Compound
CHEBI:17203
A non-essential amino acid that is synthesized from glutamic acid. It is an essential component of collagen and is important for proper functioning of joints and tendons.
What it touches on the way
Mechanistic reach
25 entities
25 entities reached.
0 reported hops25 assembled from the scaffold
- SLC38A2ProteinUNIPROT:Q96QD8transported byInferred only200 paths200 endpoints
- SLC7A5ProteinUNIPROT:Q01650transported byInferred only144 paths8 endpoints
- P4HBProteinUNIPROT:P07237substrate ofInferred only59 paths59 endpoints
- P4HA2ProteinUNIPROT:O15460substrate ofInferred only48 paths16 endpoints
- ABCA1ProteinUNIPROT:O95477transported byInferred only47 paths47 endpoints
- P4HA1ProteinUNIPROT:P13674substrate ofInferred only45 paths15 endpoints
- SLC7A9ProteinUNIPROT:P82251transported byInferred only45 paths9 endpoints
- SLC36A4ProteinUNIPROT:Q6YBV0transported byInferred only41 paths41 endpoints
- EPRS1ProteinUNIPROT:P07814substrate ofInferred only38 paths38 endpoints
- SLC38A1ProteinUNIPROT:Q9H2H9transported byInferred only38 paths38 endpoints
- SLC43A1ProteinUNIPROT:O75387transported byInferred only33 paths33 endpoints
- SLC7A6ProteinUNIPROT:Q92536transported byInferred only28 paths2 endpoints
Show the remaining 13
- P4HA3ProteinUNIPROT:Q7Z4N8substrate ofInferred only20 paths10 endpoints
- SLC7A8ProteinUNIPROT:Q9UHI5transported byInferred only18 paths18 endpoints
- SLC7A7ProteinUNIPROT:Q9UM01transported byInferred only16 paths16 endpoints
- PRODH2ProteinUNIPROT:Q9UF12substrate ofInferred only10 paths5 endpoints
- SLC6A7ProteinUNIPROT:Q99884transported byInferred only9 paths3 endpoints
- SLC36A1ProteinUNIPROT:Q7Z2H8transported byInferred only8 paths2 endpoints
- SLC3A1ProteinUNIPROT:Q07837transported byInferred only5 paths1 endpoint
- PRODHProteinUNIPROT:O43272substrate ofInferred only5 paths5 endpoints
- SLC38A4ProteinUNIPROT:Q969I6transported byInferred only2 paths2 endpoints
- SLC6A20ProteinUNIPROT:Q9NP91transported byInferred only2 paths1 endpoint
- SLC36A2ProteinUNIPROT:Q495M3transported byInferred only1 path1 endpoint
- CLTRNProteinUNIPROT:Q9HBJ8transported byInferred only1 path1 endpoint
- SLC6A15ProteinUNIPROT:Q9H2J7transported byInferred only1 path1 endpoint
What the reference databases state
Statements
85 statements
85 statements · 1 reference database · Subject: CHEBI:17203 · Sources: Human-GEM
- (S)-1-pyrroline-5-carboxylate is converted to CHEBI:17203CompoundHuman-GEM MAR03835Inferred only
- (S)-1-pyrroline-5-carboxylate is converted to CHEBI:17203CompoundHuman-GEM MAR08609Inferred only
- (S)-1-pyrroline-5-carboxylate is converted to CHEBI:17203CompoundHuman-GEM MAR03833Inferred only
- CHEBI:17203 is converted to (S)-1-pyrroline-5-carboxylateCompoundHuman-GEM MAR08610Inferred only
- CHEBI:17203 is converted to (S)-1-pyrroline-5-carboxylateCompoundHuman-GEM MAR08611Inferred only
- (S)-1-pyrroline-5-carboxylate is converted to CHEBI:17203CompoundHuman-GEM MAR03837Inferred only
- CHEBI:17203 is converted to CHEBI:18095CompoundHuman-GEM MAR01649Inferred only
- CHEBI:17203 is converted to CHEBI:18095CompoundHuman-GEM MAR04776Inferred only
- CHEBI:17203 is converted to CHEBI:18095CompoundHuman-GEM MAR04777Inferred only
- CHEBI:17203 is a substrate of EPRS1ProteinHuman-GEM MAR05146Inferred only
