Compound
D-threo-isocitrate
The D-threo-form of isocitrate(3−).
Definition from ChEBI (CHEBI:15562), read 2026-09-23. CC BY 4.0.
Structure
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- Class
- Organic compound, anion
- Formula
- C6H5O7
- Mass
- 189.099 g/mol
- Charge
- -3
- InChIKey
- ODBLHEXUDAPZAU-ZAFYKAAXSA-K
- SMILES
- O=C([O-])C[C@H](C(=O)[O-])[C@@H](O)C(=O)[O-]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
6 entities
6 entities reached.
0 reported hops6 assembled from the scaffold
- IDH1ProteinUNIPROT:O75874substrate ofInferred only30 paths30 endpoints
- SLC25A1ProteinUNIPROT:P53007transported byInferred only28 paths28 endpoints
- ACO2ProteinUNIPROT:Q99798substrate ofInferred only20 paths20 endpoints
- IDH2ProteinUNIPROT:P48735substrate ofInferred only17 paths17 endpoints
- ACO1ProteinUNIPROT:P21399substrate ofInferred only16 paths16 endpoints
- IDH3AProteinUNIPROT:P50213substrate ofInferred only15 paths15 endpoints
What the reference databases state
Statements
12 statements
12 statements · 1 reference database · Subject: D-threo-isocitrate · Sources: Rhea
- cis-aconitate is converted to D-threo-isocitrateCompoundRhea RHEA:22144Inferred only
- D-threo-isocitrate is converted to cis-aconitateCompoundRhea RHEA:22144Inferred only
- citric acid is converted to D-threo-isocitrateCompoundRhea RHEA:10336Inferred only
- D-threo-isocitrate is converted to citric acidCompoundRhea RHEA:10336Inferred only
- D-threo-isocitrate is converted to glyoxylateCompoundRhea RHEA:13245Inferred only
- glyoxylate is converted to D-threo-isocitrateCompoundRhea RHEA:13245Inferred only
- D-threo-isocitrate is a substrate of ACO1ProteinRhea RHEA:10336Inferred only
- D-threo-isocitrate is a substrate of ACO2ProteinRhea RHEA:10336Inferred only
- D-threo-isocitrate is a substrate of IDH1ProteinRhea RHEA:19629Inferred only
- D-threo-isocitrate is a substrate of IDH2ProteinRhea RHEA:19629Inferred only
- D-threo-isocitrate is a substrate of IDH3AProteinRhea RHEA:23632Inferred only
- D-threo-isocitrate is transported by SLC25A1ProteinRhea RHEA:72471Inferred only
Reactions
9 reactions
Reaction pageDirection not assertedBalanced
Rhea RHEA:10336CC BY 4.0Reference data
D-threo-isocitrateCHEBI:15563
Reaction pageDirection not assertedBalanced
Rhea RHEA:10820CC BY 4.0Reference data
D-threo-isocitrateglyoxylate+succinate(2-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:13245CC BY 4.0Reference data
D-threo-isocitrate+NADP(3-)2-oxoglutarate(2-)+carbon dioxide+NADPH(4-)
Reaction pageLeft to rightBalanced
Rhea RHEA:19629CC BY 4.0Reference data
D-threo-isocitrate+CHEBI:87136CHEBI:153067+coenzyme A(4-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:20756CC BY 4.0Reference data
cis-aconitate+waterD-threo-isocitrate
Reaction pageDirection not assertedBalanced
Rhea RHEA:22144CC BY 4.0Reference data
D-threo-isocitrate+NAD(1-)2-oxoglutarate(2-)+carbon dioxide+NADH(2-)
Catalysed by IDH3A
Reaction pageLeft to rightBalanced
Rhea RHEA:23632CC BY 4.0Reference data
D-threo-isocitrate+NADP(3-)CHEBI:153066+NADPH(4-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:25588CC BY 4.0Reference data
D-threo-isocitrate+citric acidD-threo-isocitrate+citric acid
Transported by SLC25A1
Reaction pageDirection not assertedBalanced
Rhea RHEA:72471CC BY 4.0Reference data
Where it reaches
7 systems, 11 regions, 24 tissues, 24 transporter routes — routes, not measurements: transporters known to carry D-threo-isocitrate are expressed there, and no source reports it arriving.
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Other names
2 names
Resolves to: D-threo-isocitrate
- Also called
- threo-Ds-isocitrate
- Systematic name
- (1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate