Compound
CHEBI:15971
An essential amino acid that is required for the production of histamine.
What it touches on the way
Mechanistic reach
20 entities
20 entities reached.
0 reported hops20 assembled from the scaffold
- SLC38A2ProteinUNIPROT:Q96QD8transported byInferred only400 paths200 endpoints
- SLC7A9ProteinUNIPROT:P82251transported byInferred only144 paths9 endpoints
- SLC7A7ProteinUNIPROT:Q9UM01transported byInferred only48 paths16 endpoints
- SLC7A6ProteinUNIPROT:Q92536transported byInferred only46 paths2 endpoints
- SLC7A5ProteinUNIPROT:Q01650transported byInferred only40 paths8 endpoints
- SLC3A2ProteinUNIPROT:P08195transported byInferred only36 paths12 endpoints
- SLC7A8ProteinUNIPROT:Q9UHI5transported byInferred only18 paths18 endpoints
- SLC3A1ProteinUNIPROT:Q07837transported byInferred only16 paths1 endpoint
- HARS1ProteinUNIPROT:P12081substrate ofInferred only15 paths15 endpoints
- SLC38A5ProteinUNIPROT:Q8WUX1transported byInferred only14 paths14 endpoints
- SLC7A2ProteinUNIPROT:P52569transported byInferred only13 paths13 endpoints
- SLC15A3ProteinUNIPROT:Q8IY34transported byInferred only11 paths11 endpoints
Show the remaining 8
- CARNS1ProteinUNIPROT:A5YM72substrate ofInferred only8 paths4 endpoints
- HALProteinUNIPROT:P42357substrate ofInferred only7 paths7 endpoints
- HDCProteinUNIPROT:P19113substrate ofInferred only6 paths6 endpoints
- SLC36A1ProteinUNIPROT:Q7Z2H8transported byInferred only4 paths2 endpoints
- SLC15A4ProteinUNIPROT:Q8N697transported byInferred only4 paths4 endpoints
- SLC38A4ProteinUNIPROT:Q969I6transported byInferred only2 paths2 endpoints
- SLC6A14ProteinUNIPROT:Q9UN76transported byInferred only2 paths2 endpoints
- SLC38A3ProteinUNIPROT:Q99624transported byInferred only1 path1 endpoint
What the reference databases state
Statements
112 statements
112 statements · 1 reference database · Subject: CHEBI:15971 · Sources: Human-GEM
- CHEBI:15971 is converted to histamineCompoundHuman-GEM MAR04428Inferred only
- CHEBI:15971 is converted to trans-urocanateCompoundHuman-GEM MAR04437Inferred only
- CHEBI:15971 is a substrate of CARNS1ProteinHuman-GEM MAR04606Inferred only
- CHEBI:15971 is a substrate of CARNS1ProteinHuman-GEM MAR04425Inferred only
- CHEBI:15971 is a substrate of HALProteinHuman-GEM MAR04437Inferred only
- CHEBI:15971 is a substrate of HARS1ProteinHuman-GEM MAR05139Inferred only
- CHEBI:15971 is a substrate of HDCProteinHuman-GEM MAR04428Inferred only
- CHEBI:15971 is transported by SLC15A3ProteinHuman-GEM MAR07101Inferred only
- CHEBI:15971 is transported by SLC15A4ProteinHuman-GEM MAR07101Inferred only
- CHEBI:15971 is transported by SLC25A15ProteinHuman-GEM MAR06313Inferred only
- CHEBI:15971 is transported by SLC25A2ProteinHuman-GEM MAR06309Inferred only
- CHEBI:15971 is transported by SLC25A2ProteinHuman-GEM MAR06310Inferred only
Show the remaining 100
- CHEBI:15971 is transported by SLC25A2ProteinHuman-GEM MAR06313Inferred only
- CHEBI:15971 is transported by SLC25A2ProteinHuman-GEM MAR06314Inferred only
- CHEBI:15971 is transported by SLC25A2ProteinHuman-GEM MAR06315Inferred only
- CHEBI:15971 is transported by SLC25A2ProteinHuman-GEM MAR06316Inferred only
- CHEBI:15971 is transported by SLC25A2ProteinHuman-GEM MAR06325Inferred only
- CHEBI:15971 is transported by SLC25A2ProteinHuman-GEM MAR06303Inferred only
- CHEBI:15971 is transported by SLC25A2ProteinHuman-GEM MAR06304Inferred only
- CHEBI:15971 is transported by SLC25A2ProteinHuman-GEM MAR06326Inferred only
