Compound
3',5'-cyclic GMP
The conjugate base of guanosine 3',5'-cyclic phosphate arising from deprotonation of the free phosphate OH group; major species at pH 7.3.
Definition from ChEBI (CHEBI:57746), read 2026-09-23. CC BY 4.0.
Structure
No depiction stored
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- Class
- Organic compound, anion
- Formula
- C10H11N5O7P
- Mass
- 344.2 g/mol
- Charge
- -1
- InChIKey
- ZOOGRGPOEVQQDX-UUOKFMHZSA-M
- SMILES
- Nc1nc(=O)c2ncn([C@@H]3O[C@@H]4COP(=O)([O-])O[C@H]4[C@H]3O)c2n1
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
25 entities
25 entities reached.
0 reported hops25 assembled from the scaffold
- PDE1BProteinUNIPROT:Q01064substrate ofInferred only80 paths20 endpoints
- PDE3BProteinUNIPROT:Q13370substrate ofInferred only76 paths19 endpoints
- PDE1AProteinUNIPROT:P54750substrate ofInferred only72 paths18 endpoints
- PDE4DProteinUNIPROT:Q08499substrate ofInferred only69 paths23 endpoints
- PDE1CProteinUNIPROT:Q14123substrate ofInferred only54 paths14 endpoints
- PDE5AProteinUNIPROT:O76074substrate ofInferred only52 paths13 endpoints
- PDE6AProteinUNIPROT:P16499substrate ofInferred only44 paths11 endpoints
- PDE6BProteinUNIPROT:P35913substrate ofInferred only44 paths11 endpoints
- PDE3AProteinUNIPROT:Q14432substrate ofInferred only40 paths10 endpoints
- PDE6GProteinUNIPROT:P18545substrate ofInferred only39 paths13 endpoints
- PDE10AProteinUNIPROT:Q9Y233substrate ofInferred only36 paths9 endpoints
- PDE11AProteinUNIPROT:Q9HCR9substrate ofInferred only34 paths9 endpoints
Show the remaining 13
- PDE9AProteinUNIPROT:O76083substrate ofInferred only24 paths6 endpoints
- ABCC5ProteinUNIPROT:O15440transported byInferred only22 paths11 endpoints
- ABCC4ProteinUNIPROT:O15439transported byInferred only20 paths10 endpoints
- PDE2AProteinUNIPROT:O00408substrate ofInferred only16 paths7 endpoints
- PDE4CProteinUNIPROT:Q08493substrate ofInferred only12 paths6 endpoints
- PDE7BProteinUNIPROT:Q9NP56substrate ofInferred only12 paths6 endpoints
- PDE8AProteinUNIPROT:O60658substrate ofInferred only10 paths5 endpoints
- PDE4BProteinUNIPROT:Q07343substrate ofInferred only9 paths9 endpoints
- PDE8BProteinUNIPROT:O95263substrate ofInferred only7 paths7 endpoints
- PDE6CProteinUNIPROT:P51160substrate ofInferred only4 paths1 endpoint
- PDE6HProteinUNIPROT:Q13956substrate ofInferred only4 paths1 endpoint
- SLC22A7ProteinUNIPROT:Q9Y694transported byInferred only2 paths2 endpoints
- SLC22A6ProteinUNIPROT:Q4U2R8transported byInferred only1 path1 endpoint
What the reference databases state
Statements
79 statements
79 statements · 2 reference databases · Subject: 3',5'-cyclic GMP · Sources: Human-GEM, Rhea
- 3',5'-cyclic GMP is a substrate of PDE10AProteinHuman-GEM MAR08085Inferred only
- 3',5'-cyclic GMP is a substrate of PDE10AProteinRhea RHEA:16957Inferred only
- 3',5'-cyclic GMP is a substrate of PDE10AProteinHuman-GEM MAR08083Inferred only
