Compound
melatonin
A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the pineal gland. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of sleep, mood, and reproduction. Melatonin is also an effective antioxidant.
Studied for
39 endpoints · 77 findings · 50 papers · 32 null
- Sleep onset latencylowersEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.
- All-cause mortalityno detected effectEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.
- C-reactive protein concentrationlowersEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.
- Malondialdehyde (circulating)no detected effectEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.
- Body mass indexno detected effectEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.
Structure
A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.
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- Class
- Organic compound
- Formula
- C13H16N2O2
- Mass
- 232.283 g/mol
- Charge
- 0
- InChIKey
- DRLFMBDRBRZALE-UHFFFAOYSA-N
- SMILES
- COc1ccc2ncc(CCNC(C)=O)c2c1
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What the evidence says
How to read these marks77 findings · 39 endpoints · 50 papers · 32 null · by evidence strength
- Evidence strength
- Strong
- Moderate
- Limited
- Very limited
- Insufficient
What moved
45 findings
Decreases duration of mechanical ventilation
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“However, melatonin group demonstrated significantly lower serum HMGB-1 and NT-pro-BNP concentrations along with shorter duration of MV and less need for oxygen therapy and shorter length of NICU stay compared to control group.”
Quoted verbatim from Melatonin effects on the left ventricular function in neonates with persistent pulmonary hypertension.. - Study
- RCT
- Dose
- Oral melatonin 10 mg/kg/day for five doses, started within the first 24 h; melatonin tablets crushed, suspended in 5 mL normal saline and given by orogastric tube, in addition to standard care
- Population
- Neonates of at least 36 weeks' gestation with persistent pulmonary hypertension of the newborn (PPHN), neonatal intensive care unit, Tanta University Hospitals, Egypt; n=80 randomised and analysed (40 melatonin plus standard care, 40 placebo plus standard care); duration of mechanical ventilation was a pre-specified SECONDARY clinical outcome (primary outcome was LV function at end of therapy, with LV-GLS the principal endpoint); open to clinicians, outcome assessors blinded
Melatonin effects on the left ventricular function in neonates with persistent pulmonary hypertension.2026PMID:41954764Permalink
Decreases LDL cholesterol
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“The meta-analysis indicated that melatonin supplementation significantly reduced serum TC (WMD: −6.97 mg/dL, 95% CI: −12.20, −1.74) and LDL-C levels (WMD: −6.28 mg/dL, 95% CI: −10.53, −2.03) in the melatonin group compared with the control group.”
Quoted verbatim from Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose-Response Meta-Analysis.. - Study
- meta-analysis
- Dose
- 0.3-100 mg/day oral
- Population
- adults in 63 RCTs of melatonin supplementation vs placebo across mixed clinical populations
Effect -6.28 mean difference, 95% CI -10.53 to -2.03
Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose-Response Meta-Analysis.2025PMID:41515249Permalink
Decreases malondialdehyde (circulating)
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×1“The meta-analysis indicated that melatonin supplementation considerably lowered serum MDA levels (WMD: −1.54 μmol/L, 95% CI: −2.07, −1.01) and markedly increased serum TAC levels (WMD: 0.15 mmol/L, 95% CI: 0.08, 0.22) in the melatonin-treated group versus the untreated group.”
Quoted verbatim from Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose-Response Meta-Analysis.. - Study
- meta-analysis
- Dose
- 0.3-100 mg/day oral
- Population
- adults in 63 RCTs of melatonin supplementation vs placebo across mixed clinical populations
Effect -1.54 mean difference, 95% CI -2.07 to -1.01
Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose-Response Meta-Analysis.2025PMID:41515249Permalink
Decreases intensive care unit length of stay
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×1“However, melatonin group demonstrated significantly lower serum HMGB-1 and NT-pro-BNP concentrations along with shorter duration of MV and less need for oxygen therapy and shorter length of NICU stay compared to control group.”
Quoted verbatim from Melatonin effects on the left ventricular function in neonates with persistent pulmonary hypertension.. - Study
- RCT
- Dose
- Oral melatonin 10 mg/kg/day for five doses, started within the first 24 h; melatonin tablets crushed, suspended in 5 mL normal saline and given by orogastric tube, in addition to standard care
- Population
- Neonates of at least 36 weeks' gestation with persistent pulmonary hypertension of the newborn (PPHN), neonatal intensive care unit, Tanta University Hospitals, Egypt; n=80 randomised and analysed (40 melatonin plus standard care, 40 placebo plus standard care); NICU length of stay was a pre-specified SECONDARY clinical outcome (primary outcome was LV function at end of therapy, with LV-GLS the principal endpoint); open to clinicians, outcome assessors blinded
Melatonin effects on the left ventricular function in neonates with persistent pulmonary hypertension.2026PMID:41954764Permalink
Decreases malondialdehyde (circulating)
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×1“The reduction in serum MDA in the melatonin group was also statistically significant when compared to the placebo group ( P = 0.03; Table 3).”
Quoted verbatim from Effects of melatonin on advanced glycation end products, inflammation, and oxidative stress in peritoneal dialysis patients: a randomized controlled trial.. - Study
- RCT
- Dose
- Melatonin 5 mg tablet, one tablet nightly one hour before bedtime, for 10 weeks
- Population
- Adults aged 19-75 with chronic kidney failure on continuous ambulatory peritoneal dialysis, four PD centres in Iran; 46 recruited, 44 analysed (22 melatonin, 22 placebo) after one exclusion per group for peritonitis; serum MDA was a pre-specified PRIMARY outcome; double-blind, placebo-controlled; MDA measured in serum by colorimetric commercial kit (ZellBio GmbH), intra-assay CV 5.5%; between-group comparison of change from baseline at week 10
Effects of melatonin on advanced glycation end products, inflammation, and oxidative stress in peritoneal dialysis patients: a randomized controlled trial.2025PMID:41125682Industry fundedPermalink
Decreases pittsburgh Sleep Quality Index global score
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“After treatment, the study group showed significantly decreased scores in HAMD, HAMA, and PSQI scales in contrast to the other.”
Quoted verbatim from Influence of Melatonin Treatment on Emotion, Sleep, and Life Quality in Perimenopausal Women: A Clinical Study.. - Study
- RCT
- Dose
- 3 mg in the evening, 3 cycles of 4 weeks treatment with 1 week withdrawal
- Population
- Healthy perimenopausal Chinese women aged 45-55 years; melatonin 3 mg versus placebo capsules
Influence of Melatonin Treatment on Emotion, Sleep, and Life Quality in Perimenopausal Women: A Clinical Study.2023PMID:37854169Permalink
Show the remaining 39
Decreases fasting blood glucose
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×1“The pooled analysis displayed that melatonin supplementation substantially lowered serum FBG levels in the melatonin group compared with the placebo group (WMD: −11.63 mg/dL, 95% CI: −19.16, −4.10).”
Quoted verbatim from Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose-Response Meta-Analysis.. - Study
- meta-analysis
- Dose
- 0.3-100 mg/day oral
- Population
- adults in 63 RCTs of melatonin supplementation vs placebo across mixed clinical populations
Effect -11.63 mean difference, 95% CI -19.16 to -4.1
Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose-Response Meta-Analysis.2025PMID:41515249Permalink
Increases total antioxidant capacity
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×1“Our meta-analysis indicated that melatonin intake significantly increase TAC levels (SMD: 0.87, 95% CI: 0.46, 1.28, I2 = 00.00%) compare to placebo (Table 2).”
Quoted verbatim from Effect of melatonin supplementation on cardiometabolic risk factors, oxidative stress and hormonal profile in PCOS patients: a systematic review and meta-analysis of randomized clinical trials.. - Study
- meta-analysis
- Dose
- 3-10 mg/day oral
- Population
- women with polycystic ovary syndrome; 6 double-blind RCTs
Effect 0.87 standardised mean difference, 95% CI 0.46 to 1.28
Effect of melatonin supplementation on cardiometabolic risk factors, oxidative stress and hormonal profile in PCOS patients: a systematic review and meta-analysis of randomized clinical trials.2024PMID:38965577Permalink
Decreases sleep onset latency
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×8“The pooled SMD in healthy subjects showed that exogenous melatonin significantly decreased SOL compared to placebo.”
Quoted verbatim from Melatonergic agents influence the sleep-wake and circadian rhythms in healthy and psychiatric participants: a systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Population
- Healthy adult participants; pooled RCTs of exogenous melatonin vs placebo, sleep onset latency by polysomnography or actigraphy
Melatonergic agents influence the sleep-wake and circadian rhythms in healthy and psychiatric participants: a systematic review and meta-analysis of randomized controlled trials.2022PMID:35115662Permalink
Increases total antioxidant capacity
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×1“The meta-analysis indicated that melatonin supplementation considerably lowered serum MDA levels (WMD: −1.54 μmol/L, 95% CI: −2.07, −1.01) and markedly increased serum TAC levels (WMD: 0.15 mmol/L, 95% CI: 0.08, 0.22) in the melatonin-treated group versus the untreated group.”
Quoted verbatim from Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose-Response Meta-Analysis.. - Study
- meta-analysis
- Population
- adults, pooled across 63 RCTs of melatonin supplementation across mixed clinical populations (including metabolic syndrome, chronic kidney disease, PCOS, COVID-19, multiple sclerosis, type 2 diabetes, and other conditions)
Effect 0.15 mean difference, 95% CI 0.08 to 0.22
Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose-Response Meta-Analysis.2025PMID:41515249Permalink
Decreases sleep onset latency
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×8“Our meta-analysis demonstrated melatonin had a significant benefit in reducing sleep latency.”
Quoted verbatim from Meta-analysis: melatonin for the treatment of primary sleep disorders.. - Study
- meta-analysis
- Population
- Adults and children with primary sleep disorders (insomnia, delayed sleep phase syndrome, REM sleep behaviour disorder) in placebo-controlled trials; primary outcome; fixed-effects pooled estimate, latency measured by polysomnography/actigraphy or by sleep diary depending on trial
Meta-analysis: melatonin for the treatment of primary sleep disorders.2013PMID:23691095Permalink
Decreases subjective fatigue
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“After the intervention, not only the mean fatigue score was significantly lower in melatonin group (2.93 ± 1.04 vs 1.99 ± 1.02, P < .001, P ≤ .05), but also a greater reduction in fatigue score in intervention group was evident over time (P ≤ .001).”
Quoted verbatim from A Randomized, Controlled, Parallel-Group, Trial on the Long-term Effects of Melatonin on Fatigue Associated With Breast Cancer and Its Adjuvant Treatments.. - Study
- RCT
- Dose
- 18 mg/day from 1 week before adjuvant treatments until 2 years after their completion
- Population
- Breast cancer patients receiving adjuvant treatments; melatonin versus placebo, Brief Fatigue Inventory
A Randomized, Controlled, Parallel-Group, Trial on the Long-term Effects of Melatonin on Fatigue Associated With Breast Cancer and Its Adjuvant Treatments.2023PMID:37139718Permalink
Decreases C-reactive protein concentration
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×1“During the study, serum hs-CRP levels decreased in the melatonin group, and this reduction was significant in comparison with the placebo group ( P = 0.04).”
Quoted verbatim from Effects of melatonin on advanced glycation end products, inflammation, and oxidative stress in peritoneal dialysis patients: a randomized controlled trial.. - Study
- RCT
- Dose
- Melatonin 5 mg tablet, one tablet nightly one hour before bedtime, for 10 weeks
- Population
- Adults aged 19-75 with chronic kidney failure on continuous ambulatory peritoneal dialysis, four PD centres in Iran; 46 recruited, 44 analysed (22 melatonin, 22 placebo) after one exclusion per group for peritonitis; serum hs-CRP was a pre-specified PRIMARY outcome and the variable the trial was powered on; double-blind, placebo-controlled; hs-CRP by ELISA (ZellBio GmbH), intra-assay CV 5.1%; between-group comparison of change from baseline at week 10
Effects of melatonin on advanced glycation end products, inflammation, and oxidative stress in peritoneal dialysis patients: a randomized controlled trial.2025PMID:41125682Industry fundedPermalink
Decreases total cholesterol (TC)
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“The meta-analysis indicated that melatonin supplementation significantly reduced serum TC (WMD: −6.97 mg/dL, 95% CI: −12.20, −1.74) and LDL-C levels (WMD: −6.28 mg/dL, 95% CI: −10.53, −2.03) in the melatonin group compared with the control group.”
Quoted verbatim from Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose-Response Meta-Analysis.. - Study
- meta-analysis
- Dose
- 0.3-100 mg/day oral
- Population
- adults in 63 RCTs of melatonin supplementation vs placebo across mixed clinical populations
Effect -6.97 mean difference, 95% CI -12.2 to -1.74
Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose-Response Meta-Analysis.2025PMID:41515249Permalink
Increases HDL cholesterol
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“HDL-C levels were substantially increased (WMD: 2.04 mg/dL, 95% CI: 0.50, 3.57) following melatonin supplementation.”
Quoted verbatim from Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose-Response Meta-Analysis.. - Study
- meta-analysis
- Dose
- 0.3-100 mg/day oral
- Population
- adults in 63 RCTs of melatonin supplementation vs placebo across mixed clinical populations
Effect 2.04 mean difference, 95% CI 0.5 to 3.57
Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose-Response Meta-Analysis.2025PMID:41515249Permalink
Decreases glycated haemoglobin (HbA1c)
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.Finding“Melatonin supplementation was associated with a statistically significant reduction in glycated hemoglobin (HbA1c) levels compared to placebo [mean difference [MD]: -0.65; 95% CI: -1.28, -0.02; P = 0.04]”
Quoted verbatim from The effect of melatonin supplementation on glycemic control in patients with type 2 diabetes.. - Study
- meta-analysis
- Participants
- 325
- Population
- adults with type 2 diabetes mellitus
The effect of melatonin supplementation on glycemic control in patients with type 2 diabetes.2025PMID:40698248Permalink
Decreases fasting blood glucose
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×1“The pooled findings indicated that melatonin supplementation significantly reduced fasting glucose (SMD=-6.34; 95% CI, -12.28, -0.40; p=0.04; I2: 65.0) and increased the quantitative insulin sensitivity check index (QUICKI) (SMD=0.01; 95% CI, 0.00, 0.02; p=0.01; I2: 0.0).”
Quoted verbatim from The Effects of Melatonin Supplementation on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.. - Study
- meta-analysis
- Population
- Adults enrolled in 12 RCTs of melatonin supplementation for glycaemic control
Effect -6.34 standardised mean difference, 95% CI -12.28 to -0.4
The Effects of Melatonin Supplementation on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.2018PMID:30396207Permalink
Decreases intensive care unit length of stay
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×1“However, patients who randomised to melatonin had a significantly shorter length of stay in intensive care units, with a mean difference, MD (95%CI) of -1.84 days (-2.46, -1.21); ρ < 0.001.”
Quoted verbatim from The effect of melatonin on delirium in hospitalised patients: A systematic review and meta-analyses with trial sequential analysis.. - Study
- meta-analysis
- Population
- hospitalised patients
The effect of melatonin on delirium in hospitalised patients: A systematic review and meta-analyses with trial sequential analysis.2020PMID:31279283Permalink
Decreases C-reactive protein concentration
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×1“In summary, the current meta-analysis showed the promising effect of melatonin administration on reducing CRP and IL-6, but not TNF-α levels among patients with MetS and related disorders.”
Quoted verbatim from The effects of melatonin supplementation on inflammatory markers among patients with metabolic syndrome or related disorders: a systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Population
- patients with metabolic syndrome or related disorders
The effects of melatonin supplementation on inflammatory markers among patients with metabolic syndrome or related disorders: a systematic review and meta-analysis of randomized controlled trials.2018PMID:29907916Permalink
Decreases sleep onset latency
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×8“In the 20 patients who completed the study, sleep onset latency was significantly reduced while subjects were taking melatonin as compared with both placebo and baseline.”
Quoted verbatim from A randomized, double-blind, placebo-controlled crossover study of the effect of exogenous melatonin on delayed sleep phase syndrome.. - Study
- crossover
- Participants
- 20
- Duration
- 4 weeks
- Dose
- melatonin 5 mg, taken 19:00-21:00
- Population
- 22 patients (20 completed) with delayed sleep phase syndrome, nocturnal sleep restricted to 24:00-08:00, polysomnography
A randomized, double-blind, placebo-controlled crossover study of the effect of exogenous melatonin on delayed sleep phase syndrome.2001PMID:11211063Permalink
Decreases interleukin-6 concentration
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“In summary, the current meta-analysis showed the promising effect of melatonin administration on reducing CRP and IL-6, but not TNF-α levels among patients with MetS and related disorders.”
Quoted verbatim from The effects of melatonin supplementation on inflammatory markers among patients with metabolic syndrome or related disorders: a systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Population
- patients with metabolic syndrome or related disorders
The effects of melatonin supplementation on inflammatory markers among patients with metabolic syndrome or related disorders: a systematic review and meta-analysis of randomized controlled trials.2018PMID:29907916Permalink
Decreases sleep onset latency
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×8“Melatonin decreased sleep-onset latency by 23.27 minutes (95% CI: 4.83 -41.72 min).”
Quoted verbatim from The use of exogenous melatonin in delayed sleep phase disorder: a meta-analysis.. - Study
- meta-analysis
- Population
- adults and children with delayed sleep phase disorder
The use of exogenous melatonin in delayed sleep phase disorder: a meta-analysis.2010PMID:21120122Permalink
Decreases incidence of ICU delirium
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“The subgroup analyses confirmed that melatonin significantly reduced the incidence of delirium (RR 0.70; 95% CI, 0.56~0.89, P = .003, I2 = 32%, P for heterogeneity = .22) for the special ICU patients.”
Quoted verbatim from Preventive Effects of Melatonin on Delirium in Intensive Care Unit Patients: A Meta-Analysis of Randomized Controlled Trials.. - Study
- meta-analysis
- Population
- ICU patients; subgroup analysis restricted to 'special ICU patients' (undefined further in the abstract)
Effect 0.7 risk ratio, 95% CI 0.56 to 0.89
Preventive Effects of Melatonin on Delirium in Intensive Care Unit Patients: A Meta-Analysis of Randomized Controlled Trials.2024PMID:38518134Permalink
Decreases sleep onset latency
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×8“Quantitative measures were appropriate with significant reductions in sleep onset latency (n = 6) in the melatonin condition relative to the placebo condition (p = 0.003), and bedtime resistance (n = 8) according to the CSHQ (p = 0.004).”
Quoted verbatim from A Pilot Randomised Controlled Trial of Sublingual Melatonin for Sleep Onset Insomnia in Children With Foetal Alcohol Spectrum Disorder (FASD).. - Study
- crossover
- Participants
- 6
- Duration
- 3 weeks
- Population
- children with sleep onset delay, 'at risk' of or diagnosed with foetal alcohol spectrum disorder (FASD)
A Pilot Randomised Controlled Trial of Sublingual Melatonin for Sleep Onset Insomnia in Children With Foetal Alcohol Spectrum Disorder (FASD).2026PMID:41122831Permalink
Decreases sleep onset latency
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×8“Dose-response meta-analysis showed that melatonin gradually reduces sleep onset latency and increases total sleep time, peaking at 4 mg/day.”
Quoted verbatim from Optimizing the Time and Dose of Melatonin as a Sleep-Promoting Drug: A Systematic Review of Randomized Controlled Trials and Dose-Response Meta-Analysis.. - Study
- meta-analysis
- Population
- patients with insomnia and healthy volunteers
Optimizing the Time and Dose of Melatonin as a Sleep-Promoting Drug: A Systematic Review of Randomized Controlled Trials and Dose-Response Meta-Analysis.2024PMID:38888087Permalink
Increases Mini-Mental State Examination total score
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“AD patients receiving >12 weeks of melatonin treatment improved mini-mental state examination (MMSE) score [MD: 1.82 (1.01; 2.63) p < 0.0001].”
Quoted verbatim from Neurocognitive effects of melatonin treatment in healthy adults and individuals with Alzheimer's disease and insomnia: A systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Population
- Alzheimer's disease patients receiving more than 12 weeks of melatonin treatment (meta-analysis of RCTs)
Effect 1.82 mean difference, 95% CI 1.01 to 2.63
Neurocognitive effects of melatonin treatment in healthy adults and individuals with Alzheimer's disease and insomnia: A systematic review and meta-analysis of randomized controlled trials.2021PMID:33957167Permalink
Decreases sleep onset latency
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×8“By the end of the double-blind treatment, the PRM group had significantly shorter sleep onset latency (9 min; P = 0.02) compared with the placebo group and scored significantly better in the Critical Flicker Fusion Test (P = 0.008) without negatively affecting sleep structure and architecture.”
Quoted verbatim from The effect of prolonged-release melatonin on sleep measures and psychomotor performance in elderly patients with insomnia.. - Study
- RCT
- Duration
- 3 weeks
- Dose
- prolonged-release melatonin 2 mg nightly
- Population
- Adults aged 55 years and older with primary insomnia (DSM-IV)
The effect of prolonged-release melatonin on sleep measures and psychomotor performance in elderly patients with insomnia.2009PMID:19584739Permalink
Decreases sleep onset latency
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×8“Melatonin treatment significantly reduced sleep onset latency by 4.0 min (95% CI 2.5, 5.4); increased sleep efficiency by 2.2% (95% CI 0.2, 4.2), and increased total sleep duration by 12.8 min (95% CI 2.9, 22.8).”
Quoted verbatim from Effects of exogenous melatonin on sleep: a meta-analysis.. - Study
- meta-analysis
- Population
- adults in exogenous-melatonin sleep trials; meta-analysis of 17 studies (mixed healthy and clinical populations)
Effect 4 mean difference, 95% CI 2.5 to 5.4
Effects of exogenous melatonin on sleep: a meta-analysis.2005PMID:15649737Permalink
Decreases all-cause mortality
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×1“Melatonin reduced the risk of death at 1 yr (relative risk: 0.66, 95% confidence interval: 0.59-0.73, I2=0%, heterogeneity P<or=0.56).”
