Compound
propionic acid
A short-chain saturated fatty acid comprising ethane attached to the carbon of a carboxy group.
Definition from ChEBI (CHEBI:30768), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
7 entities
7 entities reached.
0 reported hops7 assembled from the scaffold
- SLC16A1ProteinUNIPROT:P53985transported byInferred only225 paths25 endpoints
- ACSS2ProteinUNIPROT:Q9NR19substrate ofInferred only65 paths13 endpoints
- SLC16A7ProteinUNIPROT:O60669transported byInferred only48 paths6 endpoints
- ACSS3ProteinUNIPROT:Q9H6R3substrate ofInferred only40 paths10 endpoints
- ACSS1ProteinUNIPROT:Q9NUB1substrate ofInferred only36 paths9 endpoints
- SLC16A3ProteinUNIPROT:O15427transported byInferred only14 paths7 endpoints
- SLC16A8ProteinUNIPROT:O95907transported byInferred only4 paths1 endpoint
What the reference databases state
Chemical structure
- 1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine has the functional parent propionic acidCompoundChEBI CHEBI:77831Inferred only
- 2-methyl-3-oxopropanoic acid has the functional parent propionic acidCompoundChEBI CHEBI:16256Inferred only
- 3-(methylthio)propionic acid has the functional parent propionic acidCompoundChEBI CHEBI:1438Inferred only
- 3-oxopropanoic acid has the functional parent propionic acidCompoundChEBI CHEBI:17960Inferred only
- ibuprofen has the functional parent propionic acidCompoundChEBI CHEBI:5855Inferred only
- N-carbamoyl-beta-alanine has the functional parent propionic acidCompoundChEBI CHEBI:18261Inferred only
- propionyl-CoA has the functional parent propionic acidCompoundChEBI CHEBI:15539Inferred only
Statements
57 statements
57 statements · 1 reference database · Subject: propionic acid · Sources: Human-GEM
- propionic acid is a substrate of ACSS1ProteinHuman-GEM MAR04460Inferred only
- propionic acid is a substrate of ACSS1ProteinHuman-GEM MAR00153Inferred only
- propionic acid is a substrate of ACSS1ProteinHuman-GEM MAR03797Inferred only
- propionic acid is a substrate of ACSS1ProteinHuman-GEM MAR04459Inferred only
- propionic acid is a substrate of ACSS2ProteinHuman-GEM MAR00153Inferred only
- propionic acid is a substrate of ACSS2ProteinHuman-GEM MAR04460Inferred only
- propionic acid is a substrate of ACSS2ProteinHuman-GEM MAR04459Inferred only
- propionic acid is a substrate of ACSS2ProteinHuman-GEM MAR03797Inferred only
- propionic acid is a substrate of ACSS2ProteinHuman-GEM MAR11394Inferred only
- propionic acid is a substrate of ACSS3ProteinHuman-GEM MAR04459Inferred only
- propionic acid is a substrate of ACSS3ProteinHuman-GEM MAR04460Inferred only
- propionic acid is a substrate of ACSS3ProteinHuman-GEM MAR00153Inferred only
Show the remaining 45
- propionic acid is a substrate of ACSS3ProteinHuman-GEM MAR03797Inferred only
- propionic acid is transported by SLC16A1ProteinHuman-GEM MAR06032Inferred only
- propionic acid is transported by SLC16A1ProteinHuman-GEM MAR06017Inferred only
- propionic acid is transported by SLC16A1ProteinHuman-GEM MAR06024Inferred only
- propionic acid is transported by SLC16A1ProteinHuman-GEM MAR06042Inferred only
- propionic acid is transported by SLC16A1ProteinHuman-GEM MAR06045Inferred only
- propionic acid is transported by SLC16A1ProteinHuman-GEM MAR06043Inferred only
- propionic acid is transported by SLC16A1ProteinHuman-GEM MAR06037Inferred only
- propionic acid is transported by SLC16A1ProteinHuman-GEM MAR06003Inferred only
- propionic acid is transported by SLC16A1ProteinHuman-GEM MAR06010Inferred only
- propionic acid is transported by SLC16A3ProteinHuman-GEM MAR06042Inferred only
- propionic acid is transported by SLC16A3ProteinHuman-GEM MAR06017Inferred only
- propionic acid is transported by SLC16A4ProteinHuman-GEM MAR06037Inferred only
- propionic acid is transported by SLC16A4ProteinHuman-GEM MAR06024Inferred only
- propionic acid is transported by SLC16A4ProteinHuman-GEM MAR06045Inferred only
- propionic acid is transported by SLC16A4ProteinHuman-GEM MAR06017Inferred only
- propionic acid is transported by SLC16A4ProteinHuman-GEM MAR06044Inferred only
- propionic acid is transported by SLC16A4ProteinHuman-GEM MAR06010Inferred only
- propionic acid is transported by SLC16A4ProteinHuman-GEM MAR06003Inferred only
- propionic acid is transported by SLC16A4ProteinHuman-GEM MAR06043Inferred only
- propionic acid is transported by SLC16A4ProteinHuman-GEM MAR06042Inferred only
- propionic acid is transported by SLC16A4ProteinHuman-GEM MAR06032Inferred only
- propionic acid is transported by SLC16A5ProteinHuman-GEM MAR06003Inferred only
- propionic acid is transported by SLC16A5ProteinHuman-GEM MAR06045Inferred only
- propionic acid is transported by SLC16A5ProteinHuman-GEM MAR06044Inferred only
