Endpoint
CD4/CD8 ratio
CAT:outcome/cd4-cd8-ratioreported in ratio (dimensionless)2 findings from 2 compounds
What moved it
How to read these marks2 findings · 2 compounds · 1 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| L-glutamine | up | 1 | Evidence strength: strong. Randomised human trials or their synthesis, with the effect's size and interval recorded and no recorded weakness outstanding. |
| acetylsalicylic acid | no effect | 1 | Evidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited. |
Reported to move it
1 finding
L-glutamine — increases
StrongEvidence strength: strong. Randomised human trials or their synthesis, with the effect's size and interval recorded and no recorded weakness outstanding.Finding“Analysis suggested Gln enriched nutrition support could effectively increase postoperative CD3+ T-cell (MD: 3.71; 95% CI: 2.57–4.85; P < 0.05) and CD4/CD8 ratio (MD: 0.27; 95% CI: 0.12–0.42; P < 0.05) of GI cancer patients.”
Quoted verbatim from Effect of glutamine enriched nutrition support on surgical patients with gastrointestinal tumor: a meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Participants
- 322
- Population
- Surgical patients with gastrointestinal tumour given glutamine-enriched enteral or parenteral nutrition support, glutamine the only difference between arms per the review inclusion criteria; postoperative measurement; 5 pooled trials
Effect 0.27 mean difference, 95% CI 0.12 to 0.42
Effect of glutamine enriched nutrition support on surgical patients with gastrointestinal tumor: a meta-analysis of randomized controlled trials.2015PMID:25591570Permalink
Measured, no effect detected
1 finding
acetylsalicylic acid — no detected effect on
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.FindingNull result“The CD4/CD8 T-cell ratio was elevated after 5 nights of sleep restriction in the sleep restriction/placebo condition compared to control sleep/placebo, while there was no difference between sleep restriction/ASA and sleep restriction/placebo or control sleep/placebo.”
Quoted verbatim from The Effect of Low-Dose Acetylsalicylic Acid on Cellular Immune Responses to Experimental Sleep Restriction in Healthy Humans.. - Study
- crossover
- Dose
- 81 mg once daily in the evening for 14 at-home days then during the in-laboratory stay
- Population
- Healthy adults (age 19-63) under experimental sleep restriction, after 5 nights of restricted sleep (study day 8); daily low-dose aspirin versus placebo
The Effect of Low-Dose Acetylsalicylic Acid on Cellular Immune Responses to Experimental Sleep Restriction in Healthy Humans.2026PMID:41686719Permalink
How it is measured
Ratio of CD4+ to CD8+ T lymphocytes in peripheral blood from a single flow cytometry panel, computed either from the subset percentages or from the absolute counts. Which of the two was used is recorded with each finding.
Measured, not recorded
- Subject
- cd4/cd8 ratio
- Measurements
- 3 measurements
- Recorded as a finding
- No
Show what was measured
CD4/CD8 ratio
no effect, p = 0.05
the CD4/CD8 ratio remained stable in both supplement groups (CoQ10: 1.90 ± 0.09; taurine: 1.93 ± 0.09), whereas the placebo group showed a significant decline (p < 0.05 between placebo and both supplement groups)
PMID:42514298 · one of two readings recorded this
CD4/CD8 ratio
no effect, p = 0.05
the CD4/CD8 ratio remained stable in both supplement groups (CoQ10: 1.90 ± 0.09; taurine: 1.93 ± 0.09), whereas the placebo group showed a significant decline (p < 0.05 between placebo and both supplement groups)
PMID:42514298 · one of two readings recorded this
CD4/CD8 ratio
unclear
a reduction in the CD4/CD8 ratio (from 1.89 ± 0.07 to 1.94 ± 0.10, representing a 15% relative decline from baseline)
PMID:42514298 · one of two readings recorded this
Sources cited
2 papers
- Subject
- cd4/cd8 ratio
- Findings
- 2
- Papers
- 2
The Effect of Low-Dose Acetylsalicylic Acid on Cellular Immune Responses to Experimental Sleep Restriction in Healthy Humans.record2026PMID:416867191 finding
Effect of glutamine enriched nutrition support on surgical patients with gastrointestinal tumor: a meta-analysis of randomized controlled trials.record2015PMID:255915701 finding