Quoted verbatim from Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta-analysis.. - Study
- meta-analysis
- Population
- solid tumor cancer patients (10 RCTs, all conducted at the same hospital network, unblinded)
Effect 0.66 risk ratio, 95% CI 0.59 to 0.73
Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta-analysis.2005PMID:16207291Permalink
Decreases all-cause mortality
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×1“In trials combining MLT with chemotherapy, adjuvant MLT decreased 1-year mortality (RR = 0.60; 95% CI = 0.54-0.67) and improved outcomes of complete response, partial response, and stable disease; pooled RRs were 2.53 (1.36-4.71), 1.70 (1.37-2.12), and 1.15 (1.00-1.33), respectively.”
Quoted verbatim from Melatonin as adjuvant cancer care with and without chemotherapy: a systematic review and meta-analysis of randomized trials.. - Study
- meta-analysis
- Population
- solid tumor cancer patients; subgroup of trials combining melatonin with chemotherapy
Effect 0.6 risk ratio, 95% CI 0.54 to 0.67
Melatonin as adjuvant cancer care with and without chemotherapy: a systematic review and meta-analysis of randomized trials.2012PMID:22019490Permalink
Decreases sleep onset latency
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×8“A significant and clinically relevant shortening of sleep latency to the same extent as most frequently used sleep medications was also found (-24.3 vs.-12.9 minutes; p = 0.028).”
Quoted verbatim from Efficacy of prolonged release melatonin in insomnia patients aged 55-80 years: quality of sleep and next-day alertness outcomes.. - Study
- RCT
- Duration
- 3 weeks
- Dose
- prolonged-release melatonin (Circadin) 2 mg once daily, 2 h before bedtime
- Population
- Adults aged 55-80 years with primary insomnia
Efficacy of prolonged release melatonin in insomnia patients aged 55-80 years: quality of sleep and next-day alertness outcomes.2007PMID:17875243Permalink
Decreases tumour necrosis factor alpha concentration
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Enteral melatonin significantly reduced NEC incidence and mortality, accelerated achievement of full enteral feeding, and lowered TNF-α levels in preterm neonates with FI.”
Quoted verbatim from Role of melatonin for prevention of necrotizing enterocolitis in preterm infants: a randomized controlled trial.. - Study
- RCT
- Dose
- two doses of 10 mg each, 1 h apart
- Population
- preterm neonates with feeding intolerance (FI); enteral melatonin plus conventional therapy vs conventional therapy alone, measured 72 h posttreatment
Role of melatonin for prevention of necrotizing enterocolitis in preterm infants: a randomized controlled trial.2026PMID:41847903Permalink
Increases reduced glutathione concentration
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Levels of reduced glutathione, total bilirubin, and uric acid increased in TMG comparatively with TPG (all: p < 0.001) and MG (p = 0.002; p = 0.0002; p < 0.001, respectively).”
Quoted verbatim from Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.. - Study
- RCT
- Duration
- 3 months
- Dose
- 3 mg/night
- Population
- patients with multiple sclerosis (PwMS); training + melatonin (TMG) vs training + placebo (TPG), both arms also received concurrent aerobic-resistance training
Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.2026PMID:42217742Permalink
Increases serum uric acid
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Levels of reduced glutathione, total bilirubin, and uric acid increased in TMG comparatively with TPG (all: p < 0.001) and MG (p = 0.002; p = 0.0002; p < 0.001, respectively).”
Quoted verbatim from Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.. - Study
- RCT
- Duration
- 3 months
- Dose
- 3 mg/night
- Population
- patients with multiple sclerosis (PwMS); training + melatonin (TMG) vs training + placebo (TPG), both arms also received concurrent aerobic-resistance training
Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.2026PMID:42217742Permalink
Decreases total leukocyte count
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“There was a decrease in white blood cell, neutrophil, and lymphocyte counts in TMG comparatively with TPG (p = 0.0005; p = 0.0001; p = 0.014, respectively) and MG (p = 0.023; p = 0.007; p = 0.026, respectively).”
Quoted verbatim from Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.. - Study
- RCT
- Duration
- 3 months
- Dose
- 3 mg/night
- Population
- patients with multiple sclerosis (PwMS); training + melatonin (TMG) vs training + placebo (TPG), both arms also received concurrent aerobic-resistance training
Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.2026PMID:42217742Permalink
Increases lean body mass
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Lean mass increased (p = 0.025) while fat mass (p = 0.0013) and body mass index (p = 0.034) decreased in TMG compared with TPG.”
Quoted verbatim from Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.. - Study
- RCT
- Duration
- 3 months
- Dose
- 3 mg/night
- Population
- patients with multiple sclerosis (PwMS); training + melatonin (TMG) vs training + placebo (TPG), both arms also received concurrent aerobic-resistance training
Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.2026PMID:42217742Permalink
Decreases fat mass
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Lean mass increased (p = 0.025) while fat mass (p = 0.0013) and body mass index (p = 0.034) decreased in TMG compared with TPG.”
Quoted verbatim from Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.. - Study
- RCT
- Duration
- 3 months
- Dose
- 3 mg/night
- Population
- patients with multiple sclerosis (PwMS); training + melatonin (TMG) vs training + placebo (TPG), both arms also received concurrent aerobic-resistance training
Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.2026PMID:42217742Permalink
Decreases body mass index
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Lean mass increased (p = 0.025) while fat mass (p = 0.0013) and body mass index (p = 0.034) decreased in TMG compared with TPG.”
Quoted verbatim from Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.. - Study
- RCT
- Duration
- 3 months
- Dose
- 3 mg/night
- Population
- patients with multiple sclerosis (PwMS); training + melatonin (TMG) vs training + placebo (TPG), both arms also received concurrent aerobic-resistance training
Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.2026PMID:42217742Permalink
Decreases HOMA-IR
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Our results showed that melatonin administration significantly reduced insulin levels and homeostasis model assessment of insulin resistance (HOMA-IR), and increased the quantitative insulin sensitivity check index (QUICKI).”
Quoted verbatim from Effects of Melatonin Supplementation on Insulin Levels and Insulin Resistance: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.. - Study
- meta-analysis
- Population
- adults, pooled across 8 RCTs (376 participants) of melatonin supplementation for insulin resistance
Effects of Melatonin Supplementation on Insulin Levels and Insulin Resistance: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.2021PMID:34496412Permalink
Decreases alanine aminotransferase
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Alanine transaminase levels were significantly lowered with melatonin treatment but not earlier than the 4th week (P = 0.010 and 0.519, respectively).”
Quoted verbatim from The effects of melatonin therapy on the treatment of patients with Non-alcoholic steatohepatitis: A systematic review and Meta-analysis on clinical trial studies.. - Study
- meta-analysis
- Population
- NAFLD/NASH patients, pooled across 7 clinical trials of melatonin therapy; reduction significant only from the 4th week of treatment onward, not before
The effects of melatonin therapy on the treatment of patients with Non-alcoholic steatohepatitis: A systematic review and Meta-analysis on clinical trial studies.2021PMID:34058202Permalink
Decreases anxiety symptom severity (pooled across unnamed instruments)
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Compared with placebo, melatonin reduced the standardised mean difference (95% CI) pre-operative anxiety score by 0.88 (0.44-1.33) and postoperative pain score by 1.06 (0.23-1.88).”
Quoted verbatim from A systematic review of peri-operative melatonin.. - Study
- meta-analysis
- Population
- surgical patients undergoing peri-operative care, pooled across 24 RCTs (1794 participants)
Effect 0.88 standardised mean difference, 95% CI 0.44 to 1.33
A systematic review of peri-operative melatonin.2014PMID:24835540Permalink
Increases total sleep time
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×2“Total time asleep increased with melatonin (19.8 +/- 61.9 minutes) as compared to placebo (-13.6 +/- 50.6 minutes; p = .01).”
Quoted verbatim from Effect of melatonin on sleep, behavior, and cognition in ADHD and chronic sleep-onset insomnia.. - Study
- RCT
- Duration
- 4 weeks
- Dose
- 3 or 6 mg melatonin (depending on body weight), or placebo, for 4 weeks
- Population
- children aged 6-12 years, medication-free, with ADHD and chronic sleep onset insomnia
Effect of melatonin on sleep, behavior, and cognition in ADHD and chronic sleep-onset insomnia.2007PMID:17242627Permalink
Increases total sleep time
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×2“A meta-analysis of nine studies (n=541) showed that melatonin significantly improved total sleep time compared with placebo (mean difference (MD)=48.26 min, 95% CI 36.78 to 59.73, I2=31%).”
Quoted verbatim from Melatonin for the management of sleep problems in children with neurodevelopmental disorders: a systematic review and meta-analysis.. - Study
- meta-analysis
- Participants
- 541
- Population
- Children under 18 years with neurodevelopmental disorders enrolled in randomised controlled trials of melatonin versus placebo or other intervention for sleep problems (13 RCTs, n=682 total)
Effect 48.26 mean difference, 95% CI 36.78 to 59.73
Melatonin for the management of sleep problems in children with neurodevelopmental disorders: a systematic review and meta-analysis.2018PMID:29720494Permalink
Increases total sleep time
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×2“There was a statistically significant increase in diary-reported total sleep time (TST), which was the most commonly reported outcome for melatonin compared with placebo [pooled mean difference 29.6 minutes, 95% confidence interval (CI) 6.9 to 52.4 minutes; p = 0.01]; however, statistical heterogeneity was extremely high (97%).”
Quoted verbatim from Pharmacological and non-pharmacological interventions for non-respiratory sleep disturbance in children with neurodisabilities: a systematic review.. - Study
- meta-analysis
- Population
- children with neurodisabilities and non-respiratory sleep disturbance; pooled across a subset of 13 melatonin RCTs, TST reported by diary
Effect 29.6 mean difference, 95% CI 6.9 to 52.4
Pharmacological and non-pharmacological interventions for non-respiratory sleep disturbance in children with neurodisabilities: a systematic review.2018PMID:30382936Permalink
Decreases incidence of postoperative delirium
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Melatonin administered less than 5 elimination half-lives before the surgery significantly reduced the POD incidence (OR = 0.31, 95% CI 0.19-0.49, P < .00001).”
Quoted verbatim from Melatonin and its analogues for the prevention of postoperative delirium: A systematic review and meta-analysis.. - Study
- meta-analysis
- Population
- Adult surgical patients; subgroup pooled analysis (6 RCTs, 2 cohort studies, 1 case-control study) restricted to melatonin administered less than 5 elimination half-lives before surgery
Effect 0.31 odds ratio, 95% CI 0.19 to 0.49
Melatonin and its analogues for the prevention of postoperative delirium: A systematic review and meta-analysis.2020PMID:32145098Permalink
What did not
32 findings
No detected effect on serious adverse event incidence
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“In terms of safety, no serious adverse events were reported with either melatonin or placebo.”
Quoted verbatim from Effect of melatonin versus placebo for the prevention of delirium among medically hospitalised older patients: a double-blinded randomised controlled trial (project RESTORE).. - Study
- RCT
- Duration
- 5 days
- Dose
- 5 mg or 8 mg oral melatonin nightly for up to 5 days (arms pooled)
- Population
- medically hospitalised patients aged 65 years and over; safety endpoint, ITT
Effect of melatonin versus placebo for the prevention of delirium among medically hospitalised older patients: a double-blinded randomised controlled trial (project RESTORE).2026PMID:41592826Permalink
No detected effect on HOMA-IR
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“No significant effects of melatonin were found on HOMA-IR (WMD: 0.15, 95% CI: −0.18, 0.48), serum FI levels (WMD: 0.49 µIU/mL, 95% CI: −1.08, 2.05), or HbA1c (WMD: −0.22%, 95% CI: −0.66, 0.21).”
Quoted verbatim from Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose-Response Meta-Analysis.. - Study
- meta-analysis
- Population
- adults, pooled across 63 RCTs of melatonin supplementation across mixed clinical populations (including metabolic syndrome, chronic kidney disease, PCOS, COVID-19, multiple sclerosis, type 2 diabetes, and other conditions)
Effect 0.15 mean difference, 95% CI -0.18 to 0.48
Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose-Response Meta-Analysis.2025PMID:41515249Permalink
No detected effect on malondialdehyde (circulating)
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“Also, the MLT group demonstrated marginal reduction in MDA compared to placebo group (F = 3.046, p = 0.092, partial η2 = 0.095), revealing a trend towards decreased oxidative stress that did not reach statistical significance.”
Quoted verbatim from Evaluating the antioxidant and anti-inflammatory effect of melatonin in pediatric hemodialysis patients: a randomized, placebo-controlled trial.. - Study
- RCT
- Duration
- 3 months
- Dose
- 5 mg oral melatonin once daily 1 h before bedtime for 12 weeks
- Population
- children on chronic haemodialysis; primary endpoint, ANCOVA adjusted for baseline MDA and antihypertensive use; serum MDA by ELISA
Evaluating the antioxidant and anti-inflammatory effect of melatonin in pediatric hemodialysis patients: a randomized, placebo-controlled trial.2026PMID:41565787Permalink
No detected effect on all-cause mortality
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull resultreplicated ×1“We found no significant difference in mortality between patients receiving melatonin and those receiving placebo (RR, 0.90; 95% CI: 0.77–1.06; I2 = 0%).”
Quoted verbatim from Prophylactic melatonin for delirium in critically ill patients: A systematic review and meta-analysis with trial sequential analysis.. - Study
- meta-analysis
- Participants
- 2,350
- Population
- Adult ICU patients; secondary endpoint, 10 trials, longest reported follow-up
Effect 0.9 risk ratio, 95% CI 0.77 to 1.06
Prophylactic melatonin for delirium in critically ill patients: A systematic review and meta-analysis with trial sequential analysis.2022PMID:36316858Permalink
No detected effect on erythrocyte sedimentation rate
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“No statistically significant effects were revealed between the groups regarding changes in ESR (MD −0.12, 95% CI −0.64 to 0.39, p = 0.64; I2 0%, p for heterogeneity = 0.67) and NLR (MD 7.31, 95% CI −15.21 to 29.84, p = 0.52; I2 87%, p for heterogeneity < 0.01) after melatonin administration.”
Quoted verbatim from The clinical efficacy of melatonin in the treatment of patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Population
- hospitalized adults with COVID-19 receiving melatonin plus standard care versus control (predominantly standard care alone, two trials placebo-controlled)
Effect -0.12 mean difference, 95% CI -0.64 to 0.39
The clinical efficacy of melatonin in the treatment of patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials.2023PMID:37181363Permalink
No detected effect on total leukocyte count
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“In the 3 studies, there was no significant difference in WBC count between the melatonin treated group and the control group (WMD = –1.07, 95% CI = –2.44, 0.30, P =.13) (Fig..”
Quoted verbatim from The safety and efficacy of melatonin in the treatment of COVID-19: A systematic review and meta-analysis.. - Study
- meta-analysis
- Population
- Hospitalised COVID-19 patients; secondary endpoint, 3 trials of adjunctive melatonin vs control
Effect -1.07 mean difference, 95% CI -2.44 to 0.3
The safety and efficacy of melatonin in the treatment of COVID-19: A systematic review and meta-analysis.2022PMID:36181086Permalink
Show the remaining 26
No detected effect on body mass index
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“The results of random-effect meta-analysis indicated that melatonin intake has no effect on weight (SMD: −0.03, 95% CI: −0.30, 0.25, I2 = 00.00%) and BMI (SMD: −0.03, 95% CI: −0.30, 0.25, I2 = 00.00%) in patients with PCOS (Fig..).”
Quoted verbatim from Effect of melatonin supplementation on cardiometabolic risk factors, oxidative stress and hormonal profile in PCOS patients: a systematic review and meta-analysis of randomized clinical trials.. - Study
- meta-analysis
- Dose
- 3-10 mg/day oral
- Population
- women with polycystic ovary syndrome; 6 double-blind RCTs
Effect -0.03 standardised mean difference, 95% CI -0.3 to 0.25
Effect of melatonin supplementation on cardiometabolic risk factors, oxidative stress and hormonal profile in PCOS patients: a systematic review and meta-analysis of randomized clinical trials.2024PMID:38965577Permalink
No detected effect on psoriasis Area and Severity Index (PASI) score
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“Although the PASI score in the melatonin and rosuvastatin groups compared with placebo decreased, the changes were not significant.”
Quoted verbatim from Efficacy and safety of topical rosuvastatin & melatonin vs. placebo in patients with mild to moderate plaque psoriasis: A preliminary randomized double-blinded clinical trial.. - Study
- RCT
- Dose
- melatonin cream 5.0% (w/w) applied twice a day
- Population
- adults with mild-to-moderate plaque psoriasis; melatonin cream 5% w/w vs placebo cream, applied twice daily for 8 weeks
Efficacy and safety of topical rosuvastatin & melatonin vs. placebo in patients with mild to moderate plaque psoriasis: A preliminary randomized double-blinded clinical trial.2024PMID:38563131Permalink
No detected effect on diastolic blood pressure (setting unspecified)
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.FindingNull resultreplicated ×1“Mean Daytime Diastolic Blood Pressure (DBP) (SECONDARY, mmHg) -- NCT01114373: Melatonin 85.3 +/-1.8 (n=36) vs Placebo 86.6 +/-1.8 (n=36); difference -1.3; p=0.12, no significant difference”
Quoted verbatim from Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study. - Study
- crossover
- Participants
- 72
- Population
- Hypertension; 18 Years+
Effect -1.3 mean difference
Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study2015NCT01114373Permalink
No detected effect on mean arterial pressure
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.FindingNull resultreplicated ×2“Mean Daytime Mean Arterial Pressure (MAP) (SECONDARY, mmHg) -- NCT01114360: Melatonin 102.2 +/-1.7 (n=36) vs Placebo 102.1 +/-1.8 (n=36); difference 0.1; p=0.97, no significant difference”
Quoted verbatim from Melatonin and Nighttime Blood Pressure in African Americans-8 mg Study. - Study
- crossover
- Participants
- 72
- Population
- Hypertension; 18 Years+
Effect 0.1 mean difference
Melatonin and Nighttime Blood Pressure in African Americans-8 mg Study2015NCT01114360Permalink
No detected effect on systolic blood pressure (setting unspecified)
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.FindingNull resultreplicated ×1“Mean Daytime Systolic Blood Pressure (SBP) (SECONDARY, mmHg) -- NCT01114360: Melatonin 135.13 +/-2.2 (n=36) vs Placebo 133.9 +/-2.2 (n=36); difference 1.23; p=0.64, no significant difference”
Quoted verbatim from Melatonin and Nighttime Blood Pressure in African Americans-8 mg Study. - Study
- crossover
- Participants
- 72
- Population
- Hypertension; 18 Years+
Effect 1.23 mean difference
Melatonin and Nighttime Blood Pressure in African Americans-8 mg Study2015NCT01114360Permalink
No detected effect on diastolic blood pressure (setting unspecified)
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.FindingNull resultreplicated ×1“Mean Daytime Diastolic Blood Pressure (DBP) (SECONDARY, mmHg) -- NCT01114360: Melatonin 85.7 +/-1.6 (n=36) vs Placebo 86.2 +/-1.7 (n=36); difference -0.5; p=0.89, no significant difference”
Quoted verbatim from Melatonin and Nighttime Blood Pressure in African Americans-8 mg Study. - Study
- crossover
- Participants
- 72
- Population
- Hypertension; 18 Years+
Effect -0.5 mean difference
Melatonin and Nighttime Blood Pressure in African Americans-8 mg Study2015NCT01114360Permalink
No detected effect on mean arterial pressure
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.FindingNull resultreplicated ×2“Mean Nighttime Mean Arterial Pressure (MAP) (SECONDARY, mmHg) -- NCT01114360: Melatonin 92.9 +/-1.9 (n=36) vs Placebo 92.6 +/-2.0 (n=36); difference 0.3; p=0.79, no significant difference”
Quoted verbatim from Melatonin and Nighttime Blood Pressure in African Americans-8 mg Study. - Study
- crossover
- Participants
- 72
- Population
- Hypertension; 18 Years+
Effect 0.3 mean difference
Melatonin and Nighttime Blood Pressure in African Americans-8 mg Study2015NCT01114360Permalink
No detected effect on diastolic blood pressure (setting unspecified)
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.FindingNull resultreplicated ×1“Mean Nighttime Diastolic Blood Pressure (DBP) (PRIMARY, mmHg) -- NCT01114360: Melatonin 76 +/-1.7 (n=36) vs Placebo 76.2 +/-1.8 (n=36); difference -0.2; p=0.75, no significant difference”
Quoted verbatim from Melatonin and Nighttime Blood Pressure in African Americans-8 mg Study. - Study
- crossover
- Participants
- 72
- Population
- Hypertension; 18 Years+
Effect -0.2 mean difference
Melatonin and Nighttime Blood Pressure in African Americans-8 mg Study2015NCT01114360Permalink
No detected effect on systolic blood pressure (setting unspecified)
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.FindingNull resultreplicated ×1“Mean Daytime Systolic Blood Pressure (SBP) (SECONDARY, mmHg) -- NCT01114373: Melatonin 134.2 +/-2.4 (n=36) vs Placebo 137.3 +/-2.4 (n=36); difference -3.1; p=0.16, no significant difference”
Quoted verbatim from Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study. - Study
- crossover
- Participants
- 72
- Population
- Hypertension; 18 Years+
Effect -3.1 mean difference
Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study2015NCT01114373Permalink
No detected effect on mean arterial pressure
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.FindingNull resultreplicated ×2“Mean Daytime Mean Arterial Pressure (MAP) (SECONDARY, mmHg) -- NCT01114373: Melatonin 101.26 +/-1.9 (n=36) vs Placebo 103.5 +/-1.9 (n=36); difference -2.24; p=0.12, no significant difference”
Quoted verbatim from Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study. - Study
- crossover
- Participants
- 72
- Population
- Hypertension; 18 Years+
Effect -2.24 mean difference
Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study2015NCT01114373Permalink
No detected effect on C-reactive protein concentration
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.FindingNull result“However, the summary effect of melatonin on CRP was not significant (−0.18; −0.91, 0.55; p=0.62).”
