Compound

aspartame

No description recorded for this entry yet. Everything this graph holds about aspartame is below.

CHEBI:2877ChEBI

Studied for

2 endpoints, 2 findings, from 1 paper — 2 of them found no effect.

Body massno detected effectGrade D, Preliminary. Non-human or in vitro only.
Total cholesterol (TC)no detected effectGrade D, Preliminary. Non-human or in vitro only.

Every finding, with the quotes

Structure

Two-dimensional depiction. Bond angles are a drawing convention, not geometry.

Class: Organic compound
Formula: C14H18N2O5
Mass: 294.307 g/mol
Charge: 0
InChIKey: IAOZJIPTCAWIRG-QWRGUYRKSA-N
SMILES: COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O
Look it up: ChEBI By InChIKey

Identity from ChEBI. Not evidence — none of it carries a grade.

What the evidence says

How to read these marks

2 findings across 2 endpoints, from 1 paper, strongest first, 2 of them null.

Heavier lines are better evidence, and a line with a gap in the middle is an inference rather than a reported result. Two lines arriving at one endpoint are two findings of it, marked ×2. How a grade is computed.

Every finding here is a null result.

What did not

2 findings

Measured, and no effect detected. These are findings, not gaps — a trial that looked and found nothing is the most easily lost result in this field.

No detected effect on total cholesterol (TC)
PreliminaryGrade D, Preliminary. Non-human or in vitro only.FindingNull result
“Total cholesterol was not affected by aspartame consumption compared to control (-0.02 mmol/L; 95% CI, -0.31 to 0.27) or to sucrose (-0.24 mmol/L; 95% CI, -0.89 to 0.42).”
Quoted verbatim from Metabolic effects of aspartame in adulthood: A systematic review and meta-analysis of randomized clinical trials..
Study

meta-analysis
Population

adults, pooled randomized clinical trials
Metabolic effects of aspartame in adulthood: A systematic review and meta-analysis of randomized clinical trials.2018PMID:28394643
No detected effect on body mass
PreliminaryGrade D, Preliminary. Non-human or in vitro only.FindingNull result
“Body weight did not change after aspartame consumption compared to control (5.00 kg; 95% CI, -1.56 to 11.56) or to sucrose (3.78 kg; 95% CI, -2.18 to 9.74).”
Quoted verbatim from Metabolic effects of aspartame in adulthood: A systematic review and meta-analysis of randomized clinical trials..
Study

meta-analysis
Population

adults, pooled randomized clinical trials
Metabolic effects of aspartame in adulthood: A systematic review and meta-analysis of randomized clinical trials.2018PMID:28394643