Compound
a 1,2-diacyl-sn-glycero-3-phospho-L-serine
A singly-charged anionic phospholipid that is the conjugate base of 1,2-diacyl-sn-glycero-3-phosphoserine, in which the carboxy and phosphate groups are anionic and the amino group is cationic; major species at pH 7.3.
Definition from ChEBI (CHEBI:57262), read 2026-09-23. CC BY 4.0.
Structure
- Class
- Structural class, not a single molecule
- Formula
- C8H11NO10PR2
- Mass
- 312.148 g/mol
- Charge
- -1
- SMILES
- *C(=O)OC[C@H](COP(=O)([O-])OC[C@H]([NH3+])C(=O)[O-])OC(*)=O
- Look it up
- ChEBI
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
35 entities
35 entities reached.
0 reported hops35 assembled from the scaffold
- VDAC1ProteinUNIPROT:P21796transported byInferred only228 paths199 endpoints
- SERINC3ProteinUNIPROT:Q13530transported byInferred only177 paths177 endpoints
- VDAC2ProteinUNIPROT:P45880transported byInferred only166 paths137 endpoints
- PLSCR1ProteinUNIPROT:O15162transported byInferred only136 paths136 endpoints
- VMP1ProteinUNIPROT:Q96GC9transported byInferred only128 paths128 endpoints
- OSBPL9ProteinUNIPROT:Q96SU4transported byInferred only97 paths93 endpoints
- VAT1ProteinUNIPROT:Q99536transported byInferred only92 paths92 endpoints
- ATP8B1ProteinUNIPROT:O43520transported byInferred only81 paths79 endpoints
- SERINC5ProteinUNIPROT:Q86VE9transported byInferred only67 paths67 endpoints
- ATP8A1ProteinUNIPROT:Q9Y2Q0transported byInferred only66 paths65 endpoints
- OSBPL8ProteinUNIPROT:Q9BZF1transported byInferred only54 paths54 endpoints
- SERINC2ProteinUNIPROT:Q96SA4transported byInferred only50 paths47 endpoints
Show the remaining 23
- ABCA1ProteinUNIPROT:O95477transported byInferred only47 paths47 endpoints
- PLSCR3ProteinUNIPROT:Q9NRY6transported byInferred only42 paths42 endpoints
- ANO6ProteinUNIPROT:Q4KMQ2transported byInferred only36 paths36 endpoints
- PLSCR4ProteinUNIPROT:Q9NRQ2transported byInferred only24 paths24 endpoints
- PISDProteinUNIPROT:Q9UG56substrate ofInferred only13 paths13 endpoints
- PLA2G15ProteinUNIPROT:Q8NCC3substrate ofInferred only10 paths5 endpoints
- PLA1AProteinUNIPROT:Q53H76substrate ofInferred only8 paths8 endpoints
- ABCA7ProteinUNIPROT:Q8IZY2transported byInferred only8 paths8 endpoints
- ATP8A2ProteinUNIPROT:Q9NTI2transported byInferred only8 paths8 endpoints
- ATP11AProteinUNIPROT:P98196transported byInferred only8 paths8 endpoints
- TMEM41BProteinUNIPROT:Q5BJD5transported byInferred only6 paths6 endpoints
- ATG9AProteinUNIPROT:Q7Z3C6transported byInferred only6 paths6 endpoints
- DDHD1ProteinUNIPROT:Q8NEL9substrate ofInferred only5 paths5 endpoints
- OSBPL5ProteinUNIPROT:Q9H0X9transported byInferred only5 paths5 endpoints
- ANO7ProteinUNIPROT:Q6IWH7transported byInferred only4 paths4 endpoints
- ATG2BProteinUNIPROT:Q96BY7transported byInferred only4 paths4 endpoints
- OSBPL10ProteinUNIPROT:Q9BXB5transported byInferred only4 paths4 endpoints
- OSBPL6ProteinUNIPROT:Q9BZF3transported byInferred only4 paths4 endpoints
- ATG2AProteinUNIPROT:Q2TAZ0transported byInferred only3 paths3 endpoints
- ANO9ProteinUNIPROT:A1A5B4transported byInferred only3 paths3 endpoints
- PDZD8ProteinUNIPROT:Q8NEN9transported byInferred only2 paths2 endpoints
- OSBPL11ProteinUNIPROT:Q9BXB4transported byInferred only2 paths2 endpoints
- ATP11BProteinUNIPROT:Q9Y2G3transported byInferred only2 paths2 endpoints
What the reference databases state
Statements
47 statements
47 statements · 1 reference database · Subject: a 1,2-diacyl-sn-glycero-3-phospho-L-serine · Sources: Rhea
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is converted to a 1,2-diacyl-sn-glycero-3-phosphoethanolamineCompoundRhea RHEA:20828Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is converted to a CDP-1,2-diacyl-sn-glycerolCompoundRhea RHEA:16913Inferred only
- a CDP-1,2-diacyl-sn-glycerol is converted to a 1,2-diacyl-sn-glycero-3-phospho-L-serineCompoundRhea RHEA:16913Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is a substrate of ABHD16BProteinRhea RHEA:42212Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is a substrate of DDHD1ProteinRhea RHEA:42212Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is a substrate of PISDProteinRhea RHEA:20828Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is a substrate of PLA1AProteinRhea RHEA:42212Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is a substrate of PLA2G15ProteinRhea RHEA:78355Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is a substrate of PLA2G15ProteinRhea RHEA:78351Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by ABCA1ProteinRhea RHEA:38567Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by ABCA7ProteinRhea RHEA:38567Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by ANO4ProteinRhea RHEA:38663Inferred only
Show the remaining 35
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by ANO6ProteinRhea RHEA:38663Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by ANO7ProteinRhea RHEA:38663Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by ANO9ProteinRhea RHEA:38663Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by ATG2AProteinRhea RHEA:38663Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by ATG2BProteinRhea RHEA:38663Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by ATG9AProteinRhea RHEA:38663Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by ATG9BProteinRhea RHEA:38663Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by ATP11AProteinRhea RHEA:38567Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by ATP11BProteinRhea RHEA:38567Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by ATP11CProteinRhea RHEA:38567Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by ATP8A1ProteinRhea RHEA:38567Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by ATP8A2ProteinRhea RHEA:38567Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by ATP8B1ProteinRhea RHEA:38567Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by ATP8B3ProteinRhea RHEA:38567Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by OSBPL10ProteinRhea RHEA:81667Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by OSBPL11ProteinRhea RHEA:81667Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by OSBPL5ProteinRhea RHEA:81667Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by OSBPL6ProteinRhea RHEA:81667Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by OSBPL8ProteinRhea RHEA:81667Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by OSBPL9ProteinRhea RHEA:81667Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by PDZD8ProteinRhea RHEA:38663Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by PLSCR1ProteinRhea RHEA:38663Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by PLSCR3ProteinRhea RHEA:38663Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by PLSCR4ProteinRhea RHEA:38663Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by SERINC2ProteinRhea RHEA:38663Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by SERINC3ProteinRhea RHEA:38663Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by SERINC5ProteinRhea RHEA:38663Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by TMEM41BProteinRhea RHEA:38663Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by VAT1ProteinRhea RHEA:38663Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by VDAC1ProteinRhea RHEA:38663Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by VDAC2ProteinRhea RHEA:38663Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by VMP1ProteinRhea RHEA:38663Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by XKR4ProteinRhea RHEA:38663Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by XKR8ProteinRhea RHEA:38663Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine is transported by XKR9ProteinRhea RHEA:38663Inferred only
Reactions
15 reactions
a CDP-1,2-diacyl-sn-glycerol+L-seryl residuea 1,2-diacyl-sn-glycero-3-phospho-L-serine+CMP+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:16913CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-L-serine+hydrona 1,2-diacyl-sn-glycero-3-phosphoethanolamine+carbon dioxide
Catalysed by PISD
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:20828CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phosphoethanolamine+L-seryl residuea 1,2-diacyl-sn-glycero-3-phospho-L-serine+ethanolamine
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:27606CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-L-serine+2watersn-glycero-3-phospho-L-serine+2a carboxylate+2hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:32975CC BY 4.0Reference data
a 1-acyl-sn-glycero-3-phospho-L-serine+an acyl-CoAa 1,2-diacyl-sn-glycero-3-phospho-L-serine+coenzyme A(4-)
Catalysed by LPCAT4 or LPCAT3 or MBOAT1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:33191CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-L-serine+ATP(4-)+watera 1,2-diacyl-sn-glycero-3-phospho-L-serine+ADP(3-)+hydrogenphosphate+hydron
Transported by ATP8B1 or ATP8B3 or ABCA1 or ATP11A or ABCA7 or ATP11C or ATP8A2 or ATP11B or ATP8A1
Reaction pageReversibleBalance undeterminable
Rhea RHEA:38567CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-L-serinea 1,2-diacyl-sn-glycero-3-phospho-L-serine
Transported by ANO9 or PLSCR1 or VDAC1 or VDAC2 or SERINC3 or ATG2A or ANO4 or ANO6 or TMEM41B or XKR9 or XKR4 or ATG9B and 11 more alternatives
Reaction pageReversibleBalance undeterminable
Rhea RHEA:38663CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-L-serine+watera 2-acyl-sn-glycero-3-phospho-L-serine+a fatty acid+hydron
Catalysed by PLA1A or DDHD1 or ABHD16B
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:42212CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-L-serine+watera 1-acyl-sn-glycero-3-phospho-L-serine+a fatty acid+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:44672CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phosphocholine+L-seryl residuea 1,2-diacyl-sn-glycero-3-phospho-L-serine+choline
Catalysed by PTDSS1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:45088CC BY 4.0Reference data
[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine+water[protein]-C-terminal L-amino acid-glycine+a 1,2-diacyl-sn-glycero-3-phospho-L-serine
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:67576CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-L-serine+N-(acetyl)-sphing-4-enine1-O-acyl-N-(acetyl)-sphing-4-enine+a 1-acyl-sn-glycero-3-phospho-L-serine
Catalysed by PLA2G15
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:78351CC BY 4.0Reference data
Where it reaches
10 systems, 28 regions, 261 tissues, 1,353 transporter routes — routes, not measurements: transporters known to carry a 1,2-diacyl-sn-glycero-3-phospho-L-serine are expressed there, and no source reports it arriving.
Loading the model…
Other names
10 names
Resolves to: a 1,2-diacyl-sn-glycero-3-phospho-L-serine
- Also called
- 1,2-diacyl-sn-glycero-3-phospho-L-serine1,2-diacyl-sn-glycero-3-phospho-L-serine(1-)1,2-diacyl-sn-glycero-3-phospho-L-serine(1−)1,2-diacyl-sn-glycero-3-phosphoserine1,2-diacyl-sn-glycero-3-phosphoserine(1-)1,2-diacyl-sn-glycero-3-phosphoserine(1−)3-L-phosphatidyl-L-serine3-sn-phosphatidyl-L-serine anionPS
- Systematic name
- O-({[(2R)-2,3-bis(alkanoyloxy)propyl]oxy}phosphinato)-L-serine