Compound
sucralose
A disaccharide derivative consisting of 4-chloro-4-deoxy-α-D-galactopyranose and 1,6-dichloro-1,6-dideoxy-β-D-fructofuranose units linked by a glycosidic bond.
Definition from ChEBI (CHEBI:32159), read 2026-09-23. CC BY 4.0.
Studied for
2 endpoints · 2 findings · 1 paper · 2 null
- Fasting blood glucoseno detected effectGrade D, Preliminary. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.
- HOMA-IRno detected effectGrade D, Preliminary. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.
Structure
Loading the model…
- Class
- Organic compound
- Formula
- C12H19Cl3O8
- Mass
- 397.635 g/mol
- Charge
- 0
- InChIKey
- BAQAVOSOZGMPRM-QBMZZYIRSA-N
- SMILES
- OC[C@H]1O[C@H](O[C@]2(CCl)O[C@H](CCl)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@H]1Cl
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What the evidence says
How to read these marks2 findings · 2 endpoints · 1 paper · 2 null · by grade
Every finding here is a null result.
What did not
2 findings
No detected effect on HOMA-IR
PreliminaryGrade D, Preliminary. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Sucralose did not significantly alter alpha diversity (Shannon index: SMD = -0.00; 95% CI -1.16 to 1.15; p = 0.99; I2 = 25.67%), fasting blood glucose (SMD = -0.04; 95% CI = -0.63 to 0.56; p = 0.88; I2 = 69.61%), and HOMA-IR (SMD = -0.13; 95% CI = -0.36 to 0.10; p = 0.212; I2 = 0.00%).”
Quoted verbatim from Effect of Sucralose Consumption on Gut Microbiota: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.. - Study
- meta-analysis
- Population
- healthy adults; pooled from randomized controlled trials of sucralose consumption
Effect -0.13 standardised mean difference, 95% CI -0.36 to 0.1
Effect of Sucralose Consumption on Gut Microbiota: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.2026PMID:42794802Permalink
No detected effect on fasting blood glucose
PreliminaryGrade D, Preliminary. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Sucralose did not significantly alter alpha diversity (Shannon index: SMD = -0.00; 95% CI -1.16 to 1.15; p = 0.99; I2 = 25.67%), fasting blood glucose (SMD = -0.04; 95% CI = -0.63 to 0.56; p = 0.88; I2 = 69.61%), and HOMA-IR (SMD = -0.13; 95% CI = -0.36 to 0.10; p = 0.212; I2 = 0.00%).”
Quoted verbatim from Effect of Sucralose Consumption on Gut Microbiota: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.. - Study
- meta-analysis
- Population
- healthy adults; pooled from randomized controlled trials of sucralose consumption
Effect -0.04 standardised mean difference, 95% CI -0.63 to 0.56
Effect of Sucralose Consumption on Gut Microbiota: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.2026PMID:42794802Permalink
Papers screened
1 paper
- Compound
- sucralose
- Screened
- 1
- Admitted
- 1
- Discarded
- 0
- Not read
- 0
Produced a finding1 paper
- PMID:427948022026-09-27
Measured, not recorded
- Compound
- sucralose
- Endpoints measured
- 3 endpoints
- Recorded as a finding
- No
Show what was measured
faecal/serum butyrate concentration
no effect, numerical decrease, pooled effect not statistically significant, substantial heterogeneity
Butyrate showed a numerical decrease, although the pooled effect was not statistically significant and substantial heterogeneity was observed.
PMID:42794802 · one of two readings recorded this
pooled faecal/serum butyrate, short-chain fatty acid production
no effect, numerical decrease, pooled effect not statistically significant, substantial heterogeneity
Not recorded as a finding: no outcome node for short-chain fatty acid production
Butyrate showed a numerical decrease, although the pooled effect was not statistically significant and substantial heterogeneity was observed.
PMID:42794802 · one of two readings recorded this
pooled short-chain fatty acid, butyrate
Not recorded as a finding: no outcome node exists for short-chain fatty acids/butyrate; also no quantitative estimate stated for this endpoint in the abstract
Butyrate showed a numerical decrease, although the pooled effect was not statistically significant and substantial heterogeneity was observed.
PMID:42794802 · one of two readings recorded this
Sources cited
1 paper
- Subject
- sucralose
- Findings
- 2
- Papers
- 1
Other names
3 names
Resolves to: sucralose
- Also called
- Trichlorosucrose
- Systematic name
- 1,6-dichloro-1,6-dideoxy-beta-D-fructofuranosyl 4-chloro-4-deoxy-alpha-D-galactopyranoside1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl 4-chloro-4-deoxy-α-D-galactopyranoside