Compound
3',5'-cyclic AMP
An organophosphate oxoanion that is the conjugate base of 3',5'-cyclic AMP arising from deprotonation of the free phosphate OH group; major species at pH 7.3.
Definition from ChEBI (CHEBI:58165), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C10H11N5O6P
- Mass
- 328.201 g/mol
- Charge
- -1
- InChIKey
- IVOMOUWHDPKRLL-KQYNXXCUSA-M
- SMILES
- Nc1ncnc2c1ncn2[C@@H]1O[C@@H]2COP(=O)([O-])O[C@H]2[C@H]1O
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
34 entities
34 entities reached.
0 reported hops34 assembled from the scaffold
- PDE4DProteinUNIPROT:Q08499substrate ofInferred only66 paths22 endpoints
- ADCY8ProteinUNIPROT:P40145substrate ofInferred only64 paths62 endpoints
- ADCY6ProteinUNIPROT:O43306substrate ofInferred only62 paths62 endpoints
- ADCY1ProteinUNIPROT:Q08828substrate ofInferred only62 paths62 endpoints
- ADCY5ProteinUNIPROT:O95622substrate ofInferred only60 paths60 endpoints
- ADCY3ProteinUNIPROT:O60266substrate ofInferred only58 paths58 endpoints
- PDE3BProteinUNIPROT:Q13370substrate ofInferred only57 paths19 endpoints
- ADCY2ProteinUNIPROT:Q08462substrate ofInferred only57 paths57 endpoints
- ADCY7ProteinUNIPROT:P51828substrate ofInferred only56 paths56 endpoints
- ADCY4ProteinUNIPROT:Q8NFM4substrate ofInferred only52 paths52 endpoints
- PDE1BProteinUNIPROT:Q01064substrate ofInferred only52 paths18 endpoints
- ADCY9ProteinUNIPROT:O60503substrate ofInferred only51 paths51 endpoints
Show the remaining 22
- PDE1AProteinUNIPROT:P54750substrate ofInferred only49 paths17 endpoints
- PDE1CProteinUNIPROT:Q14123substrate ofInferred only43 paths15 endpoints
- PDE4AProteinUNIPROT:P27815substrate ofInferred only36 paths12 endpoints
- PDE3AProteinUNIPROT:Q14432substrate ofInferred only33 paths11 endpoints
- PDE6GProteinUNIPROT:P18545substrate ofInferred only27 paths14 endpoints
- PDE4BProteinUNIPROT:Q07343substrate ofInferred only27 paths9 endpoints
- PDE11AProteinUNIPROT:Q9HCR9substrate ofInferred only27 paths9 endpoints
- PDE10AProteinUNIPROT:Q9Y233substrate ofInferred only27 paths9 endpoints
- ABCC5ProteinUNIPROT:O15440transported byInferred only22 paths11 endpoints
- PDE8BProteinUNIPROT:O95263substrate ofInferred only21 paths7 endpoints
- PDE7AProteinUNIPROT:Q13946substrate ofInferred only21 paths7 endpoints
- PDE2AProteinUNIPROT:O00408substrate ofInferred only21 paths7 endpoints
- ABCC4ProteinUNIPROT:O15439transported byInferred only20 paths10 endpoints
- PDE7BProteinUNIPROT:Q9NP56substrate ofInferred only18 paths6 endpoints
- PDE4CProteinUNIPROT:Q08493substrate ofInferred only15 paths5 endpoints
- PDE8AProteinUNIPROT:O60658substrate ofInferred only11 paths5 endpoints
- ENPP1ProteinUNIPROT:P22413substrate ofInferred only11 paths11 endpoints
- ADCY10ProteinUNIPROT:Q96PN6substrate ofInferred only6 paths6 endpoints
- PDE6HProteinUNIPROT:Q13956substrate ofInferred only2 paths1 endpoint
- SLC22A7ProteinUNIPROT:Q9Y694transported byInferred only2 paths2 endpoints
- SLC22A6ProteinUNIPROT:Q4U2R8transported byInferred only1 path1 endpoint
