Compound
pregnenolone sulfate
A steroid sulfate oxoanion that is the conjugate base of pregnenolone sulfate, obtained by deprotonation of the sulfo group; major species at pH 7.3.
Definition from ChEBI (CHEBI:133000), read 2026-09-23. CC BY 4.0.
Structure
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- Class
- Organic compound, anion
- Formula
- C21H31O5S
- Mass
- 395.541 g/mol
- Charge
- -1
- InChIKey
- DIJBBUIOWGGQOP-QGVNFLHTSA-M
- SMILES
- [H][C@@]12CC=C3C[C@@H](OS(=O)(=O)[O-])CC[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(C)=O)CC[C@@]21[H]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
4 entities
4 entities reached.
0 reported hops4 assembled from the scaffold
What the reference databases state
Statements
9 statements
9 statements · 2 reference databases · Subject: pregnenolone sulfate · Sources: Human-GEM, Rhea
- pregnenolone is converted to pregnenolone sulfateCompoundHuman-GEM MAR01952Inferred only
- pregnenolone is converted to pregnenolone sulfateCompoundRhea RHEA:52356Inferred only
- pregnenolone sulfate is a substrate of STSProteinHuman-GEM MAR07948Inferred only
- pregnenolone sulfate is a substrate of STSProteinHuman-GEM MAR01953Inferred only
- pregnenolone sulfate is a substrate of STSProteinHuman-GEM MAR02756Inferred only
- pregnenolone sulfate is a substrate of STSProteinHuman-GEM MAR02763Inferred only
- pregnenolone sulfate is transported by ABCB1ProteinHuman-GEM MAR11773Inferred only
- pregnenolone sulfate is transported by SLC10A6ProteinRhea RHEA:71095Inferred only
- pregnenolone sulfate is transported by SLCO2B1ProteinRhea RHEA:73023Inferred only
Reactions
12 reactions
3'-phospho-5'-adenylyl sulfate+pregnenoloneproton+adenosine 3',5'-bismonophosphate+pregnenolone sulfate
Catalysed by SULT2B1
Reaction pageLeft to rightBalancedEC 2.8.2.2cytosol
Human-GEM MAR01952CC BY 4.0Reference data
water+pregnenolone sulfateproton+pregnenolone+sulfate
Catalysed by STS
Reaction pageLeft to rightBalancedEC 3.1.6.2cytosol
Human-GEM MAR01953CC BY 4.0Reference data
water+pregnenolone sulfateproton+pregnenolone+sulfate
Catalysed by STS
Reaction pageReversibleBalancedEC 3.1.6.2Golgi apparatus
Human-GEM MAR02756CC BY 4.0Reference data
water+pregnenolone sulfateproton+pregnenolone+sulfate
Catalysed by STS
Reaction pageReversibleBalancedEC 3.1.6.2lysosome
Human-GEM MAR02763CC BY 4.0Reference data
pregnenolone sulfatepregnenolone sulfate
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR07947CC BY 4.0Reference data
water+pregnenolone sulfateproton+pregnenolone+sulfate
Catalysed by STS
Reaction pageLeft to rightBalancedEC 3.1.6.2endoplasmic reticulum
Human-GEM MAR07948CC BY 4.0Reference data
ATP+water+pregnenolone sulfateADP+proton+phosphate(3-)+pregnenolone sulfate
Transported by ABCB1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR11773CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR11875CC BY 4.0Reference data
pregnenolone+3'-phosphoadenylyl sulfatepregnenolone sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT2B1 or SULT2A1
Reaction pageLeft to rightBalanced
Rhea RHEA:52356CC BY 4.0Reference data
pregnenolone sulfate+2sodium(1+)pregnenolone sulfate+2sodium(1+)
Transported by SLC10A6
Reaction pageDirection not assertedBalanced
Rhea RHEA:71095CC BY 4.0Reference data
pregnenolone sulfatepregnenolone sulfate
Transported by SLCO2B1
Reaction pageDirection not assertedBalanced
Rhea RHEA:73023CC BY 4.0Reference data
pregnenolone sulfate+nhydronpregnenolone sulfate+nhydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:75495CC BY 4.0Reference data
Where it reaches
7 systems, 14 regions, 23 tissues, 24 transporter routes — routes, not measurements: transporters known to carry pregnenolone sulfate are expressed there, and no source reports it arriving.
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Other names
4 names
Resolves to: pregnenolone sulfate
- Also called
- (3beta)-20-oxopregn-5-en-3-yl sulfate(3β)-20-oxopregn-5-en-3-yl sulfate
- Systematic name
- 20-oxopregn-5-en-3beta-yl sulfate20-oxopregn-5-en-3β-yl sulfate