Compound
ursodeoxycholate
A bile acid anion that is the conjugate base of ursodeoxycholic acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.
Definition from ChEBI (CHEBI:78604), read 2026-09-23. CC BY 4.0.
Structure
- Class
- Organic compound, anion
- Formula
- C24H39O4
- Mass
- 391.572 g/mol
- Charge
- -1
- InChIKey
- RUDATBOHQWOJDD-UZVSRGJWSA-M
- SMILES
- [H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]1([H])CC[C@@]3(C)[C@@]([H])(CC[C@]3([H])[C@H](C)CCC(=O)[O-])[C@]1([H])[C@@H](O)C2
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
11 entities
11 entities reached.
0 reported hops11 assembled from the scaffold
- SULT2A1ProteinUNIPROT:Q06520metabolized byInferred only48 paths24 endpoints
- ABCC3ProteinUNIPROT:O15438transported byInferred only33 paths30 endpoints
- ABCC2ProteinUNIPROT:Q92887transported byInferred only15 paths15 endpoints
- SLCO1B3ProteinUNIPROT:Q9NPD5transported byInferred only15 paths2 endpoints
- ABCC4ProteinUNIPROT:O15439transported byInferred only10 paths10 endpoints
- SLC51BProteinUNIPROT:Q86UW2transported byInferred only9 paths9 endpoints
- SLC51AProteinUNIPROT:Q86UW1transported byInferred only5 paths5 endpoints
- ABCB11ProteinUNIPROT:O95342transported byInferred only4 paths3 endpoints
- SLCO1B1ProteinUNIPROT:Q9Y6L6transported byInferred only3 paths2 endpoints
- SLC10A2ProteinUNIPROT:Q12908transported byInferred only2 paths2 endpoints
- SLC10A1ProteinUNIPROT:Q14973transported byInferred only2 paths2 endpoints
What the reference databases state
Chemical structure
- ursodeoxycholate 3-sulfate has the functional parent ursodeoxycholateCompoundChEBI CHEBI:234529Inferred only
Statements
20 statements
20 statements · 2 reference databases · Subject: ursodeoxycholate · Sources: Human-GEM, Rhea
- ursodeoxycholate is metabolised by SULT2A1ProteinRhea RHEA:85723Inferred only
- ursodeoxycholate is metabolised by SULT2A1ProteinHuman-GEM MAR12305Inferred only
- ursodeoxycholate is transported by ABCB11ProteinHuman-GEM MAR10453Inferred only
- ursodeoxycholate is transported by ABCC2ProteinHuman-GEM MAR10453Inferred only
- ursodeoxycholate is transported by ABCC3ProteinHuman-GEM MAR10453Inferred only
- ursodeoxycholate is transported by ABCC4ProteinHuman-GEM MAR10453Inferred only
- ursodeoxycholate is transported by SLC10A1ProteinHuman-GEM MAR12307Inferred only
- ursodeoxycholate is transported by SLC10A2ProteinHuman-GEM MAR12307Inferred only
- ursodeoxycholate is transported by SLC51AProteinHuman-GEM MAR12306Inferred only
- ursodeoxycholate is transported by SLC51BProteinHuman-GEM MAR12306Inferred only
- ursodeoxycholate is transported by SLCO1A2ProteinHuman-GEM MAR06078Inferred only
- ursodeoxycholate is transported by SLCO1A2ProteinHuman-GEM MAR06079Inferred only
Show the remaining 8
- ursodeoxycholate is transported by SLCO1A2ProteinHuman-GEM MAR06077Inferred only
- ursodeoxycholate is transported by SLCO1A2ProteinHuman-GEM MAR06063Inferred only
- ursodeoxycholate is transported by SLCO1B1ProteinHuman-GEM MAR12306Inferred only
