Compound
thiamine triphosphate
3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-4-methyl-5-(4,6,8,8-tetrahydroxy-3,5,7-trioxa-4,6,8-triphosphaoct-1-yl)thiazolium hydroxide, inner salt, P,P',P''-trioxide. The triphosphate ester of thiamine. In Leigh's disease, this compound is present in decreased amounts in the brain due to a metabolic block in its formation.
Structure
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- Class
- Organic compound, anion
- Formula
- C12H16N4O10P3S
- Mass
- 501.267 g/mol
- Charge
- -3
- InChIKey
- IWLROWZYZPNOFC-UHFFFAOYSA-K
- SMILES
- Cc1ncc(C[n+]2csc(CCOP(=O)([O-])OP(=O)([O-])OP(=O)([O-])[O-])c2C)c(N)n1
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
1 entity
1 entities reached.
0 reported hops1 assembled from the scaffold
What the reference databases state
Statements
5 statements
5 statements · 1 reference database · Subject: thiamine triphosphate · Sources: Human-GEM
- thiamine triphosphate is converted to thiamine(1+) diphosphateCompoundHuman-GEM MAR04207Inferred only
- thiamine(1+) diphosphate is converted to thiamine triphosphateCompoundHuman-GEM MAR04206Inferred only
- thiamine triphosphate is a substrate of THTPAProteinHuman-GEM MAR04207Inferred only
- thiamine triphosphate is transported by SLC19A1ProteinHuman-GEM MAR01793Inferred only
- thiamine triphosphate is transported by SLC19A1ProteinHuman-GEM MAR07687Inferred only
Reactions
8 reactions
3water+thiamine triphosphate3water+thiamine triphosphate
Transported by SLC19A1
Reaction pageLeft to rightBalancedGO:0005615, GO:0005829
Human-GEM MAR01793CC BY 4.0Reference data
ATP+thiamine(1+) diphosphateADP+thiamine triphosphate
Catalysed by TPK1
Reaction pageLeft to rightBalancedEC 2.7.6.2GO:0005829
Human-GEM MAR04206CC BY 4.0Reference data
water+thiamine triphosphateproton+phosphate(3-)+thiamine(1+) diphosphate
Catalysed by THTPA
Reaction pageLeft to rightBalancedEC 3.6.1.28GO:0005829
Human-GEM MAR04207CC BY 4.0Reference data
3water+thiamine triphosphate3water+thiamine triphosphate
Transported by SLC19A1
Reaction pageLeft to rightBalancedGO:0005615, GO:0005829
Human-GEM MAR07687CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableGO:0005615
Human-GEM MAR09106CC BY 4.0Reference data
thiamine diphosphate+ATP(4-)thiamine triphosphate+ADP(3-)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:11240CC BY 4.0Reference data
thiamine triphosphate+waterthiamine diphosphate+hydrogenphosphate+hydron
Catalysed by THTPA
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:11744CC BY 4.0Reference data
thiamine diphosphate+ADP(3-)thiamine triphosphate+AMP
Catalysed by AK1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:69180CC BY 4.0Reference data
Where it reaches
1 system, 1 region, 1 tissue, 1 transporter route — routes, not measurements: transporters known to carry thiamine triphosphate are expressed there, and no source reports it arriving.
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Other names
9 names
Resolves to: thiamine triphosphate
- Also called
- thiamin triphosphate trianionthiamin triphosphate(3-)thiamin triphosphate(3−)thiamine triphosphate trianionthiamine triphosphate(3-)thiamine triphosphate(3−)TTP(3-)TTP(3−)
- Systematic name
- 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-5-(2-{[oxido({[oxido(phosphonatooxy)phosphoryl]oxy})phosphoryl]oxy}ethyl)-1,3-thiazol-3-ium