- 3',5'-cyclic GMP is a substrate of PDE10AProteinHuman-GEM MAR04048Inferred only
- 3',5'-cyclic GMP is a substrate of PDE11AProteinHuman-GEM MAR04048Inferred only
- 3',5'-cyclic GMP is a substrate of PDE11AProteinHuman-GEM MAR08085Inferred only
- 3',5'-cyclic GMP is a substrate of PDE11AProteinRhea RHEA:16957Inferred only
- 3',5'-cyclic GMP is a substrate of PDE11AProteinHuman-GEM MAR08083Inferred only
- 3',5'-cyclic GMP is a substrate of PDE1AProteinRhea RHEA:16957Inferred only
- 3',5'-cyclic GMP is a substrate of PDE1AProteinHuman-GEM MAR08083Inferred only
- 3',5'-cyclic GMP is a substrate of PDE1AProteinHuman-GEM MAR04048Inferred only
- 3',5'-cyclic GMP is a substrate of PDE1AProteinHuman-GEM MAR08085Inferred only
Show the remaining 67
- 3',5'-cyclic GMP is a substrate of PDE1BProteinRhea RHEA:16957Inferred only
- 3',5'-cyclic GMP is a substrate of PDE1BProteinHuman-GEM MAR04048Inferred only
- 3',5'-cyclic GMP is a substrate of PDE1BProteinHuman-GEM MAR08085Inferred only
- 3',5'-cyclic GMP is a substrate of PDE1BProteinHuman-GEM MAR08083Inferred only
- 3',5'-cyclic GMP is a substrate of PDE1CProteinHuman-GEM MAR08085Inferred only
- 3',5'-cyclic GMP is a substrate of PDE1CProteinHuman-GEM MAR04048Inferred only
- 3',5'-cyclic GMP is a substrate of PDE1CProteinRhea RHEA:16957Inferred only
- 3',5'-cyclic GMP is a substrate of PDE1CProteinHuman-GEM MAR08083Inferred only
- 3',5'-cyclic GMP is a substrate of PDE2AProteinRhea RHEA:16957Inferred only
- 3',5'-cyclic GMP is a substrate of PDE2AProteinHuman-GEM MAR08083Inferred only
- 3',5'-cyclic GMP is a substrate of PDE2AProteinHuman-GEM MAR04048Inferred only
- 3',5'-cyclic GMP is a substrate of PDE2AProteinHuman-GEM MAR08085Inferred only
- 3',5'-cyclic GMP is a substrate of PDE3AProteinHuman-GEM MAR08085Inferred only
- 3',5'-cyclic GMP is a substrate of PDE3AProteinRhea RHEA:16957Inferred only
- 3',5'-cyclic GMP is a substrate of PDE3AProteinHuman-GEM MAR04048Inferred only
- 3',5'-cyclic GMP is a substrate of PDE3AProteinHuman-GEM MAR08083Inferred only
- 3',5'-cyclic GMP is a substrate of PDE3BProteinHuman-GEM MAR04048Inferred only
- 3',5'-cyclic GMP is a substrate of PDE3BProteinHuman-GEM MAR08083Inferred only
- 3',5'-cyclic GMP is a substrate of PDE3BProteinHuman-GEM MAR08085Inferred only
- 3',5'-cyclic GMP is a substrate of PDE3BProteinRhea RHEA:16957Inferred only
- 3',5'-cyclic GMP is a substrate of PDE4BProteinHuman-GEM MAR08083Inferred only
- 3',5'-cyclic GMP is a substrate of PDE4CProteinHuman-GEM MAR08083Inferred only
- 3',5'-cyclic GMP is a substrate of PDE4CProteinHuman-GEM MAR08085Inferred only
- 3',5'-cyclic GMP is a substrate of PDE4DProteinHuman-GEM MAR04048Inferred only
- 3',5'-cyclic GMP is a substrate of PDE4DProteinHuman-GEM MAR08085Inferred only
- 3',5'-cyclic GMP is a substrate of PDE4DProteinHuman-GEM MAR08083Inferred only
- 3',5'-cyclic GMP is a substrate of PDE5AProteinHuman-GEM MAR04048Inferred only
- 3',5'-cyclic GMP is a substrate of PDE5AProteinRhea RHEA:16957Inferred only
