Compound
an N-acylsphinganine
A ceramide consisting of sphinganine in which one of the amino hydrogens is substituted by a fatty acyl group.
Definition from ChEBI (CHEBI:31488), read 2026-09-23. CC BY 4.0.
Structure
- Class
- Organic compound
- Formula
- C19H38NO3R
- Mass
- 328.511 g/mol
- Charge
- 0
- SMILES
- [1*]C(=O)N[C@@H](CO)[C@H](O)CCCCCCCCCCCCCCC
- Look it up
- ChEBI
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
12 entities
12 entities reached.
0 reported hops12 assembled from the scaffold
- DEGS1ProteinUNIPROT:O15121substrate ofInferred only60 paths12 endpoints
- CERT1ProteinUNIPROT:Q9Y5P4transported byInferred only47 paths47 endpoints
- DEGS2ProteinUNIPROT:Q6QHC5substrate ofInferred only42 paths6 endpoints
- ASAH1ProteinUNIPROT:Q13510substrate ofInferred only26 paths26 endpoints
- SGMS2ProteinUNIPROT:Q8NHU3substrate ofInferred only20 paths10 endpoints
- ACER1ProteinUNIPROT:Q8TDN7substrate ofInferred only10 paths5 endpoints
- SGMS1ProteinUNIPROT:Q86VZ5substrate ofInferred only10 paths10 endpoints
- ACER2ProteinUNIPROT:Q5QJU3substrate ofInferred only8 paths4 endpoints
- ACER3ProteinUNIPROT:Q9NUN7substrate ofInferred only8 paths4 endpoints
- ASAH2ProteinUNIPROT:Q9NR71substrate ofInferred only7 paths7 endpoints
- SAMD8ProteinUNIPROT:Q96LT4substrate ofInferred only4 paths4 endpoints
- FADS3ProteinUNIPROT:Q9Y5Q0substrate ofInferred only1 path1 endpoint
What the reference databases state
Chemical structure
- an N-acylsphinganine-1-phosphoethanolamine has the functional parent an N-acylsphinganineCompoundChEBI CHEBI:78655Inferred only
- an N-acylsphinganine has the functional parent CHEBI:16566CompoundChEBI CHEBI:31488Inferred only
Statements
31 statements
31 statements · 2 reference databases · Subject: an N-acylsphinganine · Sources: Human-GEM, Rhea
- an N-acylsphinganine is converted to an N-acyl-(4R)-4-hydroxysphinganineCompoundHuman-GEM MAR00715Inferred only
- an N-acylsphinganine is converted to an N-acylsphing-4-enineCompoundHuman-GEM MAR08219Inferred only
- an N-acylsphinganine is converted to an N-acylsphing-4-enineCompoundHuman-GEM MAR03238Inferred only
- an N-acylsphinganine is converted to an N-acylsphing-4-enineCompoundHuman-GEM MAR00754Inferred only
- an N-acylsphinganine is converted to an N-acylsphing-4-enineCompoundHuman-GEM MAR08220Inferred only
- an N-acylsphinganine is a substrate of ACER1ProteinRhea RHEA:33551Inferred only
- an N-acylsphinganine is a substrate of ACER1ProteinHuman-GEM MAR00753Inferred only
- an N-acylsphinganine is a substrate of ACER2ProteinRhea RHEA:33551Inferred only
- an N-acylsphinganine is a substrate of ACER2ProteinHuman-GEM MAR00753Inferred only
- an N-acylsphinganine is a substrate of ACER3ProteinRhea RHEA:33551Inferred only
- an N-acylsphinganine is a substrate of ACER3ProteinHuman-GEM MAR00753Inferred only
- an N-acylsphinganine is a substrate of ASAH1ProteinHuman-GEM MAR00753Inferred only
Show the remaining 19
- an N-acylsphinganine is a substrate of ASAH2ProteinHuman-GEM MAR00753Inferred only
- an N-acylsphinganine is a substrate of DEGS1ProteinRhea RHEA:46544Inferred only
- an N-acylsphinganine is a substrate of DEGS1ProteinHuman-GEM MAR08220Inferred only
- an N-acylsphinganine is a substrate of DEGS1ProteinHuman-GEM MAR08219Inferred only
- an N-acylsphinganine is a substrate of DEGS1ProteinHuman-GEM MAR00715Inferred only
- an N-acylsphinganine is a substrate of DEGS1ProteinHuman-GEM MAR00754Inferred only
- an N-acylsphinganine is a substrate of DEGS2ProteinHuman-GEM MAR12041Inferred only
- an N-acylsphinganine is a substrate of DEGS2ProteinHuman-GEM MAR00715Inferred only
