Endpoint
Incidence of coronary heart disease
CAT:outcome/coronary-heart-disease-incidencereported in relative risk3 findings from 3 compounds
What moved it
How to read these marks3 findings · 3 compounds · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| linoleic acid | down | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| lutein | down | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
| magnesium(2+) | down | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
Reported to move it
3 findings
linoleic acid — decreases
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Across 10 cohort studies that examined the association between LA and total CHD events (14 estimates), LA consumption was inversely associated with risk of total CHD events.”
Quoted verbatim from Dietary linoleic acid and risk of coronary heart disease: a systematic review and meta-analysis of prospective cohort studies.. - Study
- cohort
- Population
- Adults in 10 prospective cohort studies (14 estimates) pooled; observational comparison of highest versus lowest category of dietary linoleic acid intake, not a dosed exposure
Dietary linoleic acid and risk of coronary heart disease: a systematic review and meta-analysis of prospective cohort studies.2014PMID:25161045Permalink
lutein — decreases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Meta-analysis showed a lower risk of coronary heart disease (pooled RR: 0.88; 95% CI: 0.80, 0.98) and stroke (pooled RR: 0.82; 95% CI: 0.72, 0.93) for the highest compared with the lowest tertile of lutein blood concentration or intake.”
Quoted verbatim from The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis.. - Study
- meta-analysis
- Population
- highest vs lowest tertile of lutein blood concentration or dietary intake
The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis.2016PMID:26762372Permalink
magnesium(2+) — decreases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Dietary magnesium (per 200-mg/d increment) was not significantly associated with CVD (RR: 0.89; 95% CI: 0.75, 1.05) but was associated with a 22% lower risk of IHD (RR: 0.78; 95% CI: 0.67, 0.92).”
Quoted verbatim from Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.. - Study
- meta-analysis
- Population
- Adults in prospective cohort studies; dietary magnesium per 200-mg/d increment; abstract-only source, no full text available
Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.2013PMID:23719551Permalink
How it is measured
Incident coronary heart disease events — fatal and non-fatal coronary events including angina and coronary revascularisation — over the follow-up the source states.
Sources cited
3 papers
- Subject
- incidence of coronary heart disease
- Findings
- 3
- Papers
- 3
The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis.record2016PMID:267623721 finding
Dietary linoleic acid and risk of coronary heart disease: a systematic review and meta-analysis of prospective cohort studies.record2014PMID:251610451 finding
Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.record2013PMID:237195511 finding