- 3',5'-cyclic GMP is a substrate of PDE5AProteinHuman-GEM MAR08085Inferred only
- 3',5'-cyclic GMP is a substrate of PDE5AProteinHuman-GEM MAR08083Inferred only
- 3',5'-cyclic GMP is a substrate of PDE6AProteinRhea RHEA:16957Inferred only
- 3',5'-cyclic GMP is a substrate of PDE6AProteinHuman-GEM MAR04048Inferred only
- 3',5'-cyclic GMP is a substrate of PDE6AProteinHuman-GEM MAR08083Inferred only
- 3',5'-cyclic GMP is a substrate of PDE6AProteinHuman-GEM MAR08085Inferred only
- 3',5'-cyclic GMP is a substrate of PDE6BProteinHuman-GEM MAR08083Inferred only
- 3',5'-cyclic GMP is a substrate of PDE6BProteinHuman-GEM MAR04048Inferred only
- 3',5'-cyclic GMP is a substrate of PDE6BProteinHuman-GEM MAR08085Inferred only
- 3',5'-cyclic GMP is a substrate of PDE6BProteinRhea RHEA:16957Inferred only
- 3',5'-cyclic GMP is a substrate of PDE6CProteinHuman-GEM MAR08085Inferred only
- 3',5'-cyclic GMP is a substrate of PDE6CProteinHuman-GEM MAR04048Inferred only
- 3',5'-cyclic GMP is a substrate of PDE6CProteinRhea RHEA:16957Inferred only
- 3',5'-cyclic GMP is a substrate of PDE6CProteinHuman-GEM MAR08083Inferred only
- 3',5'-cyclic GMP is a substrate of PDE6GProteinHuman-GEM MAR08085Inferred only
- 3',5'-cyclic GMP is a substrate of PDE6GProteinHuman-GEM MAR08083Inferred only
- 3',5'-cyclic GMP is a substrate of PDE6GProteinHuman-GEM MAR04048Inferred only
- 3',5'-cyclic GMP is a substrate of PDE6HProteinRhea RHEA:16957Inferred only
- 3',5'-cyclic GMP is a substrate of PDE6HProteinHuman-GEM MAR08085Inferred only
- 3',5'-cyclic GMP is a substrate of PDE6HProteinHuman-GEM MAR08083Inferred only
- 3',5'-cyclic GMP is a substrate of PDE6HProteinHuman-GEM MAR04048Inferred only
- 3',5'-cyclic GMP is a substrate of PDE7BProteinHuman-GEM MAR04048Inferred only
- 3',5'-cyclic GMP is a substrate of PDE7BProteinHuman-GEM MAR08083Inferred only
- 3',5'-cyclic GMP is a substrate of PDE8AProteinHuman-GEM MAR08085Inferred only
- 3',5'-cyclic GMP is a substrate of PDE8AProteinHuman-GEM MAR04048Inferred only
- 3',5'-cyclic GMP is a substrate of PDE8BProteinHuman-GEM MAR04048Inferred only
- 3',5'-cyclic GMP is a substrate of PDE9AProteinHuman-GEM MAR04048Inferred only
- 3',5'-cyclic GMP is a substrate of PDE9AProteinRhea RHEA:16957Inferred only
- 3',5'-cyclic GMP is a substrate of PDE9AProteinHuman-GEM MAR08083Inferred only
- 3',5'-cyclic GMP is a substrate of PDE9AProteinHuman-GEM MAR08085Inferred only
- 3',5'-cyclic GMP is a substrate of PRUNE1ProteinRhea RHEA:16957Inferred only
- 3',5'-cyclic GMP is transported by ABCC11ProteinRhea RHEA:66188Inferred only
- 3',5'-cyclic GMP is transported by ABCC11ProteinHuman-GEM MAR07692Inferred only
- 3',5'-cyclic GMP is transported by ABCC4ProteinRhea RHEA:66188Inferred only
- 3',5'-cyclic GMP is transported by ABCC4ProteinHuman-GEM MAR07692Inferred only
- 3',5'-cyclic GMP is transported by ABCC5ProteinHuman-GEM MAR07692Inferred only
- 3',5'-cyclic GMP is transported by ABCC5ProteinRhea RHEA:66188Inferred only
