Compound
D-serine
A serine zwitterion obtained by transfer of a proton from the carboxy to the amino group of D-serine.
Definition from ChEBI (CHEBI:35247), read 2026-09-23. CC BY 4.0.
Structure
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- Class
- Organic compound
- Formula
- C3H7NO3
- Mass
- 105.093 g/mol
- Charge
- 0
- InChIKey
- MTCFGRXMJLQNBG-UWTATZPHSA-N
- SMILES
- [NH3+][C@H](CO)C(=O)[O-]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
6 entities
6 entities reached.
0 reported hops6 assembled from the scaffold
- SLC1A5ProteinUNIPROT:Q15758transported byInferred only135 paths44 endpoints
- SLC1A4ProteinUNIPROT:P43007transported byInferred only128 paths32 endpoints
- SRRProteinUNIPROT:Q9GZT4substrate ofInferred only15 paths5 endpoints
- DAOProteinUNIPROT:P14920substrate ofInferred only11 paths11 endpoints
- SLC36A1ProteinUNIPROT:Q7Z2H8transported byInferred only2 paths2 endpoints
- SLC36A2ProteinUNIPROT:Q495M3transported byInferred only1 path1 endpoint
What the reference databases state
Statements
25 statements
25 statements · 1 reference database · Subject: D-serine · Sources: Rhea
- D-serine is converted to 2-aminoprop-2-enoateCompoundRhea RHEA:43008Inferred only
- 2-aminoprop-2-enoate is converted to D-serineCompoundRhea RHEA:43008Inferred only
- D-serine is converted to 3-hydroxypyruvateCompoundRhea RHEA:77027Inferred only
- D-serine is converted to 3-hydroxypyruvateCompoundRhea RHEA:70951Inferred only
- 3-hydroxypyruvate is converted to D-serineCompoundRhea RHEA:77027Inferred only
- O-phospho-D-serine is converted to D-serineCompoundRhea RHEA:24873Inferred only
- D-serine is converted to pyruvateCompoundRhea RHEA:13977Inferred only
- pyruvate is converted to D-serineCompoundRhea RHEA:13977Inferred only
- D-serine is a substrate of DAOProteinRhea RHEA:70951Inferred only
- D-serine is a substrate of SRRProteinRhea RHEA:10980Inferred only
- D-serine is a substrate of SRRProteinRhea RHEA:13977Inferred only
- D-serine is a substrate of SRRProteinRhea RHEA:43008Inferred only
Show the remaining 13
- D-serine is transported by SLC1A4ProteinRhea RHEA:84363Inferred only
- D-serine is transported by SLC1A4ProteinRhea RHEA:84319Inferred only
- D-serine is transported by SLC1A4ProteinRhea RHEA:84323Inferred only
- D-serine is transported by SLC1A4ProteinRhea RHEA:75311Inferred only
- D-serine is transported by SLC1A5ProteinRhea RHEA:75307Inferred only
- D-serine is transported by SLC1A5ProteinRhea RHEA:75311Inferred only
- D-serine is transported by SLC1A5ProteinRhea RHEA:84327Inferred only
- D-serine is transported by SLC36A1ProteinRhea RHEA:70647Inferred only
- D-serine is transported by SLC36A2ProteinRhea RHEA:70647Inferred only
- D-serine is transported by SLC5A8ProteinRhea RHEA:68260Inferred only
- D-serine is transported by SLC7A10ProteinRhea RHEA:74035Inferred only
- D-serine is transported by SLC7A10ProteinRhea RHEA:74299Inferred only
- D-serine is transported by SLC7A10ProteinRhea RHEA:29455Inferred only
Reactions
22 reactions
Catalysed by SRR
Reaction pageDirection not assertedBalanced
Rhea RHEA:10980CC BY 4.0Reference data
Catalysed by SRR
Reaction pageDirection not assertedBalanced
Rhea RHEA:13977CC BY 4.0Reference data
O-phospho-D-serine+waterD-serine+hydrogenphosphate
Catalysed by PSPH
Reaction pageLeft to rightBalanced
Rhea RHEA:24873CC BY 4.0Reference data
D-serine+D-alanine+ATP(4-)CHEBI:60390+ADP(3-)+hydrogenphosphate+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:27706CC BY 4.0Reference data
Transported by SLC7A10
Reaction pageDirection not assertedBalanced
Rhea RHEA:29455CC BY 4.0Reference data
D-serine+NADP(3-)CHEBI:77662+NADPH(4-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:30107CC BY 4.0Reference data
D-serine+A+water3-hydroxypyruvate+AH2+ammonium
Reaction pageDirection not assertedBalanced
Rhea RHEA:37019CC BY 4.0Reference data
D-serine2-aminoprop-2-enoate+water
Catalysed by SRR
Reaction pageDirection not assertedBalanced
Rhea RHEA:43008CC BY 4.0Reference data
D-serine+2sodium(1+)D-serine+2sodium(1+)
Transported by SLC5A8
Reaction pageDirection not assertedBalanced
Rhea RHEA:68260CC BY 4.0Reference data
D-serine+hydronD-serine+hydron
Transported by SLC36A2 or SLC36A1
Reaction pageDirection not assertedBalanced
Rhea RHEA:70647CC BY 4.0Reference data
D-serine+dioxygen+water3-hydroxypyruvate+hydrogen peroxide+ammonium
Catalysed by DAO
Reaction pageLeft to rightBalanced
Rhea RHEA:70951CC BY 4.0Reference data
D-serine+L-alanineD-serine+L-alanine
Transported by SLC7A10
Reaction pageDirection not assertedBalanced
Rhea RHEA:74035CC BY 4.0Reference data
On the label
Labelled products
1 product
Source: NIH DSLD · Ingredient: D-serine · 1 product · Declared amount per serving: 1.5–1.5 Gram(s) (1 products)
1 label states an amount0 do not
- Prototype NutritionDS Powder1.5 Gram(s)per 1.5 Gram(s)DSLD:233112
Label record: NIH Office of Dietary Supplements · CC0
Where it reaches
10 systems, 19 regions, 50 tissues, 71 transporter routes — routes, not measurements: transporters known to carry D-serine are expressed there, and no source reports it arriving.
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Other names
2 names
Resolves to: D-serine
- Also called
- D-serine zwitterion
- Systematic name
- (2R)-2-ammonio-3-hydroxypropanoate