Compound
17beta-estradiol 3-O-(beta-D-glucuronate)
A steroid glucuronide anion that is the conjugate base of 17β-estradiol 3-O-(β-D-glucuronide) arising from deprotonation of the carboxylic acid function; major species at pH 7.3.
Definition from ChEBI (CHEBI:136641), read 2026-09-23. CC BY 4.0.
Structure
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- Class
- Organic compound, anion
- Formula
- C24H31O8
- Mass
- 447.504 g/mol
- Charge
- -1
- InChIKey
- MUOHJTRCBBDUOW-QXYWQCSFSA-M
- SMILES
- [H][C@@]12CCc3cc(O[C@@H]4O[C@H](C(=O)[O-])[C@@H](O)[C@H](O)[C@H]4O)ccc3[C@@]1([H])CC[C@]1(C)[C@@H](O)CC[C@@]21[H]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
8 entities
8 entities reached.
0 reported hops8 assembled from the scaffold
- ABCA8ProteinUNIPROT:O94911transported byInferred only49 paths48 endpoints
- ABCC2ProteinUNIPROT:Q92887transported byInferred only15 paths15 endpoints
- ABCC4ProteinUNIPROT:O15439transported byInferred only10 paths10 endpoints
- CHST10ProteinUNIPROT:O43529substrate ofInferred only10 paths10 endpoints
- SLCO4A1ProteinUNIPROT:Q96BD0transported byInferred only8 paths4 endpoints
- SLCO1B3ProteinUNIPROT:Q9NPD5transported byInferred only6 paths2 endpoints
- SLCO1B1ProteinUNIPROT:Q9Y6L6transported byInferred only6 paths2 endpoints
- SLCO1C1ProteinUNIPROT:Q9NYB5transported byInferred only4 paths2 endpoints
What the reference databases state
Statements
17 statements
17 statements · 2 reference databases · Subject: 17beta-estradiol 3-O-(beta-D-glucuronate) · Sources: Human-GEM, Rhea
- 17beta-estradiol is converted to 17beta-estradiol 3-O-(beta-D-glucuronate)CompoundRhea RHEA:52460Inferred only
- 17beta-estradiol is converted to 17beta-estradiol 3-O-(beta-D-glucuronate)CompoundHuman-GEM MAR07648Inferred only
- 17beta-estradiol 3-O-(beta-D-glucuronate) is converted to 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate)CompoundRhea RHEA:68696Inferred only
- 17beta-estradiol 3-O-(beta-D-glucuronate) is a substrate of CHST10ProteinRhea RHEA:68696Inferred only
- 17beta-estradiol 3-O-(beta-D-glucuronate) is transported by ABCA8ProteinHuman-GEM MAR09879Inferred only
- 17beta-estradiol 3-O-(beta-D-glucuronate) is transported by ABCC2ProteinRhea RHEA:86855Inferred only
- 17beta-estradiol 3-O-(beta-D-glucuronate) is transported by ABCC4ProteinHuman-GEM MAR07650Inferred only
- 17beta-estradiol 3-O-(beta-D-glucuronate) is transported by SLCO1A2ProteinHuman-GEM MAR07651Inferred only
- 17beta-estradiol 3-O-(beta-D-glucuronate) is transported by SLCO1A2ProteinHuman-GEM MAR07649Inferred only
- 17beta-estradiol 3-O-(beta-D-glucuronate) is transported by SLCO1B1ProteinHuman-GEM MAR07649Inferred only
- 17beta-estradiol 3-O-(beta-D-glucuronate) is transported by SLCO1B1ProteinHuman-GEM MAR07651Inferred only
- 17beta-estradiol 3-O-(beta-D-glucuronate) is transported by SLCO1B3ProteinHuman-GEM MAR07651Inferred only
Show the remaining 5
- 17beta-estradiol 3-O-(beta-D-glucuronate) is transported by SLCO1B3ProteinHuman-GEM MAR07649Inferred only
- 17beta-estradiol 3-O-(beta-D-glucuronate) is transported by SLCO1C1ProteinHuman-GEM MAR07651Inferred only
- 17beta-estradiol 3-O-(beta-D-glucuronate) is transported by SLCO1C1ProteinHuman-GEM MAR07649Inferred only
- 17beta-estradiol 3-O-(beta-D-glucuronate) is transported by SLCO4A1ProteinHuman-GEM MAR07649Inferred only
- 17beta-estradiol 3-O-(beta-D-glucuronate) is transported by SLCO4A1ProteinHuman-GEM MAR07651Inferred only
Reactions
9 reactions
17beta-estradiol+UDP-alpha-D-glucuronate17beta-estradiol 3-O-(beta-D-glucuronate)+UDP
Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives
Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum
Human-GEM MAR07648CC BY 4.0Reference data
17beta-estradiol 3-O-(beta-D-glucuronate)17beta-estradiol 3-O-(beta-D-glucuronate)
Transported by SLCO1A2 or SLCO4A1 or SLCO1B3 or SLCO1B1 or SLCO1C1
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR07649CC BY 4.0Reference data
ATP+17beta-estradiol 3-O-(beta-D-glucuronate)+waterADP+17beta-estradiol 3-O-(beta-D-glucuronate)+proton+phosphate(3-)
Transported by ABCC4
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07650CC BY 4.0Reference data
17beta-estradiol 3-O-(beta-D-glucuronate)+hydrogencarbonate17beta-estradiol 3-O-(beta-D-glucuronate)+hydrogencarbonate
Transported by SLCO1A2 or SLCO4A1 or SLCO1B3 or SLCO1B1 or SLCO1C1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR07651CC BY 4.0Reference data
17beta-estradiol 3-O-(beta-D-glucuronate)
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR09129CC BY 4.0Reference data
ATP+17beta-estradiol 3-O-(beta-D-glucuronate)+waterADP+17beta-estradiol 3-O-(beta-D-glucuronate)+proton+phosphate(3-)
Transported by ABCA8
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR09879CC BY 4.0Reference data
17beta-estradiol+UDP-alpha-D-glucuronate17beta-estradiol 3-O-(beta-D-glucuronate)+UDP+hydron
Catalysed by UGT2A1 or UGT2A2 or UGT1A1 or UGT1A3 or UGT1A10 or UGT1A8
Reaction pageLeft to rightBalanced
Rhea RHEA:52460CC BY 4.0Reference data
17beta-estradiol 3-O-(beta-D-glucuronate)+3'-phosphoadenylyl sulfate17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate)+adenosine 3',5'-bisphosphate+hydron
Catalysed by CHST10
Reaction pageLeft to rightBalanced
Rhea RHEA:68696CC BY 4.0Reference data
17beta-estradiol 3-O-(beta-D-glucuronate)+ATP(4-)+water17beta-estradiol 3-O-(beta-D-glucuronate)+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCC2
Reaction pageLeft to rightBalanced
Rhea RHEA:86855CC BY 4.0Reference data
Where it reaches
8 systems, 21 regions, 64 tissues, 72 transporter routes — routes, not measurements: transporters known to carry 17beta-estradiol 3-O-(beta-D-glucuronate) are expressed there, and no source reports it arriving.
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Other names
2 names
Resolves to: 17beta-estradiol 3-O-(beta-D-glucuronate)
- Systematic name
- 17beta-hydroxyestra-1,3,5(10)-trien-3-yl beta-D-glucopyranosiduronate17β-hydroxyestra-1,3,5(10)-trien-3-yl β-D-glucopyranosiduronate