- CHEBI:15971 is transported by SLC36A1ProteinHuman-GEM MAR05054Inferred only
- CHEBI:15971 is transported by SLC36A1ProteinHuman-GEM MAR05070Inferred only
- CHEBI:15971 is transported by SLC38A2ProteinHuman-GEM MAR05333Inferred only
- CHEBI:15971 is transported by SLC38A2ProteinHuman-GEM MAR06384Inferred only
- CHEBI:15971 is transported by SLC38A3ProteinHuman-GEM MAR05335Inferred only
- CHEBI:15971 is transported by SLC38A4ProteinHuman-GEM MAR05333Inferred only
- CHEBI:15971 is transported by SLC38A5ProteinHuman-GEM MAR06384Inferred only
- CHEBI:15971 is transported by SLC3A1ProteinHuman-GEM MAR05960Inferred only
- CHEBI:15971 is transported by SLC3A1ProteinHuman-GEM MAR05966Inferred only
- CHEBI:15971 is transported by SLC3A1ProteinHuman-GEM MAR05965Inferred only
- CHEBI:15971 is transported by SLC3A1ProteinHuman-GEM MAR05964Inferred only
- CHEBI:15971 is transported by SLC3A1ProteinHuman-GEM MAR05963Inferred only
- CHEBI:15971 is transported by SLC3A1ProteinHuman-GEM MAR05962Inferred only
- CHEBI:15971 is transported by SLC3A1ProteinHuman-GEM MAR05961Inferred only
- CHEBI:15971 is transported by SLC3A1ProteinHuman-GEM MAR05959Inferred only
- CHEBI:15971 is transported by SLC3A1ProteinHuman-GEM MAR05955Inferred only
- CHEBI:15971 is transported by SLC3A1ProteinHuman-GEM MAR05956Inferred only
- CHEBI:15971 is transported by SLC3A1ProteinHuman-GEM MAR05970Inferred only
- CHEBI:15971 is transported by SLC3A1ProteinHuman-GEM MAR05957Inferred only
- CHEBI:15971 is transported by SLC3A1ProteinHuman-GEM MAR05969Inferred only
- CHEBI:15971 is transported by SLC3A1ProteinHuman-GEM MAR05958Inferred only
- CHEBI:15971 is transported by SLC3A1ProteinHuman-GEM MAR05968Inferred only
- CHEBI:15971 is transported by SLC3A1ProteinHuman-GEM MAR05967Inferred only
- CHEBI:15971 is transported by SLC3A2ProteinHuman-GEM MAR05070Inferred only
- CHEBI:15971 is transported by SLC3A2ProteinHuman-GEM MAR07102Inferred only
- CHEBI:15971 is transported by SLC3A2ProteinHuman-GEM MAR07105Inferred only
- CHEBI:15971 is transported by SLC6A14ProteinHuman-GEM MAR09593Inferred only
- CHEBI:15971 is transported by SLC7A2ProteinHuman-GEM MAR05070Inferred only
- CHEBI:15971 is transported by SLC7A3ProteinHuman-GEM MAR05070Inferred only
- CHEBI:15971 is transported by SLC7A5ProteinHuman-GEM MAR05580Inferred only
- CHEBI:15971 is transported by SLC7A5ProteinHuman-GEM MAR05070Inferred only
- CHEBI:15971 is transported by SLC7A5ProteinHuman-GEM MAR05583Inferred only
- CHEBI:15971 is transported by SLC7A5ProteinHuman-GEM MAR05585Inferred only
- CHEBI:15971 is transported by SLC7A5ProteinHuman-GEM MAR05586Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05580Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05905Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05959Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05870Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05960Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05865Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05961Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05850Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05962Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05845Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05963Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05840Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05964Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05835Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