- CHEBI:17203 is a substrate of P4HA1ProteinHuman-GEM MAR01649Inferred only
- CHEBI:17203 is a substrate of P4HA1ProteinHuman-GEM MAR04776Inferred only
Show the remaining 73
- CHEBI:17203 is a substrate of P4HA1ProteinHuman-GEM MAR04777Inferred only
- CHEBI:17203 is a substrate of P4HA2ProteinHuman-GEM MAR01649Inferred only
- CHEBI:17203 is a substrate of P4HA2ProteinHuman-GEM MAR04777Inferred only
- CHEBI:17203 is a substrate of P4HA2ProteinHuman-GEM MAR04776Inferred only
- CHEBI:17203 is a substrate of P4HA3ProteinHuman-GEM MAR04776Inferred only
- CHEBI:17203 is a substrate of P4HA3ProteinHuman-GEM MAR04777Inferred only
- CHEBI:17203 is a substrate of P4HBProteinHuman-GEM MAR01649Inferred only
- CHEBI:17203 is a substrate of PRODHProteinHuman-GEM MAR08611Inferred only
- CHEBI:17203 is a substrate of PRODH2ProteinHuman-GEM MAR08611Inferred only
- CHEBI:17203 is a substrate of PRODH2ProteinHuman-GEM MAR08610Inferred only
- CHEBI:17203 is transported by ABCA1ProteinHuman-GEM MAR05527Inferred only
- CHEBI:17203 is transported by CLTRNProteinHuman-GEM MAR07194Inferred only
- CHEBI:17203 is transported by SLC36A1ProteinHuman-GEM MAR05087Inferred only
- CHEBI:17203 is transported by SLC36A1ProteinHuman-GEM MAR01650Inferred only
- CHEBI:17203 is transported by SLC36A1ProteinHuman-GEM MAR06373Inferred only
- CHEBI:17203 is transported by SLC36A1ProteinHuman-GEM MAR05059Inferred only
- CHEBI:17203 is transported by SLC36A2ProteinHuman-GEM MAR06373Inferred only
- CHEBI:17203 is transported by SLC36A3ProteinHuman-GEM MAR06373Inferred only
- CHEBI:17203 is transported by SLC36A4ProteinHuman-GEM MAR06373Inferred only
- CHEBI:17203 is transported by SLC38A1ProteinHuman-GEM MAR05322Inferred only
- CHEBI:17203 is transported by SLC38A2ProteinHuman-GEM MAR05322Inferred only
- CHEBI:17203 is transported by SLC38A4ProteinHuman-GEM MAR05322Inferred only
- CHEBI:17203 is transported by SLC3A1ProteinHuman-GEM MAR05917Inferred only
- CHEBI:17203 is transported by SLC3A1ProteinHuman-GEM MAR05981Inferred only
- CHEBI:17203 is transported by SLC3A1ProteinHuman-GEM MAR05949Inferred only
- CHEBI:17203 is transported by SLC3A1ProteinHuman-GEM MAR05965Inferred only
- CHEBI:17203 is transported by SLC3A1ProteinHuman-GEM MAR05933Inferred only
- CHEBI:17203 is transported by SLC43A1ProteinHuman-GEM MAR05087Inferred only
- CHEBI:17203 is transported by SLC6A15ProteinHuman-GEM MAR05322Inferred only
- CHEBI:17203 is transported by SLC6A20ProteinHuman-GEM MAR07194Inferred only
- CHEBI:17203 is transported by SLC6A20ProteinHuman-GEM MAR05322Inferred only
- CHEBI:17203 is transported by SLC6A7ProteinHuman-GEM MAR05322Inferred only
- CHEBI:17203 is transported by SLC6A7ProteinHuman-GEM MAR08938Inferred only
- CHEBI:17203 is transported by SLC6A7ProteinHuman-GEM MAR09617Inferred only
- CHEBI:17203 is transported by SLC7A5ProteinHuman-GEM MAR05551Inferred only
- CHEBI:17203 is transported by SLC7A5ProteinHuman-GEM MAR05481Inferred only
- CHEBI:17203 is transported by SLC7A5ProteinHuman-GEM MAR05494Inferred only
- CHEBI:17203 is transported by SLC7A5ProteinHuman-GEM MAR05506Inferred only
- CHEBI:17203 is transported by SLC7A5ProteinHuman-GEM MAR05517Inferred only
- CHEBI:17203 is transported by SLC7A5ProteinHuman-GEM MAR05527Inferred only