Quoted verbatim from Anti-inflammatory effects of melatonin: A systematic review and meta-analysis of clinical trials.. - Study
- meta-analysis
- Population
- Adults in placebo-controlled clinical trials of exogenous melatonin, mixed clinical populations
Anti-inflammatory effects of melatonin: A systematic review and meta-analysis of clinical trials.2021PMID:33581247Permalink
No detected effect on mean arterial pressure
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.FindingNull resultreplicated ×2“Mean Nighttime Mean Arterial Pressure (MAP) (SECONDARY, mmHg) -- NCT01114373: Melatonin 93.9 +/-1.8 (n=36) vs Placebo 94.4 +/-1.8 (n=36); difference -0.5; p=0.91, no significant difference”
Quoted verbatim from Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study. - Study
- crossover
- Participants
- 72
- Population
- Hypertension; 18 Years+
Effect -0.5 mean difference
Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study2015NCT01114373Permalink
No detected effect on total sleep time
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.FindingNull resultreplicated ×2“The median in-hospital sleep duration was 6.0 hours (IQR: 5.0–6.2), with slightly longer duration in the melatonin group (6.0 (5.3–6.3) vs 5.8 (5.0–6.0), p=0.136), though this difference was not statistically significant.”
Quoted verbatim from Effect of melatonin versus placebo for the prevention of delirium among medically hospitalised older patients: a double-blinded randomised controlled trial (project RESTORE).. - Study
- RCT
- Duration
- 5 days
- Dose
- 5 mg or 8 mg oral melatonin nightly for up to 5 days (arms pooled)
- Population
- medically hospitalised patients aged 65 years and over; secondary endpoint, ITT; sleep duration from patient report and nursing observation, not polysomnography
Effect of melatonin versus placebo for the prevention of delirium among medically hospitalised older patients: a double-blinded randomised controlled trial (project RESTORE).2026PMID:41592826Permalink
No detected effect on HDL cholesterol
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“No significant effect of melatonin on high density lipoprotein cholesterol (HDL-C) and anthropometric indices was found.”
Quoted verbatim from The effect of melatonin supplementation on lipid profile and anthropometric indices: A systematic review and meta-analysis of clinical trials.. - Study
- meta-analysis
- Dose
- 0.8-30 mg
- Population
- Adults enrolled in 12 RCTs of melatonin supplementation for dyslipidaemia and anthropometric indices (641 participants total)
The effect of melatonin supplementation on lipid profile and anthropometric indices: A systematic review and meta-analysis of clinical trials.2019PMID:31235113Permalink
No detected effect on incidence of ICU delirium
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Our primary analysis was based on six RCTs with 2209 patients and did not show any difference in the incidence of delirium attributable to the treatment with melatonin (RR 0.89, [95% confidence interval (CI) 0.73-1.09]).”
Quoted verbatim from Melatonin and delirium in the intensive care units: a systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Participants
- 2,209
- Population
- critically ill patients in intensive care units
Melatonin and delirium in the intensive care units: a systematic review and meta-analysis of randomized controlled trials.2025PMID:41051561Permalink
No detected effect on muscle strength (pooled across mixed instruments)
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Also, melatonin supplementation did not affect strength performance (0.19; 95% CI: -0.28 to 0.65).”
Quoted verbatim from Is melatonin as an ergogenic hormone a myth? a systematic review and meta-analysis.. - Study
- meta-analysis
- Population
- healthy subjects (athletes and exercise practitioners)
Is melatonin as an ergogenic hormone a myth? a systematic review and meta-analysis.2024PMID:37658244Permalink
No detected effect on catalase activity
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Melatonin intake was not shown to significantly affect nitric oxide (NO) levels (SMD: -0.24; 95 % CI: -0.61, 0.14; I2 = 00.0 %) or catalase (CAT) activity (SMD: -1.38; 95 % CI: -1.42, 4.18; I2 = 96.6 %).”
Quoted verbatim from Effect of melatonin supplementation on oxidative stress parameters: A systematic review and meta-analysis.. - Study
- meta-analysis
- Population
- unhealthy patients in randomized controlled trials of melatonin supplementation versus placebo
Effect of melatonin supplementation on oxidative stress parameters: A systematic review and meta-analysis.2020PMID:33007423Permalink
No detected effect on sleep onset latency
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Nine randomised controlled trials with 427 participants showed no evidence that melatonin had an effect on sleep onset latency in people who had sleep disorders accompanying sleep restriction (-1.0 (-2.3 to 0.3) min).”
Quoted verbatim from Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis.. - Study
- meta-analysis
- Participants
- 427
- Population
- people with sleep disorders accompanying sleep restriction
Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis.2006PMID:16473858Permalink
No detected effect on total sleep time
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull resultreplicated ×2“Total Sleep Time (SECONDARY, minutes) -- NCT01114373: Melatonin 415.8 +/-10.9 (n=36) vs Placebo 413.4 +/-10.6 (n=36); difference 2.4; p=0.39, no significant difference”
Quoted verbatim from Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study. - Study
- crossover
- Participants
- 72
- Population
- Hypertension; 18 Years+
Effect 2.4 mean difference
Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study2015NCT01114373Permalink
No detected effect on activities of daily living score
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“From two studies, we found no effect of melatonin on cognition or performance of activities of daily living (ADL).”
Quoted verbatim from Pharmacotherapies for sleep disturbances in dementia.. - Study
- meta-analysis
- Population
- patients with moderate-to-severe Alzheimer's disease dementia and an identified sleep disturbance, melatonin doses up to 10 mg; no specific ADL instrument named
Pharmacotherapies for sleep disturbances in dementia.2016PMID:27851868Permalink
No detected effect on glycated haemoglobin (HbA1c)
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“HbA1c levels were largely unaffected by melatonin treatment compared with placebo (g: 0.14 [-0.19 to 0.46], n = 142).”
Quoted verbatim from Effects of daily administration of melatonin before bedtime on fasting insulin, glucose and insulin sensitivity in healthy adults and patients with metabolic diseases. A systematic review and meta-analysis.. - Study
- meta-analysis
- Participants
- 142
- Population
- healthy adults and patients with metabolic diseases, daily melatonin treatment for at least 2 weeks, pooled random-effects meta-analysis
Effects of daily administration of melatonin before bedtime on fasting insulin, glucose and insulin sensitivity in healthy adults and patients with metabolic diseases. A systematic review and meta-analysis.2021PMID:34370338Permalink
No detected effect on all-cause mortality
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull resultreplicated ×1“No association was found between mortality and melatonin in the primary (seven RCTs, 2165 patients, RR 0.87, [95% CI 0.73-1.02]) and secondary (8 RCTs, 2396 patients, RR 0.92, [95% CI 0.79-1.06]) analyses.”
Quoted verbatim from Melatonin and delirium in the intensive care units: a systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Participants
- 2,165
- Population
- critically ill patients in intensive care units
Melatonin and delirium in the intensive care units: a systematic review and meta-analysis of randomized controlled trials.2025PMID:41051561Permalink
No detected effect on mean arterial pressure
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull resultreplicated ×2“The absolute and percent change in MAP during IHG was not different between conditions (all P > 0.05).”
Quoted verbatim from Melatonin supplementation reduces nighttime blood pressure but does not affect blood pressure reactivity in normotensive adults on a high-sodium diet.. - Study
- RCT
- Participants
- 22
- Duration
- 10 days
- Dose
- 10 mg/day melatonin supplementation during a 10-day high-sodium diet
- Population
- normotensive young adults on a 10-day high-sodium diet; MAP reactivity during isometric handgrip (IHG) exercise at 40% maximal voluntary contraction
Melatonin supplementation reduces nighttime blood pressure but does not affect blood pressure reactivity in normotensive adults on a high-sodium diet.2023PMID:37642281Permalink
No detected effect on total sleep time
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull resultreplicated ×2“Total Sleep Time (SECONDARY, minutes) -- NCT01114360: Melatonin 399.8 +/-11.0 (n=36) vs Placebo 412.2 +/-11.1 (n=36); difference -12.4; p=0.52, no significant difference”
Quoted verbatim from Melatonin and Nighttime Blood Pressure in African Americans-8 mg Study. - Study
- crossover
- Participants
- 72
- Population
- Hypertension; 18 Years+
Effect -12.4 mean difference
Melatonin and Nighttime Blood Pressure in African Americans-8 mg Study2015NCT01114360Permalink
No detected effect on adverse event occurrence (oral or enteral supplement)
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“17 randomised controlled trials with 651 participants showed no evidence of adverse effects of melatonin with short term use (three months or less).”
Quoted verbatim from Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis.. - Study
- meta-analysis
- Participants
- 651
- Population
- participants in randomised controlled trials of short-term melatonin (three months or less)
Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis.2006PMID:16473858Permalink
No detected effect on alanine aminotransferase
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Melatonin had no significant effect on alanine aminotransferase (ALT) regarding the overall effect size.”
Quoted verbatim from The effect of melatonin supplementation on liver indices in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis of randomized clinical trials.. - Study
- meta-analysis
- Population
- Patients with non-alcoholic fatty liver disease (NAFLD) (meta-analysis of RCTs, melatonin vs placebo)
The effect of melatonin supplementation on liver indices in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis of randomized clinical trials.2020PMID:32951697Permalink
What it touches on the way
Mechanistic reach
7 entities
7 entities reached.
0 reported hops7 assembled from the scaffold
- CYP1A2ProteinUNIPROT:P05177metabolized byInferred only78 paths39 endpoints
- CYP1A1ProteinUNIPROT:P04798metabolized byInferred only64 paths32 endpoints
- CYP1B1ProteinUNIPROT:Q16678metabolized byInferred only60 paths30 endpoints
- CYP2C19ProteinUNIPROT:P33261metabolized byInferred only26 paths26 endpoints
- IDO1ProteinUNIPROT:P14902substrate ofInferred only15 paths15 endpoints
- ASMTProteinUNIPROT:P46597substrate ofInferred only9 paths9 endpoints
- IDO2ProteinUNIPROT:Q6ZQW0substrate ofInferred only7 paths7 endpoints
What the reference databases state
Regulatory determinations
LiverTox likelihood score ELiverTox
LiverTox Likelihood Score E — despite extensive use, no evidence that the agent has caused liver injury. Chapter: "Melatonin". Source: LiverTox Master List (NBK571102).
The document·Public Domain (NLM/NIH)·Transcribed, not assessed
Chemical structure
- melatonin has the functional parent tryptamineCompoundChEBI CHEBI:16796Inferred only
Statements
17 statements
17 statements · 2 reference databases · Subject: melatonin · Sources: Human-GEM, Rhea
- CHEBI:308079 is converted to melatoninCompoundHuman-GEM MAR04548Inferred only
- melatonin is converted to CHEBI:308079CompoundHuman-GEM MAR03119Inferred only
- melatonin is converted to CHEBI:308079CompoundHuman-GEM MAR04548Inferred only
- melatonin is converted to CHEBI:308079CompoundHuman-GEM MAR08566Inferred only
- CHEBI:308079 is converted to melatoninCompoundHuman-GEM MAR03119Inferred only
- melatonin is converted to N-acetylserotoninCompoundRhea RHEA:15573Inferred only
- N-acetylserotonin is converted to melatoninCompoundHuman-GEM MAR04547Inferred only
- melatonin is metabolised by CYP1A1ProteinHuman-GEM MAR08566Inferred only
- melatonin is metabolised by CYP1A1ProteinHuman-GEM MAR04548Inferred only
- melatonin is metabolised by CYP1A2ProteinHuman-GEM MAR04548Inferred only
- melatonin is metabolised by CYP1A2ProteinHuman-GEM MAR08566Inferred only
- melatonin is metabolised by CYP1B1ProteinHuman-GEM MAR04548Inferred only
Show the remaining 5
- melatonin is metabolised by CYP1B1ProteinHuman-GEM MAR08566Inferred only
- melatonin is metabolised by CYP2C19ProteinHuman-GEM MAR08566Inferred only
- melatonin is a substrate of ASMTProteinRhea RHEA:15573Inferred only
- melatonin is a substrate of IDO1ProteinHuman-GEM MAR04550Inferred only
- melatonin is a substrate of IDO2ProteinHuman-GEM MAR04550Inferred only
Reactions
14 reactions
water+melatoninCHEBI:308079+2proton
Reaction pageReversibleUnbalancedEC 3.4.21.59cytosol
Human-GEM MAR03119CC BY 4.0Reference data
4proton+3melatonin+4superoxide3MAM01839c+2water
Reaction pageLeft to rightBalancedEC 2.5.1.18cytosol
Human-GEM MAR03120CC BY 4.0Reference data
water+melatoninproton+MAM02459c
Reaction pageReversibleUnbalancedEC 3.4.15.1cytosol
Human-GEM MAR03168CC BY 4.0Reference data
N-acetylserotonin+S-adenosyl-L-methionineproton+melatonin+CHEBI:16680
Catalysed by ASMT
Reaction pageLeft to rightBalancedEC 2.1.1.4cytosol
Human-GEM MAR04547CC BY 4.0Reference data
CHEBI:308079+protonwater+melatonin
Catalysed by CYP1B1 or CYP1A1 or CYP1A2
Reaction pageReversibleUnbalancedEC 1.14.14.1cytosol
Human-GEM MAR04548CC BY 4.0Reference data
Reaction pageLeft to rightBalancedEC 1.13.11.52cytosol
Human-GEM MAR04550CC BY 4.0Reference data
Reaction pageReversibleUnbalancedcytosol
Human-GEM MAR04552CC BY 4.0Reference data
proton+melatonin+NADPH(4-)+dioxygenCHEBI:308079+water+NADP(3-)
Catalysed by CYP1B1 or CYP1A1 or CYP1A2 or CYP2C19
Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol
Human-GEM MAR08566CC BY 4.0Reference data
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR11919CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR11920CC BY 4.0Reference data
N-acetylserotonin+S-adenosyl-L-methioninemelatonin+S-adenosyl-L-homocysteine+hydron
Catalysed by ASMT
Reaction pageRight to leftBalanced
Rhea RHEA:15573CC BY 4.0Reference data
melatonin+2-oxoglutarate(2-)+dioxygenCHEBI:145792+succinate(2-)+carbon dioxide
Reaction pageDirection not assertedBalanced
Rhea RHEA:62512CC BY 4.0Reference data
On the label
Labelled products
1,519 products
Source: NIH DSLD · Ingredient: melatonin · 1,519 products · Declared amount per serving: 0.2–60 mg (978 products) · Showing 1,000 of 1,519
1,000 labels state an amount0 do not
- 1st PhormComplete Prostate PM1.5 mgper 2 Vegan Capsule(s)DSLD:242735
- 1st PhormNight-T3 mgper 3 Capsule(s)DSLD:242929
- 1st PhormNight-T3 mgper 3 Capsule(s)DSLD:305209
- 21st CenturyMelatonin 10 mg10 mgper 1 Tablet(s)DSLD:258473
- 21st CenturyMelatonin 10 mg10 mgper 1 Tablet(s)DSLD:258614
- 21st CenturyMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:206991
- 21st CenturyMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:258474
- 21st CenturyMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:304111
- 21st CenturyMelatonin 5 mg5 mgper 1 Tablet(s)DSLD:206773
- 21st Century VitaJoy GummiesExtra Strength Melatonin 10 mg Strawberry Flavor10 mgper 2 Gummy(ies)DSLD:304117
- 21st Century VitaJoy GummiesMelatonin 5 mg Strawberry Flavor5 mgper 2 Gummy(ies)DSLD:304120
- 8 Hour Sleep8Hr Sleep with Melatonin10 mgper 1 Capsule(s)DSLD:304126
Show the remaining 1,507
- Ab Cuts Sleek & LeanDreamweaver PM1 mgper 3 Softgel(s)DSLD:23443
- Absorb HealthMelatonin 5 mg5 mgper 1 Capsule(s)DSLD:216060
- Adaptogen ResearchMelatonin 2 mg2 mgper 1 Capsule(s)DSLD:247127
- Adaptogen ResearchMelatonin 6 mg6 mgper 1 Tablet(s)DSLD:247128
- AdvoCareSleepWorks Lavender Spearmint0.75 mgper 2 fl. Oz.DSLD:178347
- Alani NuSleep Lemon1 mgper 3.9 Gram(s)DSLD:251177
- Allergy Research GroupLiposomal Melatonin1 mgper 0.2 mLDSLD:258255
- Allergy Research GroupMelatonin 20 mg20 mgper 1 Capsule(s)DSLD:258265