- 3',5'-cyclic GMP is transported by SLC22A6ProteinRhea RHEA:76131Inferred only
- 3',5'-cyclic GMP is transported by SLC22A7ProteinRhea RHEA:76207Inferred only
Reactions
14 reactions
GTP3',5'-cyclic GMP+diphosphate(3-)
Catalysed by GUCY1A1 & GUCY1B1 or GUCY2C or ADCY2 or GUCY2F or ADCY7 or GUCY2D or ADCY3 or ADCY10 or GUCY1A2 or ADCY8 or NPR2 or NPR1
Reaction pageLeft to rightBalancedEC 4.6.1.1, 4.6.1.2cytosol
Human-GEM MAR04022CC BY 4.0Reference data
3',5'-cyclic GMP+waterGMP+proton
Catalysed by PDE8A or PDE6C or PDE10A or PDE8B or PDE4D or PDE1A or PDE1B or PDE11A or PDE6A or PDE6B or PDE5A or PDE6H and 7 more alternatives
Reaction pageLeft to rightBalancedEC 3.1.4.17, 3.1.4.35cytosol
Human-GEM MAR04048CC BY 4.0Reference data
ATP+3',5'-cyclic GMP+waterADP+3',5'-cyclic GMP+proton+phosphate(3-)
Transported by ABCC5 or ABCC11 or ABCC4
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07692CC BY 4.0Reference data
3',5'-cyclic GMP3',5'-cyclic GMP
Reaction pageReversibleBalancedcytosol, nucleus
Human-GEM MAR08082CC BY 4.0Reference data
3',5'-cyclic GMP+waterGMP+proton
Catalysed by PDE6C or PDE4C or PDE10A or PDE4D or PDE1A or PDE1B or PDE11A or PDE6A or PDE6B or PDE5A or PDE6H or PDE3B and 7 more alternatives
Reaction pageLeft to rightBalancedEC 3.1.4.35nucleus
Human-GEM MAR08083CC BY 4.0Reference data
3',5'-cyclic GMP3',5'-cyclic GMP
Reaction pageReversibleBalancedcytosol, Golgi apparatus
Human-GEM MAR08084CC BY 4.0Reference data
3',5'-cyclic GMP+waterGMP+proton
Catalysed by PDE8A or PDE6C or PDE4C or PDE10A or PDE4D or PDE1A or PDE1B or PDE11A or PDE6A or PDE6B or PDE5A or PDE6H and 6 more alternatives
Reaction pageLeft to rightBalancedEC 3.1.4.17Golgi apparatus
Human-GEM MAR08085CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR09220CC BY 4.0Reference data
GTP3',5'-cyclic GMP+diphosphate(3-)
Catalysed by NPR1 or NPR2 or GUCY2C or GUCY1A2 or GUCY2F or GUCY1A1 or GUCY1B1 or GUCY2D
Reaction pageLeft to rightBalanced
Rhea RHEA:13665CC BY 4.0Reference data
3',5'-cyclic GMP+waterGMP+hydron
Catalysed by PDE2A or PDE5A or PDE9A or PDE6A or PDE6B or PDE6C or PDE1A or PDE1B or PDE3B or PDE6H or PDE1C or PDE3A and 3 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:16957CC BY 4.0Reference data
3',5'-cyclic GMP+ATP(4-)+water3',5'-cyclic GMP+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCC4 or ABCC5 or ABCC11
Reaction pageLeft to rightBalanced
Rhea RHEA:66188CC BY 4.0Reference data
3',5'-cyclic GMP+NAD(1-)CHEBI:142721+nicotinamide+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:71899CC BY 4.0Reference data
Where it reaches
4 systems, 9 regions, 20 tissues, 20 transporter routes — routes, not measurements: transporters known to carry 3',5'-cyclic GMP are expressed there, and no source reports it arriving.
Loading the model…
Other names
2 names
Resolves to: 3',5'-cyclic GMP
- Also called
- 3',5'-cyclic GMP anion
- Systematic name
- guanosine 3',5'-phosphate