Compound

leukotriene D4

One of the biologically active principles of srs-a. It is generated from leukotriene C4 after partial hydrolysis of the peptide chain, i.e., cleavage of the gamma-glutamyl portion. Its biological actions include stimulation of vascular and nonvascular smooth muscle, and increases in vascular permeability. (From Dictionary of Prostaglandins and Related Compounds, 1990)

Definition from MeSH (D017998), National Library of Medicine, read 2026-09-23. NLM revises MeSH; this copy may not reflect its current record.

CHEBI:63166ChEBI

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Structure

2D depiction

No three-dimensional record for this entry.

Class: Organic compound, anion
Formula: C25H39N2O6S
Mass: 495.662 g/mol
Charge: -1
InChIKey: YEESKJGWJFYOOK-IJHYULJSSA-M
SMILES: CCCCC/C=CC/C=CC=CC=C[C@@H](SC[C@H]([NH3+])C(=O)NCC(=O)[O-])[C@@H](O)CCCC(=O)[O-]
Look it up: ChEBI By InChIKey

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

3 entities

3 entities reached.

0 reported hops3 assembled from the scaffold

What the reference databases state

Statements

4 statements

4 statements · 1 reference database · Subject: leukotriene D4 · Sources: Rhea

Order

leukotriene C4 is converted to leukotriene D4CompoundRhea RHEA:31563Inferred only
leukotriene D4 is a substrate of DPEP1ProteinRhea RHEA:48616Inferred only
leukotriene D4 is a substrate of DPEP2ProteinRhea RHEA:48616Inferred only
leukotriene D4 is transported by ABCC2ProteinRhea RHEA:86951Inferred only

Reactions

3 reactions

leukotriene C4+waterleukotriene D4+L-glutamate(1-)
Catalysed by GGT1 or GGT5
Reaction pageLeft to rightBalanced
Rhea RHEA:31563CC BY 4.0Reference data
leukotriene D4+waterleukotriene E4+glycine
Catalysed by DPEP1 or DPEP2
Reaction pageLeft to rightBalanced
Rhea RHEA:48616CC BY 4.0Reference data
leukotriene D4+ATP(4-)+waterleukotriene D4+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCC2
Reaction pageLeft to rightBalanced
Rhea RHEA:86951CC BY 4.0Reference data

Where it reaches

1 system, 4 regions, 6 tissues, 6 transporter routes — routes, not measurements: transporters known to carry leukotriene D4 are expressed there, and no source reports it arriving.

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Digestive

Other names

5 names

Resolves to: leukotriene D4

Also called: leukotriene D4 anionleukotriene D4 monoanionLTD4
Systematic name: (5S,6R,7E,9E,11Z,14Z)-6-({(2R)-2-amino-3-[(carboxylatomethyl)amino]-3-oxopropyl}sulfanyl)-5-hydroxyicosa-7,9,11,14-tetraenoateS-{(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxylato-1-hydroxybutyl]pentadeca-2,4,6,9-tetraen-1-yl}-L-cysteinylglycinate