- Allergy Research GroupMelatonin 3 mg6 mgper 1 Tablet(s)DSLD:208124
- Allergy Research GroupSlow Motion Melatonin1.2 mgper 1 Tablet(s)DSLD:304278
- Allergy Research GroupSustained Release Melatonin3.6 mgper 1 Tablet(s)DSLD:20284
- Alpha LionNight Burn3 mgper 2 Capsule(s)DSLD:288563
- AlterilAlteril All Natural Sleep Aid with L-Tryptophan4 mgper 2 Softgel(s)DSLD:248477
- AlterilAlteril All Natural Sleep Aid with L-Tryptophan4 mgper 2 Soft Gel(s)DSLD:250695
- AlterilAlteril Natural Sleep Aid4 mgper 2 Tablet(s)DSLD:248489
- AlterilAlteril Natural Sleep Aid4 mgper 2 Tablet(s)DSLD:248491
- AlterilAlteril PM All Natural Sleep Aid with Turmeric4 mgper 2 Tablet(s)DSLD:248483
- Amazing MuscleRelax1.5 mgper 1 Capsule(s)DSLD:251205
- AmerixMelatonin 5 mg Strawberry5 mgper 2 Gummy(ies)DSLD:264284
- AmvilabGood Night3 mgper 1 Capsule(s)DSLD:298148
- AmvilabMelatonin 3 mg Chewable3 mgper 1 Chewable Tablet(s)DSLD:298161
- AN Amazing Nutrition Amazing FormulasMelatonin 1 mg Strawberry FlavorMelatonin (Form: as N-Acetyl-5-Methoxytryptamine)1 mgper 1 Tablet(s)DSLD:251813
- AN Amazing Nutrition Amazing FormulasMelatonin 10 mgMelatonin (Form: as N-Acetyl-5-Methoxytryptamine)10 mgper 1 Softgel(s)DSLD:256090
- AN Amazing Nutrition Amazing FormulasMelatonin 10 mgMelatonin (Form: as N-Acetyl-5-Methoxytryptamine)10 mgper 1 Tablet(s)DSLD:256092
- AN Amazing Nutrition Amazing FormulasMelatonin 10 mgMelatonin (Form: as N-Acetyl-5-Methoxytryptamine)10 mgper 1 Tablet(s)DSLD:256093
- AN Amazing Nutrition Amazing FormulasMelatonin 10 mg Citrus FlavorMelatonin (Form: as N-Acetyl-5-Methoxytryptamine)10 mgper 1 Tablet(s)DSLD:251807
- AN Amazing Nutrition Amazing FormulasMelatonin 12 mgMelatonin (Form: as N-Acetyl-5-Methoxytryptamine)12 mgper 1 Tablet(s)DSLD:256094
- AN Amazing Nutrition Amazing FormulasMelatonin 5 mgMelatonin (Form: as N-Acetyl-5-Methoxytryptamine)5 mgper 1 Tablet(s)DSLD:251811
- AN Amazing Nutrition Amazing FormulasMelatonin 5 mg Citrus FlavorMelatonin (Form: as N-Acetyl-5-Methoxytryptamine)5 mgper 1 Tablet(s)DSLD:256097
- AN Amazing Nutrition Amazing FormulasMelatonin Plus L-TheanineMelatonin (Form: as N-Acetyl-5-Methoxytryptamine)10 mgper 1 Tablet(s)DSLD:251809
- AN Amazing Nutrition Amazing FormulasSleep Support1.5 mgper 1 Capsule(s)DSLD:251436
- Angry SupplementsBedtime Beauty with L-Theanine & Melatonin2.5 mgper 2 Capsule(s)DSLD:264378
- Angry SupplementsGarcinia Cambogia with Melatonin4 mgper 2 Tablet(s)DSLD:294595
- Angry SupplementsSkinny Dreams with Melatonin & Valerian Root4 mgper 2 Tablet(s)DSLD:294605
- AOR Advanced Orthomolecular Research AdvancedOrtho Sleep3 mgper 2 Capsule(s)DSLD:214855
- AurohealthMelatonin Liquid Sleep Berry Vanilla Flavor1 mgper 4 mLDSLD:264476
- AurohealthMelatonin Liquid Sleep Berry Vanilla Flavor 1 mg/4 mL1 mgper 4 mLDSLD:263278
- AvPakMaximum Strength Melatonin 5 mg5 mgper 1 Tablet(s)DSLD:178874
- AvPakMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:178870
- AvPAKMaximum Strength Melatonin 5 mg50 mgper 1 Tablet(s)DSLD:271381
- Basic VitaminsMelatonin 10 mg10 mgper 1 Tablet(s)DSLD:251001
- Basic VitaminsMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:250176
- Basic VitaminsMelatonin 3 mg Natural Orange Flavor3 mgper 1 mLDSLD:251960
- Basic VitaminsMelatonin 5 mg5 mgper 1 Tablet(s)DSLD:250177
- Basic VitaminsSublingual Melatonin 2.5 mg With Vitamin B-6 Orange Flavored2.5 mgper 1 Tablet(s)DSLD:250359
- BayerAlka-Seltzer PM Gummies Mixed Berry3 mgper 2 Gummy(ies)DSLD:256980
- BayerAlka-Seltzer PM Gummies Mixed Berry3 mgper 2 Gummy(ies)DSLD:270748
- BeachbodyLast Thing1.5 mgper 3 Capsule(s)DSLD:277784
- BeamDream6 mgper 2 Capsule(s)DSLD:266783
- BeastSleep Formula2 mgper 1 Vegetable Capsule(s)DSLD:277647
- Best NaturalsMelatonin 1 mg1 mgper 1 Tablet(s)DSLD:269882
- Best NaturalsMelatonin 10 mg10 mgper 1 Tablet(s)DSLD:270671
- Best NaturalsMelatonin 10 mg10 mgper 1 Tablet(s)DSLD:270673
- Best NaturalsMelatonin 10 mg10 mgper 1 Tablet(s)DSLD:270674
- Best NaturalsMelatonin 12 mg12 mgper 1 Tablet(s)DSLD:270676
- Best NaturalsMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:270662
- Best NaturalsMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:270667
- Best NaturalsMelatonin 5 mg5 mgper 1 Tablet(s)DSLD:270668
- BestHealthMelatonin Gummies 5 mg Natural Strawberry Flavor5 mgper 2 Gummy(ies)DSLD:306032
- Bio NutritionMelatonin 10 mg10 mgper 1 Tablet(s)DSLD:200714
- Bio NutritionSleep Wellness2 mgper 1 Vegetarian Capsule(s)DSLD:200778
- Bio-Tech PharmacalMelatonin 1 mg1 mgper 1 Capsule(s)DSLD:217388
- Bio-Tech PharmacalMelatonin 20 mg20 mgper 1 Capsule(s)DSLD:217283
- Bio-Tech PharmacalMelatonin 3 mg3 mgper 1 Capsule(s)DSLD:217287
- Bio-Tech PharmacalMelatonin SR 2 mgMelatonin2 mgper 1 Capsule(s)DSLD:229382
- Bioclinic NaturalsSomno-Pro Tropical Breeze3 mgper 2 Tablet(s)DSLD:20876
- BioNeurixMellodyn3 mgper 1 Capsule(s)DSLD:249116
- BioSchwartzNighttime Stress Relief1 mgper 2 Capsule(s)DSLD:249901
- BioSchwartzTurmeric Curcumin PM3 mgper 2 Veggie Capsule(s)DSLD:249912
- BIOVEAMelatonin 1 mg1 mgper 1 Vegetarian Capsule(s)DSLD:277895
- BIOVEAMelatonin 1 mg Natural Orange Flavor1 mgper 0.8 mLDSLD:277896
- BIOVEAMelatonin 10 mg Mixed Berry Flavor10 mgper 1 Vegetarian Tablet(s)DSLD:282797
- BIOVEAMelatonin 10 mg Time Release10 mgper 1 Vegetarian Tablet(s)DSLD:282949
- BIOVEAMelatonin 2 mg2 mgper 1 Vegetarian Capsule(s)DSLD:278615
- BIOVEAMelatonin 3 mg3 mgper 1 Vegetarian Capsule(s)DSLD:280406
- BIOVEAMelatonin 3 mg3 mgper 1 Vegetarian Capsule(s)DSLD:284753
- BIOVEAMelatonin 3 mg3 mgper 1 Vegetarian Tablet(s)DSLD:303219
- BIOVEAMelatonin 3 mg3 mgper 1 Vegetarian Tablet(s)DSLD:303220
- BIOVEAMelatonin 3 mg Mixed Berry Flavor3 mgper 1 Vegetarian Tablet(s)DSLD:278628
- BIOVEAMelatonin 3 mg Natural Orange Flavor3 mgper 0.8 mLDSLD:280407
- BIOVEAMelatonin 3 mg Time Release3 mgper 1 Vegetarian Tablet(s)DSLD:303218
- BIOVEAMelatonin 5 mg5 mgper 1 Vegetable Tablet(s)DSLD:282950
- BIOVEAMelatonin 5 mg Mixed Berry Flavor5 mgper 1 Vegetarian Tablet(s)DSLD:282798
- BIOVEAMelatonin 5 mg Time Release5 mgper 1 Vegetarian Tablet(s)DSLD:278629
- BIOVEAMelatonin Gummies 10 mg Mixed Berry Flavored10 mgper 2 Gummy(ies)DSLD:249157
- BIOVEAMelatonin Gummies 5 mg Mixed Berry Flavored5 mgper 1 Gummy(ies)DSLD:303221
- Blackstone LabsGrowth3 mgper 3 Capsule(s)DSLD:204967
- Bluebird BotanicalsSnooze Support CBD Soft Gels 15 mg3 mgper 1 Softgel(s)DSLD:307858
- Bluebird BotanicalsSnooze Support CBD Soft Gels 15 mg3 mgper 1 Softgel(s)DSLD:310071
- Bluebonnet EarthSweet ChewablesMelatonin 1 mg Natural Raspberry Flavor1 mgper 1 Tablet(s)DSLD:179068
- Bluebonnet EarthSweet ChewablesMelatonin 1 mg Natural Raspberry Flavor1 mgper 1 Tablet(s)DSLD:179069
- Bluebonnet EarthSweet ChewablesMelatonin 3 mg Raspberry Flavor3 mgper 1 Tablet(s)DSLD:204826
- Bluebonnet EarthSweet ChewablesMelatonin 5 mg Natural Raspberry Flavor5 mgper 1 Tablet(s)DSLD:179081
- Bluebonnet EarthSweet ChewablesMelatonin 5 mg Raspberry Flavor5 mgper 1 Tablet(s)DSLD:204832
- Bluebonnet EarthSweet ChewablesMelatonin 5 mg Raspberry Flavor5 mgper 1 Tablet(s)DSLD:204838
- Body DynamixSlim PM3 mgper 2 Capsule(s)DSLD:274650
- BodyHealthHealthy Sleep Ultra3 mgper 1 Capsule(s)DSLD:259268
- Botanic ChoiceAloe Assist3 mgper 2 Capsule(s)DSLD:193236
- Botanic ChoicePro-Advanced Formula #2203 mgper 2 Capsule(s)DSLD:251988
- Breckenridge PharmaceuticalMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:230150
- BronsonMelatonin 10 mg Cherry Flavor10 mgper 1 Tablet(s)DSLD:233039
- BronsonMelatonin 12 mg Fast Dissolve Peppermint Flavor12 mgper 1 Lozenge(s)DSLD:298892
- BronsonMelatonin 12 mg Fast Dissolve Peppermint Flavor12 mgper 1 Lozenge(s)DSLD:298893
- BronsonMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:257631
- BronsonMelatonin 5 mg Fast Dissolve Orange Flavor5 mgper 1 Lozenge(s)DSLD:259227
- BronsonMelatonin 5 mg Fast Dissolve Peppermint Flavor5 mgper 1 Lozenge(s)DSLD:259228
- BronsonPM Sleep Formula with Melatonin5 mgper 1 Capsule(s)DSLD:258131
- BulkSupplements.comMelatonin Softgels10 mgper 1 Softgel(s)DSLD:294404
- BulkSupplements.comMelatonin Softgels10 mgper 1 Softgel(s)DSLD:294405
- BulletproofSleep ModeMelatonin · Melatonin (Form: from Rice Plants PlantPart: aerial parts Genus: Oryza Species: sativa, Green Algae Genus: Chlorella Species: pyrenoidosa, and Alfalfa PlantPart: aerial parts) (Alt. Name: Herbatonin)300 mcgper 2 Softgel(s)DSLD:213936
- Buried Treasure NutritionalsSleep Complete3 mgper 30 mLDSLD:250815
- Cardiovascular ResearchMelatone 3 mg3 mgper 1 Capsule(s)DSLD:22730
- Cardiovascular ResearchMelatone 5 mg5 mgper 1 Softgel(s)DSLD:271452
- Cardiovascular ResearchMicrotonin 500 mcg0.5 mgper 1 Capsule(s)DSLD:22946
- Cardiovascular ResearchMultiphasic Melatonin-SR 1.8 mg1.8 mgper 1 Tablet(s)DSLD:283442
- Cardiovascular ResearchOncotonin10 mgper 1 Capsule(s)DSLD:304418
- Cardiovascular ResearchOncotonin Liposomal Melatonin 10 mg10 mgper 1 Capsule(s)DSLD:22980
- care/ofDream Team2.5 mgper 1 Gram(s)DSLD:243234
- CarlsonKid's Chewable Melatonin Natural Strawberry Lemon Flavor300 mcgper 1 Tablet(s)DSLD:304781
- CarlsonMelatonin 300 mcg Natural Strawberry Lemon Flavor300 mcgper 1 Tablet(s)DSLD:268212
- CarlsonMelatonin Gummies 2.5 mg Natural Strawberry Flavor2.5 mgper 1 Gummy(ies)DSLD:241936
- CarlsonMelatonin Gummies 2.5 mg Natural Strawberry Flavor2.5 mgper 1 Gummy(ies)DSLD:307412
- CellucorCOR-Performance ZMA1 mgper 4 Capsule(s)DSLD:18932
- CentrumCentrum Rest & Rejuvenate Blueberry Blackberry5 mgper 2 Gummy(ies)DSLD:251346
- CentrumCentrum Sleep3 mgper 1 Capsule(s)DSLD:256990
- Charlotte's Web Stanley BrothersSleep Raspberry Flavor3 mgper 2 Gummy(ies)DSLD:239226
- Charlotte's Web Stanley BrothersSleep Raspberry Flavor3 mgper 2 Gummy(ies)DSLD:239237
- Charlotte's Web Stanley BrothersSleep Raspberry Flavor3 mgper 2 Gummy(ies)DSLD:239238
- CHK NutritionMelatonin 3 mg3 mgper 1 Vegetarian Tablet(s)DSLD:228548
- CHK NutritionMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:252938
- Clinical Synergy Professional FormulasRegeneRest0.5 mgper 2 Capsule(s)DSLD:216716
- CodeageMulti Collagen Beauty Night6 mgper 3 Capsule(s)DSLD:269368
- Codeage NanofoodTeen Sleep + Chocolate Smoothie1.5 mgper 2.5 mLDSLD:298426
- CognizanceSleep1 mgper 1 Vegetable Capsule(s)DSLD:246508
- Cooper CompleteMelatonin Prolonged Release 3 mg3 mgper 1 Tablet(s)DSLD:238859
- Cooper CompleteMelatonin Quick Release 3 mg3 mgper 1 Tablet(s)DSLD:238860
- Core NutritionalsZZZ Blueberry Lemonade5 mgper 13.4 Gram(s)DSLD:298371
- Core NutritionalsZZZ Cherry Bomb5 mgper 14.3 Gram(s)DSLD:218278
- Core NutritionalsZZZ Pineapple Peach5 mgper 13.5 Gram(s)DSLD:298370
- Corr-Jensen LabsDreamweaver Advanced Sleep Formula0.67 mgper 1 Softgel(s)DSLD:14838
- Country LifeMelatonin 10 mg10 mgper 1 Capsule(s)DSLD:258839
- Country LifeMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:183594
- CV SciencesPlusCBD Sleep Raspberry3 mgper 1 Gummy(ies)DSLD:256715
- CVS HealthMelatonin 10 mg10 mgper 1 Capsule(s)DSLD:207551
- CVS HealthMelatonin 3 mgMelatonin (Form: as N-Acetyl-5-Methoxytryptamine)3 mgper 1 Tablet(s)DSLD:210467
- CVS HealthMelatonin 5 mg5 mgper 1 Tablet(s)DSLD:278553
- CVS HealthMelatonin Liquid 1 mg Berry Natural Flavor1 mgper 4 mLDSLD:264231
- CVS PharmacyMelatonin All Natural Strawberry Flavor5 mgper 2 Gummy(ies)DSLD:18142
- Daily HealthDaily Night-Time Hemp5 mgper 1 Gummy(ies)DSLD:248012
- DaVinci LaboratoriesMelatonin-3 3 mg3 mgper 1 Capsule(s)DSLD:305236
- DCChildren's Melatonin + C Natural Orange Flavor1 mgper 1 Chewable Tablet(s)DSLD:266781
- DCFormula 2562.5 mgper 1 Tablet(s)DSLD:266557
- DCFormula 2562.5 mgper 1 Tablet(s)DSLD:266581
- DCFormula 2562.5 mgper 1 Tablet(s)DSLD:266583
- DCFormula 2562.5 mgper 1 Tablet(s)DSLD:266589
- DCFormula 2562.5 mgper 1 Tablet(s)DSLD:266590
- DCFormula 256 Melatonin 2.5 mg (2,500 mcg) Sublingual Fruit Flavored2.5 mgper 1 Tablet(s)DSLD:244674
- DCFormula 7433 mgper 1 Vegetable Tablet(s)DSLD:245210
- DCFormula 7433 mgper 1 Vegetable Tablet(s)DSLD:265857
- DCFormula 7433 mgper 1 Vegetable Tablet(s)DSLD:265858
- DCFormula 7433 mgper 1 Vegetable Tablet(s)DSLD:265859
- DCMelatonin 10 mg10 mgper 1 Vegetable Tablet(s)DSLD:309912
- DCMelatonin 5 mg5 mgper 1 Softgel(s)DSLD:245332
- DCMelatonin 5 mg5 mgper 1 Softgel(s)DSLD:265903
- DCMelatonin 5 mg5 mgper 1 Softgel(s)DSLD:265904
- DCMelatonin 5 mg5 mgper 1 Softgel(s)DSLD:265907
- Designer WellnessSleep Support Gummies Strawberry Flavored5 mgper 2 Gummy(ies)DSLD:295176
- Designs for HealthInsomnitol3 mgper 2 Capsule(s)DSLD:22936
- Designs for HealthMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:22659
- Doctor's BestMelatonin 5 mg Natural Mint Flavor5 mgper 1 Chewable Tablet(s)DSLD:203221
- Doctor's BestMelatonin Chocolate Mint Flavor 2.5 mg2.5 mgper 1 Chewable Tablet(s)DSLD:203073
- Doctor's BestMelatonin Gummies 5 mg Strawberry Delight5 mgper 2 Gummy(ies)DSLD:209357
- Doctor's BestQuick Melt Melatonin 2.5 mg2.5 mgper 1 Chewable Tablet(s)DSLD:25516
- Doctor's BestSuperior Sleep5 mgper 2 Veggie Capsule(s)DSLD:271112
- Doctors' PreferredSleep Answer4 mgper 1 Vegan Capsule(s)DSLD:309884
- Douglas Cooper Co.Melatonin 3 mg3 mgper 1 Veg Capsule(s)DSLD:247370
- Douglas LaboratoriesGoodnight Gummy Natural Raspberry Tea FlavorMelatonin · Sustained-released complex0.5 mgper 1 Gummy(ies)DSLD:286493
- Douglas LaboratoriesMelatonin 1 mg1 mgper 1 Tablet(s)DSLD:237902
- Douglas LaboratoriesMelatonin 3 mg3 mgper 1 Capsule(s)DSLD:176589
- Douglas LaboratoriesMelatonin 3 mg3 mgper 1 Vegetarian Capsule(s)DSLD:232792
- Douglas LaboratoriesMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:274072
- Douglas LaboratoriesMelatonin 3 mg Sublingual Tablets3 mgper 1 Tablet(s)DSLD:10000
- Douglas LaboratoriesMelatonin 3 mg Sublingual Tablets3 mgper 1 Tablet(s)DSLD:10002
- Douglas LaboratoriesMelatonin 3 mg Sublingual Tablets3 mgper 1 Tablet(s)DSLD:10003
- Douglas LaboratoriesMelatonin Controlled-Release 2 mg2 mgper 1 Tablet(s)DSLD:237921
- Douglas LaboratoriesMelatonin P.R. 3 mg Prolonged-Release3 mgper 1 Tablet(s)DSLD:245312
- Douglas LaboratoriesMelatonin P.R. Prolonged-Release 3 mg3 mgper 1 Tablet(s)DSLD:232188
- Douglas LaboratoriesRest Reset3 mgper 1 Vegetarian Capsule(s)DSLD:286501
- Dr. Clark StoreMelatonin 3 mg3 mgper 1 Capsule(s)DSLD:219976
- Dr. Emil NutritionBedtime Burn5 mgper 2 Capsule(s)DSLD:272251
- Dr. MercolaSleep Support Melatonin 1.5 mg1.5 mgper 1 Capsule(s)DSLD:287337
- Dr. MercolaSleep Support Melatonin 1.5 mg1.5 mgper 1 Capsule(s)DSLD:291605
- Dr. MercolaSleep Support Melatonin 10 mg10 mgper 1 Capsule(s)DSLD:291607
- Dr. MercolaSleep Support Melatonin 5 mg1.5 mgper 1 Capsule(s)DSLD:291606
- DreamBrandsInternal Harmony For Women Sleep Aid2 mgper 1 Capsule(s)DSLD:179038
- DrFormulasNatural Sleep Aid1 mgper 1 Capsule(s)DSLD:203717
- Dynamic Health Laboratories Inc.Dynamic Health Tart Cherry Completestd to 25 mcg/g Melatonin12.5 mcgper 1 Vegetarian Capsule(s)DSLD:18569
- EA EnhnacedSleep Juice Sweet Tea0.5 mgper 8.8 Gram(s)DSLD:228244
- EmeraldMelatonin 3 mg3 mgper 1 Capsule(s)DSLD:302621
- EmeraldMelatonin 3 mg Time-Release3 mgper 1 Capsule(s)DSLD:302622
- EmeraldMelatonin Mint Flavor0.75 mgper 0.75 mgDSLD:302624
- Emerald LabsMelatonin 3 mg3 mgper 1 Capsule(s)DSLD:302620
- Emerald LabsMelatonin 3 mg Time-Release3 mgper 1 Capsule(s)DSLD:302623
- Emerald LabsMelatonin Mint Flavor0.75 mgper 0.75 mgDSLD:302625
- Emerald LabsSleep Health1 mgper 2 Capsule(s)DSLD:302743
- Emergen-CEmergen-Zzzz Nighttime Sleep Aid with Melotonin Berry PM3 mgper 7.8 Gram(s)DSLD:205953
- Emergen-CEmergen-Zzzz Nighttime Sleep Aid with Melotonin Mellow Berry3 mgper 7.8 Gram(s)DSLD:205967
- ENPRestorative Slumber3 mgper 30 mLDSLD:283723
- EstrovenMenopause Relief + Sleep2 mgper 1 Caplet(s)DSLD:242640
- EuroMedicaAndrographis Immune5 mgper 1 Capsule(s)DSLD:261420
- EuroMedicaCuraphen PM2.5 mgper 1 Capsule(s)DSLD:261678
- EuroMedicaMelatonin 10 mgMelatonin10 mgper 1 Tablet(s)DSLD:261535
- Eurovital NutraceuticalsLiquid Melatonin 1 mg Natural Orange Flavor1 mgper 0.9 mLDSLD:256119
- Eurovital NutraceuticalsMelatonin 1 mg1 mgper 1 Capsule(s)DSLD:256122
- Eurovital NutraceuticalsMelatonin 10 mg10 mgper 1 Vegetarian Tablet(s)DSLD:256629
- Eurovital NutraceuticalsMelatonin 10 mg Natural Fruit Flavor10 mgper 1 Vegetarian Tablet(s)DSLD:256631
- Eurovital NutraceuticalsMelatonin 2 mg2 mgper 1 Vegetarian Capsule(s)DSLD:256138
- Eurovital NutraceuticalsMelatonin 3 mg3 mgper 1 Vegetarian Capsule(s)DSLD:260077
- Eurovital NutraceuticalsMelatonin 3 mg3 mgper 1 Vegetarian Tablet(s)DSLD:260990
