Compound
nicotinate
A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and nadp. It has pellagra-curative, vasodilating, and antilipemic properties.
Structure
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- Class
- Organic compound, anion
- Formula
- C6H4NO2
- Mass
- 122.103 g/mol
- Charge
- -1
- InChIKey
- PVNIIMVLHYAWGP-UHFFFAOYSA-M
- SMILES
- O=C([O-])c1cccnc1
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
4 entities
4 entities reached.
0 reported hops4 assembled from the scaffold
- CD38ProteinUNIPROT:P28907substrate ofInferred only28 paths14 endpoints
- NAPRTProteinUNIPROT:Q6XQN6substrate ofInferred only9 paths9 endpoints
- nicotinamideCompoundCHEBI:17154converted toInferred only8 paths8 endpoints
- SLC5A12ProteinUNIPROT:Q1EHB4transported byInferred only1 path1 endpoint
What the reference databases state
Statements
10 statements
10 statements · 1 reference database · Subject: nicotinate · Sources: Rhea
- nicotinamide is converted to nicotinateCompoundRhea RHEA:14545Inferred only
- nicotinate is converted to nicotinamideCompoundRhea RHEA:14545Inferred only
- nicotinate is a substrate of CD38ProteinRhea RHEA:38607Inferred only
- nicotinate is a substrate of CD38ProteinRhea RHEA:38599Inferred only
- nicotinate is a substrate of NAPRTProteinRhea RHEA:36163Inferred only
- nicotinate is transported by SLC22A12ProteinRhea RHEA:72023Inferred only
- nicotinate is transported by SLC22A12ProteinRhea RHEA:72039Inferred only
- nicotinate is transported by SLC22A13ProteinRhea RHEA:72023Inferred only
- nicotinate is transported by SLC5A12ProteinRhea RHEA:75795Inferred only
- nicotinate is transported by SLC5A8ProteinRhea RHEA:72955Inferred only
Reactions
18 reactions
CHEBI:15890+nicotinate beta-D-ribonucleotideCHEBI:57918+nicotinate+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:11196CC BY 4.0Reference data
nicotinate+NADP(3-)+waterCHEBI:57664+NADPH(4-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:12236CC BY 4.0Reference data
nicotinamide+waternicotinate+ammonium
Reaction pageDirection not assertedBalanced
Rhea RHEA:14545CC BY 4.0Reference data
nicotinate+UDP-alpha-D-glucoseCHEBI:49125+UDP
Reaction pageDirection not assertedBalanced
Rhea RHEA:19437CC BY 4.0Reference data
nicotinate+S-adenosyl-L-methionineCHEBI:18123+S-adenosyl-L-homocysteine
Reaction pageDirection not assertedBalanced
Rhea RHEA:20241CC BY 4.0Reference data
2Fe(III)-[cytochrome]+nicotinate+water2Fe(II)-[cytochrome]+CHEBI:57664+2hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:27417CC BY 4.0Reference data
5-phospho-alpha-D-ribose 1-diphosphate+nicotinate+ATP(4-)+waternicotinate beta-D-ribonucleotide+ADP(3-)+hydrogenphosphate+diphosphate(3-)
Catalysed by NAPRT
Reaction pageDirection not assertedBalanced
Rhea RHEA:36163CC BY 4.0Reference data
nicotinate+NADP(3-)NAADP(+)+nicotinamide
Catalysed by CD38
Reaction pageLeft to rightBalanced
Rhea RHEA:38599CC BY 4.0Reference data
2'-phospho-cyclic ADP-ribose+nicotinateNAADP(+)
Catalysed by CD38
Reaction pageReversibleBalanced
Rhea RHEA:38607CC BY 4.0Reference data
nicotinate beta-D-ribonucleotide+CHEBI:15882CHEBI:75992+nicotinate+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:38619CC BY 4.0Reference data
nicotinate+ATP(4-)+coenzyme A(4-)CHEBI:149703+AMP+diphosphate(3-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:64332CC BY 4.0Reference data
nicotinate+uratenicotinate+urate
Transported by SLC22A12 or SLC22A13
Reaction pageLeft to rightBalanced
Rhea RHEA:72023CC BY 4.0Reference data
Where it reaches
1 system, 1 region, 1 tissue, 1 transporter route — routes, not measurements: transporters known to carry nicotinate are expressed there, and no source reports it arriving.
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Other names
2 names
Resolves to: nicotinate
- Also called
- 3-pyridinecarboxylate
- Systematic name
- pyridine-3-carboxylate