- CHEBI:17203 is transported by SLC7A5ProteinHuman-GEM MAR05536Inferred only
- CHEBI:17203 is transported by SLC7A5ProteinHuman-GEM MAR05544Inferred only
- CHEBI:17203 is transported by SLC7A5ProteinHuman-GEM MAR05557Inferred only
- CHEBI:17203 is transported by SLC7A5ProteinHuman-GEM MAR05563Inferred only
- CHEBI:17203 is transported by SLC7A5ProteinHuman-GEM MAR05564Inferred only
- CHEBI:17203 is transported by SLC7A5ProteinHuman-GEM MAR05567Inferred only
- CHEBI:17203 is transported by SLC7A5ProteinHuman-GEM MAR05596Inferred only
- CHEBI:17203 is transported by SLC7A5ProteinHuman-GEM MAR05611Inferred only
- CHEBI:17203 is transported by SLC7A5ProteinHuman-GEM MAR05626Inferred only
- CHEBI:17203 is transported by SLC7A5ProteinHuman-GEM MAR05641Inferred only
- CHEBI:17203 is transported by SLC7A5ProteinHuman-GEM MAR05656Inferred only
- CHEBI:17203 is transported by SLC7A5ProteinHuman-GEM MAR05671Inferred only
- CHEBI:17203 is transported by SLC7A6ProteinHuman-GEM MAR05933Inferred only
- CHEBI:17203 is transported by SLC7A6ProteinHuman-GEM MAR05626Inferred only
- CHEBI:17203 is transported by SLC7A6ProteinHuman-GEM MAR05596Inferred only
- CHEBI:17203 is transported by SLC7A6ProteinHuman-GEM MAR05981Inferred only
- CHEBI:17203 is transported by SLC7A6ProteinHuman-GEM MAR05716Inferred only
- CHEBI:17203 is transported by SLC7A6ProteinHuman-GEM MAR05739Inferred only
- CHEBI:17203 is transported by SLC7A6ProteinHuman-GEM MAR05877Inferred only
- CHEBI:17203 is transported by SLC7A6ProteinHuman-GEM MAR05878Inferred only
- CHEBI:17203 is transported by SLC7A6ProteinHuman-GEM MAR05879Inferred only
- CHEBI:17203 is transported by SLC7A6ProteinHuman-GEM MAR05880Inferred only
- CHEBI:17203 is transported by SLC7A6ProteinHuman-GEM MAR05881Inferred only
- CHEBI:17203 is transported by SLC7A6ProteinHuman-GEM MAR05965Inferred only
- CHEBI:17203 is transported by SLC7A6ProteinHuman-GEM MAR05949Inferred only
- CHEBI:17203 is transported by SLC7A6ProteinHuman-GEM MAR05917Inferred only
- CHEBI:17203 is transported by SLC7A7ProteinHuman-GEM MAR05087Inferred only
- CHEBI:17203 is transported by SLC7A8ProteinHuman-GEM MAR05087Inferred only
- CHEBI:17203 is transported by SLC7A9ProteinHuman-GEM MAR05949Inferred only
- CHEBI:17203 is transported by SLC7A9ProteinHuman-GEM MAR05965Inferred only
- CHEBI:17203 is transported by SLC7A9ProteinHuman-GEM MAR05917Inferred only
- CHEBI:17203 is transported by SLC7A9ProteinHuman-GEM MAR05981Inferred only
- CHEBI:17203 is transported by SLC7A9ProteinHuman-GEM MAR05933Inferred only
Reactions
151 reactions
L-alanine+L-arginine+L-asparagine+L-aspartate+CHEBI:1307929+a cholesterol ester+a cardiolipin+MAM01602c+L-cysteine+MAM01721n+MAM01722n+L-glutamate(1-)+L-glutamine+glycine+CHEBI:15971+L-isoleucine+L-leucine+MAM02392c+CHEBI:18019+L-methionine+L-phenylalanine+phosphatidic acid+1-phosphatidyl-1D-myo-inositol+CHEBI:17203+MAM02847c+L-seryl residue+a sphingomyelin+CHEBI:16857+L-tryptophan+CHEBI:17895+L-valine+MAM03161cMAM03970c
Reaction pageBlockedBalance undeterminablecytosol, endoplasmic reticulum, nucleus
Human-GEM MAR00021CC BY 4.0Reference data
2-oxoglutarate(2-)+dioxygen+CHEBI:17203carbon dioxide+succinate(2-)+CHEBI:18095
Catalysed by P4HB & P4HA1 or P4HA2 & P4HB