- Eurovital NutraceuticalsMelatonin 3 mg3 mgper 1 Vegetarian Tablet(s)DSLD:260991
- Eurovital NutraceuticalsMelatonin 3 mg3 mgper 1 Capsule(s)DSLD:260999
- Eurovital NutraceuticalsMelatonin 3 mg3 mgper 1 Vegetarian Capsule(s)DSLD:261001
- Eurovital NutraceuticalsMelatonin 3 mg Natural Fruit Flavor3 mgper 1 Vegetarian Tablet(s)DSLD:260078
- Eurovital NutraceuticalsMelatonin 3 mg Natural Orange Flavor3 mgper 0.9 mLDSLD:256139
- Eurovital NutraceuticalsMelatonin 5 mg5 mgper 1 Vegetarian Tablet(s)DSLD:260992
- Eurovital NutraceuticalsMelatonin 5 mg5 mgper 1 Vegetarian Tablet(s)DSLD:260993
- Eurovital NutraceuticalsMelatonin 5 mg Natural Berry Flavor5 mgper 1 Vegetarian Tablet(s)DSLD:256123
- Evlution NutritionNightLean5 mgper 1 Veggie Capsule(s)DSLD:302131
- Evlution NutritionSleepMode5.5 mgper 2 Veggie Capsule(s)DSLD:302143
- Exchange SelectMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:200390
- eXplicit SupplementszZz Night10 mgper 2 Veggie Capsule(s)DSLD:310051
- EZ MeltsMelatonin 5 mg Cool Mint5 mgper 1 Tablet(s)DSLD:260919
- Fairhaven HealthFH PRO for Women2 mgper 6 Capsule(s)DSLD:260632
- Feel Great Vitamin Co.Melatonin Night Night Gummies 5 mg5 mgper 2 Gummie(s)DSLD:243700
- FinestTime Release Melatonin 5 mg5 mgper 1 Tablet(s)DSLD:13250
- Finest NutritionMelatonin 5 mg Timed Release5 mgper 1 Tablet(s)DSLD:273792
- Finest Nutrition Free & PureMelatonin Gummies 5 mg Natural Strawberry Flavor5 mgper 2 Gummie(s)DSLD:273793
- Foods PlusMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:302455
- Force FactorSomnapure Gummies with 10 mg Melatonin10 mgper 2 Gummy(ies)DSLD:260354
- FreedaChewable Melatonin 0.5 mg0.5 mgper 1 Tablet(s)DSLD:221610
- FreedaChewable Melatonin 0.5 mg0.5 mgper 1 Tablet(s)DSLD:221615
- FreedaChewable Melatonin 0.5 mg0.5 mgper 1 Tablet(s)DSLD:221623
- Fresh NutritionSleep Aid5 mgper 3 Capsule(s)DSLD:242081
- Fully FloraLean Dream2 mgper 1 Vegetable Capsule(s)DSLD:282464
- FuturebioticsMelatonin 5 mg Lozenges Orange Flavor5 mgper 1 Lozenge(s)DSLD:259142
- FuturebioticsMelatonin 5 mg Lozenges Peppermint Flavor5 mgper 1 Lozenge(s)DSLD:261057
- Garcoa LaboratoriesSleep-Max PM1.5 mgper 1 Capsule(s)DSLD:26248
- GenacolGenacol Sleep & Joints9 mgper 3 Capsule(s)DSLD:229356
- Genestra BrandsMelatonin Spray Natural Spearmint Flavor3 mgper 0.45 mLDSLD:239066
- Genestra BrandsSleep Gummies Natural Raspberry-Tea Flavor0.5 mgper 1 Gummy(ies)DSLD:288588
- Geri-CareMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:255325
- Global Product ManagementAlteril All Natural Sleep Aid with L-Tryptophan4 mgper 2 Tablet(s)DSLD:206028
- Glow by Nature MadeSkin Moisture + Sleep1 mgper 2 Softgel(s)DSLD:179913
- GNCMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:224770
- GNCMelatonin 3 mg Blueberry Lavender3 mgper 1 Soft Chew(s)DSLD:243079
- GNCMelatonin 3 mg Timed-Release3 mgper 1 Tablet(s)DSLD:224757
- GNCMelatonin 5 mg5 mgper 1 Tablet(s)DSLD:224768
- GNCMelatonin 5 mg Quick-Dissolving Lozenges Peppermint5 mgper 1 Lozenge(s)DSLD:243019
- GNCMelatonin Gummies 5 mg Blackberry5 mgper 2 Gummy(ies)DSLD:260265
- GNCMelatonin Lozenges 1 mg Cherry1 mgper 1 Lozenge(s)DSLD:224743
- GNCMelatonin Lozenges 1 mg Cherry1 mgper 1 Lozenge(s)DSLD:224755
- GNC Preventive NutritionSleep Soundly Advanced3 mgper 1 Caplet(s)DSLD:1850
- Gorilla MindGorilla Dream3 mgper 3 Capsule(s)DSLD:232844
- Gorilla MindGorilla Dream3 mgper 3 Capsule(s)DSLD:232848
- Gut ResponseSleep Probiotic3 mgper 1 Caplet(s)DSLD:307900
- Happy Healthy HippieNamastay in Bed0.5 mgper 2 Capsule(s)DSLD:228952
- Havasu NutritionMelatonin Chewables for Kids0.2 mgper 1 Tablet(s)DSLD:230640
- Havasu NutritionSaw Palmetto PM Extra Strength3 mgper 1 Capsule(s)DSLD:230707
- Health StarMelatonin 1 mg1 mgper 1 Tablet(s)DSLD:255320
- Health StarMelatonin 1 mg1 mgper 1 Tablet(s)DSLD:309720
- Health StarMelatonin 1 mg1 mgper 1 Tablet(s)DSLD:309721
- Health StarMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:206591
- Healthy DirectionsSleep Answer0.9 mgper 1 Capsule(s)DSLD:201980
- Healthy DirectionsSleep Answer0.9 mgper 1 Capsule(s)DSLD:243719
- Heaven's OrganicsPremium Grade CBD Softgels Melatonin Formula1 mgper 1 Softgel(s)DSLD:276581
- Hello BelloSleep Well Tropical Punch Flavor5 mgper 2 Gummie(s)DSLD:276702
- Hemp BombsCBD Capsules Sleep 15 mg5 mgper 1 Capsule(s)DSLD:278534
- Hemp BombsCBD Capsules Sleep 15 mg5 mgper 1 Capsule(s)DSLD:285594
- Hemp BombsCBD Capsules Sleep 15 mg5 mgper 1 Capsule(s)DSLD:285595
- Hemp BombsCBD Gummies Sleep5 mgper 1 Gummy(ies)DSLD:247544
- Hemp BombsCBD Gummies Sleep5 mgper 1 Gummy(ies)DSLD:247546
- Hemp BombsCBD Gummies Sleep5 mgper 1 Gummy(ies)DSLD:247551
- Hemp BombsCBD Gummies Sleep5 mgper 1 Gummy(ies)DSLD:247552
- HempMedsSleep Support2 mgper 1 Capsule(s)DSLD:219766
- HempWorxCBD+ Melatonin5 mgper 1 Softgel(s)DSLD:309408
- Herbalife NutritionSleep Now2 mgper 1 Tablet(s)DSLD:309908
- HerbTonicsNight Time Burn2 mgper 1 Capsule(s)DSLD:287060
- HerbTonicsNight Time Fat Burner2 mgper 2 Vegetable Capsule(s)DSLD:259372
- HerbTonicsSleep Tonic5 mgper 2 Vegetable Capsule(s)DSLD:258998
- High LevelHibernate10 mgper 2 Veggie Capsule(s)DSLD:287457
- High LevelHibernate Gummy Edition Natural Passionfruit Flavor2 mgper 2 Gummie(s)DSLD:287451
- HMS NutritionSleep Support4 mgper 2 Capsule(s)DSLD:229881
- HMS NutritionSleep Support4 mgper 2 Capsule(s)DSLD:255600
- HoltraCeuticalsMelatonin 3 mg SL3 mgper 1 Quick Dissolve Tablet(s)DSLD:273748
- HoltraCeuticalsMelatonin Vanilla Mint10 mgper 0.5 Strip(s)DSLD:273749
- HoltraCeuticalsSleep Tight3 mgper 3 Capsule(s)DSLD:270840
- HTLT EssentialsSleep Aid4.5 mgper 1 Capsule(s)DSLD:265453
- Huge NutritionHibernate Peach Mango3 mgper 9.3 Gram(s)DSLD:299808
- INNOSUPPSNight Shred3 mgper 2 Vegetarian Capsule(s)DSLD:271438
- INNOSUPPSNight Shred3 mgper 2 Vegetarian Capsule(s)DSLD:303531
- Integrative TherapeuticsVitaline Melatonin Forte With L-Theanine3 mgper 0.5 Tablet(s)DSLD:24173
- Irwin NaturalsMelatonin plus 5-HTP & Rhodiola3 mgper 3 Liquid Softgel(s)DSLD:292081
- Irwin NaturalsPower to Sleep PM2 mgper 2 Liquid Softgel(s)DSLD:292084
- Irwin NaturalsPower to Sleep PM2 mgper 2 Liquid Soft-Gel(s)DSLD:292085
- Irwin NaturalsPower to Sleep PM 6 mg Melatonin6 mgper 2 Liquid Softgel(s)DSLD:292137
- Iso-SportRest3 mgper 1 Capsule(s)DSLD:247225
- IsodiolBioactive Sleep Shot Dreamberry1 mgper 1.93 Fluid Ounce(s)DSLD:219608
- IVLMelatonin Gummies5 mgper 2 Gummy(ies)DSLD:307016
- IVLSimply Snooze6 mgper 2 Capsule(s)DSLD:278397
- IVL Institute For Vibrant LivingSweet Dreams Sleep FormulaMelatonin Note: 98%2 mgper 2 Vegetarian Capsule(s)DSLD:15625
- Jacked FactoryLean PM5 mgper 2 Capsule(s)DSLD:257767
- Jacked FactoryLean PM5 mgper 2 Capsule(s)DSLD:261027
- Jacked Factory JFTest PM5 mgper 2 Capsule(s)DSLD:292142
- Jarrow FormulasSleep Optimizer0.3 mgper 2 Capsule(s)DSLD:307735
- Joy NutritionPremium CBD Softgels Melatonin Formula1 mgper 1 Softgel(s)DSLD:250207
- KALMelatonin 1 mg Chocolate Mint1 mgper 1 Tablet(s)DSLD:286790
- KaraMDSleep Guard4 mgper 2 Veggie Capsule(s)DSLD:243843
- KarunaMelatonin3 mgper 1 Capsule(s)DSLD:24661
- Key NutrientsLights Out3 mgper 2 Capsule(s)DSLD:259081
- KirkmanChildren's Chewable Melatonin 3 mg Chocolate Tablets3 mgper 1 Tablet(s)DSLD:296972
- KirkmanMelatonin Extended Release 2.5 mg2.5 mgper 1 Tablet(s)DSLD:297227
- KirkmanMelatonin Plus Magnesium1 mgper 1 Capsule(s)DSLD:25025
- Klean AthleteKlean Melatonin Natural Raspberry Lemonade Flavor3 mgper 0.86 mLDSLD:237080
- KonsylDeep ZZZ Melatonin Gummies 5 mg5 mgper 2 Gummy(ies)DSLD:272244
- KonsylRest & Relax Melatonin Gummies 4 mg2 mgper 2 Gummie(s)DSLD:272277
- Lazarus NaturalsSleep + Melatonin Full Spectrum Cannabinoid Capsules5 mgper 0.4 Gram(s)DSLD:305975
- LegionLunar Chamomile500 mcgper 5.1 Gram(s)DSLD:248739
- LES LabsRest & Renew0.3 mgper 1 Capsule(s)DSLD:276528
- Life ExtensionCircadian SleepMelatonin1.5 mgper 1 Vegetarian Capsule(s)DSLD:232447
- Life ExtensionMelatonin 1 mg1 mgper 1 Capsule(s)DSLD:231640
- Life ExtensionMelatonin 10 mg10 mgper 1 Vegetarian Capsule(s)DSLD:231645
- Life ExtensionMelatonin 3 mg3 mgper 1 Vegetarian Capsule(s)DSLD:231643
- Life ExtensionMelatonin 3 mg 6 Hour Timed Release3 mgper 1 Vegetarian Tablet(s)DSLD:232359
- Life ExtensionMelatonin 3 mg 6 Hour Timed Release3 mgper 1 Vegetarian Tablet(s)DSLD:232365
- Life ExtensionMelatonin 300 mcg300 mcgper 1 Vegetarian Capsule(s)DSLD:232159
- Life ExtensionMelatonin 500 mcg500 mcgper 1 Vegetarian Capsule(s)DSLD:231759
- Life ExtensionMelatonin Lozenges 3 mg3 mgper 1 Vegetarian Lozenge(s)DSLD:231659
- Life ExtensionMen's Bladder Control2 mgper 1 Vegetarian Capsule(s)DSLD:232811
- Life ExtensionQuiet Sleep Melatonin 3 mgMelatonin Note: immediate release3 mgper 1 Vegetarian Capsule(s)DSLD:231875
- Life ExtensionQuiet Sleep Melatonin 5 mgMelatonin Note: immediate release5 mgper 1 Vegetarian Capsule(s)DSLD:231879
- Life RenewSleep Aid2 mgper 1 Capsule(s)DSLD:217527
- LifeLinkMelatonin 33 mgper 1 Tablet(s)DSLD:11741
- Lifted NaturalsMicro Melatonin 100 mcg100 mcgper 1 Capsule(s)DSLD:263495
- Liquid Health NaturalsSleep Well3 mgper 1 mLDSLD:214611
- Longevity Medical ClinicMelatonin 1 mg1 mgper 1 Capsule(s)DSLD:308017
- Longevity Medical ClinicMelatonin 10 mg10 mgper 1 Capsule(s)DSLD:308020
- Longevity Medical ClinicMelatonin 3 mg3 mgper 1 Capsule(s)DSLD:308018
- Longevity Medical ClinicMelatonin 5 mg5 mgper 1 Capsule(s)DSLD:308019
- LuckyVitaminChewable Melatonin 3 mg3 mgper 1 Lozenge(s)DSLD:283142
- LuckyVitaminExtra Strength Melatonin 10 mg10 mgper 1 Veg Capsule(s)DSLD:283176
- LuckyVitaminLiquid Melatonin 3 mg3 mgper 0.9 mLDSLD:283220
- LuckyVitaminMaximum Strength Melatonin 20 mg20 mgper 1 Veg Capsule(s)DSLD:283232
- LuckyVitaminMelatonin 1 mg1 mgper 1 Tablet(s)DSLD:283234
- LuckyVitaminMelatonin 3 mg3 mgper 1 Veg Capsule(s)DSLD:283235
- LuckyVitaminMelatonin 5 mg5 mgper 1 Veg Capsule(s)DSLD:283236
- LuminiteLuminite Sleep Support4 mgper 1 Capsule(s)DSLD:249956
- MajorMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:202180
- MajorMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:215883
- Major PharmaceuticalsMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:202162
- Major PharmaceuticalsMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:202164
- Martin Avenue PharmacyMelatonin 1 mg Sublingual1 mgper 1 Tablet(s)DSLD:18919
- Martin Avenue PharmacyMelatonin 3 mg Long Acting3 mgper 1 Tablet(s)DSLD:18920
- Martin Avenue PharmacyMelatonin 3 mg With Vitamin B-63 mgper 1 Tablet(s)DSLD:19002
- Mason NaturalMelatonin 10 mg10 mgper 1 Caplet(s)DSLD:244505
- Mason NaturalMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:244498
- Mason NaturalMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:244502
- Mason NaturalMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:276921
- Mason NaturalMelatonin 5 mg5 mgper 1 Tablet(s)DSLD:244472
- Mason NaturalMelatonin 5 mg5 mgper 1 Tablet(s)DSLD:244481
- Mason NaturalQuick Dissolve Melatonin 500 mcg500 mcgper 1 Tablet(s)DSLD:244710
- Maxi HealthFormula 6053 mgper 1 Capsule(s)DSLD:304175
- Maxi HealthFormula 6053 mgper 1 Capsule(s)DSLD:304176
- Maxi YumMel-O-Licious! Gummies1 mgper 1 Capsule(s)DSLD:304211
- MBi NutraceuticalsBio-Melatonin5 mgper 1 Tablet(s)DSLD:231519
- MD PrescriptivesLiposomal Melatonin Spray3 mgper 0.4 mLDSLD:261511
- MD PrescriptivesMelatonin 3 mg3 mgper 1 Capsule(s)DSLD:261510
- MD PrescriptivesNAC MD150 mcgper 1 Capsule(s)DSLD:261514
- Medi-SultingMedi-Doze6 mgper 1 Capsule(s)DSLD:264314
- Medterra HEMPHemp Gummies Sleep Tight 50 mg Strawberry3 mgper 1 Gummy(ies)DSLD:273568
- MegaFoodMelatonin Berry Good Sleep 3 mg Berry3 mgper 2 Gummy(ies)DSLD:257098
- MeijerChildren's Chewable Melatonin 1 mg1 mgper 1 Tablet(s)DSLD:271769
- MeijerMelatonin 10 mg10 mgper 1 Tablet(s)DSLD:271902
- MeijerMelatonin 10 mg10 mgper 1 Capsule(s)DSLD:296575
- MeijerMelatonin 12 mg Berry Flavor12 mgper 1 Tablet(s)DSLD:273034
- MeijerMelatonin 3 mg Quick Dissolve Natural Berry Flavor3 mgper 1 Tablet(s)DSLD:296593
- MeijerMelatonin 5 mg5 mgper 1 Tablet(s)DSLD:296573
- MeijerMelatonin 5 mg Gummy Natural Blackberry Flavor5 mgper 2 Gummy Vitamin(s)DSLD:296509
- MeijerMelatonin 5 mg Gummy Natural Strawberry Flavor5 mgper 2 Gummy(ies)DSLD:296507
- MeijerMelatonin 5 mg Gummy Natural Strawberry Flavor5 mgper 2 Gummy(ies)DSLD:296508
- MeijerMelatonin 5 mg Jelly Bean5 mgper 4 Jelly Bean(s)DSLD:296574
- MeijerMelatonin 5 mg Orange Flavor5 mgper 1 Tablet(s)DSLD:271901
- MeijerQuick Dissolve Low Dose Melatonin 1 mg1 mgper 1 Tablet(s)DSLD:296592
- Member's MarkMelatonin 5 mg Fast Dissolve Strawberry Flavor5 mgper 1 Tablet(s)DSLD:277378
- Metabolic MaintenanceMelatonin 2 mg2 mgper 1 Capsule(s)DSLD:274080
- Metabolic MaintenanceMelatonin Time-Release2 mgper 1 Capsule(s)DSLD:25030
- Metabolic MaintenanceR.E.M. Maintenance1 mgper 6 Gram(s)DSLD:274192
- MetagenicsBenesom3 mgper 1 Tablet(s)DSLD:295539
- MH Michael's Health Naturopathic ProgramsSleep Factors10 mgper 3 Veggie Capsule(s)DSLD:303377
- MH Michael's Health Naturopathic ProgramsSleep Factors10 mgper 3 Veggie Cap(s)DSLD:303378
- MH Michael's Health Naturopathic ProgramsSleep Factors10 mgper 3 Veggie Cap(s)DSLD:303379
- Micro IngredientsMelatonin Tablet12 mgper 1 Tablet(s)DSLD:231808
- Micro IngredientsMelatonin Tablet 15 mg15 mgper 1 Tablet(s)DSLD:256806
- MN Morphogen NutritionMorphorem2.5 mgper 3 Capsule(s)DSLD:212724
- MNP Michael's Naturopathic ProgramsSleep Facotrs10 mgper 3 Capsule(s)DSLD:272652
- Mommy's BlissKids Sleep Chewable Natural Grape Flavor1 mgper 1 Tablet(s)DSLD:273063
- Mommy's BlissKids Sleep Gummies Strawberry1 mgper 1 Gummy(ies)DSLD:273064
- Mommy's BlissKids Sleep Liquid Natural Grape Flavor0.5 mgper 2 mLDSLD:273061
- Monster TestPM Monster Test Sleep & Grow Testosterone Booster2.5 mgper 2 Capsule(s)DSLD:294603
- Mountain Meadow HerbsBed-Time Drops3 mgper 0.25 Teaspoon(s)DSLD:259402
- Mountain Meadow HerbsBed-Time Drops3 mgper 0.12 Teaspoon(s)DSLD:261066
- Mountain Meadow KidsBerry Bedtime3 mgper 0.06 Teaspoon(s)DSLD:259345
- Mountain Meadow KidsBerry Bedtime3 mgper 0.06 Teaspoon(s)DSLD:261068
- MRM NutritionRelax-ALL Sleep5 mgper 2 Vegan Capsule(s)DSLD:305119
- Mt. Angel VitaminsSleepy Sleep1 mgper 1 Vegetarian Capsule(s)DSLD:211780
- MusclePharmZMA Max3 mgper 1 Capsule(s)DSLD:17924
- MusclePharm MP EssentialsZ-PM3 mgper 1 Capsule(s)DSLD:265440
- MyBite VitaminsSweet Zzzz3 mgper 1 Piece(s)DSLD:213887
- N by NutriliteSweet Dreams Blueberry Lavender3 mgper 2 Gummy(ies)DSLD:246407
- NanoNutraLiposomal Melatonin3 mgper 0.4 mLDSLD:229084
- NanoNutraLiposomal Melatonin3 mgper 0.4 mLDSLD:251279
- Natrium HealthMelatonin Capsules 300 mcg300 mcgper 1 Capsule(s)DSLD:233389
- Natrol3 a.m. Melatonin Fast Dissolve Lavender Vanilla3 mgper 1 Tablet(s)DSLD:256967
- Natrol3 a.m. Melatonin Fast Dissolve Lavender Vanilla3 mgper 1 Tablet(s)DSLD:306514
- NatrolAdvanced Sleep Melatonin 10 mg Time Release10 mgper 1 Tablet(s)DSLD:257059
- NatrolLiquid Melatonin 10 mg Berry Natural Flavor10 mgper 4 mLDSLD:202802
- NatrolLiquid Melatonin 5 mg Berry Natural Flavor5 mgper 2 mLDSLD:202813
- NatrolLiquid Melatonin 5 mg Berry Natural Flavor5 mgper 4 tspDSLD:203299
- NatrolMelatonin + 5-HTP Time Release6 mgper 1 Tablet(s)DSLD:306526
- NatrolMelatonin 1 mg Strawberry1 mgper 1 Tablet(s)DSLD:274879
- NatrolMelatonin 10 mg Advanced Sleep Time Release10 mgper 1 Tablet(s)DSLD:306530
- NatrolMelatonin 10 mg Fast Dissolve Strawberry10 mgper 1 Tablet(s)DSLD:274880
- NatrolMelatonin 10 mg Strawberry10 mgper 2 Gummie(s)DSLD:257024
- NatrolMelatonin 3 mg Strawberry3 mgper 1 Tablet(s)DSLD:274873
- NatrolMelatonin 5 mg Fast Dissolve Strawberry Natural Flavor5 mgper 1 Tablet(s)DSLD:230440
- NatrolMelatonin 5 mg Strawberry5 mgper 1 Tablet(s)DSLD:274733
- NatrolMelatonin 5 mg Time Release5 mgper 1 Tablet(s)DSLD:287520
- NatrolMelatonin Calm Sleep Strawberry Natural Flavor6 mgper 1 Tablet(s)DSLD:203359
- NatrolMelatoninMax 10 mg Blueberry10 mgper 1 Gummy(ies)DSLD:306531
- NatrolMidnight Sleep Fast Dissolve Lavender Vanilla3 mgper 1 Tablet(s)DSLD:257017
- NatrolNight3 mgper 1 Tablet(s)DSLD:203170
- NatrolNight3 mgper 1 Tablet(s)DSLD:257112
- NatrolNight3 mgper 1 Tablet(s)DSLD:274872
- NatrolRelax+ Night Calm Berry3 mgper 2 Gummy(ies)DSLD:274681
- NatrolRelaxia Night Calm Berry3 mgper 2 Gummie(s)DSLD:257109
- NatrolSleep 'n Restore3 mgper 1 Tablet(s)DSLD:306536
- NatrolSleep + Calm Strawberry6 mgper 2 Gummie(s)DSLD:274861
- NatrolSleep+ Beauty6 mgper 2 Gummy(ies)DSLD:274855
- NatrolSleep+ Calm Strawberry6 mgper 2 Gummy(ies)DSLD:306537