- propionic acid is transported by SLC16A5ProteinHuman-GEM MAR06043Inferred only
- propionic acid is transported by SLC16A5ProteinHuman-GEM MAR06042Inferred only
- propionic acid is transported by SLC16A5ProteinHuman-GEM MAR06010Inferred only
- propionic acid is transported by SLC16A5ProteinHuman-GEM MAR06017Inferred only
- propionic acid is transported by SLC16A5ProteinHuman-GEM MAR06024Inferred only
- propionic acid is transported by SLC16A5ProteinHuman-GEM MAR06032Inferred only
- propionic acid is transported by SLC16A5ProteinHuman-GEM MAR06037Inferred only
- propionic acid is transported by SLC16A7ProteinHuman-GEM MAR06043Inferred only
- propionic acid is transported by SLC16A7ProteinHuman-GEM MAR06042Inferred only
- propionic acid is transported by SLC16A7ProteinHuman-GEM MAR06024Inferred only
- propionic acid is transported by SLC16A7ProteinHuman-GEM MAR06017Inferred only
- propionic acid is transported by SLC16A7ProteinHuman-GEM MAR06032Inferred only
- propionic acid is transported by SLC16A7ProteinHuman-GEM MAR06010Inferred only
- propionic acid is transported by SLC16A7ProteinHuman-GEM MAR06003Inferred only
- propionic acid is transported by SLC16A7ProteinHuman-GEM MAR06045Inferred only
- propionic acid is transported by SLC16A8ProteinHuman-GEM MAR06017Inferred only
- propionic acid is transported by SLC16A8ProteinHuman-GEM MAR06003Inferred only
- propionic acid is transported by SLC16A8ProteinHuman-GEM MAR06044Inferred only
- propionic acid is transported by SLC16A8ProteinHuman-GEM MAR06042Inferred only
- propionic acid is transported by SLC5A8ProteinHuman-GEM MAR09900Inferred only
Reactions
22 reactions
ATP+CHEBI:1146900+propionic acidAMP+diphosphate(3-)+propionyl-CoA
Catalysed by ACSS3 or ACSS2 or ACSS1
Reaction pageLeft to rightBalancedEC 6.2.1.17, 6.2.1.1, 3.1.2.2cytosol
Human-GEM MAR00153CC BY 4.0Reference data
water+propionyl-CoACHEBI:1146900+proton+propionic acid
Catalysed by ACOT7
Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol
Human-GEM MAR00154CC BY 4.0Reference data
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR01640CC BY 4.0Reference data
Reaction pageLeft to rightBalancedcytosol, mitochondrial matrix
Human-GEM MAR01641CC BY 4.0Reference data
water+propionyl-CoACHEBI:1146900+proton+propionic acid
Catalysed by ACOT8
Reaction pageLeft to rightBalancedEC 3.1.2.2peroxisome
Human-GEM MAR03009CC BY 4.0Reference data
ATP+CHEBI:1146900+propionic acidAMP+diphosphate(3-)+propionyl-CoA
Catalysed by ACSS3 or ACSS2 or ACSS1
Reaction pageLeft to rightBalancedEC 6.2.1.17mitochondrial matrix
Human-GEM MAR03797CC BY 4.0Reference data
water+propionyl-CoACHEBI:1146900+proton+propionic acid
Catalysed by ACOT7 or ACOT2 or BAAT or ACOT4 or ACOT1 or ACOT6 or ACOT9
Reaction pageLeft to rightBalancedEC 3.1.2.2mitochondrial matrix
Human-GEM MAR03799CC BY 4.0Reference data
ATP+proton+propionic aciddiphosphate(3-)+MAM02775c
Catalysed by ACSS3 or ACSS2 or ACSS1
Reaction pageLeft to rightBalancedEC 6.2.1.1, 6.2.1.17cytosol
Human-GEM MAR04459CC BY 4.0Reference data
ATP+proton+propionic aciddiphosphate(3-)+MAM02775m
Catalysed by ACSS3 or ACSS2 or ACSS1
Reaction pageLeft to rightBalancedEC 6.2.1.1, 6.2.1.17mitochondrial matrix
Human-GEM MAR04460CC BY 4.0Reference data
acetoacetate+propionic acidacetoacetate+propionic acid
Transported by SLC16A8 or SLC16A7 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06003CC BY 4.0Reference data
2-hydroxybutyric acid+propionic acid2-hydroxybutyric acid+propionic acid
Transported by SLC16A7 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06010CC BY 4.0Reference data
propionic acid+pyruvatepropionic acid+pyruvate
Transported by SLC16A8 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06017CC BY 4.0Reference data
On the label
Labelled products
3 products
Source: NIH DSLD · Ingredient: propionic acid · 3 products · Declared amount per serving: 100–100 mg (3 products)
3 labels state an amount0 do not
- Genestra BrandsST-TN CapsulesCalcium Propionate · Propionic Acid (Form: as Calcium Propionate)100 mgper 1 Capsule(s)DSLD:264508
- Genestra BrandsST-TN CapsulesCalcium Propionate · Propionic Acid (Form: as Calcium Propionate)100 mgper 1 Vegetarian Capsule(s)DSLD:265535
- Vinco'sCaprylistatCalcium {Propionate}100 mgper 1 Capsule(s)DSLD:33864
Label record: NIH Office of Dietary Supplements · CC0
Where it reaches
9 systems, 17 regions, 34 tissues, 34 transporter routes — routes, not measurements: transporters known to carry propionic acid are expressed there, and no source reports it arriving.
Loading the model…
Other names
12 names
Resolves to: propionic acid
- Also called
- carboxyethaneCH3-CH2-COOHCH3‒CH2‒COOHethanecarboxylic acidethylformic acidmetacetonic acidmethylacetic acidPAPropanoic acidpropioic acidpropoic acidpseudoacetic acid