Compound
N(tau)-methylhistamine
Conjugate acid of Nτ-methylhistamine.
Definition from ChEBI (CHEBI:58600), read 2026-09-23. CC BY 4.0.
Structure
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- Class
- Organic compound, cation
- Formula
- C6H12N3
- Mass
- 126.183 g/mol
- Charge
- +1
- InChIKey
- FHQDWPCFSJMNCT-UHFFFAOYSA-O
- SMILES
- Cn1cnc(CC[NH3+])c1
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
7 entities
7 entities reached.
0 reported hops7 assembled from the scaffold
- MAOAProteinUNIPROT:P21397metabolized byInferred only36 paths36 endpoints
- AOC1ProteinUNIPROT:P19801substrate ofInferred only24 paths12 endpoints
- MAOBProteinUNIPROT:P27338metabolized byInferred only13 paths13 endpoints
- HNMTProteinUNIPROT:P50135substrate ofInferred only11 paths11 endpoints
- AOC3ProteinUNIPROT:Q16853substrate ofInferred only5 paths5 endpoints
- SLC22A3ProteinUNIPROT:O75751transported byInferred only4 paths4 endpoints
- AOC2ProteinUNIPROT:O75106substrate ofInferred only3 paths3 endpoints
What the reference databases state
Statements
14 statements
14 statements · 2 reference databases · Subject: N(tau)-methylhistamine · Sources: Human-GEM, Rhea
- N(tau)-methylhistamine is converted to 1-methylimidazole-4-acetaldehydeCompoundHuman-GEM MAR04430Inferred only
- N(tau)-methylhistamine is converted to 1-methylimidazole-4-acetaldehydeCompoundRhea RHEA:78367Inferred only
- histamine is converted to N(tau)-methylhistamineCompoundRhea RHEA:19301Inferred only
- histamine is converted to N(tau)-methylhistamineCompoundHuman-GEM MAR04429Inferred only
- histamine is converted to N(tau)-methylhistamineCompoundHuman-GEM MAR11777Inferred only
- N(tau)-methylhistamine is converted to histamineCompoundRhea RHEA:19301Inferred only
- N(tau)-methylhistamine is metabolised by MAOAProteinHuman-GEM MAR04430Inferred only
- N(tau)-methylhistamine is metabolised by MAOBProteinHuman-GEM MAR04430Inferred only
- N(tau)-methylhistamine is a substrate of AOC1ProteinRhea RHEA:78367Inferred only
- N(tau)-methylhistamine is a substrate of AOC1ProteinHuman-GEM MAR04430Inferred only
- N(tau)-methylhistamine is a substrate of AOC2ProteinHuman-GEM MAR04430Inferred only
- N(tau)-methylhistamine is a substrate of AOC3ProteinHuman-GEM MAR04430Inferred only
Show the remaining 2
- N(tau)-methylhistamine is a substrate of HNMTProteinRhea RHEA:19301Inferred only
- N(tau)-methylhistamine is transported by SLC22A3ProteinHuman-GEM MAR11782Inferred only
Reactions
7 reactions
histamine+S-adenosyl-L-methionineproton+N(tau)-methylhistamine+CHEBI:16680
Catalysed by HNMT
Reaction pageLeft to rightBalancedEC 2.1.1.8cytosol
Human-GEM MAR04429CC BY 4.0Reference data
water+N(tau)-methylhistamine+dioxygenproton+hydrogen peroxide+1-methylimidazole-4-acetaldehyde+ammonium
Catalysed by AOC1 or MAOB or AOC3 or AOC2 or MAOA
Reaction pageLeft to rightBalancedEC 1.4.3.4cytosol
Human-GEM MAR04430CC BY 4.0Reference data
histamine+S-adenosyl-L-methionineproton+N(tau)-methylhistamine+CHEBI:16680
Catalysed by HNMT
Reaction pageLeft to rightBalancedextracellular space
Human-GEM MAR11777CC BY 4.0Reference data
N(tau)-methylhistamineN(tau)-methylhistamine
Transported by SLC22A3
Reaction pageReversibleBalancedEC 7.6.2.2cytosol, extracellular space
Human-GEM MAR11782CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR11930CC BY 4.0Reference data
histamine+S-adenosyl-L-methionineN(tau)-methylhistamine+S-adenosyl-L-homocysteine+hydron
Catalysed by HNMT
Reaction pageDirection not assertedBalanced
Rhea RHEA:19301CC BY 4.0Reference data
N(tau)-methylhistamine+dioxygen+water1-methylimidazole-4-acetaldehyde+hydrogen peroxide+ammonium
Catalysed by AOC1
Reaction pageLeft to rightBalanced
Rhea RHEA:78367CC BY 4.0Reference data
Where it reaches
1 system, 1 region, 3 tissues, 3 transporter routes — routes, not measurements: transporters known to carry N(tau)-methylhistamine are expressed there, and no source reports it arriving.
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Other names
1 name
Resolves to: N(tau)-methylhistamine
- Systematic name
- 2-(1-methyl-1H-imidazol-4-yl)ethanaminium