Compound
5-hydroxytryptophan
The immediate precursor in the biosynthesis of serotonin from tryptophan. It is used as an antiepileptic and antidepressant.
What it touches on the way
Mechanistic reach
5 entities
5 entities reached.
0 reported hops5 assembled from the scaffold
- DDCProteinUNIPROT:P20711substrate ofInferred only19 paths19 endpoints
- IDO1ProteinUNIPROT:P14902substrate ofInferred only15 paths15 endpoints
- SLC18A2ProteinUNIPROT:Q05940transported byInferred only14 paths7 endpoints
- SLC18A1ProteinUNIPROT:P54219transported byInferred only12 paths6 endpoints
- IDO2ProteinUNIPROT:Q6ZQW0substrate ofInferred only7 paths7 endpoints
What the reference databases state
Statements
8 statements
8 statements · 1 reference database · Subject: 5-hydroxytryptophan · Sources: Human-GEM
- 5-hydroxytryptophan is converted to serotoninCompoundHuman-GEM MAR04545Inferred only
- 5-hydroxytryptophan is a substrate of DDCProteinHuman-GEM MAR04545Inferred only
- 5-hydroxytryptophan is a substrate of IDO1ProteinHuman-GEM MAR06716Inferred only
- 5-hydroxytryptophan is a substrate of IDO2ProteinHuman-GEM MAR06716Inferred only
- 5-hydroxytryptophan is transported by SLC18A1ProteinHuman-GEM MAR00052Inferred only
- 5-hydroxytryptophan is transported by SLC18A1ProteinHuman-GEM MAR07634Inferred only
- 5-hydroxytryptophan is transported by SLC18A2ProteinHuman-GEM MAR07634Inferred only
- 5-hydroxytryptophan is transported by SLC18A2ProteinHuman-GEM MAR00052Inferred only
Reactions
7 reactions
5-hydroxytryptophan+ATP+water5-hydroxytryptophan+ADP+proton+phosphate(3-)
Transported by SLC18A1 or SLC18A2
Reaction pageLeft to rightBalancedEC 1.13.11.52GO:0005829, GO:0005615
Human-GEM MAR00052CC BY 4.0Reference data
dioxygen+5,6,7,8-tetrahydrobiopterin+L-tryptophan5-hydroxytryptophan+MAM01698c+water
Reaction pageLeft to rightBalancedEC 1.14.16.4GO:0005829
Human-GEM MAR02119CC BY 4.0Reference data
dioxygen+5,6,7,8-tetrahydrobiopterin+L-tryptophan4a-hydroxytetrahydrobiopterin+5-hydroxytryptophan
Reaction pageLeft to rightBalancedEC 1.14.16.4GO:0005829
Human-GEM MAR04537CC BY 4.0Reference data
5-hydroxytryptophan+protoncarbon dioxide+serotonin
Catalysed by DDC
Reaction pageLeft to rightBalancedEC 4.1.1.28GO:0005829
Human-GEM MAR04545CC BY 4.0Reference data
5-hydroxytryptophan+dioxygenMAM01108c
Reaction pageLeft to rightBalancedEC 1.13.11.52GO:0005829
Human-GEM MAR06716CC BY 4.0Reference data
35-hydroxytryptophan+2ATP+2water35-hydroxytryptophan+2ADP+2proton+2phosphate(3-)
Transported by SLC18A1 or SLC18A2
Reaction pageLeft to rightBalancedGO:0005829, GO:0005615
Human-GEM MAR07634CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableGO:0005615
Human-GEM MAR09094CC BY 4.0Reference data
Where it reaches
5 systems, 6 regions, 10 tissues, 11 transporter routes — routes, not measurements: transporters known to carry 5-hydroxytryptophan are expressed there, and no source reports it arriving.
Loading the model…
Other names
8 names
Resolves to: 5-hydroxytryptophan
- Also called
- (+-)-5-hydroxytryptophan(±)-5-hydroxytryptophan5-HTP5-hydroxy-DL-tryptophan5-hydroxytryptophan DL-formDL-5-HTPDL-5-hydroxytryptophan
- Systematic name
- 2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid