Endpoint
Time to first postoperative analgesic request
CAT:outcome/time-to-first-postoperative-analgesic-requestreported in hours1 finding from 1 compound
What moved it
How to read these marks1 finding · 1 compound · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| meloxicam | up | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
Reported to move it
1 finding
meloxicam — increases
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Time from EOS to first use of opioid rescue medication (via IV or oral administration) was significantly longer with meloxicam IV versus placebo (P =.0003) (Table 4).”
Quoted verbatim from Safety and Efficacy of Perioperative Intravenous Meloxicam for Moderate-to-Severe Pain Management in Total Knee Arthroplasty: A Randomized Clinical Trial.. - Study
- RCT
- Dose
- 30 mg IV bolus before incision, then every 24 hours
- Population
- Adults undergoing elective primary total knee arthroplasty; both arms received multimodal analgesia (oral acetaminophen, gabapentin, tranexamic acid, bupivacaine infiltration)
Safety and Efficacy of Perioperative Intravenous Meloxicam for Moderate-to-Severe Pain Management in Total Knee Arthroplasty: A Randomized Clinical Trial.2021PMID:33502533Industry fundedPermalink
How it is measured
Elapsed time from the end of a surgical or anaesthetic procedure to the patient's first request for, or administration of, rescue analgesia.
Sources cited
1 paper
- Subject
- time to first postoperative analgesic request
- Findings
- 1
- Papers
- 1