Compound
a cholesterol ester
Fatty acid esters of cholesterol which constitute about two-thirds of the cholesterol in the plasma. The accumulation of cholesterol esters in the arterial intima is a characteristic feature of atherosclerosis.
Structure
- Class
- Organic compound
- Formula
- C28H45O2R
- Mass
- 413.656 g/mol
- Charge
- 0
- SMILES
- *C(=O)O[C@H]1CC[C@@]2(C)C(=CC[C@@]3([H])[C@]4([H])CC[C@]([H])([C@H](C)CCCC(C)C)[C@@]4(C)CC[C@@]32[H])C1
- Look it up
- ChEBI
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
12 entities
12 entities reached.
0 reported hops12 assembled from the scaffold
- PLIN2ProteinUNIPROT:Q99541substrate ofInferred only21 paths21 endpoints
- CES1ProteinUNIPROT:P23141metabolized byInferred only20 paths20 endpoints
- PLIN1ProteinUNIPROT:O60240substrate ofInferred only19 paths19 endpoints
- PLIN3ProteinUNIPROT:O60664substrate ofInferred only19 paths19 endpoints
- NCEH1ProteinUNIPROT:Q6PIU2substrate ofInferred only6 paths6 endpoints
- PLIN4ProteinUNIPROT:Q96Q06substrate ofInferred only6 paths6 endpoints
- MTTPProteinUNIPROT:P55157transported byInferred only5 paths5 endpoints
- LIPNProteinUNIPROT:Q5VXI9substrate ofInferred only3 paths3 endpoints
- FITM2ProteinUNIPROT:Q8N6M3substrate ofInferred only3 paths3 endpoints
- BSCL2ProteinUNIPROT:Q96G97substrate ofInferred only3 paths3 endpoints
- FITM1ProteinUNIPROT:A5D6W6substrate ofInferred only3 paths3 endpoints
- SCARB1ProteinUNIPROT:Q8WTV0transported byInferred only2 paths2 endpoints
What the reference databases state
Chemical structure
- a cholesterol ester has the functional parent cholesterolCompoundChEBI CHEBI:17002Inferred only
Statements
13 statements
13 statements · 2 reference databases · Subject: a cholesterol ester · Sources: Human-GEM, Rhea
- a cholesterol ester is metabolised by CES1ProteinRhea RHEA:36403Inferred only
- a cholesterol ester is a substrate of BSCL2ProteinHuman-GEM MAR00031Inferred only
- a cholesterol ester is a substrate of FITM1ProteinHuman-GEM MAR00031Inferred only
- a cholesterol ester is a substrate of FITM2ProteinHuman-GEM MAR00031Inferred only
- a cholesterol ester is a substrate of LDAHProteinRhea RHEA:36403Inferred only
- a cholesterol ester is a substrate of LIPNProteinRhea RHEA:36403Inferred only
- a cholesterol ester is a substrate of NCEH1ProteinRhea RHEA:36403Inferred only
- a cholesterol ester is a substrate of PLIN1ProteinHuman-GEM MAR00031Inferred only
- a cholesterol ester is a substrate of PLIN2ProteinHuman-GEM MAR00031Inferred only
- a cholesterol ester is a substrate of PLIN3ProteinHuman-GEM MAR00031Inferred only
- a cholesterol ester is a substrate of PLIN4ProteinHuman-GEM MAR00031Inferred only
- a cholesterol ester is transported by MTTPProteinRhea RHEA:39007Inferred only
Show the remaining 1
- a cholesterol ester is transported by SCARB1ProteinHuman-GEM MAR00019Inferred only
Reactions
27 reactions
MAM02048e20CHEBI:1307929+160a cholesterol ester+MAM02047e
Catalysed by LPL
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.34extracellular space
Human-GEM MAR00013CC BY 4.0Reference data
MAM02353e680CHEBI:1307929+1515a cholesterol ester+MAM02352e
Catalysed by LPL
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.34extracellular space
Human-GEM MAR00014CC BY 4.0Reference data
a cholesterol estera cholesterol ester
Transported by SCARB1
Reaction pageLeft to rightBalance undeterminableextracellular space, lysosome
Human-GEM MAR00019CC BY 4.0Reference data
a cholesterol estera cholesterol ester
Reaction pageReversibleBalance undeterminablecytosol, endoplasmic reticulum
Human-GEM MAR00020CC BY 4.0Reference data
