Endpoint
Erythrocyte sedimentation rate
Measurement of rate of settling of erythrocytes in blood.
CAT:outcome/erythrocyte-sedimentation-ratereported in mm/h4 findings from 4 compounds
What moved it
How to read these marks4 findings · 4 compounds · 2 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| all-cis-5,8,11,14,17-icosapentaenoic acid | down | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| coenzyme Q10 | no effect | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| curcumin | down | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| melatonin | no effect | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
Reported to move it
2 findings
all-cis-5,8,11,14,17-icosapentaenoic acid — decreases
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Serum ESR and CRP levels significantly decreased in the EPA-rich fish oil (p < 0.001).”
Quoted verbatim from Eicosapentaenoic acid decreases inflammation and improves glucose homeostasis in patients with burns: a randomized clinical trial.. - Study
- RCT
- Participants
- 24
- Duration
- 3 weeks
- Dose
- 1.5 g/day EPA as EPA-rich fish oil capsules (500 mg EPA per capsule, three times daily with meals)
- Population
- Hospitalised adults aged 18-65 with non-severe burns covering less than 20% of total body surface area, able to take more than 90% of their daily calorie requirement by mouth, without diabetes, organ failure, cancer or immune disorder; both the EPA arm and the control arm also received 600 mg/day DHA.
Eicosapentaenoic acid decreases inflammation and improves glucose homeostasis in patients with burns: a randomized clinical trial.2025PMID:41254027Permalink
curcumin — decreases
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“We found a conflicting effect of curcumin supplementation on systemic inflammation markers, with a significantly large decrease in the ESR but not in the CRP level ( Table 2).”
Quoted verbatim from A Meta-Analysis of the Impact of Nutritional Supplementation on Osteoarthritis Symptoms.. - Study
- meta-analysis
- Population
- patients with knee osteoarthritis; inflammation-marker outcome pooled across the curcumin trials (placebo and active comparators), all studies and timepoints
A Meta-Analysis of the Impact of Nutritional Supplementation on Osteoarthritis Symptoms.2022PMID:35458170Permalink
Measured, no effect detected
2 findings
melatonin — no detected effect on
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“No statistically significant effects were revealed between the groups regarding changes in ESR (MD −0.12, 95% CI −0.64 to 0.39, p = 0.64; I2 0%, p for heterogeneity = 0.67) and NLR (MD 7.31, 95% CI −15.21 to 29.84, p = 0.52; I2 87%, p for heterogeneity < 0.01) after melatonin administration.”
Quoted verbatim from The clinical efficacy of melatonin in the treatment of patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Population
- hospitalized adults with COVID-19 receiving melatonin plus standard care versus control (predominantly standard care alone, two trials placebo-controlled)
Effect -0.12 mean difference, 95% CI -0.64 to 0.39
The clinical efficacy of melatonin in the treatment of patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials.2023PMID:37181363Permalink
coenzyme Q10 — no detected effect on
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“The differences in the CRP and ESR levels were not significant between CoQ10 and placebo groups (P = 0.550 and P = 0.306, respectively) (Table 2).”
Quoted verbatim from Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.. - Study
- RCT
- Participants
- 52
- Duration
- 10 days
- Dose
- 100 mg three times a day after meals, total 300 mg/day
- Population
- Adults aged 18-65 with 20-60% total body surface area burns admitted to a burn ICU in Isfahan, Iran, all receiving routine burn care and the unit's standard vitamin, selenium, zinc and B-complex supplementation in both arms; primary outcome.
Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.2024PMID:38431600Permalink
How it is measured
Erythrocyte sedimentation rate by the Westergren method — the distance red cells fall through an anticoagulated whole-blood column in one hour. Automated alternatives to the Westergren tube are recorded with each finding and are calibrated against it rather than identical to it.
Measured, not recorded
- Subject
- erythrocyte sedimentation rate
- Measurements
- 7 measurements
- Recorded as a finding
- No
Show what was measured
Erythrocyte sedimentation rate
decreases
Erythrocyte Sedimentation Rate mm | 33.0 ± 3.6 | 30.3 ± 3.0 | 33.9 ± 3.4 | 28.5 ± 3.1a
PMID:17974032 · one of two readings recorded this
Erythrocyte sedimentation rate
decreases, p = 0.048
erythrocyte sedimentation rate (P = 0.048)
PMID:31168845 · one of two readings recorded this
Erythrocyte sedimentation rate
decreases, p = 0.021, n = 75
mean ESR and CRP, as indicators of inflammation, were significantly lower in the intervention group compared to the control (p = 0.021 and p = 0.009, respectively; two-sided T-test)
PMID:35997951 · one of two readings recorded this
Erythrocyte sedimentation rate
n = 43
ESR | Control | 43 | 54.1512 | 30.70027 | 20.68241 | 0.002 | 3.370 | 73 | 43 | 43.0349 | 30.74674 | 23.09738 | 0.000 | 4.124 | 73 | 0.009*
PMID:35997951 · one of two readings recorded this
Erythrocyte sedimentation rate
n = 32
Intervention | 32 | 33.4688 | 18.71688 | 20.68241 | 32 | 19.9375 | 8.63951 | 23.09738
PMID:35997951 · one of two readings recorded this
erythrocyte sedimentation rate
no effect, pooled SMD = -1.49, 95% CI -3.71 to 0.72
No significant difference between groups was observed (pooled SMD = − 1.49, 95% CI − 3.71 to 0.72) (Fig. B).
PMID:41372521 · one of two readings recorded this
erythrocyte sedimentation rate
decreases
Aspartate aminotransferase and alanine aminotransferase levels decreased, accompanied by lower values of C-reactive protein and erythrocyte sedimentation rate
PMID:42282227 · one of two readings recorded this
Sources cited
4 papers
- Subject
- erythrocyte sedimentation rate
- Findings
- 4
- Papers
- 4
Eicosapentaenoic acid decreases inflammation and improves glucose homeostasis in patients with burns: a randomized clinical trial.record2025PMID:412540271 finding
Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.record2024PMID:384316001 finding
The clinical efficacy of melatonin in the treatment of patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials.record2023PMID:371813631 finding
A Meta-Analysis of the Impact of Nutritional Supplementation on Osteoarthritis Symptoms.record2022PMID:354581701 finding