05965Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05830Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05966Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05586Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05967Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05585Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05968Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05583Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05969Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05900Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05970Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR07102Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05860Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR07105Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05855Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05895Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05955Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05890Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05956Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05885Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05957Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05880Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05958Inferred only
- CHEBI:15971 is transported by SLC7A6ProteinHuman-GEM MAR05875Inferred only
- CHEBI:15971 is transported by SLC7A7ProteinHuman-GEM MAR07105Inferred only
- CHEBI:15971 is transported by SLC7A7ProteinHuman-GEM MAR07102Inferred only
- CHEBI:15971 is transported by SLC7A7ProteinHuman-GEM MAR05070Inferred only
- CHEBI:15971 is transported by SLC7A8ProteinHuman-GEM MAR05070Inferred only
- CHEBI:15971 is transported by SLC7A9ProteinHuman-GEM MAR05965Inferred only
- CHEBI:15971 is transported by SLC7A9ProteinHuman-GEM MAR05957Inferred only
- CHEBI:15971 is transported by SLC7A9ProteinHuman-GEM MAR05958Inferred only
- CHEBI:15971 is transported by SLC7A9ProteinHuman-GEM MAR05966Inferred only
- CHEBI:15971 is transported by SLC7A9ProteinHuman-GEM MAR05959Inferred only
- CHEBI:15971 is transported by SLC7A9ProteinHuman-GEM MAR05955Inferred only
- CHEBI:15971 is transported by SLC7A9ProteinHuman-GEM MAR05964Inferred only
- CHEBI:15971 is transported by SLC7A9ProteinHuman-GEM MAR05970Inferred only
- CHEBI:15971 is transported by SLC7A9ProteinHuman-GEM MAR05956Inferred only
- CHEBI:15971 is transported by SLC7A9ProteinHuman-GEM MAR05967Inferred only
- CHEBI:15971 is transported by SLC7A9ProteinHuman-GEM MAR05960Inferred only
- CHEBI:15971 is transported by SLC7A9ProteinHuman-GEM MAR05961Inferred only
- CHEBI:15971 is transported by SLC7A9ProteinHuman-GEM MAR05968Inferred only
- CHEBI:15971 is transported by SLC7A9ProteinHuman-GEM MAR05962Inferred only
- CHEBI:15971 is transported by SLC7A9ProteinHuman-GEM MAR05969Inferred only
- CHEBI:15971 is transported by SLC7A9ProteinHuman-GEM MAR05963Inferred only
Reactions
145 reactions
L-alanine+L-arginine+L-asparagine+L-aspartate+CHEBI:1307929+a cholesterol ester+a cardiolipin+MAM01602c+L-cysteine+MAM01721n+MAM01722n+L-glutamate(1-)+L-glutamine+glycine+CHEBI:15971+L-isoleucine+L-leucine+MAM02392c+CHEBI:18019+L-methionine+L-phenylalanine+phosphatidic acid+1-phosphatidyl-1D-myo-inositol+CHEBI:17203+MAM02847c+L-seryl residue+a sphingomyelin+CHEBI:16857+L-tryptophan+CHEBI:17895+L-valine+MAM03161cMAM03970c
Reaction pageBlockedBalance undeterminablecytosol, endoplasmic reticulum, nucleus
Human-GEM MAR00021CC BY 4.0Reference data
