Compound
4-aminobutanoate
The most common inhibitory neurotransmitter in the central nervous system.
Structure
Loading the model…
- Class
- Organic compound
- Formula
- C4H9NO2
- Mass
- 103.121 g/mol
- Charge
- 0
- InChIKey
- BTCSSZJGUNDROE-UHFFFAOYSA-N
- SMILES
- [NH3+]CCCC(=O)[O-]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
12 entities
12 entities reached.
0 reported hops12 assembled from the scaffold
- SLC6A1ProteinUNIPROT:P30531transported byInferred only138 paths45 endpoints
- SLC6A6ProteinUNIPROT:P31641transported byInferred only34 paths34 endpoints
- ABATProteinUNIPROT:P80404substrate ofInferred only30 paths15 endpoints
- SLC6A13ProteinUNIPROT:Q9NSD5transported byInferred only12 paths4 endpoints
- SLC32A1ProteinUNIPROT:Q9H598transported byInferred only9 paths3 endpoints
- CARNS1ProteinUNIPROT:A5YM72substrate ofInferred only8 paths4 endpoints
- SLC6A12ProteinUNIPROT:P48065transported byInferred only8 paths2 endpoints
- GATMProteinUNIPROT:P50440substrate ofInferred only8 paths8 endpoints
- SLC36A1ProteinUNIPROT:Q7Z2H8transported byInferred only6 paths2 endpoints
- SLC6A11ProteinUNIPROT:P48066transported byInferred only6 paths2 endpoints
- BEST1ProteinUNIPROT:O76090transported byInferred only3 paths3 endpoints
- SLC36A2ProteinUNIPROT:Q495M3transported byInferred only1 path1 endpoint
What the reference databases state
Chemical structure
- 4-(trimethylamino)butanoate has the functional parent 4-aminobutanoateCompoundChEBI CHEBI:16244Inferred only
Statements
39 statements
39 statements · 2 reference databases · Subject: 4-aminobutanoate · Sources: Human-GEM, Rhea
- 4-aminobutanoate is converted to 4-aminobutanalCompoundRhea RHEA:30803Inferred only
- 4-aminobutanal is converted to 4-aminobutanoateCompoundRhea RHEA:19105Inferred only
- 4-aminobutanal is converted to 4-aminobutanoateCompoundRhea RHEA:30803Inferred only
- CHEBI:17769 is converted to 4-aminobutanoateCompoundHuman-GEM MAR04688Inferred only
- CHEBI:17769 is converted to 4-aminobutanoateCompoundHuman-GEM MAR04689Inferred only
- CHEBI:17769 is converted to 4-aminobutanoateCompoundHuman-GEM MAR04605Inferred only
- 4-aminobutanoate is converted to succinate semialdehydeCompoundRhea RHEA:23352Inferred only
- succinate semialdehyde is converted to 4-aminobutanoateCompoundRhea RHEA:61280Inferred only
- 4-aminobutanoate is converted to succinate semialdehydeCompoundRhea RHEA:61280Inferred only
- 4-aminobutanoate is converted to succinic semialdehydeCompoundHuman-GEM MAR04693Inferred only
- succinic semialdehyde is converted to 4-aminobutanoateCompoundHuman-GEM MAR04693Inferred only
- 4-aminobutanoate is a substrate of ABATProteinRhea RHEA:23352Inferred only
Show the remaining 27
- 4-aminobutanoate is a substrate of ABATProteinHuman-GEM MAR04693Inferred only
- 4-aminobutanoate is a substrate of CARNS1ProteinHuman-GEM MAR04606Inferred only
- 4-aminobutanoate is a substrate of CARNS1ProteinRhea RHEA:59568Inferred only
- 4-aminobutanoate is a substrate of GATMProteinRhea RHEA:75939Inferred only
- 4-aminobutanoate is transported by BEST1ProteinRhea RHEA:35035Inferred only
- 4-aminobutanoate is transported by SLC32A1ProteinHuman-GEM MAR07738Inferred only
- 4-aminobutanoate is transported by SLC32A1ProteinRhea RHEA:70979Inferred only
- 4-aminobutanoate is transported by SLC32A1ProteinHuman-GEM MAR01314Inferred only
- 4-aminobutanoate is transported by SLC36A1ProteinHuman-GEM MAR08355Inferred only
- 4-aminobutanoate is transported by SLC36A1ProteinRhea RHEA:28915Inferred only
- 4-aminobutanoate is transported by SLC36A1ProteinHuman-GEM MAR08354Inferred only
- 4-aminobutanoate is transported by SLC36A2ProteinRhea RHEA:28915Inferred only
- 4-aminobutanoate is transported by SLC6A1ProteinRhea RHEA:70687Inferred only