- an N-acylsphinganine is a substrate of DEGS2ProteinHuman-GEM MAR00754Inferred only
- an N-acylsphinganine is a substrate of DEGS2ProteinRhea RHEA:46544Inferred only
- an N-acylsphinganine is a substrate of DEGS2ProteinHuman-GEM MAR08219Inferred only
- an N-acylsphinganine is a substrate of DEGS2ProteinRhea RHEA:46364Inferred only
- an N-acylsphinganine is a substrate of DEGS2ProteinHuman-GEM MAR08220Inferred only
- an N-acylsphinganine is a substrate of FADS3ProteinRhea RHEA:76563Inferred only
- an N-acylsphinganine is a substrate of SAMD8ProteinRhea RHEA:42136Inferred only
- an N-acylsphinganine is a substrate of SGMS1ProteinRhea RHEA:44620Inferred only
- an N-acylsphinganine is a substrate of SGMS2ProteinRhea RHEA:44620Inferred only
- an N-acylsphinganine is a substrate of SGMS2ProteinRhea RHEA:42136Inferred only
- an N-acylsphinganine is transported by CERT1ProteinRhea RHEA:86011Inferred only
Reactions
21 reactions
an N-acylsphinganine+proton+NADPH(4-)+dioxygenwater+NADP(3-)+an N-acyl-(4R)-4-hydroxysphinganine
Reaction pageLeft to rightBalance undeterminableEC 1.14.-.-cytosol
Human-GEM MAR00715CC BY 4.0Reference data
CHEBI:16566+an acyl-CoACHEBI:1146900+an N-acylsphinganine+proton
Catalysed by CERS4 or CERS5 or CERS2 or CERS3 or CERS6 or CERS1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.24cytosol
Human-GEM MAR00750CC BY 4.0Reference data
an N-acylsphinganine+waterCHEBI:16566+fatty acid
Catalysed by ACER3 or ASAH1 or ACER1 or ACER2 or ASAH2
Reaction pageReversibleBalance undeterminableEC 3.5.1.23cytosol
Human-GEM MAR00753CC BY 4.0Reference data
an N-acylsphinganine+proton+NADPH(4-)+dioxygenan N-acylsphing-4-enine+2water+NADP(3-)
Reaction pageLeft to rightBalance undeterminableEC 1.14.-.-cytosol
Human-GEM MAR00754CC BY 4.0Reference data
an N-acylsphinganine+proton+NADH(2-)+dioxygenan N-acylsphing-4-enine+2water+NAD(+)
Reaction pageLeft to rightBalance undeterminablecytosol
Human-GEM MAR03238CC BY 4.0Reference data
an N-acylsphinganine+NADP(3-)an N-acylsphing-4-enine+proton+NADPH(4-)
Reaction pageLeft to rightBalance undeterminablecytosol
Human-GEM MAR08219CC BY 4.0Reference data
an N-acylsphinganine+FADan N-acylsphing-4-enine+FADH2
Reaction pageLeft to rightBalance undeterminablecytosol
Human-GEM MAR08220CC BY 4.0Reference data
an N-acylsphinganine+proton+NADPH(4-)+dioxygenwater+NADP(3-)+MAM03863c
Catalysed by DEGS2
Reaction pageLeft to rightBalance undeterminablecytosol
Human-GEM MAR12041CC BY 4.0Reference data
an N-acylsphinganinean N-acylsphinganine
Reaction pageLeft to rightBalance undeterminablecytosol, Golgi apparatus
Human-GEM MAR12107CC BY 4.0Reference data
an N-acylsphinganinean N-acylsphinganine
Reaction pageLeft to rightBalance undeterminablecytosol, endoplasmic reticulum
Human-GEM MAR12108CC BY 4.0Reference data
an N-acylsphinganine+a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)CHEBI:64941+a 1,2-diacyl-sn-glycerol
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:33475CC BY 4.0Reference data
an N-acylsphinganine+watersphinganine+a fatty acid
Catalysed by ACER2 or ACER1 or ACER3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:33551CC BY 4.0Reference data
Where it reaches
8 systems, 19 regions, 42 tissues, 42 transporter routes — routes, not measurements: transporters known to carry an N-acylsphinganine are expressed there, and no source reports it arriving.
Loading the model…
Other names
9 names
Resolves to: an N-acylsphinganine
- Also called
- Cer(d18:0)Ceramide (d18:0)DihydroceramidedihydroceramidesN-acyl-sphinganineN-acyldihydrosphingosineN-acyldihydrosphingosinesN-AcylsphinganineN-acylsphinganines