What it touches on the way
Mechanistic reach
4 entities
4 entities reached.
0 reported hops4 assembled from the scaffold
What the reference databases state
Statements
9 statements
9 statements · 1 reference database · Subject: 3alpha-hydroxy-5alpha-pregnan-20-one · Sources: Human-GEM
- 5alpha-pregnane-3,20-dione is converted to 3alpha-hydroxy-5alpha-pregnan-20-oneCompoundHuman-GEM MAR02004Inferred only
- 3alpha-hydroxy-5alpha-pregnan-20-one is converted to 5alpha-pregnane-3,20-dioneCompoundHuman-GEM MAR02004Inferred only
- 5alpha-pregnane-3,20-dione is converted to 3alpha-hydroxy-5alpha-pregnan-20-oneCompoundHuman-GEM MAR02003Inferred only
- 3alpha-hydroxy-5alpha-pregnan-20-one is converted to 5alpha-pregnane-3,20-dioneCompoundHuman-GEM MAR02003Inferred only
- 3alpha-hydroxy-5alpha-pregnan-20-one is a substrate of AKR1C1ProteinHuman-GEM MAR02003Inferred only
- 3alpha-hydroxy-5alpha-pregnan-20-one is a substrate of AKR1C2ProteinHuman-GEM MAR02003Inferred only
- 3alpha-hydroxy-5alpha-pregnan-20-one is a substrate of AKR1C3ProteinHuman-GEM MAR02003Inferred only
- 3alpha-hydroxy-5alpha-pregnan-20-one is a substrate of AKR1C4ProteinHuman-GEM MAR02004Inferred only
- 3alpha-hydroxy-5alpha-pregnan-20-one is a substrate of AKR1C4ProteinHuman-GEM MAR02003Inferred only
Reactions
10 reactions
16alpha-hydroxyestrone+16alpha-hydroxyestrone+MAM00432r+MAM00604c+MAM00624c+MAM00641c+MAM00641m+MAM00641r+MAM00641x+MAM00642c+MAM00642m+MAM00642r+MAM00642x+MAM00644c+MAM00645c+2-hydroxy-17beta-estradiol+2-hydroxy-17beta-estradiol+MAM00651c+MAM00651m+MAM00651r+MAM00651x+MAM00652c+MAM00652m+MAM00652r+MAM00652x+2-methoxy-17beta-estradiol+2-methoxyestrone+2-methoxyestrone+MAM00747r+MAM00828r+MAM00830c+MAM00925c+MAM00927c+MAM00945c+MAM00947c+MAM00949c+MAM00987c+MAM00987m+MAM00987r+MAM00987x+(E)-4-hydroxynon-2-enal+MAM01001c+MAM01001m+MAM01001r+MAM01001x+MAM01011c+4-methoxyestrone+3alpha-hydroxy-5alpha-pregnan-20-one+MAM01792r+MAM01794r+MAM02469cMAM10001e
Reaction pageLeft to rightBalance undeterminableGO:0005829, GO:0005783, GO:0005759, GO:0005777, GO:0005764, GO:0005615
Human-GEM MAR00037CC BY 4.0Reference data
3alpha-hydroxy-5alpha-pregnan-20-one+NADP(3-)5alpha-pregnane-3,20-dione+proton+NADPH(4-)
Catalysed by AKR1C2 or AKR1C1 or AKR1C3 or AKR1C4
Reaction pageReversibleBalancedEC 1.1.1.213GO:0005829
Human-GEM MAR02003CC BY 4.0Reference data
5alpha-pregnane-3,20-dione+proton+NADH(2-)3alpha-hydroxy-5alpha-pregnan-20-one+NAD(+)
Catalysed by AKR1C4
Reaction pageReversibleBalancedEC 1.1.1.50GO:0005829
Human-GEM MAR02004CC BY 4.0Reference data
3alpha-hydroxy-5alpha-pregnan-20-one+proton+NADH(2-)+dioxygenMAM00604c+water+NAD(+)
Catalysed by CYP21A2
Reaction pageLeft to rightBalancedEC 1.14.14.16GO:0005829
Human-GEM MAR02005CC BY 4.0Reference data
3alpha-hydroxy-5alpha-pregnan-20-one+proton+NADH(2-)+dioxygenMAM00604r+water+NAD(+)
Catalysed by CYP21A2
Reaction pageLeft to rightBalancedEC 1.14.14.16GO:0005783
Human-GEM MAR03038CC BY 4.0Reference data
3alpha-hydroxy-5alpha-pregnan-20-one+ATP+waterADP+3alpha-hydroxy-5alpha-pregnan-20-one+proton+phosphate(3-)
Transported by ABCB1
Reaction pageLeft to rightBalancedGO:0005829, GO:0005615
Human-GEM MAR11769CC BY 4.0Reference data
3alpha-hydroxy-5alpha-pregnan-20-one
Reaction pageReversibleBalance undeterminableGO:0005615
Human-GEM MAR11868CC BY 4.0Reference data
3alpha-hydroxy-5alpha-pregnan-20-one+NAD(1-)5alpha-pregnane-3,20-dione+NADH(2-)+hydron
Catalysed by HSD17B6 or HSD17B10 or DHRS9
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:41980CC BY 4.0Reference data
5alpha-pregnane-3,20-dione+NADPH(4-)+hydron3alpha-hydroxy-5alpha-pregnan-20-one+NADP(3-)
Catalysed by AKR1C4 or AKR1C2 or AKR1C1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:84155CC BY 4.0Reference data
3alpha-hydroxy-5alpha-pregnan-20-one+NADPH(4-)+hydronCHEBI:81470+NADP(3-)
Catalysed by AKR1C4 or AKR1C2 or AKR1C1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:84159CC BY 4.0Reference data