L-alanine+L-arginine+L-asparagine+L-aspartate+CHEBI:1307929+a cholesterol ester+a cardiolipin+MAM01602c+L-cysteine+MAM01721n+MAM01722n+L-glutamate(1-)+L-glutamine+glycine+CHEBI:15971+L-isoleucine+L-leucine+MAM02392c+CHEBI:18019+L-methionine+L-phenylalanine+phosphatidic acid+1-phosphatidyl-1D-myo-inositol+CHEBI:17203+MAM02847c+L-seryl residue+a sphingomyelin+CHEBI:16857+L-tryptophan+CHEBI:17895+L-valine+MAM03161cMAM03970c
Reaction pageBlockedBalance undeterminablecytosol, endoplasmic reticulum, nucleus
Human-GEM MAR00021CC BY 4.0Reference data
0.19a 1,2-diacyl-sn-glycerol+0.0014MAM00511c+0.0024a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine+0.00061-O-acyl-sn-glycero-3-phosphocholine(1+)+0.005CHEBI:1307929+0.34a cholesterol ester+0.00081-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine+0.00921,2-diacyl-sn-glycero-3-phosphocholine(1+)+0.0034phosphatidylethanolamine+0.00161-phosphatidyl-1D-myo-inositol+0.0002phosphatidyl-L-serine+0.0004a sphingomyelin+0.44a triacylglycerol+0.005fatty acidMAM02392c
Catalysed by PLIN3 or FITM1 or PLIN2 or PLIN1 or PLIN4 or BSCL2 or FITM2
Reaction pageLeft to rightBalance undeterminablecytosol
Human-GEM MAR00031CC BY 4.0Reference data
CHEBI:1307929+1,2-diacyl-sn-glycero-3-phosphocholine(1+)1-O-acyl-sn-glycero-3-phosphocholine(1+)+a cholesterol ester
Catalysed by LCAT
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.43cytosol
Human-GEM MAR00634CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR00714CC BY 4.0Reference data
CHEBI:1307929+1,2-diacyl-sn-glycero-3-phosphocholine(1+)1-O-acyl-sn-glycero-3-phosphocholine(1+)+a cholesterol ester
Catalysed by LCAT
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.43extracellular space
Human-GEM MAR01475CC BY 4.0Reference data
a cholesterol estera cholesterol ester
Reaction pageReversibleBalance undeterminableextracellular space, cytosol
Human-GEM MAR01827CC BY 4.0Reference data
a cholesterol ester0.0001MAM01452l+0.0001MAM01453l+0.0001MAM01454l+0.0001MAM01455l+0.0001MAM01456l+0.0001MAM01457l+0.0001MAM01458l+0.0001MAM01459l+0.0001MAM01460l+0.0001MAM01461l+0.0001MAM01462l+0.0001MAM01463l+0.0001MAM01464l+0.0001MAM01465l+0.0041MAM01466l+0.0001MAM01467l+0.0071(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol+0.0001MAM01469l+0.0001MAM01470l+0.0001MAM01471l+0.0001MAM01472l+0.0001MAM01473l+0.0001MAM01474l+0.0001MAM01475l+0.0001MAM01476l+0.0406MAM01477l+0.0001MAM01478l+0.0001MAM01479l+0.0001MAM01480l+0.0001MAM01481l+0.0001MAM01482l+0.0001MAM01483l+0.0001MAM01484l+0.0001MAM01485l+0.0001MAM01486l+0.0001MAM01487l+0.0518MAM01488l+0.0001MAM01489l+0.005cholesteryl (8Z,11Z,14Z)-eicosatrienoate+0.0001MAM01491l+0.0001MAM01492l+0.0001MAM01493l+0.0001MAM01494l+0.0001MAM01495l+0.0001MAM01496l+0.0001MAM01497l+0.0001MAM01498l+0.5254cholesteryl (9Z,12Z)-octadecadienoate+0.0061MAM01500l+0.0081MAM01501l+0.0001MAM01502l+0.1958cholesteryl (9Z-octadecenoate)+0.138cholesteryl hexadecanoate+0.0001MAM01505l+0.0001MAM01506l+0.0132cholesteryl octadecanoate+0.0001MAM01508l+0.0001MAM01509l+0.0001MAM01510l
Reaction pageLeft to rightBalance undeterminablelysosome
Human-GEM MAR03537CC BY 4.0Reference data
a cholesterol estera cholesterol ester
Reaction pageLeft to rightBalance undeterminablelysosome, endoplasmic reticulum
Human-GEM MAR03597CC BY 4.0Reference data
Where it reaches
1 system, 2 regions, 4 tissues, 4 transporter routes — routes, not measurements: transporters known to carry a cholesterol ester are expressed there, and no source reports it arriving.
Loading the model…
Other names
3 names
Resolves to: a cholesterol ester
- Also called
- Cholesterol estercholesterol esterscholesteryl esters