- NatrolSleep+ Immune Health Berry6 mgper 2 Gummy(ies)DSLD:274865
- Natrol GummiesMelatonin 5 mg Strawberry5 mgper 1 Gummy(ies)DSLD:230564
- Natrol KidsSleep+ Calm Strawberry0.5 mgper 1 Gummy(ies)DSLD:274724
- Natrol KidsSleep+ Immune Health Berry1 mgper 1 Gummie(s)DSLD:274766
- Natural ClinicianClinical Sleep1.5 mgper 1 Capsule(s)DSLD:18687
- Natural Factors Stress-RelaxExtra Strength Tranquil Sleep6 mgper 1 Tablet(s)DSLD:282191
- Natural Factors Stress-RelaxMelatonin 10 mg10 mgper 1 Tablet(s)DSLD:220431
- Natural Factors Stress-RelaxMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:220412
- Natural Factors Stress-RelaxMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:220419
- Natural Factors Stress-RelaxMelatonin 5 mg5 mgper 1 Tablet(s)DSLD:220422
- Natural Factors Stress-RelaxMelatonin 5 mg5 mgper 1 Tablet(s)DSLD:220426
- Natural Factors Stress-RelaxTranquil Sleep3 mgper 2 Softgel(s)DSLD:220732
- Natural Factors Stress-RelaxTranquil Sleep3 mgper 2 Tablet(s)DSLD:220739
- Natural Factors Stress-RelaxTranquil Sleep3 mgper 2 Softgel(s)DSLD:220752
- Natural Factors Stress-RelaxTranquil Sleep3 mgper 2 Tablet(s)DSLD:282636
- Natural Grocers by Vitamin CottageMelatonin 1 mg Chocolate1 mgper 1 Melt(s)DSLD:256843
- Natural Grocers by Vitamin CottageMelatonin 5 mg Vanilla-Strawberry5 mgper 1 Melt(s)DSLD:256908
- Natural Healthy ConceptsSleep Support with Melatonin3 mgper 1 Capsule(s)DSLD:230888
- Natural NutraMelatonin 1 mg Lozenge Natural Peppermint Flavor1 mgper 1 Lozenge(s)DSLD:246993
- Natural NutraMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:246994
- Natural NutraMelatonin Plus 5 mg5 mgper 1 Tablet(s)DSLD:246995
- Nature MadeGood Sleep Gummies Dreamy Strawberry4 mgper 1 Gummy(ies)DSLD:270958
- Nature MadeMelatonin + 200 mg L-Theanine3 mgper 1 Softgel(s)DSLD:271095
- Nature MadeMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:179777
- Nature MadeMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:180147
- Nature MadeMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:180228
- Nature MadeMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:270948
- Nature MadeMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:271540
- Nature MadeMelatonin 3 mg With L-Theanine3 mgper 1 Softgel(s)DSLD:271557
- Nature MadeMelatonin 5 mg5 mgper 1 Tablet(s)DSLD:179965
- Nature MadeMelatonin 5 mg5 mgper 1 Tablet(s)DSLD:180126
- Nature MadeMelatonin 5 mg5 mgper 1 Tablet(s)DSLD:271543
- Nature MadeMelatonin Adult Gummies Strawberry2.5 mgper 1 Gummie(s)DSLD:180264
- Nature MadeMelatonin Adult Gummies Strawberry2.5 mgper 1 Gummie(s)DSLD:180288
- Nature MadeMelatonin Adult Gummies Strawberry2.5 mgper 1 Gummie(s)DSLD:180295
- Nature MadeMelatonin Adult Gummies Strawberry2.5 mgper 1 Gummie(s)DSLD:180296
- Nature MadeMelatonin Adult Gummies Strawberry2.5 mgper 1 Gummie(s)DSLD:180311
- Nature MadeMelatonin Adult Gummies Strawberry2.5 mgper 1 Gummie(s)DSLD:180337
- Nature MadeMelatonin Adult Gummies Strawberry2.5 mgper 1 Gummy(ies)DSLD:209660
- Nature MadeMelatonin Maximum Strength 5 mg5 mgper 1 Tablet(s)DSLD:209485
- Nature MadeSleep3 mgper 1 Softgel(s)DSLD:179653
- Nature Made KIDS FIRSTSleep Gummies Strawberry1 mgper 1 Gummy(ies)DSLD:259249
- Nature Made VitaMeltsSleep Chocolate Mint3 mgper 1 Tablet(s)DSLD:179774
- Nature Made VitaMeltsSleep Chocolate Mint3 mgper 1 Tablet(s)DSLD:180250
- Nature Made VitaMeltsSleep Chocolate Mint3 mgper 1 Tablet(s)DSLD:180266
- Nature's AnswerMelatonin Sleep Gummies Extra Strength 5 mg Mixed Berry Flavor5 mgper 3 Gram(s)DSLD:264258
- Nature's AnswerMelatonin+ 5 mg5 mgper 1 Capsule(s)DSLD:174765
- Nature's BlendQuick Dissolve Melatonin 5 mg5 mgper 1 Tablet(s)DSLD:274680
- Nature's BlendTimed Release Melatonin 3 mg3 mgper 1 Tablet(s)DSLD:310407
- Nature's BountyMelatonin 1 mg1 mgper 1 Tablet(s)DSLD:239805
- Nature's BountyMelatonin 10 mg10 mgper 1 Capsule(s)DSLD:253065
- Nature's BountyMelatonin 10 mg10 mgper 1 Capsule(s)DSLD:253193
- Nature's BountyMelatonin 10 mg Natural Cherry Flavor10 mgper 1 Quick Dissolve Tablet(s)DSLD:253069
- Nature's BountyMelatonin 5 mg5 mgper 1 Softgel(s)DSLD:240122
- Nature's BountyQuick Dissolve Melatonin 10 mg Natural Cherry Flavor10 mgper 1 Quick Dissolve Tablet(s)DSLD:308205
- Nature's BountySleep Gummies Tropical Punch Flavored Gummies3 mgper 2 Gummy(ies)DSLD:242541
- Nature's BountySleep Gummies Tropical Punch Flavored Gummies3 mgper 2 Gummie(s)DSLD:308207
- Nature's BountySleep Jelly Beans Mixed Berry Flavored2 mgper 1 Jelly Bean(s)DSLD:308208
- Nature's BountySleep310 mgper 1 Tablet(s)DSLD:308206
- Nature's BountyTriple Strength Melatonin 3 mgMelatonin (Form: as N-Acetyl-5-Methoxytryptamine)3 mgper 1 Tablet(s)DSLD:17393
- Nature's Bounty Optimal SolutionsGorgeous Sleep Gummies Berry Flavored5 mgper 2 Gummy(ies)DSLD:253211
- Nature's Bounty Optimal SolutionsP.M. Formula300 mcgper 1 Tablet(s)DSLD:236945
- Nature's CraftSleep Support10 mgper 2 Capsule(s)DSLD:296728
- Nature's HarmonySleep Tight Liquid Melatonin 3 mg Berry Flavour!Melatonin Note: synthetic3 mgper 1 mLDSLD:21928
- Nature's HarmonySleep Tight Melatonin 1 mgMelatonin Note: synthetic1 mgper 1 Capsule(s)DSLD:21883
- Nature's HarmonySleep Tight Melatonin 3 mgMelatonin Note: synthetic3 mgper 1 Capsule(s)DSLD:21886
- Nature's MeasureMelatonin 10 mg10 mgper 1 Tablet(s)DSLD:240097
- Nature's MeasureMelatonin 3 mg with Vitamin B-63 mgper 1 Tablet(s)DSLD:239689
- Nature's MeasureRelax & Sleep0.2 mgper 1 Tablet(s)DSLD:17076
- Nature's SunshineMelatonin Extra3 mgper 1 Capsule(s)DSLD:255365
- Nature's TroveMelatonin 1 mg Cherry Flavor1 mgper 1 Tablet(s)DSLD:229454
- Nature's TroveMelatonin 10 mg Strawberry Flavor10 mgper 1 Tablet(s)DSLD:229435
- Nature's TroveMelatonin 3 mg + L-Theanine 200 mg3 mgper 1 Capsule(s)DSLD:229374
- Nature's TroveMelatonin 3 mg Cherry Flavor3 mgper 1 Tablet(s)DSLD:229445
- Nature's TroveMelatonin 5 mg Cherry Flavor5 mgper 1 Tablet(s)DSLD:229462
- Nature's TruthExtra Strength Liquid Melatonin 10 mg Natural Berry Flavor10 mgper 1 mLDSLD:306688
- Nature's TruthExtra Strength Melatonin 10 mg Gummies Natural Berry Flavor10 mgper 2 Vegan Gummy(ies)DSLD:306691
- Nature's TruthFast Dissolve Melatonin 12 mg Natural Berry Flavor12 mgper 0.5 Fast Dissolve Tablet(s)DSLD:308423
- Nature's TruthFast Dissolve Melatonin 12 mg Natural Berry Flavor12 mgper 1 Fast Dissolve Tablet(s)DSLD:308425
- Nature's TruthFast Dissolve Melatonin 3 mg Natural Berry Flavor3 mgper 1 Fast Dissolve Tablet(s)DSLD:306698
- Nature's TruthFast Dissolve Melatonin 5 mg Natural Berry Flavor5 mgper 1 Fast Dissolving Tablet(s)DSLD:307088
- Nature's TruthJust 4 Kids Sleep Melatonin Gummies Natural Cherrylicious Flavor1 mgper 1 Vegan Gummy(ies)DSLD:306733
- Nature's TruthLow Dose Melatonin 1 mg Gummies Natural Cherry Pomegranate Flavor1 mgper 1 Vegan Gummy(ies)DSLD:306743
- Nature's TruthLow Dose Melatonin 300 mcg300 mcgper 1 Tablet(s)DSLD:306744
- Nature's TruthMelatonin 1 mg1 mgper 1 Tablet(s)DSLD:306776
- Nature's TruthMelatonin 10 mg plus L-Theanine10 mgper 1 Tablet(s)DSLD:306777
- Nature's TruthMelatonin 12 mg Gummies Natural Berry Flavor12 mgper 2 Vegan Gummy(ies)DSLD:309973
- Nature's TruthRapid Release Melatonin 10 mg Softgels10 mgper 1 Rapid Release Liquid Softgel(s)DSLD:306801
- Nature's WayMelatonin Lozenge 2.5 mg2.5 mgper 1 Lozenge(s)DSLD:213478
- Nature's WaySambucus for Kids HoneyBerry Night Time Cough Syrup0.5 mgper 1.5 Teaspoon(s)DSLD:249723
- Nature's WaySambucus Night Time Cough Syrup HoneyBerry2 mgper 15 mLDSLD:256173
- Nature's WaySambucus Night Time Cough Syrup HoneyBerry Ages 4+1 mgper 7.5 mLDSLD:304687
- Nature's WaySambucus Nighttime Syrup with Melatonin1.5 mgper 10 mLDSLD:293389
- Nature's WaySleep tonight Melatonin Lozenges 2.5 mg2.5 mgper 1 Lozenge(s)DSLD:213788
- Nature's WaySleep tonight Melatonin Lozenges 2.5 mg2.5 mgper 1 Lozenge(s)DSLD:213982
- Nature's WaySleep Well Berry Flavored5 mgper 2 Gummy(ies)DSLD:275087
- NATURELO Premium SupplementsMelatonin Gummies for Kids Strawberry Flavor1 mgper 1 Gummy(ies)DSLD:262683
- NATURELO Premium SupplementsMelatonin Gummies Strawberry Flavor7.5 mgper 3 Gummie(s)DSLD:262684
- Natures CraftKids Melatonin Gummies Passiflora Flavored1 mgper 1 Gummy(ies)DSLD:256470
- Natures CraftKids Melatonin Gummies Strawberry Flavored1 mgper 1 Gummy(ies)DSLD:296787
- Natures CraftMelatonin Gummies Strawberry Flavored5 mgper 2 Gummy(ies)DSLD:256469
- Natures MeasureRelax & Sleep200 mcgper 1 Tablet(s)DSLD:206057
- Natures NectarKeep Calm1 mgper 2 Capsule(s)DSLD:246708
- NaturesPlusMelatonin 1 mg1 mgper 1 Tablet(s)DSLD:298555
- NaturesPlusMelatonin 10 mg10 mgper 1 Tablet(s)DSLD:298558
- NaturesPlusMelatonin 20 mg20 mgper 1 Tablet(s)DSLD:298559
- NaturesPlusMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:298556
- NaturesPlusMelatonin 5 mg5 mgper 1 Tablet(s)DSLD:298557
- NaturesPlus AgeLossSleep Support6 mgper 1 Tablet(s)DSLD:252978
- NDXSleep DX5 mgper 2 Gummy(ies)DSLD:201238
- NerviveNervive Nerve Relief PM2 mgper 1 Tablet(s)DSLD:291980
- Nested NaturalsLUNA Berry Chewables4 mgper 1 Chewable Tablet(s)DSLD:286812
- Nested NaturalsLuna Gentle Sleep Aid6 mgper 1 Vegetarian Capsule(s)DSLD:221699
- Nested NaturalsLUNA Kids Tropical Berry Flavor0.2 mgper 1 Chewable Tablet(s)DSLD:286814
- Nested NaturalsLUNA with Melatonin6 mgper 1 Capsule(s)DSLD:286813
- NeubriaNeubria Drift3 mgper 1 Capsule(s)DSLD:242845
- New AgeSleep Gummies6 mgper 2 Gummy(ies)DSLD:268775
- New ChapterRestful Sleep and Pain Relief1 mgper 1 Capsule(s)DSLD:288218
- New SunCBD Restful Sleep3 mgper 1 Softgel(s)DSLD:298572
- New SunMelatonin 3 mg3 mgper 1 Capsule(s)DSLD:12379
- NewtonEverettMelatonin 10 mg10 mgper 1 Vegetarian Capsule(s)DSLD:292212
- NewtonEverettSuperFlex-PM6 mgper 2 Tablet(s)DSLD:213337
- NFHLiquid Melatonin SAP1,760 mcgper 0.5 mLDSLD:273400
- NHC Natural Healthy ConceptsLiposomal Melatonin Spray3 mgper 0.4 mLDSLD:256096
- NHC Natural Healthy ConceptsMelatonin 10 mg10 mgper 1 Tablet(s)DSLD:294105
- NHC Natural Healthy ConceptsMelatonin 3 mg3 mgper 1 Capsule(s)DSLD:256144
- NHC Natural Healthy ConceptsSleep Support with Melatonin3 mgper 1 Capsule(s)DSLD:256275
- Nobi NutritionTurmeric PM5 mgper 3 Vegetarian Capsule(s)DSLD:242506
- Nootropics DepotMelatonin Capsules 300 mcg300 mcgper 1 Capsule(s)DSLD:251109
- Nova NutritionsMelatonin 10 mg10 mgper 1 Tablet(s)DSLD:229283
- NOWMelatonin 1 mg1 mgper 1 Tablet(s)DSLD:14830
- NOWMelatonin 1 mg1 mgper 1 Tablet(s)DSLD:313768
- NOWMelatonin 20 mg20 mgper 1 Veg Capsule(s)DSLD:313769
- NOWMelatonin 3 mg3 mgper 1 Veg Capsule(s)DSLD:205917
- NOWMelatonin 3 mg3 mgper 1 Veg Capsule(s)DSLD:205923
- NOWMelatonin 5 mg5 mgper 1 Tablet(s)DSLD:313770
- NOWSleep Regimen 3-in-13 mgper 1 Veg Capsule(s)DSLD:244780
- NOW SportsR&R Rest and Repair5 mgper 3 Veg Capsule(s)DSLD:303939
- NS Natural StacksDream CBD0.5 mgper 1 Liquid Capsule(s)DSLD:213999
- NS Natural StacksDream CBD0.5 mgper 1 Liquid Capsule(s)DSLD:274234
- NS NeuroScienceAlpha GABA PM3 mgper 2 Capsule(s)DSLD:244018
- NS NeuroScienceKavie OS Chocolate Coconut Flavored Emulsion5 mgper 15 mLDSLD:244101
- NS NeuroScienceKavinace OS Capsules5 mgper 2 Capsule(s)DSLD:267640
- NS NeuroScienceKavinace OS Capsules5 mgper 2 Capsule(s)DSLD:267642
- NS NeuroScienceKavinace OS Chocolate Coconut5 mgper 15 mLDSLD:244099
- NugenixNugenix PM ZMA Testosterone Support2 mgper 4 Capsule(s)DSLD:199839
- Nugenix PMZMA Testosterone Support2 mgper 4 Capsule(s)DSLD:252285
- NutraChampsDreamrite6 mgper 2 Capsule(s)DSLD:228727
- NutraKeyMelatonin3 mgper 1 Capsule(s)DSLD:287417
- Nutri-WestTotal 5-HTP1 mgper 1 Tablet(s)DSLD:28290
- NutriCologyLiposomal Melatonin1 mgper 0.2 mLDSLD:234765
- NutriCologyMelatonin2.6 mgper 1 Capsule(s)DSLD:235277
- NutriCologyMelatonin 20 mg20 mgper 1 Capsule(s)DSLD:258641
- NutriCologyMelatonin 3 mg6 mgper 1 Tablet(s)DSLD:235290
- NutricostSleep Aid Complex3 mgper 3 Capsule(s)DSLD:224703
- Nutricost KidsMelatonin 1 mg1 mgper 1 Gummy(ies)DSLD:306354
- NUU3Deep Sleep Gummies Vanilla & Raspberry Flavor2 mgper 2 Gummy(ies)DSLD:306426
- OL Olympian LabsRest Easy1.5 mgper 2 Capsule(s)DSLD:176042
- OLLYExtra Strength Sleep Blackberry Zen5 mgper 2 Gummy(ies)DSLD:290588
- OLLYExtra Strength Sleep Blackberry Zen5 mgper 2 Gummie(s)DSLD:290589
- OLLYExtra Strength Sleep Blackberry Zen5 mgper 2 Gummie(s)DSLD:293779
- OLLYImmunity Sleep + Elderberry Midnight Berry3 mgper 2 Gummy(ies)DSLD:273622
- OLLYImmunity Sleep + Elderberry Midnight Berry3 mgper 2 Gummie(s)DSLD:290625
- OLLYKids Sleep Razzberry0.5 mgper 1 Gummy(ies)DSLD:291235
- OLLYKids Sleep Razzzberry0.5 mgper 1 Gummy(ies)DSLD:230232
- OLLYMuscle Recovery Sleep Berry Rested3 mgper 2 Gummy(ies)DSLD:256875
- OLLYRelaxing Sleep Fast Dissolve Tablets Apple Berry3 mgper 1 Tablet(s)DSLD:303971
- OLLYRestful Sleep Blackberry Zen3 mgper 2 Gummy(ies)DSLD:273643
- OLLYSleep Blackberry Zen3 mgper 2 Gummy(ies)DSLD:291265
- OLLYSleep Blackberry Zen3 mgper 2 Gummy(ies)DSLD:291266
- OLLYSleep Blackberry Zen3 mgper 2 Gummy(ies)DSLD:291267
- OLLYSleep Blackberry Zen3 mgper 2 Gummy(ies)DSLD:310256
- OLLYSleep Fast Dissolve Tablets Strawberry3 mgper 1 Tablet(s)DSLD:303972
- OLLYSleep Strawberry Sunset3 mgper 2 Gummy(ies)DSLD:291292
- OLLYUltra Sleep10 mgper 2 Softgel(s)DSLD:267697
- OLLYUltra Strength Sleep10 mgper 1 Softgel(s)DSLD:291376
- Om Mushroom SuperfoodSleep4 mgper 3 Capsule(s)DSLD:272020
- OnnitInstant Melatonin 3 mg Fresh Mint Flavor3 mgper 0.96 mLDSLD:295160
- Optimal AlphaPower Down3 mgper 0.5 mLDSLD:218319
- Ortho Molecular ProductsMelatonin1 mgper 1 Tablet(s)DSLD:174425
- Ortho Molecular ProductsMelatonin 10 mg10 mgper 1 Tablet(s)DSLD:269622
- Outwork NutritionSleep2 mgper 2 Capsule(s)DSLD:305216
- OXZGENHemp Derived CBD Sleep Support Gummies 450 mg5 mgper 1 Gummy(ies)DSLD:250938
- Patient One 1 MediNutritionalsMelatonin 3 mg Gradual ReleaseMelatonin Note: gradual release3 mgper 1 Capsule(s)DSLD:249320
- Patient One 1 MediNutritionalsMelatonin 5 mg5 mgper 1 Capsule(s)DSLD:249321
- PeptivaPeptiva + Sleep SupportMelatonin Note: immediate release0.75 mgper 1 Vegetarian Capsule(s)DSLD:241132
- PEScienceREM-30.3 mgper 1 Capsule(s)DSLD:264657
- Pharmaxa LabsSomulin3 mgper 1 Capsule(s)DSLD:306940
- Physician's ChoiceSleep Aid5 mgper 2 Veggie Capsule(s)DSLD:259674
- Physician's SealREMfreshMelatonin2 mgper 1 Caplet(s)DSLD:259596
- Physician's SealREMfresh Extra StrengthMelatonin5 mgper 1 Caplet(s)DSLD:259604
- Physician's SealREMfresh Extra StrengthMelatonin5 mgper 1 Caplet(s)DSLD:259622
- Physician's SealREMfresh LITEMelatonin0.5 mgper 1 Caplet(s)DSLD:259630
- PhytAge LabsFast Asleep 91110 mgper 2 Capsule(s)DSLD:276429
- PhytoralAdvanced Melatonin Gummies Strawberry Flavored5 mgper 2 Gummy(ies)DSLD:277149
- PhytoralMelatonin Gummies Strawberry Flavored1 mgper 1 Gummy(ies)DSLD:277162
- Premier Research LabsMelatonin-NDFermented in a probiotic culture which is inactivated after fermentation; preserved with organic cane (non-GMO) alcohol.8 mgper 1 mLDSLD:269091
- Premium CertifiedCalmMD Night2.5 mgper 1 Capsule(s)DSLD:248570
- Premium CertifiedInsomniaMD Premium6 mgper 2 Capsule(s)DSLD:248664
- Premium CertifiedMenoMD Night2.5 mgper 1 Capsule(s)DSLD:248687
- Primal LabsSleep Refined4 mgper 1 Bi-Layer Tablet(s)DSLD:200990
- Primal PharmSLEEP10 mgper 2 Vegetable Capsule(s)DSLD:276419
- PrimeMelatonin Plus10 mgper 1 Capsule(s)DSLD:313430
- Princess LifestyleZizzz3 mgper 2 Capsule(s)DSLD:240509
- Priority One Nutritional SupplementsMelatonin3 mgper 1 Capsule(s)DSLD:236813
- ProEnzolRest2 mgper 2 Vegetarian Capsule(s)DSLD:221705
- Progressive Professional from Progressive LaboratoriesMelatonin3 mgper 1 Capsule(s)DSLD:299199
- Progressive Professional from Progressive LaboratoriesMelatonin 20 mg20 mgper 1 Vegetable Capsule(s)DSLD:261971
- Progressive Professional from Progressive LaboratoriesMelatonin 20 mg20 mgper 1 Vegetable Capsule(s)DSLD:299200
- Progressive Professional from Progressive LaboratoriesTwilight Time5 mgper 1 Capsule(s)DSLD:263260
- Progressive Professional from Progressive LaboratoriesVisio Plex3 mgper 8 Capsule(s)DSLD:263281
- ProperSleep + Restore3 mgper 2 Capsule(s)DSLD:239932
- Pure EncapsulationsBest-Rest Formula1 mgper 2 Capsule(s)DSLD:184359
- Pure EncapsulationsBest-Rest Formula1 mgper 2 Capsule(s)DSLD:293903
- Pure EncapsulationsBest-Rest Gummy Natural Raspberry-Tea FlavorMelatonin · microactive melatonin sustained-release complex0.5 mgper 1 Gummy(ies)DSLD:293904
- Pure EncapsulationsDaily Pure Pack Healthy Sleep1 mgper 3 Capsule(s)DSLD:293951
- Pure EncapsulationsMelatonin 0.5 mg0.5 mgper 1 Capsule(s)DSLD:294020
