Compound
indoxyl sulfate
A substance occurring in the urine of mammals and also in blood plasma as the normal metabolite of tryptophan. An increased urinary excretion of indican is seen in Hartnup disease from the bacterial degradation of unabsorbed tryptophan.
Structure
No depiction stored
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- Class
- Organic compound, anion
- Formula
- C8H6NO4S
- Mass
- 212.206 g/mol
- Charge
- -1
- InChIKey
- BXFFHSIDQOFMLE-UHFFFAOYSA-M
- SMILES
- O=S(=O)([O-])Oc1cnc2ccccc12
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
3 entities
3 entities reached.
What the reference databases state
Statements
8 statements
8 statements · 2 reference databases · Subject: indoxyl sulfate · Sources: Human-GEM, Rhea
- indoxyl is converted to indoxyl sulfateCompoundRhea RHEA:82887Inferred only
- indoxyl sulfate is converted to indoxylCompoundRhea RHEA:82887Inferred only
- indoxyl is converted to indoxyl sulfateCompoundHuman-GEM MAR10462Inferred only
- indoxyl sulfate is transported by ABCG2ProteinRhea RHEA:61332Inferred only
- indoxyl sulfate is transported by SLC17A3ProteinRhea RHEA:82891Inferred only
- indoxyl sulfate is transported by SLC22A6ProteinRhea RHEA:75987Inferred only
- indoxyl sulfate is transported by SLC22A6ProteinHuman-GEM MAR10464Inferred only
- indoxyl sulfate is transported by SLC22A8ProteinRhea RHEA:75987Inferred only
Reactions
7 reactions
3'-phospho-5'-adenylyl sulfate+indoxyladenosine 3',5'-bismonophosphate+indoxyl sulfate
Catalysed by SULT1A1
Reaction pageLeft to rightBalancedEC 2.8.2.1cytosol
Human-GEM MAR10462CC BY 4.0Reference data
2-oxoglutarate(2-)+indoxyl sulfate2-oxoglutarate(2-)+indoxyl sulfate
Transported by SLC22A6
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR10464CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR10478CC BY 4.0Reference data
indoxyl sulfate+ATP(4-)+waterindoxyl sulfate+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCG2
Reaction pageLeft to rightBalanced
Rhea RHEA:61332CC BY 4.0Reference data
indoxyl sulfate+a dicarboxylateindoxyl sulfate+a dicarboxylate
Transported by SLC22A6 or SLC22A8
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:75987CC BY 4.0Reference data
indoxyl+3'-phosphoadenylyl sulfateindoxyl sulfate+adenosine 3',5'-bisphosphate+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:82887CC BY 4.0Reference data
indoxyl sulfateindoxyl sulfate
Transported by SLC17A3
Reaction pageRight to leftBalanced
Rhea RHEA:82891CC BY 4.0Reference data
Where it reaches
5 systems, 8 regions, 15 tissues, 15 transporter routes — routes, not measurements: transporters known to carry indoxyl sulfate are expressed there, and no source reports it arriving.
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Other names
1 name
Resolves to: indoxyl sulfate
- Systematic name
- 1H-indol-3-yl sulfate