate is converted to pyruvateCompoundHuman-GEM MAR11430Inferred only
- oxaloacetate is converted to pyruvateCompoundRhea RHEA:15641Inferred only
- pyruvate is converted to oxaloacetateCompoundHuman-GEM MAR04143Inferred only
- oxaloacetate is a substrate of AGXT2ProteinRhea RHEA:77343Inferred only
- oxaloacetate is a substrate of AGXT2ProteinRhea RHEA:77347Inferred only
- oxaloacetate is a substrate of CSProteinRhea RHEA:16845Inferred only
- oxaloacetate is a substrate of CSProteinHuman-GEM MAR04145Inferred only
- oxaloacetate is a substrate of FAHD1ProteinHuman-GEM MAR11430Inferred only
- oxaloacetate is a substrate of FAHD1ProteinRhea RHEA:15641Inferred only
- oxaloacetate is a substrate of FAHD1ProteinHuman-GEM MAR20110Inferred only
- oxaloacetate is a substrate of GOT1ProteinHuman-GEM MAR03829Inferred only
- oxaloacetate is a substrate of GOT1L1ProteinHuman-GEM MAR03829Inferred only
- oxaloacetate is a substrate of GOT2ProteinHuman-GEM MAR03827Inferred only
- oxaloacetate is a substrate of GOT2ProteinHuman-GEM MAR08098Inferred only
- oxaloacetate is a substrate of MDH1ProteinRhea RHEA:21432Inferred only
- oxaloacetate is a substrate of MDH1ProteinHuman-GEM MAR04139Inferred only
- oxaloacetate is a substrate of MDH1BProteinHuman-GEM MAR04139Inferred only
- oxaloacetate is a substrate of MDH2ProteinHuman-GEM MAR04141Inferred only
- oxaloacetate is a substrate of MDH2ProteinRhea RHEA:21432Inferred only
- oxaloacetate is a substrate of ME1ProteinRhea RHEA:15641Inferred only
- oxaloacetate is a substrate of ME2ProteinRhea RHEA:15641Inferred only
- oxaloacetate is a substrate of ME3ProteinRhea RHEA:15641Inferred only
- oxaloacetate is a substrate of PCK1ProteinHuman-GEM MAR04101Inferred only
- oxaloacetate is a substrate of PCK1ProteinRhea RHEA:10388Inferred only
- oxaloacetate is a substrate of PCK2ProteinHuman-GEM MAR04103Inferred only
- oxaloacetate is a substrate of PCK2ProteinRhea RHEA:10388Inferred only
- oxaloacetate is a substrate of PHGDHProteinRhea RHEA:21432Inferred only
- oxaloacetate is transported by SLC25A11ProteinRhea RHEA:71603Inferred only
- oxaloacetate is transported by UCP2ProteinRhea RHEA:73303Inferred only
Reactions
80 reactions
2-oxoglutarate(2-)+L-aspartateL-glutamate(1-)+oxaloacetate
Catalysed by GOT2
Reaction pageReversibleBalancedEC 2.6.1.1mitochondrial matrix
Human-GEM MAR03827CC BY 4.0Reference data
2-oxoglutarate(2-)+L-aspartateL-glutamate(1-)+oxaloacetate
Reaction pageReversibleBalancedEC 2.6.1.1cytosol
Human-GEM MAR03829CC BY 4.0Reference data
(S)-malate+oxaloacetate(S)-malate+oxaloacetate
Reaction pageLeft to rightBalancedmitochondrial matrix, cytosol
Human-GEM MAR03949CC BY 4.0Reference data
GTP+oxaloacetatecarbon dioxide+GDP+phosphoenolpyruvic acid
Catalysed by PCK1
Reaction pageLeft to rightBalancedEC 4.1.1.32cytosol
Human-GEM MAR04101CC BY 4.0Reference data
GTP+oxaloacetatecarbon dioxide+GDP+phosphoenolpyruvic acid
Catalysed by PCK2
Reaction pageLeft to rightBalancedEC 4.1.1.32mitochondrial matrix
Human-GEM MAR04103CC BY 4.0Reference data
proton+NADH(2-)+oxaloacetate(S)-malate+NAD(+)
Reaction pageReversibleBalancedEC 1.1.1.37cytosol
Human-GEM MAR04139CC BY 4.0Reference data
proton+NADH(2-)+oxaloacetate(S)-malate+NAD(+)
Catalysed by MDH2
Reaction pageReversibleBalancedEC 1.1.1.37mitochondrial matrix
Human-GEM MAR04141CC BY 4.0Reference data
ATP+hydrogencarbonate+pyruvateADP+proton+oxaloacetate+phosphate(3-)
Catalysed by PC
Reaction pageLeft to rightBalancedEC 6.4.1.1mitochondrial matrix
Human-GEM MAR04143CC BY 4.0Reference data
CHEBI:15351+water+oxaloacetatecitric acid+CHEBI:1146900+proton
Catalysed by CS
Reaction pageLeft to rightBalancedEC 2.3.3.1, 2.3.3.3mitochondrial matrix
Human-GEM MAR04145CC BY 4.0Reference data
ATP+citric acid+CHEBI:1146900CHEBI:15351+ADP+oxaloacetate+phosphate(3-)
Catalysed by ACLY
Reaction pageLeft to rightBalancedEC 2.3.3.8cytosol
Human-GEM MAR04149CC BY 4.0Reference data
D-aspartic acid+FAD+waterFADH2+proton+ammonium+oxaloacetate
Catalysed by DDO
Reaction pageLeft to rightBalancedEC 1.4.3.1peroxisome
Human-GEM MAR07641CC BY 4.0Reference data
water+oxaloacetate+propionyl-CoAMAM00665c+CHEBI:1146900+proton
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR08078CC BY 4.0Reference data
On the label
Labelled products
4 products
Source: NIH DSLD · Ingredient: oxaloacetate · 4 products · Declared amount per serving: 17–200 mg (4 products)
4 labels state an amount0 do not
- AOR Advanced Orthomolecular Research AdvancedbenaGene100 mgper 1 Capsule(s)DSLD:214435
- AOR Advanced Orthomolecular Research UltraMito-Charger17 mgper 1 Capsule(s)DSLD:214778
- MitachromeOAA Oxaloacetic Acid200 mgper 1 Capsule(s)DSLD:274571
- Terra BiologicalbenaGene Lozenges Raspberry Limethermally stabilized100 mgper 1 Lozenge(s)DSLD:334632
Label record: NIH Office of Dietary Supplements · CC0
Where it reaches
8 systems, 19 regions, 60 tissues, 63 transporter routes — routes, not measurements: transporters known to carry oxaloacetate are expressed there, and no source reports it arriving.
Loading the model…
Other names
7 names
Resolves to: oxaloacetate
- Also called
- oxalacetateoxaloacetate dianionoxobutanedioateoxobutanedioic acid, ion(2-)oxobutanedioic acid, ion(2−)oxosuccinate
- Systematic name
- 2-oxobutanedioate