- PDE6CProteinUNIPROT:P51160substrate ofInferred only1 path1 endpoint
What the reference databases state
Statements
74 statements
74 statements · 2 reference databases · Subject: 3',5'-cyclic AMP · Sources: Human-GEM, Rhea
- 3',5'-cyclic AMP is a substrate of ADCY1ProteinRhea RHEA:15389Inferred only
- 3',5'-cyclic AMP is a substrate of ADCY10ProteinRhea RHEA:15389Inferred only
- 3',5'-cyclic AMP is a substrate of ADCY2ProteinRhea RHEA:15389Inferred only
- 3',5'-cyclic AMP is a substrate of ADCY3ProteinRhea RHEA:15389Inferred only
- 3',5'-cyclic AMP is a substrate of ADCY4ProteinRhea RHEA:15389Inferred only
- 3',5'-cyclic AMP is a substrate of ADCY5ProteinRhea RHEA:15389Inferred only
- 3',5'-cyclic AMP is a substrate of ADCY6ProteinRhea RHEA:15389Inferred only
- 3',5'-cyclic AMP is a substrate of ADCY7ProteinRhea RHEA:15389Inferred only
- 3',5'-cyclic AMP is a substrate of ADCY8ProteinRhea RHEA:15389Inferred only
- 3',5'-cyclic AMP is a substrate of ADCY9ProteinRhea RHEA:15389Inferred only
- 3',5'-cyclic AMP is a substrate of ENPP1ProteinRhea RHEA:25277Inferred only
- 3',5'-cyclic AMP is a substrate of PDE10AProteinHuman-GEM MAR08087Inferred only
Show the remaining 62
- 3',5'-cyclic AMP is a substrate of PDE10AProteinRhea RHEA:25277Inferred only
- 3',5'-cyclic AMP is a substrate of PDE10AProteinHuman-GEM MAR04014Inferred only
- 3',5'-cyclic AMP is a substrate of PDE11AProteinHuman-GEM MAR04014Inferred only
- 3',5'-cyclic AMP is a substrate of PDE11AProteinHuman-GEM MAR08087Inferred only
- 3',5'-cyclic AMP is a substrate of PDE11AProteinRhea RHEA:25277Inferred only
- 3',5'-cyclic AMP is a substrate of PDE1AProteinRhea RHEA:25277Inferred only
- 3',5'-cyclic AMP is a substrate of PDE1AProteinHuman-GEM MAR04014Inferred only
- 3',5'-cyclic AMP is a substrate of PDE1AProteinHuman-GEM MAR08087Inferred only
- 3',5'-cyclic AMP is a substrate of PDE1BProteinRhea RHEA:25277Inferred only
- 3',5'-cyclic AMP is a substrate of PDE1BProteinHuman-GEM MAR08087Inferred only
- 3',5'-cyclic AMP is a substrate of PDE1BProteinHuman-GEM MAR04014Inferred only
- 3',5'-cyclic AMP is a substrate of PDE1CProteinRhea RHEA:25277Inferred only
- 3',5'-cyclic AMP is a substrate of PDE1CProteinHuman-GEM MAR04014Inferred only
- 3',5'-cyclic AMP is a substrate of PDE1CProteinHuman-GEM MAR08087Inferred only
- 3',5'-cyclic AMP is a substrate of PDE2AProteinHuman-GEM MAR04014Inferred only
- 3',5'-cyclic AMP is a substrate of PDE2AProteinRhea RHEA:25277Inferred only
- 3',5'-cyclic AMP is a substrate of PDE2AProteinHuman-GEM MAR08087Inferred only
- 3',5'-cyclic AMP is a substrate of PDE3AProteinRhea RHEA:25277Inferred only
- 3',5'-cyclic AMP is a substrate of PDE3AProteinHuman-GEM MAR04014Inferred only
- 3',5'-cyclic AMP is a substrate of PDE3AProteinHuman-GEM MAR08087Inferred only
- 3',5'-cyclic AMP is a substrate of PDE3BProteinRhea RHEA:25277Inferred only
- 3',5'-cyclic AMP is a substrate of PDE3BProteinHuman-GEM MAR08087Inferred only
- 3',5'-cyclic AMP is a substrate of PDE3BProteinHuman-GEM MAR04014Inferred only
- 3',5'-cyclic AMP is a substrate of PDE4AProteinHuman-GEM MAR08087Inferred only
- 3',5'-cyclic AMP is a substrate of PDE4AProteinRhea RHEA:25277Inferred only
- 3',5'-cyclic AMP is a substrate of PDE4AProteinHuman-GEM MAR04014Inferred only
- 3',5'-cyclic AMP is a substrate of PDE4BProteinHuman-GEM MAR08087Inferred only
- 3',5'-cyclic AMP is a substrate of PDE4BProteinHuman-GEM MAR04014Inferred only
- 3',5'-cyclic AMP is a substrate of PDE4BProteinRhea RHEA:25277Inferred only
- 3',5'-cyclic AMP is a substrate of PDE4CProteinHuman-GEM MAR08087Inferred only
- 3',5'-cyclic AMP is a substrate of PDE4CProteinHuman-GEM MAR04014Inferred only
- 3',5'-cyclic AMP is a substrate of PDE4CProteinRhea RHEA:25277Inferred only
- 3',5'-cyclic AMP is a substrate of PDE4DProteinHuman-GEM MAR04014Inferred only
- 3',5'-cyclic AMP is a substrate of PDE4DProteinHuman-GEM MAR08087Inferred only
- 3',5'-cyclic AMP is a substrate of PDE4DProteinRhea RHEA:25277Inferred only
- 3',5'-cyclic AMP is a substrate of PDE6CProteinHuman-GEM MAR04014Inferred only
- 3',5'-cyclic AMP is a substrate of PDE6GProteinHuman-GEM MAR04014Inferred only
- 3',5'-cyclic AMP is a substrate of PDE6GProteinHuman-GEM MAR08087Inferred only
- 3',5'-cyclic AMP is a substrate of PDE6HProteinHuman-GEM MAR08087Inferred only
- 3',5'-cyclic AMP is a substrate of PDE6HProteinHuman-GEM MAR04014Inferred only
- 3',5'-cyclic AMP is a substrate of PDE7AProteinHuman-GEM MAR04014Inferred only
- 3',5'-cyclic AMP is a substrate of PDE7AProteinHuman-GEM MAR08087Inferred only
- 3',5'-cyclic AMP is a substrate of PDE7AProteinRhea RHEA:25277Inferred only
- 3',5'-cyclic AMP is a substrate of PDE7BProteinHuman-GEM MAR08087Inferred only
- 3',5'-cyclic AMP is a substrate of PDE7BProteinRhea RHEA:25277Inferred only
- 3',5'-cyclic AMP is a substrate of PDE7BProteinHuman-GEM MAR04014Inferred only
- 3',5'-cyclic AMP is a substrate of PDE8AProteinHuman-GEM MAR04014Inferred only
- 3',5'-cyclic AMP is a substrate of PDE8AProteinRhea RHEA:25277Inferred only
- 3',5'-cyclic AMP is a substrate of PDE8AProteinHuman-GEM MAR08087Inferred only
- 3',5'-cyclic AMP is a substrate of PDE8BProteinHuman-GEM MAR04014Inferred only
- 3',5'-cyclic AMP is a substrate of PDE8BProteinHuman-GEM MAR08087Inferred only
- 3',5'-cyclic AMP is a substrate of PDE8BProteinRhea RHEA:25277Inferred only
- 3',5'-cyclic AMP is a substrate of PRUNE1ProteinRhea RHEA:25277Inferred only
- 3',5'-cyclic AMP is transported by ABCC11ProteinHuman-GEM MAR07691Inferred only
- 3',5'-cyclic AMP is transported by ABCC11ProteinRhea RHEA:66184Inferred only
- 3',5'-cyclic AMP is transported by ABCC4ProteinRhea RHEA:66184Inferred only
- 3',5'-cyclic AMP is transported by ABCC4ProteinHuman-GEM MAR07691Inferred only
- 3',5'-cyclic AMP is transported by ABCC5ProteinHuman-GEM MAR07691Inferred only
- 3',5'-cyclic AMP is transported by ABCC5ProteinRhea RHEA:66184Inferred only
- 3',5'-cyclic AMP is transported by SLC22A6ProteinRhea RHEA:76127Inferred only