- ursodeoxycholate is transported by SLCO1B3ProteinHuman-GEM MAR06077Inferred only
- ursodeoxycholate is transported by SLCO1B3ProteinHuman-GEM MAR06078Inferred only
- ursodeoxycholate is transported by SLCO1B3ProteinHuman-GEM MAR12306Inferred only
- ursodeoxycholate is transported by SLCO1B3ProteinHuman-GEM MAR06079Inferred only
- ursodeoxycholate is transported by SLCO1B3ProteinHuman-GEM MAR06063Inferred only
Reactions
20 reactions
Reaction pageReversibleBalance undeterminableGO:0005615
Human-GEM MAR04173CC BY 4.0Reference data
CHEBI:16856+hydrogencarbonate+ursodeoxycholateCHEBI:16856+hydrogencarbonate+ursodeoxycholate
Transported by SLCO1A2 & SLCO1B3
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR06063CC BY 4.0Reference data
MAM01980c+hydrogencarbonate+ursodeoxycholateMAM01980e+hydrogencarbonate+ursodeoxycholate
Transported by SLCO1A2 & SLCO1B3
Reaction pageReversibleBalance undeterminableGO:0005829, GO:0005615
Human-GEM MAR06077CC BY 4.0Reference data
hydrogencarbonate+2,4-dinitrophenyl-S-glutathione+ursodeoxycholatehydrogencarbonate+2,4-dinitrophenyl-S-glutathione+ursodeoxycholate
Transported by SLCO1A2 & SLCO1B3
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR06078CC BY 4.0Reference data
hydrogencarbonate+MAM02901c+ursodeoxycholatehydrogencarbonate+MAM02901e+ursodeoxycholate
Transported by SLCO1A2 & SLCO1B3
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR06079CC BY 4.0Reference data
ATP+CHEBI:1146900+ursodeoxycholateAMP+diphosphate(3-)+MAM10042c
Reaction pageLeft to rightBalancedGO:0005829
Human-GEM MAR10128CC BY 4.0Reference data
water+MAM10042cCHEBI:1146900+proton+ursodeoxycholate
Reaction pageLeft to rightBalancedGO:0005829
Human-GEM MAR10129CC BY 4.0Reference data
proton+NADPH(4-)+MAM03313cNADP(3-)+ursodeoxycholate
Reaction pageLeft to rightBalancedGO:0005829
Human-GEM MAR10449CC BY 4.0Reference data
ATP+CHEBI:1146900+ursodeoxycholateAMP+diphosphate(3-)+MAM04061c
Reaction pageLeft to rightBalancedGO:0005829
Human-GEM MAR10450CC BY 4.0Reference data
ATP+water+ursodeoxycholateADP+proton+phosphate(3-)+ursodeoxycholate
Transported by ABCC2 or ABCB11 or ABCC3 or ABCC4
Reaction pageLeft to rightBalancedGO:0005829, GO:0005615
Human-GEM MAR10453CC BY 4.0Reference data
3'-phospho-5'-adenylyl sulfate+ursodeoxycholateproton+adenosine 3',5'-bismonophosphate+MAM04058c
Catalysed by SULT2A1
Reaction pageLeft to rightBalancedEC 2.8.2.14GO:0005829
Human-GEM MAR12305CC BY 4.0Reference data
hydrogencarbonate+ursodeoxycholatehydrogencarbonate+ursodeoxycholate
Transported by SLCO1B3 or SLCO1B1 or SLC51A or SLC51B
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR12306CC BY 4.0Reference data
Where it reaches
8 systems, 17 regions, 39 tissues, 67 transporter routes — routes, not measurements: transporters known to carry ursodeoxycholate are expressed there, and no source reports it arriving.
Loading the model…
Other names
3 names
Resolves to: ursodeoxycholate
- Also called
- 3alpha,7beta-dihydroxy-5beta-cholan-24-oate
- Systematic name
- (3alpha,5beta,7beta)-3,7-dihydroxycholan-24-oate(3α,5β,7β)-3,7-dihydroxycholan-24-oate