Structure
No depiction stored
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- Class
- Organic compound, anion
- Formula
- C20H23N7O6
- Mass
- 457.447 g/mol
- Charge
- -2
- InChIKey
- ZNOVTXRBGFNYRX-STQMWFEESA-L
- SMILES
- CN1c2c(nc(N)nc2=O)NC[C@@H]1CNc1ccc(C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])cc1
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
3 entities
3 entities reached.
What the reference databases state
Statements
6 statements
6 statements · 1 reference database · Subject: (6S)-5-methyl-5,6,7,8-tetrahydrofolate · Sources: Rhea
- (6S)-5-methyl-5,6,7,8-tetrahydrofolate is converted to (6R)-5,10-methylene-5,6,7,8-tetrahydrofolateCompoundRhea RHEA:19821Inferred only
- (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is converted to (6S)-5-methyl-5,6,7,8-tetrahydrofolateCompoundRhea RHEA:19817Inferred only
- (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is converted to (6S)-5-methyl-5,6,7,8-tetrahydrofolateCompoundRhea RHEA:19821Inferred only
- (6S)-5-methyl-5,6,7,8-tetrahydrofolate is a substrate of MTRProteinRhea RHEA:11172Inferred only
- (6S)-5-methyl-5,6,7,8-tetrahydrofolate is transported by SLC19A1ProteinRhea RHEA:60460Inferred only
- (6S)-5-methyl-5,6,7,8-tetrahydrofolate is transported by SLC46A1ProteinRhea RHEA:70167Inferred only
Reactions
15 reactions
(6S)-5-methyl-5,6,7,8-tetrahydrofolate+L-homocysteine(6S)-5,6,7,8-tetrahydrofolate+L-methionine
Catalysed by MTR
Reaction pageLeft to rightBalanced
Rhea RHEA:11172CC BY 4.0Reference data
trimethylsulfonium+(6S)-5,6,7,8-tetrahydrofolatedimethyl sulfide+(6S)-5-methyl-5,6,7,8-tetrahydrofolate+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:13693CC BY 4.0Reference data
(6S)-5-methyl-5,6,7,8-tetrahydrofolate+2oxidized [2Fe-2S]-[ferredoxin](6R)-5,10-methylene-5,6,7,8-tetrahydrofolate+2reduced [2Fe-2S]-[ferredoxin]+2hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:14229CC BY 4.0Reference data
(6S)-5-methyl-5,6,7,8-tetrahydrofolate+NADP(3-)(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate+NADPH(4-)+hydron
Catalysed by MTHFR
Reaction pageRight to leftBalanced
Rhea RHEA:19817CC BY 4.0Reference data
(6S)-5-methyl-5,6,7,8-tetrahydrofolate+NAD(1-)(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate+NADH(2-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:19821CC BY 4.0Reference data
CHEBI:16457+(6S)-5,6,7,8-tetrahydrofolate3-(methylsulfanyl)propanoate+(6S)-5-methyl-5,6,7,8-tetrahydrofolate+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:35467CC BY 4.0Reference data
methyl-Co(III)-[corrinoid Fe-S protein]+(6S)-5,6,7,8-tetrahydrofolateCo(I)-[corrinoid Fe-S protein]+(6S)-5-methyl-5,6,7,8-tetrahydrofolate+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:45200CC BY 4.0Reference data
CHEBI:16632+(6S)-5,6,7,8-tetrahydrofolate(6S)-5-methyl-5,6,7,8-tetrahydrofolate+CHEBI:36241
Reaction pageDirection not assertedBalanced
Rhea RHEA:52276CC BY 4.0Reference data
CHEBI:19950+(6S)-5,6,7,8-tetrahydrofolateCHEBI:16918+(6S)-5-methyl-5,6,7,8-tetrahydrofolate
Reaction pageDirection not assertedBalanced
Rhea RHEA:52280CC BY 4.0Reference data
CHEBI:132111+(6S)-5,6,7,8-tetrahydrofolateCHEBI:19950+(6S)-5-methyl-5,6,7,8-tetrahydrofolate
Reaction pageDirection not assertedBalanced
Rhea RHEA:59840CC BY 4.0Reference data