- Pure EncapsulationsMelatonin 0.5 mg0.5 mgper 1 Capsule(s)DSLD:295530
- Pure EncapsulationsMelatonin 20 mg20 mgper 1 Capsule(s)DSLD:184638
- Pure EncapsulationsMelatonin 20 mg20 mgper 1 Capsule(s)DSLD:294021
- Pure EncapsulationsMelatonin 3 mg3 mgper 1 Capsule(s)DSLD:185032
- Pure EncapsulationsMelatonin 3 mg3 mgper 1 Capsule(s)DSLD:294022
- Pure EncapsulationsMelatonin 3 mg3 mgper 1 Capsule(s)DSLD:299063
- Pure EncapsulationsMelatonin Liquid2.5 mgper 1 mLDSLD:294023
- Pure EncapsulationsMelatonin-SRMelatonin · Melatonin (Alt. Name: MicroActive Melatonin) Note: sustained-release complex3 mgper 1 Capsule(s)DSLD:277770
- Pure EncapsulationsMelatonin-SRMicroActive melatonin sustained-release complex3 mgper 1 Capsule(s)DSLD:299064
- Pure EncapsulationsSleep Solution (Single Dose Liquid)2 mgper 58 mLDSLD:294056
- Pure EncapsulationsSleep Solution (Single Dose Liquid) Raspberry-Lemonade Flavor2 mgper 1.96 fl. Oz.DSLD:184885
- Purely Inspired EssentialsSleep5 mgper 1 Caplet(s)DSLD:264552
- Puritan's PrideBi-Layered Melatonin5 mgper 1 Tablet(s)DSLD:286410
- Puritan's PrideHemp + Sleep5 mgper 1 Softgel(s)DSLD:286201
- Puritan's PrideMelatonin 10 mg10 mgper 1 Capsule(s)DSLD:286131
- Puritan's PrideMelatonin 12 mg12 mgper 1 Capsule(s)DSLD:286130
- Puritan's PrideMelatonin 2.5 mg Natural Strawberry Flavor2.5 mgper 1 Gummy(ies)DSLD:286127
- Puritan's PrideMelatonin 3 mgMelatonin (Form: as N-Acetyl-5-Methoxytryptamine)3 mgper 1 Tablet(s)DSLD:242416
- Puritan's PrideMelatonin 300 mcg300 mcgper 1 Tablet(s)DSLD:286129
- Puritan's PrideMelatonin 5 mg5 mgper 1 Tablet(s)DSLD:286128
- Puritan's PrideNighttime Circuleg3 mgper 1 Capsule(s)DSLD:286101
- Puritan's PrideQuick Dissolve Melatonin 10 mg Natural Cherry Flavor10 mgper 1 Tablet(s)DSLD:286010
- Puritan's PrideQuick Dissolve Melatonin 10 mg Natural Cherry Flavor10 mgper 1 Tablet(s)DSLD:286011
- Puritan's PrideSleep Complex Gummies Tropical Punch Flavored3 mgper 2 Gummy(ies)DSLD:285299
- Puritan's PrideSleep Gummies Strawberry Flavored7 mgper 2 Gummie(s)DSLD:285658
- Puritan's PrideSuper Snooze with Melatonin5 mgper 1 Capsule(s)DSLD:285655
- Puritan's PrideTart Cherry Extract + Melatonin & Herbal Relaxation Blend1 mgper 2 Capsule(s)DSLD:285654
- Puritan's PrideTri-Layer Sleep10 mgper 1 Tablet(s)DSLD:285648
- Puritan's Pride PremiumMelatonin Liquid 10 mg Natural Black Cherry Flavor10 mgper 0.5 mLDSLD:286126
- Puritan's Pride PremiumSuper Strength Melatonin 10 mg10 mgper 1 Capsule(s)DSLD:207659
- Puritan's Pride PremiumSuper Strength Melatonin 10 mg10 mgper 1 Capsule(s)DSLD:250826
- Purity ProductsNiteVites1 mgper 3 Tablet(s)DSLD:243871
- Purity ProductsNiteVites Extra Strength3 mgper 3 Tablet(s)DSLD:243904
- Purity ProductsSlumberMelt Delicious Blueberry Flavor2 mgper 1 Tablet(s)DSLD:244181
- Quality Of LifeMelatonin-SRMelatonin5 mgper 1 Vegicap(s)DSLD:299345
- Quality Of LifeRestwelleMelatonin2 mgper 1 Vegicap(s)DSLD:299347
- Quantum Nutrition LabsQultured Melatonin DropsFermented in a probiotic culture which is inactivated after fermentation; preserved with organic cane (non-GMO) alcohol.8 mgper 1 mLDSLD:302378
- Quicksilver ScientificCBD Synergies-SP0.25 mgper 2 mLDSLD:222757
- Quicksilver ScientificCBD Synergies-SP0.25 mgper 2 mLDSLD:247914
- Quicksilver ScientificLiposomal Melatonin4 mgper 0.2 mLDSLD:248530
- Quicksilver ScientificLiposomal Melatonin1 mgper 0.2 mLDSLD:248535
- QunolSleep Gummies Berry Flavor5 mgper 2 Gummie(s)DSLD:304328
- Rapid FireSleep Herbal Tea Shot Cherry Berry2.5 mgper 50 mLDSLD:232509
- RapidCBDSleep Caps3 mgper 1 Capsule(s)DSLD:219659
- RapidCBDSleep Caps5 mgper 1 Capsule(s)DSLD:276159
- RapidCBDSleep Shot Dreamberry1 mgper 1.93 fl. Oz.DSLD:247258
- RebalanceDream Catcher2.5 mgper 1 Lozenge(s)DSLD:271799
- Redcon1Fade Out Grape5 mgper 11 Gram(s)DSLD:237102
- Rejuvica HealthMelatonin3 mgper 1.23 mLDSLD:259460
- Rejuvica HealthNoctuRest3 mgper 1.23 mLDSLD:259300
- Rejuvica Health Healthy EssentialsMelatonin3 mgper 1.23 mLDSLD:240918
- RelaxiumSleep5 mgper 2 Capsule(s)DSLD:310269
- REMfreshREMfreshMelatonin2 mgper 1 Caplet(s)DSLD:287202
- REMfreshREMfreshMelatonin2 mgper 1 Caplet(s)DSLD:289153
- REMfreshREMfreshMelatonin2 mgper 1 Caplet(s)DSLD:289154
- REMfreshREMfreshMelatonin2 mgper 1 Caplet(s)DSLD:289155
- REMfreshREMfresh Extra StrengthMelatonin5 mgper 1 Caplet(s)DSLD:287203
- REMfreshREMfresh Extra StrengthMelatonin5 mgper 1 Caplet(s)DSLD:289157
- REMfreshREMfresh Extra StrengthMelatonin5 mgper 1 Caplet(s)DSLD:289158
- REMfreshREMfresh Extra Strength Advanced Ion-Powered MelatoninMelatonin5 mgper 1 Caplet(s)DSLD:289156
- REMfreshREMfresh LiteMelatonin0.5 mgper 1 Caplet(s)DSLD:287204
- REMfreshREMfresh Max StrengthMelatonin10 mgper 1 Caplet(s)DSLD:287205
- REMfreshREMfresh Max StrengthMelatonin10 mgper 1 Caplet(s)DSLD:288649
- Reset/360Sleep Tight3 mgper 1 Tablet(s)DSLD:249343
- REVSCIRegains Max Muscle Mango500 mcgper 10.5 Gram(s)DSLD:288809
- RexallMelatonin 10 mg10 mgper 1 Capsule(s)DSLD:239514
- RexallMelatonin 5 mg5 mgper 1 Tablet(s)DSLD:26194
- RexallTime Released Melatonin 5 mg5 mgper 1 Tablet(s)DSLD:207116
- Rise-N-ShineMelatonin Gummy Vitamins for Adults2.5 mgper 1 Gummy(ies)DSLD:297114
- Rite Aid PharmacyMelatonin 1 mg Cherry1 mgper 1 Tablet(s)DSLD:210094
- RoexLights Out3 mgper 1 Capsule(s)DSLD:211513
- RugbyMelatonin 1 mg1 mgper 1 Tablet(s)DSLD:201259
- RugbyMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:200467
- RugbyMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:28376
- RugbyMelatonin 5 mg5 mgper 1 Tablet(s)DSLD:201125
- RugbyMelatonin 5 mg5 mgper 1 Tablet(s)DSLD:201260
- RunFit NutritionRunner's Sleep Recovery5 mgper 2 Capsule(s)DSLD:286063
- SafrelMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:263935
- SafrelMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:263936
- SANMelatonin5 mgper 1 Capsule(s)DSLD:175451
- Seeking HealthMelatonin 5 mg5 mgper 1 Lozenge(s)DSLD:174529
- SeniorLife HealthSleep All Nite Naturals1 mgper 1 Capsule(s)DSLD:2176
- SeniorLife HealthSleep Support Formula2 mgper 1 Vegetable Capsule(s)DSLD:256616
- Sheer Strength LabsGood Night Extra Strength Sleep Aid1 mgper 2 Capsule(s)DSLD:261293
- Sheer Strength LabsSheer Shred PM3 mgper 2 Capsule(s)DSLD:219472
- Simple TruthMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:206868
- Sleep DropsPeaceful Sleep Grape Flavor2 mgper 5 Gram(s)DSLD:260201
- Sleep SoundlyBeauty Sleep Gummies Berry Flavor5 mgper 2 Gummy(ies)DSLD:302452
- Sleep SoundlyMelamint Melatonin 5 mg Cool Mint Tablets5 mgper 1 Melt(s)DSLD:180650
- Sleep SoundlyMelatonin 10 mg10 mgper 1 Tablet(s)DSLD:231833
- Sleep SoundlyMelatonin with Magnesium 5 mg Berry Flavor5 mgper 1 Gummy(ies)DSLD:259735
- Sleep SoundlySnooze & Lose5 mgper 1 Capsule(s)DSLD:302453
- Smarter NutritionSleep4.5 mgper 2 Chewable Tablet(s)DSLD:276240
- SmartyPantsHealthy Immunity Nighttime Elderberry Flavor2 mgper 2 Gummie(s)DSLD:251376
- SmartyPantsHealthy Immunity Nighttime Elderberry Flavor2 mgper 2 Gummie(s)DSLD:251377
- SmartyPantsRelax & Sleep Wild Cherry Flavor3 mgper 2 Gummy(ies)DSLD:306752
- SmartyPants FunctionalAdult Sleep3 mgper 2 Gummie(s)DSLD:256079
- SmartyPants FunctionalAdult Sleep3 mgper 2 Gummie(s)DSLD:256103
- SolarayExtra-Strength ibuActin PM3 mgper 3 VegCap(s)DSLD:255690
- SolgarFull Spectrum Curcumin Sleep Ease5 mgper 1 Softgel(s)DSLD:222791
- SolgarFull Spectrum Curcumin Sleep Ease5 mgper 2 Capsule(s)DSLD:242477
- SolgarLiquid Melatonin 10 mg Natural Black Cherry FlavorMelatonin (Form: as N-Acetyl-5-Methoxytryptamine)10 mgper 0.5 mLDSLD:216981
- SolgarMelatonin 5 mg5 mgper 1 Vegetarian Tablet(s)DSLD:218548
- SolgarTriple Action Sleep10 mgper 1 Tablet(s)DSLD:242482
- SolgarTriple Action Sleep10 mgper 1 Tablet(s)DSLD:242488
- SolimoMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:239571
- SolubiomixHypnosom Tablets2 mgper 1 Tablet(s)DSLD:264221
- Source NaturalsMelatonin 1 mg3 mgper 1 Tablet(s)DSLD:26952
- Source NaturalsMelatonin 1 mg3 mgper 1 Tablet(s)DSLD:296056
- Source NaturalsMelatonin 2.5 mg Orange Flavor2.5 mgper 1 Lozenge(s)DSLD:296062
- Source NaturalsMelatonin 2.5 mg Peppermint Flavor2.5 mgper 1 Lozenge(s)DSLD:296065
- Source NaturalsMelatonin 3 mg Timed Release3 mgper 0.5 Tablet(s)DSLD:296070
- Source NaturalsMelatonin 3.0 mg3 mgper 1 Tablet(s)DSLD:275050
- Source NaturalsMelatonin 5 mg5 mgper 0.5 Tablet(s)DSLD:296071
- Source NaturalsMelatonin 5 mg Orange Flavored Sublingual5 mgper 0.5 Tablet(s)DSLD:296072
- Source NaturalsMelatonin Timed Release 3 mg3 mgper 1 Tablet(s)DSLD:296067
- Source NaturalsMelatonin Timed Release 3 mg3 mgper 0.5 Tablet(s)DSLD:296068
- Source NaturalsNightRest with Melatonin5 mgper 1 Tablet(s)DSLD:296105
- Source NaturalsNightRest With Melatonin5 mgper 1 Tablet(s)DSLD:296104
- Source NaturalsNightWell1.5 mgper 10 mLDSLD:296106
- Source NaturalsNightWell for Immune Wellness & Restful Sleep with Melatonin1.5 mgper 2 tspDSLD:182369
- Source NaturalsVegan True Melatonin 2.5 mg Orange Flavored 2.5 mgper 1 Lozenge(s)DSLD:275457
- Source NaturalsVegan True Melatonin 3 mg3 mgper 1 Capsule(s)DSLD:296339
- Source Naturals Sleep ScienceMelatonin 1.0 mg1 mgper 1 Tablet(s)DSLD:275312
- Source Naturals Sleep ScienceMelatonin 1.0 mg Orange Flavor1 mgper 1 Lozenge(s)DSLD:272867
- Source Naturals Sleep ScienceMelatonin 1.0 mg Orange Flavor1 mgper 1 Lozenge(s)DSLD:275453
- Source Naturals Sleep ScienceMelatonin 1.0 mg Orange Flavor1 mgper 1 Lozenge(s)DSLD:296058
- Source Naturals Sleep ScienceMelatonin 1.0 mg Peppermint Flavor1 mgper 1 Lozenge(s)DSLD:272871
- Source Naturals Sleep ScienceMelatonin 1.0 mg Peppermint Flavor1 mgper 1 Lozenge(s)DSLD:275628
- Source Naturals Sleep ScienceMelatonin 2.0 mg2 mgper 1 Tablet(s)DSLD:275054
- Source Naturals Sleep ScienceMelatonin 2.5 mg Orange Flavor2.5 mgper 1 Lozenge(s)DSLD:275052
- Source Naturals Sleep ScienceMelatonin 2.5 mg Orange Flavor2.5 mgper 1 Lozenge(s)DSLD:296063
- Source Naturals Sleep ScienceMelatonin 2.5 mg Peppermint Flavor2.5 mgper 1 Lozenge(s)DSLD:275222
- Source Naturals Sleep ScienceMelatonin 2.5 mg Peppermint Flavor2.5 mgper 1 Lozenge(s)DSLD:275629
- Source Naturals Sleep ScienceMelatonin 5.0 mg5 mgper 1 Tablet(s)DSLD:272828
- Source Naturals Sleep ScienceMelatonin 5.0 mg Orange Flavor5 mgper 1 Lozenge(s)DSLD:296074
- Source Naturals Sleep ScienceMelatonin 5.0 mg Peppermint Flavor5 mgper 1 Lozenge(s)DSLD:275239
- Source Naturals Sleep ScienceMelatonin 5.0 mg Peppermint Flavor5 mgper 1 Lozenge(s)DSLD:296073
- Source Naturals Sleep ScienceMelatonin Complex 3.0 mg Orange Flavor3 mgper 1 Lozenge(s)DSLD:296075
- Source Naturals Sleep ScienceMelatonin Complex 3.0 mg Peppermint Flavor3 mgper 1 Lozenge(s)DSLD:296076
- Source Naturals Sleep ScienceMelatonin Complex 3.0 mg Peppermint Flavor3 mgper 1 Lozenge(s)DSLD:296077
- Source Naturals Sleep ScienceMelatonin Liquid 1.0 mg Orange Flavor1 mgper 1 mLDSLD:272330
- Source Naturals Sleep ScienceMelatonin Liquid 1.0 mg Orange Flavor1 mgper 1 mLDSLD:296078
- Source Naturals Sleep ScienceMelatonin Peppermint Flavor 5.0 mg5 mgper 1 Lozenge(s)DSLD:208445
- Spray For LifeFast Acting Melatonin Spearmint & Lemon Flavor1.5 mgper 0.042 mLDSLD:176283
- Spring ValleyAdult Gummy Melatonin 5 mg Natural Strawberry Flavor5 mgper 2 Gummy(ies)DSLD:178273
- Spring ValleyAdult Gummy Melatonin 5 mg Natural Strawberry Flavor5 mgper 2 Gummy(ies)DSLD:211422
- Spring ValleyFast Acting Liquid Melatonin 5 mg Natural Citrus Flavor5 mgper 1 TbspDSLD:178688
- Spring ValleyFast-Dissolve Melatonin 3 mg Artificial Strawberry Flavor3 mgper 1 Fast Dissolve Tablet(s)DSLD:211439
- Spring ValleyLiquid Melatonin 1 mg1 mgper 1 mLDSLD:271605
- Spring ValleyMelatonin 1 mg1 mgper 1 Tablet(s)DSLD:211171
- Spring ValleyMelatonin 10 mg10 mgper 1 Tablet(s)DSLD:239815
- Spring ValleyMelatonin 10 mg10 mgper 1 Tablet(s)DSLD:271339
- Spring ValleyMelatonin 5 mg5 mgper 1 Tablet(s)DSLD:12210
- Spring ValleySleep Aid Formula10 mgper 1 Vegetarian Capsule(s)DSLD:271342
- Sterling HealthPremium Melatonin10 mgper 1 Tablet(s)DSLD:249460
- StressballsDe-Stress + Snooze2 mgper 2 Gummy(ies)DSLD:278094
- StressballsDe-Stress+Snooze2 mgper 2 Gummy(ies)DSLD:278087
- StressballsNight Calming Blackberry2 mgper 1 Gummy(ies)DSLD:277456
- Sundance VitaminsUltra Melatonin 5 mg Natural Berry Flavor5 mgper 1 Fast Dissolve Tablet(s)DSLD:277579
- SundownDissolvable Melatonin 5 mg Cherry Flavored5 mgper 1 Microlozenge(s)DSLD:212400
- SundownLiquid Melatonin Cherry Flavored1 mgper 1 mLDSLD:308044
- SundownMelatonin 10 mg10 mgper 1 Capsule(s)DSLD:212077
- SundownMelatonin 10 mg10 mgper 1 Capsule(s)DSLD:308046
- SundownMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:212175
- SundownMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:212355
- SundownMelatonin 300 mcg300 mcgper 1 Tablet(s)DSLD:212381
- SundownMelatonin 5 mg5 mgper 1 Tablet(s)DSLD:212307
- SundownMelatonin Gummies 5 mg Strawberry Flavored5 mgper 2 Gummie(s)DSLD:212086
- SundownMelatonin Gummies 5 mg Strawberry Flavored5 mgper 2 Gummy(ies)DSLD:308047
- Sundown NaturalsMelatonin 3 mgMelatonin (Form: as N-Acetyl-5-Methoxytryptamine)3 mgper 1 Tablet(s)DSLD:30617
- Sundown NaturalsSuper Snooze Melatonin5 mgper 1 Capsule(s)DSLD:175328
- Sundown NaturalsSuper Snooze Melatonin Formula5 mgper 1 Capsule(s)DSLD:30017
- Sundown NaturalsSuper Snooze Melatonin with Herbal Blend5 mgper 1 Capsule(s)DSLD:205462
- Sunshine NaturalsMelatonin 3000 mcg with Vitamin B-63,000 mcgper 1 Tablet(s)DSLD:271293
- Superior SourceSuper Slumber Helper5 mgper 1 MicroLingual(R) Tablet(s)DSLD:212739
- SuperiorLabsMelatonin Complex5 mgper 1 Vegetarian Capsule(s)DSLD:227942
- Supplement SpotMelatonin 3 mg3 mgper 1 Chewable Tablet(s)DSLD:264636
- Supplement SpotMelatonin Gummies Strawberry Flavored5 mgper 2 Gummy(ies)DSLD:264637
- Supplement SpotSleep Well2 mgper 1 Vegetable Capsule(s)DSLD:264652
- Swanson5-HTP & Melatonin3 mgper 1 Veggie Capsule(s)DSLD:308442
- SwansonMelatonin 1 mg1 mgper 1 Capsule(s)DSLD:308669
- SwansonMelatonin 3 mg3 mgper 1 Capsule(s)DSLD:203897
- SwansonSleep Essentials3 mgper 1 Veggie Capsule(s)DSLD:188647
- SwansonTriple Strength Melatonin 10 mg10 mgper 1 Capsule(s)DSLD:308793
- Systemic Formulas Bio ChallengeDREM Sleep Aid0.5 mgper 1 Capsule(s)DSLD:22162
- Terra OriginSleep5 mgper 1 Capsule(s)DSLD:248031
- Terry NaturallyCuramin PM5 mgper 1 Capsule(s)DSLD:176694
- Terry NaturallyCuramin PM5 mgper 1 Capsule(s)DSLD:176700
- Terry NaturallyCuramin PM5 mgper 1 Capsule(s)DSLD:301356
- The Genius BrandGenius Sleep Aid0.5 mgper 2 Veggie Capsule(s)DSLD:263240
- The Vitamin ShoppeMelatonin 10 mg10 mgper 1 Tablet(s)DSLD:207872
- The Vitamin ShoppeMelatonin 10 mg10 mgper 1 Tablet(s)DSLD:277620
- The Vitamin ShoppeMelatonin 3 mg3 mgper 1 Capsule(s)DSLD:180669
- The Vitamin ShoppeMelatonin 3 mg3 mgper 1 Capsule(s)DSLD:180721
- The Vitamin ShoppeMelatonin 3 mg3 mgper 1 Capsule(s)DSLD:180723
- The Vitamin ShoppeMelatonin 5 mg5 mgper 1 Tablet(s)DSLD:180947
- The Vitamin ShoppeSleep Support2 mgper 2 Capsule(s)DSLD:204019
- The Vitamin ShoppeSnooze-In with Melatonin3 mgper 1 Capsule(s)DSLD:204082
- The Vitamin ShoppeSnooze-In with Melatonin3 mgper 1 Capsule(s)DSLD:204090
- ThorneMelaton-33 mgper 1 Capsule(s)DSLD:298036
- ThrivousSerenity Nightly Nootropic5 mgper 2 Capsule(s)DSLD:277319
- Thymely SolutionsMelatonin 3 mg3 mgper 1 mLDSLD:211858
- Thymely SolutionsSleepstandardized Melatonin2.5 mgper 1 Veggie Cap(s)DSLD:211832
- Tishcon Corp.Sleep WellMelatonin1.5 mgper 1 Vege Capsule(s)DSLD:243422
- Tishcon Corp.Sleep WellMelatonin1.5 mgper 1 Vege Capsule(s)DSLD:243455
- tnvitaminsSuper Snooze with Melatonin5 mgper 1 Capsule(s)DSLD:217457
- Totally ProductsSkinny Sleep1 mgper 1 Vegetable Capsule(s)DSLD:294212
- Totally ProductsSleep Eazy2 mgper 1 Vegetable Capsule(s)DSLD:294258
- Trader Joe'sChewable Melatonin 3 mg Peppermint Flavor3 mgper 1 Tablet(s)DSLD:240156
- Ultimate NutritionREM Zone2 mgper 1 Capsule(s)DSLD:293467
- Ultimate Nutrition Platinum SeriesMelatonin 3 mg3 mgper 1 Capsule(s)DSLD:293466
- Ultra6 NutritionUltra Sleep2 mgper 1 mLDSLD:270739
- up&upMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:19984
- up&upMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:277427
- up&upMelatonin 5 mg5 mgper 1 Tablet(s)DSLD:19985
- Upstate Elevator Supply CoDeep Dreams CBD Gummies 10 mg Mixed Fruit5 mgper 1 Gummy(ies)DSLD:283500
- Upstate Elevator Supply CoDeep Dreams CBD Gummies 10 mg Mixed Fruit5 mgper 1 Gummy(ies)DSLD:288652
- ValiSleep Well3 mgper 2 Vegetarian Capsule(s)DSLD:284133
- VerVitaReGenerZyme Heart10 mcgper 3 Tablet(s)DSLD:207060