- 4-aminobutanoate is transported by SLC6A1ProteinHuman-GEM MAR04691Inferred only
- 4-aminobutanoate is transported by SLC6A1ProteinHuman-GEM MAR09613Inferred only
- 4-aminobutanoate is transported by SLC6A11ProteinRhea RHEA:70687Inferred only
- 4-aminobutanoate is transported by SLC6A11ProteinHuman-GEM MAR04691Inferred only
- 4-aminobutanoate is transported by SLC6A11ProteinHuman-GEM MAR09613Inferred only
- 4-aminobutanoate is transported by SLC6A12ProteinHuman-GEM MAR04691Inferred only
- 4-aminobutanoate is transported by SLC6A12ProteinHuman-GEM MAR09886Inferred only
- 4-aminobutanoate is transported by SLC6A12ProteinRhea RHEA:70731Inferred only
- 4-aminobutanoate is transported by SLC6A12ProteinHuman-GEM MAR09604Inferred only
- 4-aminobutanoate is transported by SLC6A13ProteinRhea RHEA:70687Inferred only
- 4-aminobutanoate is transported by SLC6A13ProteinHuman-GEM MAR04691Inferred only
- 4-aminobutanoate is transported by SLC6A13ProteinHuman-GEM MAR09613Inferred only
- 4-aminobutanoate is transported by SLC6A6ProteinRhea RHEA:70687Inferred only
- 4-aminobutanoate is transported by SLC7A14ProteinRhea RHEA:35035Inferred only
Reactions
41 reactions
4-aminobutanoate+ATP+water4-aminobutanoate+ADP+proton+phosphate(3-)
Transported by SLC32A1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR01314CC BY 4.0Reference data
CHEBI:17769+water+NADP(3-)4-aminobutanoate+2proton+NADPH(4-)
Catalysed by ALDH3A2 or ALDH2 or ALDH1B1 or ALDH9A1 or ALDH7A1
Reaction pageLeft to rightBalancedEC 1.2.1.3mitochondrial matrix
Human-GEM MAR04605CC BY 4.0Reference data
4-aminobutanoate+ATP+CHEBI:15971AMP+proton+L-homocarnosine+diphosphate(3-)
Catalysed by CARNS1
Reaction pageLeft to rightBalancedEC 6.3.2.11cytosol
Human-GEM MAR04606CC BY 4.0Reference data
water+L-homocarnosine4-aminobutanoate+CHEBI:15971
Reaction pageLeft to rightBalancedEC 3.4.13.18, 3.4.13.20cytosol
Human-GEM MAR04607CC BY 4.0Reference data
CHEBI:17769+water+NAD(+)4-aminobutanoate+2proton+NADH(2-)
Catalysed by ALDH3A2 or ALDH2 or ALDH1B1 or ALDH9A1 or ALDH7A1
Reaction pageLeft to rightBalancedEC 1.2.1.3, 1.2.1.19mitochondrial matrix
Human-GEM MAR04688CC BY 4.0Reference data
CHEBI:17769+water+NAD(+)4-aminobutanoate+2proton+NADH(2-)
Catalysed by ALDH9A1
Reaction pageLeft to rightBalancedEC 1.2.1.19cytosol
Human-GEM MAR04689CC BY 4.0Reference data
L-glutamate(1-)+proton4-aminobutanoate+carbon dioxide
Reaction pageLeft to rightBalancedEC 4.1.1.15cytosol
Human-GEM MAR04690CC BY 4.0Reference data
4-aminobutanoate+2sodium(1+)4-aminobutanoate+2sodium(1+)
Transported by SLC6A13 or SLC6A12 or SLC6A11 or SLC6A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR04691CC BY 4.0Reference data
4-aminobutanoate4-aminobutanoate
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR04692CC BY 4.0Reference data
4-aminobutanoate+2-oxoglutarate(2-)L-glutamate(1-)+succinic semialdehyde
Catalysed by ABAT
Reaction pageReversibleBalancedEC 2.6.1.19mitochondrial matrix
Human-GEM MAR04693CC BY 4.0Reference data
34-aminobutanoate+ATP+water34-aminobutanoate+ADP+proton+phosphate(3-)
Transported by SLC32A1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07738CC BY 4.0Reference data
4-aminobutanoate4-aminobutanoate
Reaction pageLeft to rightBalancedcytosol, nucleus
Human-GEM MAR07752CC BY 4.0Reference data
Where it reaches
9 systems, 23 regions, 81 tissues, 92 transporter routes — routes, not measurements: transporters known to carry 4-aminobutanoate are expressed there, and no source reports it arriving.
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Other names
4 names
Resolves to: 4-aminobutanoate
- Also called
- 4-amino-butanoic acid4-Aminobutanoic acid4-ammoniobutanoate
- Systematic name
- 4-azaniumylbutanoate