Reaction pageLeft to rightBalancedEC 1.14.11.2endoplasmic reticulum
Human-GEM MAR01649CC BY 4.0Reference data
proton+CHEBI:17203proton+CHEBI:17203
Transported by SLC36A1
Reaction pageReversibleBalancedEC 1.14.11.2lysosome, cytosol
Human-GEM MAR01650CC BY 4.0Reference data
Reaction pageLeft to rightBalancedEC 1.5.5.2cytosol, mitochondrial matrix
Human-GEM MAR01654CC BY 4.0Reference data
(S)-1-pyrroline-5-carboxylate+2proton+NADPH(4-)NADP(3-)+CHEBI:17203
Reaction pageLeft to rightBalancedEC 1.5.1.2cytosol
Human-GEM MAR03833CC BY 4.0Reference data
(S)-1-pyrroline-5-carboxylate+2proton+NADH(2-)NAD(+)+CHEBI:17203
Reaction pageLeft to rightBalancedEC 1.5.1.2cytosol
Human-GEM MAR03835CC BY 4.0Reference data
(S)-1-pyrroline-5-carboxylate+2proton+NADH(2-)NAD(+)+CHEBI:17203
Reaction pageLeft to rightBalancedEC 1.5.1.2mitochondrial matrix
Human-GEM MAR03837CC BY 4.0Reference data
0.505626L-alanine+0.35926L-arginine+0.279425L-asparagine+0.352607L-aspartate+20.704451ATP+0.020401CHEBI:1307929+0.011658a cardiolipin+0.039036CHEBI:17677+0.046571L-cysteine+0.013183CHEBI:16284+0.009442dCTP+0.009898CHEBI:16497+0.013091dTTP+0.275194D-glucopyranose 6-phosphate+0.385872L-glutamate(1-)+0.325996L-glutamine+0.538891glycine+0.036117GTP+20.650823water+0.126406CHEBI:15971+0.286078L-isoleucine+0.545544L-leucine+0.592114CHEBI:18019+0.153018L-methionine+0.1544631,2-diacyl-sn-glycero-3-phosphocholine(1+)+0.055374phosphatidylethanolamine+0.002914MAM02715c+0.259466L-phenylalanine+0.0233151-phosphatidyl-1D-myo-inositol+0.412484CHEBI:17203+0.005829phosphatidyl-L-serine+0.392525L-seryl residue+0.017486a sphingomyelin+0.31269CHEBI:16857+0.013306L-tryptophan+0.159671CHEBI:17895+0.053446UTP+0.352607L-valine20.650823ADP+20.650823proton+20.650823phosphate(3-)+MAM03970c
Reaction pageBlockedBalance undeterminablecytosol, nucleus
Human-GEM MAR04413CC BY 4.0Reference data
2-oxoglutarate(2-)+dioxygen+CHEBI:17203carbon dioxide+succinate(2-)+CHEBI:18095
Catalysed by P4HA2 or P4HA1 or P4HA3
Reaction pageLeft to rightBalancedEC 1.14.11.2cytosol
Human-GEM MAR04776CC BY 4.0Reference data
2-oxoglutarate(2-)+dioxygen+CHEBI:17203carbon dioxide+succinate(2-)+CHEBI:18095
Catalysed by P4HA2 or P4HA1 or P4HA3
Reaction pageLeft to rightBalancedEC 1.14.11.2mitochondrial matrix
Human-GEM MAR04777CC BY 4.0Reference data
L-glutamate(1-)+CHEBI:17203L-glutamate(1-)+CHEBI:17203
Reaction pageLeft to rightBalancedmitochondrial matrix, cytosol
Human-GEM MAR04963CC BY 4.0Reference data
Transported by SLC36A1
Reaction pageLeft to rightBalancedlysosome, cytosol
Human-GEM MAR05059CC BY 4.0Reference data
Where it reaches
10 systems, 28 regions, 222 tissues, 369 transporter routes — routes, not measurements: transporters known to carry CHEBI:17203 are expressed there, and no source reports it arriving.
Loading the model…
Other names
19 names
Resolves to: CHEBI:17203
- Also called
- (-)-(S)-proline(-)-2-pyrrolidinecarboxylic acid(-)-proline(−)-(S)-proline(−)-2-pyrrolidinecarboxylic acid(−)-proline(2S)-pyrrolidine-2-carboxylic acid(S)-2-carboxypyrrolidine(S)-2-pyrrolidinecarboxylic acid(S)-pyrrolidine-2-carboxylic acid2-Pyrrolidinecarboxylic acidL-(-)-prolineL-(−)-prolineL-alpha-pyrrolidinecarboxylic acidL-ProlinL-ProlineL-pyrrolidine-2-carboxylic acidL-α-pyrrolidinecarboxylic acidproline