0.505626L-alanine+0.35926L-arginine+0.279425L-asparagine+0.352607L-aspartate+20.704451ATP+0.020401CHEBI:1307929+0.011658a cardiolipin+0.039036CHEBI:17677+0.046571L-cysteine+0.013183CHEBI:16284+0.009442dCTP+0.009898CHEBI:16497+0.013091dTTP+0.275194D-glucopyranose 6-phosphate+0.385872L-glutamate(1-)+0.325996L-glutamine+0.538891glycine+0.036117GTP+20.650823water+0.126406CHEBI:15971+0.286078L-isoleucine+0.545544L-leucine+0.592114CHEBI:18019+0.153018L-methionine+0.1544631,2-diacyl-sn-glycero-3-phosphocholine(1+)+0.055374phosphatidylethanolamine+0.002914MAM02715c+0.259466L-phenylalanine+0.0233151-phosphatidyl-1D-myo-inositol+0.412484CHEBI:17203+0.005829phosphatidyl-L-serine+0.392525L-seryl residue+0.017486a sphingomyelin+0.31269CHEBI:16857+0.013306L-tryptophan+0.159671CHEBI:17895+0.053446UTP+0.352607L-valine20.650823ADP+20.650823proton+20.650823phosphate(3-)+MAM03970c
Reaction pageBlockedBalance undeterminablecytosol, nucleus
Human-GEM MAR04413CC BY 4.0Reference data
ATP+beta-alanine+CHEBI:15971AMP+CHEBI:15727+proton+diphosphate(3-)
Catalysed by CARNS1
Reaction pageLeft to rightBalancedEC 6.3.2.11cytosol
Human-GEM MAR04425CC BY 4.0Reference data
CHEBI:15727+waterbeta-alanine+CHEBI:15971
Reaction pageLeft to rightBalancedEC 3.4.13.18, 3.4.13.20cytosol
Human-GEM MAR04427CC BY 4.0Reference data
proton+CHEBI:15971carbon dioxide+histamine
Catalysed by HDC
Reaction pageLeft to rightBalancedEC 4.1.1.22, 4.1.1.28cytosol
Human-GEM MAR04428CC BY 4.0Reference data
CHEBI:15971proton+ammonium+trans-urocanate
Catalysed by HAL
Reaction pageLeft to rightBalancedEC 4.3.1.3cytosol
Human-GEM MAR04437CC BY 4.0Reference data
4-aminobutanoate+ATP+CHEBI:15971AMP+proton+L-homocarnosine+diphosphate(3-)
Catalysed by CARNS1
Reaction pageLeft to rightBalancedEC 6.3.2.11cytosol
Human-GEM MAR04606CC BY 4.0Reference data
water+L-homocarnosine4-aminobutanoate+CHEBI:15971
Reaction pageLeft to rightBalancedEC 3.4.13.18, 3.4.13.20cytosol
Human-GEM MAR04607CC BY 4.0Reference data
Transported by SLC36A1
Reaction pageLeft to rightBalancedlysosome, cytosol
Human-GEM MAR05054CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A2 or SLC7A5 or SLC36A1 or SLC7A7 or SLC7A3
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05070CC BY 4.0Reference data
ATP+CHEBI:15971+MAM03071cAMP+MAM02380c+diphosphate(3-)
Catalysed by HARS1
Reaction pageLeft to rightBalance undeterminableEC 6.1.1.21cytosol
Human-GEM MAR05139CC BY 4.0Reference data
MAM01308c+608ATP+1216water608ADP+63L-alanine+27L-arginine+17L-asparagine+36L-aspartate+35L-cysteine+62L-glutamate(1-)+20L-glutamine+13glycine+619proton+16CHEBI:15971+9L-isoleucine+64L-leucine+60CHEBI:18019+7L-methionine+35L-phenylalanine+608phosphate(3-)+24CHEBI:17203+28L-seryl residue+29CHEBI:16857+2L-tryptophan+19CHEBI:17895+43L-valine
Catalysed by ALB
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR05258CC BY 4.0Reference data
Where it reaches
10 systems, 28 regions, 215 tissues, 295 transporter routes — routes, not measurements: transporters known to carry CHEBI:15971 are expressed there, and no source reports it arriving.
Loading the model…
Other names
11 names
Resolves to: CHEBI:15971
- Also called
- (S)-4-(2-Amino-2-carboxyethyl)imidazole(S)-alpha-amino-1H-Imidazole-4-propanoic acid(S)-alpha-Amino-1H-imidazole-4-propionic acid(S)-α-amino-1H-Imidazole-4-propanoic acidHisHISTIDINEL-(-)-histidineL-(−)-histidineL-Histidin
- Systematic name
- (2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acidL-histidine