Endpoint
Peak postprandial blood glucose
CAT:outcome/peak-postprandial-glucosereported in mmol/L3 findings from 3 compounds
What moved it
How to read these marks3 findings · 3 compounds · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| sodium(1+) | down | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| sucralose | up | 1 | Evidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited. |
| L-isoleucine | down | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
Reported to move it
3 findings
sodium(1+) — decreases
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“NaCl supplementation resulted in 6% lower peak plasma glucose (mean difference − 0.481 mmol/L, 95% CI: -0.880 to -0.083 mmol/L, p = 0.022).”
Quoted verbatim from The Effect of Increased Sodium Intake with a Carbohydrate-Rich Meal on Glucose Homeostasis in People without Diabetes after Roux-en-Y Gastric Bypass: a Proof-of-Concept, Randomized, Open-Label, Crossover Study.. - Study
- crossover
- Dose
- 2 g additional NaCl (about 785 mg sodium) dissolved in 170 mL orange juice, single mixed meal tolerance test, versus the same meal without added NaCl
- Population
- Eleven adults without diabetes, at least 12 months after Roux-en-Y gastric bypass; mixed meal tolerance test (orange juice and yoghurt) with versus without added NaCl
Effect -0.481 mean difference, 95% CI -0.88 to -0.083
The Effect of Increased Sodium Intake with a Carbohydrate-Rich Meal on Glucose Homeostasis in People without Diabetes after Roux-en-Y Gastric Bypass: a Proof-of-Concept, Randomized, Open-Label, Crossover Study.2026PMID:41313432An author is affiliated with a producerPermalink
sucralose — increases
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.Finding“Mean peak plasma glucose concentration was higher and the subsequent nadir was lower after sucralose than after water ingestion (and Table 1).”
Quoted verbatim from Sucralose affects glycemic and hormonal responses to an oral glucose load.. - Study
- crossover
- Dose
- single dose of 48 mg sucralose in 60 mL water (2 mmol/L), 10 min before 75 g glucose
- Population
- Obese adults who did not use nonnutritive sweeteners and were not markedly insulin resistant; sucralose or water drunk 10 min before a 75 g oral glucose load, randomized crossover
Sucralose affects glycemic and hormonal responses to an oral glucose load.2013PMID:23633524Industry fundedPermalink
L-isoleucine — decreases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Compared with the control, isoleucine-10g reduced the blood glucose AUC and peak blood glucose (P < 0.01), whereas effects of isoleucine-5g were NS.”
Quoted verbatim from Intragastric administration of leucine or isoleucine lowers the blood glucose response to a mixed-nutrient drink by different mechanisms in healthy, lean volunteers.. - Study
- crossover
- Dose
- 10 g isoleucine, single intragastric infusion, 15 min before a mixed-nutrient drink
- Population
- healthy, lean subjects; isoleucine 10 g intragastric dose (isoleucine 5 g dose was not significant)
Intragastric administration of leucine or isoleucine lowers the blood glucose response to a mixed-nutrient drink by different mechanisms in healthy, lean volunteers.2017PMID:27655440Permalink
How it is measured
Highest blood glucose concentration recorded during serial sampling after a fixed mixed-nutrient drink or oral glucose load.
Sources cited
3 papers
- Subject
- peak postprandial blood glucose
- Findings
- 3
- Papers
- 3
The Effect of Increased Sodium Intake with a Carbohydrate-Rich Meal on Glucose Homeostasis in People without Diabetes after Roux-en-Y Gastric Bypass: a Proof-of-Concept, Randomized, Open-Label, Crossover Study.record2026PMID:413134321 finding
Intragastric administration of leucine or isoleucine lowers the blood glucose response to a mixed-nutrient drink by different mechanisms in healthy, lean volunteers.record2017PMID:276554401 finding
Sucralose affects glycemic and hormonal responses to an oral glucose load.record2013PMID:236335241 finding