5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide+(6S)-5-methyl-5,6,7,8-tetrahydrofolate5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide+(6S)-5-methyl-5,6,7,8-tetrahydrofolate
Transported by SLC19A1
Reaction pageLeft to rightBalanced
Rhea RHEA:60460CC BY 4.0Reference data
methyl-Co(III)-[glycine betaine-specific corrinoid protein]+(6S)-5,6,7,8-tetrahydrofolateCo(I)-[glycine betaine-specific corrinoid protein]+(6S)-5-methyl-5,6,7,8-tetrahydrofolate+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:66000CC BY 4.0Reference data
On the label
Labelled products
11 products
Source: NIH DSLD · Ingredient: (6S)-5-methyl-5,6,7,8-tetrahydrofolate · 11 products · Declared amount per serving: 25–999 mcg (11 products)
11 labels state an amount0 do not
- Coast ScienceMale Fertility MFSG5(6S)-5-Methyltetrahydrofolate (Alt. Name: Quatrefolic, MTHF) Note: equivalent to 916 mcg Dietary Folate Equivalent (DFE at 1.7x)999 mcgper 2 Veggie Capsule(s)DSLD:268727
- Coast Science She-ologyMenopause Plus(6S)-5-Methyltetrahydrofolate (Alt. Name: Quatrefolic, MTHF) Note: equivalent to 916 mcg Dietary Folate Equivalent (DFE at 1.7x)999 mcgper 6 Veggie Capsule(s)DSLD:241330
- Coast Science She-ologyPeri-Menopause Plus(6S)-5-Methyltetrahydrofolate (Alt. Name: Quatrefolic, MTHF) Note: equivalent to 916 mcg Dietary Folate Equivalent (DFE at 1.7x)999 mcgper 6 Veggie Capsule(s)DSLD:241324
- Coast Science She-ologyPMS Plus(6S)-5-Methyltetrahydrofolate (Alt. Name: Quatrefolic, MTHF) Note: equivalent to 916 mcg Dietary Folate Equivalent (DFE at 1.7x)999 mcgper 6 Veggie Capsule(s)DSLD:241317
- EmeraldCoEnzymated Complete 1-Daily Multi(6S)-5-Methyltetrahydrofolate (Alt. Name: MTHF) Note: equivalent to200 mcgper 1 Capsule(s)DSLD:227945
- EmeraldCoEnzymated Complete Clinical+Multi 4 Daily(6S)-5-Methyltetrahydrofolate (Alt. Name: MTHF) Note: equivalent to400 mcgper 2 Capsule(s)DSLD:220809
- EmeraldCoEnzymated Men's 1-Daily Multi(6S)-5-Methyltetrahydrofolate (Alt. Name: MTHF) Note: equivalent to200 mcgper 1 Capsule(s)DSLD:223500
- Emerald LaboratoriesCoEnzymated Complete Premium+Multi 2 Daily(6S)-5-Methyltetrahydrofolate Acid, Glucosamine Salt · (6S)-5-Methyltetrahydrofolate (Form: equivalent to 741 mg of (6S)-5-Methyltetrahydrofolate Acid, Glucosamine Salt Note: non-GMO, vegan-sourced) (Alt. Name: MTHF)400 mcgper 2 Capsule(s)DSLD:221512
- Emerald LabsEstrogen Detoxequivalent to 46 mcg of (6S)-5-Methyltetrahydrofolate acid, Glucosamine Salt)25 mcgper 2 Capsule(s)DSLD:302594
- PerqueLife Guard Mini TabsulesQuatrefolic(TM) · (6S)-5-Methyltetrahydrofolate (Form: as Quatrefolic(TM))100 mcgper 2 Tabsule(s)DSLD:18782
- PerqueLife Guard Mini TabsulesQuatrefolic(TM) · (6S)-5-Methyltetrahydrofolate (Form: as Quatrefolic(TM))100 mcgper 2 Tabsule(s)DSLD:18785
Label record: NIH Office of Dietary Supplements · CC0
Where it reaches
1 system, 1 region, 2 tissues, 3 transporter routes — routes, not measurements: transporters known to carry (6S)-5-methyl-5,6,7,8-tetrahydrofolate are expressed there, and no source reports it arriving.
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Other names
2 names
Resolves to: (6S)-5-methyl-5,6,7,8-tetrahydrofolate
- Also called
- (6S)-5-methyltetrahydrofolate
- Systematic name
- (2S)-2-{[4-({[(6S)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]amino}pentanedioate