- 3',5'-cyclic AMP is transported by SLC22A7ProteinRhea RHEA:76223Inferred only
- 3',5'-cyclic AMP is transported by TAS2R14ProteinRhea RHEA:76223Inferred only
Reactions
12 reactions
ATP3',5'-cyclic AMP+diphosphate(3-)
Catalysed by GUCY1A1 & GUCY1B1 or ADCY2 or ADCY7 or ADCY4 or ADCY3 or ADCY10 or ADCY8 or NPR2 or ADCY9 or ADCY1 or ADCY5 or ADCY6
Reaction pageLeft to rightBalancedEC 4.6.1.1, 4.6.1.2cytosol
Human-GEM MAR04000CC BY 4.0Reference data
3',5'-cyclic AMP+waterAMP+proton
Catalysed by PDE4A or PDE8A or PDE6C or PDE4C or PDE10A or PDE8B or PDE4D or PDE1A or PDE1B or PDE11A or PDE6H or PDE3B and 7 more alternatives
Reaction pageLeft to rightBalancedEC 3.1.4.17cytosol
Human-GEM MAR04014CC BY 4.0Reference data
ATP+3',5'-cyclic AMP+waterADP+3',5'-cyclic AMP+proton+phosphate(3-)
Transported by ABCC5 or ABCC11 or ABCC4
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07691CC BY 4.0Reference data
3',5'-cyclic AMP3',5'-cyclic AMP
Reaction pageReversibleBalancedcytosol, Golgi apparatus
Human-GEM MAR08086CC BY 4.0Reference data
3',5'-cyclic AMP+waterAMP+proton
Catalysed by PDE4A or PDE8A or PDE4C or PDE10A or PDE8B or PDE4D or PDE1A or PDE1B or PDE11A or PDE6H or PDE3B or PDE1C and 6 more alternatives
Reaction pageLeft to rightBalancedEC 3.1.4.17Golgi apparatus
Human-GEM MAR08087CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR09275CC BY 4.0Reference data
ATP(4-)3',5'-cyclic AMP+diphosphate(3-)
Catalysed by ADCY6 or ADCY3 or ADCY9 or ADCY5 or ADCY8 or ADCY7 or ADCY2 or ADCY1 or ADCY4 or ADCY10
Reaction pageDirection not assertedBalanced
Rhea RHEA:15389CC BY 4.0Reference data
3',5'-cyclic AMP+water+hydronCHEBI:134197+ammonium
Reaction pageDirection not assertedBalanced
Rhea RHEA:22908CC BY 4.0Reference data
3',5'-cyclic AMP+waterAMP+hydron
Catalysed by PDE2A or PDE8A or PDE8B or ENPP1 or PDE4A or PDE1A or PDE1B or PDE4B or PDE4C or PDE4D or PDE3B or PDE7A and 6 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:25277CC BY 4.0Reference data
3',5'-cyclic AMP+ATP(4-)+water3',5'-cyclic AMP+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCC4 or ABCC5 or ABCC11
Reaction pageLeft to rightBalanced
Rhea RHEA:66184CC BY 4.0Reference data
3',5'-cyclic AMP+a dicarboxylate3',5'-cyclic AMP+a dicarboxylate
Transported by SLC22A6
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:76127CC BY 4.0Reference data
3',5'-cyclic AMP3',5'-cyclic AMP
Transported by TAS2R14 or SLC22A7
Reaction pageDirection not assertedBalanced
Rhea RHEA:76223CC BY 4.0Reference data
Where it reaches
4 systems, 9 regions, 20 tissues, 20 transporter routes — routes, not measurements: transporters known to carry 3',5'-cyclic AMP are expressed there, and no source reports it arriving.
Loading the model…
Other names
6 names
Resolves to: 3',5'-cyclic AMP
- Also called
- 3',5'-cyclic AMP anionadenosine 3',5'-cyclic monophosphateadenosine 3',5'-cyclic monophosphate anionadenosine 3',5'-cyclic monophosphate(1-)adenosine 3',5'-cyclic monophosphate(1−)
- Systematic name
- adenosine 3',5'-phosphate