- VicksPure Zzzs Kidz Melatonin + Chamomile & Lavender Natural Berry Flavor1 mgper 1 Gummy(ies)DSLD:277454
- Vicks ZzzQuilPure Zzzs Sleep + Muscle Relaxation2 mgper 1 Gummie(s)DSLD:291992
- Vicks ZzzQuil Pure ZzzsDe-Stress & Sleep Blackberry Vanilla Flavored2 mgper 1 Gummie(s)DSLD:277457
- Village VitalityMelatonin 3 mg3 mgper 1 mLDSLD:216072
- Village VitalitySleep with Valerian & Melatonin3 mgper 1 mLDSLD:216778
- Village VitalitySleep with Valerian & Melatoninstandardized Melatonin3 mgper 1 Veggie Cap(s)DSLD:216782
- Village VitalitySleep with Valerian & Melatonin3 mgper 1 Veggie Cap(s)DSLD:216783
- ViMultiRestful Sleep2 mgper 2 Vegetarian Capsule(s)DSLD:231025
- VincoMelatonin 10 mg10 mgper 1 Capsule(s)DSLD:258797
- VincoNight Calm with Melatonin Citrus Flavor8 mgper 1 mLDSLD:258865
- Vita LogicMelanite3 mgper 1 Vegetarian Capsule(s)DSLD:248240
- VitaDropsMeltatonin 5 mg Gummies Strawberry Flavor5 mgper 2 Gummy(ies)DSLD:260191
- vitafusionBeauty Sleep Natural Berry Flavor5 mgper 2 Gummy Supplement(s)DSLD:241493
- vitafusionBeauty Sleep Natural Berry Flavor5 mgper 2 Gummy Supplement(s)DSLD:246232
- vitafusionMelatonin 10 mg Strawberry10 mgper 2 Gummy(ies)DSLD:246281
- vitafusionMelatonin 3 mg Sugar Free3 mgper 2 Gummy(ies)DSLD:267359
- vitafusionMelatonin 3 mg Sugar Free3 mgper 2 Gummy(ies)DSLD:267363
- vitafusionMelatonin Extra Strength 5 mg Natural Blackberry Flavor5 mgper 2 Gummy Supplement(s)DSLD:267297
- vitafusionMelatonin Max Strength 10 mg Natural Strawberry Flavor10 mgper 2 Gummy(ies)DSLD:267349
- vitafusionMelatonin Max Strength 10 mg Natural Strawberry Flavor10 mgper 2 Gummy(ies)DSLD:286393
- vitafusionMelatonin Sugarfree3 mgper 2 Gummy(ies)DSLD:271754
- vitafusionSleepWell3 mgper 2 Gummy(ies)DSLD:241585
- vitafusionSleepWell Melatonin 3 mg3 mgper 2 Gummy(ies)DSLD:286334
- vitafusion KidsMelatonin 1.5 mg Natural Tropical Peach Flavor1.5 mgper 1 Gummy(ies)DSLD:271645
- Vital NutrientsMelatonin 10 mg10 mgper 1 Vegetarian Capsule(s)DSLD:305093
- Vital NutrientsMelatonin 20 mg20 mgper 1 Vegetarian Capsule(s)DSLD:305094
- Vital NutrientsMelatonin 3 mg6 mgper 1 Vegetarian Capsule(s)DSLD:305095
- Vital NutrientsSleep Aide0.75 mgper 1 Vegetarian Capsule(s)DSLD:305162
- Vital ProteinsBlueberry Moon Milk Collagen Latte1 mgper 32 Gram(s)DSLD:302828
- VitalBulkMelatonin 3 mg3 mgper 1 Tablet(s)DSLD:258745
- VitalBulkSleep with Valerian & Melatonin3 mgper 1 mLDSLD:209168
- VitamaticMelatonin 20 mg Fast Dissolve Natural Berry Flavor20 mgper 0.5 Fast Dissolve Tablet(s)DSLD:283036
- VitamaticMelatonin 20 mg Fast Dissolve Natural Berry Flavor20 mgper 0.5 Fast Dissolve Tablet(s)DSLD:283038
- VitamaticMelatonin 30 mg Fast Dissolve Natural Berry Flavor30 mgper 0.5 Fast Dissolve Tablet(s)DSLD:283039
- VitamaticMelatonin 60 mg Natural Berry Flavor60 mgper 0.5 Fast Dissolve Tablet(s)DSLD:283040
- VitamaticMelatonin Gummies 10 mg Natural Blackberry Flavor10 mgper 2 Gummie(s)DSLD:283041
- VitamaticMelatonin Gummies 20 mg Natural Blackberry Flavor20 mgper 2 Gummy(ies)DSLD:283042
- VitamaticMelatonin Gummies 5 mg Natural Blackberry Flavor5 mgper 2 Gummie(s)DSLD:283043
- Vitamin WorldChewable Melatonin 3 mgMelatonin (Form: as N-Acetyl-5-Methoxytryptamine)9 mgper 1 Tablet(s)DSLD:20329
- Vitamin WorldExtra Strength Melatonin 5 mg5 mgper 1 Softgel(s)DSLD:20324
- Vitamin WorldExtra Strength Melatonin 5 mg5 mgper 1 Tablet(s)DSLD:20914
- Vitamin WorldLow Dose Melatonin 200 mcg200 mcgper 1 Tablet(s)DSLD:20908
- Vitamin WorldMelatonin 1 mgMelatonin (Form: as N-Acetyl-5-Methoxytryptamine)1 mgper 1 Tablet(s)DSLD:1202
- Vitamin WorldMelatonin 3 mgMelatonin (Form: as N-Acetyl-5-Methoxytryptamine)3 mgper 1 Tablet(s)DSLD:1741
- Vitamin WorldMelatonin 3 mgMelatonin (Form: as N-Acetyl-5-Methoxytryptamine)3 mgper 1 Tablet(s)DSLD:20695
- Vitamin WorldMelatonin With St. John's Wort3 mgper 3 Capsule(s)DSLD:20340
- Vitamin WorldSuper Strength Melatonin 10 mg10 mgper 1 Capsule(s)DSLD:1499
- Vitamins DirectTranquell1.5 mgper 2 Caplet(s)DSLD:28997
- VitaMistSleep GVM Raspberry Orange Flavor0.5 mgper 0.47 mLDSLD:271886
- VitanicaSleepBlend1 mgper 1 Capsule(s)DSLD:302811
- Viva NaturalsKids Sleep Gummies1 mgper 1 Gummy(ies)DSLD:273134
- Viva VitaminsMelatonin 1.5 mg1.5 mgper 1 Tablet(s)DSLD:238786
- Walgreens EssentialsQuick Dissolve Melatonin 3 mg Cherry Flavor3 mgper 1 Tablet(s)DSLD:274218
- Warp WellnessDream Goddess10 mgper 2 Capsule(s)DSLD:310090
- Well At WalgreensQuick Dissolve Melatonin 3 mg Cherry Flavor3 mgper 1 Tablet(s)DSLD:207327
- WellthySleep8 mgper 2 Capsule(s)DSLD:276531
- WellyRest Gently5 mgper 2 Softgel(s)DSLD:286771
- WholeHealthMelatonin 3 mg3 mgper 1 Lozenge(s)DSLD:309837
- Wholly LiquidMelatonin3 mgper 2 Spray(s)DSLD:272110
- Windmill Natural VitaminsMelatonin 1 mg1 mgper 1 Tablet(s)DSLD:299525
- Windmill Natural VitaminsMelatonin 5 mg5 mgper 1 Tablet(s)DSLD:299527
- Windmill Natural VitaminsTranquil PM10 mgper 1 Tablet(s)DSLD:260251
- WockleanPurple Syrup10 mgper 30 mLDSLD:273959
- Wonder LaboratoriesMelatonin 3 mg3 mgper 1 Vegetable Tablet(s)DSLD:215481
- Wonder LaboratoriesMelatonin 3 mg3 mgper 1 Vegetable Tablet(s)DSLD:263440
- Wonder LaboratoriesMelatonin 3 mg3 mgper 1 Vegetable Tablet(s)DSLD:263441
- Wonder LaboratoriesMelatonin 3 mg3 mgper 1 Vegetable Tablet(s)DSLD:263442
- Wonder LaboratoriesMelatonin 5 mg5 mgper 1 Softgel(s)DSLD:263612
- Wonder LaboratoriesMelatonin Sublingual 2.5 mg (2,500 mcg) Fruit Flavored2.5 mgper 1 Tablet(s)DSLD:215450
- Wonder LaboratoriesMelatonin Sublingual 2.5 mg (2,500 mcg) Fruit Flavored2.5 mgper 1 Tablet(s)DSLD:262082
- Wonder LabsKids Melatonin with Vitamin C1 mgper 1 Chewable Tablet(s)DSLD:260956
- Woodstock VitaminsMelatonin 1 mg Lozenge Peppermint Flavor1 mgper 1 Chewable Lozenge(s)DSLD:310271
- Woodstock VitaminsMelatonin 10 mg10 mgper 1 Tablet(s)DSLD:263480
- Woodstock VitaminsMelatonin 10 mg10 mgper 1 Tablet(s)DSLD:310272
- Woodstock VitaminsMelatonin 3 mg Peppermint Flavor3 mgper 1 Quick-Dissolve Tablet(s)DSLD:310274
- Woodstock VitaminsMelatonin Plus 5 mg5 mgper 1 Tablet(s)DSLD:263093
- Woodstock VitaminsMelatonin Plus 5 mg5 mgper 1 Tablet(s)DSLD:310275
- Woodstock VitaminsSleep-Ease CR5 mgper 1 Tablet(s)DSLD:216703
- XYMOGENMelatonin CR5 mgper 1 Tablet(s)DSLD:294757
- XYMOGENMelatonin Peppermint Flavor3 mgper 1 Quick Dissolve Tablet(s)DSLD:303748
- XYMOGENMelatonin Peppermint Flavor3 mgper 1 Quick Dissolve Tablet(s)DSLD:303749
- Young Living Essential OilsImmuPro4.2 mgper 1 Tablet(s)DSLD:273853
- youtheorySleep1 mgper 4.34 Gram(s)DSLD:257015
- youtheorySleep Nighttime Powder0.3 mgper 5.73 Gram(s)DSLD:271978
- youtheorySleep Nighttime Powder0.3 mgper 5.73 Gram(s)DSLD:272057
- Zarbee'sChildren's Sleep Chewable Tablet with Melatonin Natural Grape Flavor2 mgper 1 Tablet(s)DSLD:288603
- Zarbee'sChildren's Sleep Chewable Tablet with Melatonin Natural Grape Flavor1 mgper 1 Tablet(s)DSLD:303428
- Zarbee'sChildren's Sleep Liquid with Melatonin Mixed Berry Flavor1 mgper 0.5 mLDSLD:303429
- Zarbee'sChildren's Sleep with Melatonin Natural Berry Flavor2 mgper 1 Gummy(ies)DSLD:303431
- Zarbee'sChildren's Sleep with Melatonin Natural Berry Flavor1 mgper 1 Gummy(ies)DSLD:309661
- Zarbee'sSleep with Melatonin Natural Berry Flavor3 mgper 1 Gummy(ies)DSLD:303412
- Zarbee'sSleep with Melatonin Natural Orange Flavor5 mgper 1 Tablet(s)DSLD:302889
- Zarbee's NaturalsChildren's Sleep with Melatonin Natural Grape Flavor1 mgper 1 Chewable Tablet(s)DSLD:277583
- Zarbee's NaturalsCough Syrup + Mucus Natural Grape Flavor0.5 mgper 5 mLDSLD:271542
- Zarbee's NaturalsImmune Support + Sleep Natural Citrus Lemon Flavor3 mgper 10.2 Gram(s)DSLD:277166
- Zenith LabsSleep Wave3 mgper 2 Capsule(s)DSLD:276031
- ZenwiseSleep Support6 mgper 2 Capsule(s)DSLD:257224
- ZicamZicam Sleep + Immune Support Blackberry Lavender Flavor3 mgper 3 Gummy Vitamin(s)DSLD:286733
- zoltDreamy + Collagen Boost Ginger Honey Tea3 mgper 4.35 Gram(s)DSLD:249546
- zolt.Dreamy + CBD Isolate Honey Citrus Tea3 mgper 6 Gram(s)DSLD:296879
- zolt.Dreamy + Collagen Boost Ginger Honey Tea3 mgper 4 Gram(s)DSLD:296880
- zolt.Dreamy +CBD Isolate3 mgper 6 Gram(s)DSLD:296870
- zolt.Well Dreamy +Collagen Boost3 mgper 4 Gram(s)DSLD:296878
Label record: NIH Office of Dietary Supplements · CC0
Registered, and not reported
- Source
- ClinicalTrials.gov
- Intervention
- melatonin
- Status
- Completed, terminated or suspended
- Results posted
- No
Trials without posted results
325 trials
325 registered trials without posted results · Overdue (FDAAA 801): 102 · Showing 120 of 325
102 past the window18 within it, or no actual date
- NCT07735806completed2026-08-02a university or hospital
- NCT06382610completed2026-07-31a university or hospital
- NCT07138443completed2026-07-20a university or hospital
- NCT05820555completed2026-05-16a university or hospital
- NCT07669766completed2026-04-17industry
- NCT06476392completed2026-03-28a university or hospital
- NCT07380568completed2026-03-01a university or hospital
- NCT06404112completed2026-02-26a university or hospital
- NCT03540485terminated— Early termination due to operational feasibility reasons, resulting from a slow recruitment rate and logistical and financial difficulties that prevent reaching the planned sample size within the study schedule.2026-02-18a university or hospital
- NCT07475156completed2026-01-15a university or hospital
- NCT07605767completed2026-01-05a university or hospital
- NCT06404086completed2025-12-31a university or hospital
Show the remaining 313
- NCT07095270completed2025-12-31a university or hospital
- NCT07382843completed2025-12-31a university or hospital
- NCT07461402completed2025-12-02a university or hospital
- NCT07592442completed2025-11-24a university or hospital
- NCT06393296completed2025-10-24a university or hospital
- NCT04791943completed2025-10-01a university or hospitalpast the reporting window
- NCT06012175completed2025-09-24a university or hospitalpast the reporting window
- NCT05513547completed2025-09-12a university or hospitalpast the reporting window
- NCT07162272completed2025-08-28a university or hospitalpast the reporting window
- NCT06821425completed2025-08-01a university or hospitalpast the reporting window
- NCT07192835completed2025-08-01a university or hospitalpast the reporting window
- NCT07103564completed2025-07-15a university or hospitalpast the reporting window
- NCT03785158completed2025-07-05a university or hospitalpast the reporting window
- NCT06094699completed2025-07-01a university or hospitalpast the reporting window
- NCT06455579completed2025-07-01a university or hospitalpast the reporting window
- NCT06872944completed2025-06-21a university or hospitalpast the reporting window
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Papers screened
4,732 papers
- Compound
- melatonin
- Screened
- 4,732
- Admitted
- 34
- Discarded
- 2,734
- Not read
- 1,964
- Showing
- 200 of 4,732
Read and discarded2,734 papers
- PMID:12749556cited by PMID:20668840; not about the subject it would be filed under2026-10-13
- PMID:14592388cited by PMID:20668840; not about the subject it would be filed under2026-10-13
- PMID:16718480cited by PMID:20668840; not about the subject it would be filed under2026-10-13
- PMID:18173940cited by PMID:20668840; not about the subject it would be filed under2026-10-13
- PMID:18391144cited by PMID:20668840; not about the subject it would be filed under2026-10-13
- PMID:7536203cited by PMID:20668840; not about the subject it would be filed under2026-10-13
- PMID:8795841cited by PMID:20668840; not about the subject it would be filed under2026-10-13
- PMID:9158439cited by PMID:20668840; not about the subject it would be filed under2026-10-13
- PMID:9668221cited by PMID:20668840; not about the subject it would be filed under2026-10-13
- PMID:16793787no PMID parsed, abstract under 200 characters, or no record returned by efetch2026-10-13
- PMID:34229896no claim extracted — quote_not_self_supporting2026-10-12
- PMID:34560112no claim extracted — no_outcome_node — measured: haemodynamic response to intubation, maximum percentage rise in heart rate and blood pressure from pre-induction baseline | haemodynamic response to laryngoscopy and intubation, percentage rise in heart rate and blood pressure from baseline2026-10-12
and 2,722 more.
Not read yet1,964 papers
- PMID:428569192026-10-12
- PMID:240333522026-10-10
- PMID:163135012026-10-10
- PMID:173715452026-10-10
and 1,960 more.
Measured, not recorded
- Compound
- melatonin
- Endpoints measured
- 2,398 endpoints
- Recorded as a finding
- No
Show what was measured
blood pressure (systolic/diastolic not distinguished), carotid artery pulsatility index, and catecholamine levels
decreases
Not recorded as a finding: the paper never states the instrument the node requires
The administration of melatonin significantly reduced blood pressure, the pulsatility index in the internal carotid artery, and catecholamines levels within 90 minutes.
PMID:10235107 · one of two readings recorded this
blood pressure (systolic/diastolic not distinguished, device not stated)
decreases
Not recorded as a finding: the paper never states the instrument the node requires
The administration of melatonin significantly reduced blood pressure, the pulsatility index in the internal carotid artery, and catecholamines levels within 90 minutes.
PMID:10235107 · one of two readings recorded this
blood pressure (systolic/diastolic not distinguished)
decreases
The administration of melatonin significantly reduced blood pressure, the pulsatility index in the internal carotid artery, and catecholamines levels within 90 minutes.
PMID:10235107 · one of two readings recorded this
blood pressure
decreases
The administration of melatonin significantly reduced blood pressure, the pulsatility index in the internal carotid artery, and catecholamines levels within 90 minutes.
PMID:10235107 · one of two readings recorded this
catecholamine levels
decreases
The administration of melatonin significantly reduced blood pressure, the pulsatility index in the internal carotid artery, and catecholamines levels within 90 minutes.
PMID:10235107 · both readings recorded this
internal carotid artery pulsatility index
decreases
The administration of melatonin significantly reduced blood pressure, the pulsatility index in the internal carotid artery, and catecholamines levels within 90 minutes.
PMID:10235107 · one of two readings recorded this
pulsatility index change relative to baseline value
unclear
The effect of melatonin on the artery pulsatility index was related to baseline values, being greater in men with higher baseline values.
PMID:10235107 · one of two readings recorded this
pulsatility index, internal carotid artery
decreases
The administration of melatonin significantly reduced blood pressure, the pulsatility index in the internal carotid artery, and catecholamines levels within 90 minutes.
PMID:10235107 · one of two readings recorded this
delayed sleep onset and sleep maintenance, assessed by sleep charts and clinical follow-up, fast-release vs controlled-release melatonin
FR melatonin most effective for delayed sleep onset only; CR formulations more useful for sleep maintenance
Not recorded as a finding: the comparison was against another active treatment
The studies showed that the FR melatonin was most effective when there was only delayed sleep onset, but CR formulations were more useful for sleep maintenance.
PMID:10949538 · one of two readings recorded this
delayed sleep onset and sleep maintenance, sleep charts and clinical follow-up
FR most effective for delayed sleep onset only; CR more useful for sleep maintenance
The studies showed that the FR melatonin was most effective when there was only delayed sleep onset, but CR formulations were more useful for sleep maintenance.
PMID:10949538 · one of two readings recorded this
total sleep time
no effect, no evidence that melatonin altered total sleep time (as compared with baseline total sleep time), but there was a significant decrease in total sleep time while patients were taking placebo, n = 20
There was no evidence that melatonin altered total sleep time (as compared with baseline total sleep time), but there was a significant decrease in total sleep time while patients were taking placebo.
PMID:11211063 · one of two readings recorded this
self-reported sleepiness and fatigue after an imposed sleep period, unnamed instrument
decreases, less sleepy and fatigued on melatonin than on placebo, n = 20
Not recorded as a finding: instrument not named (instrument_not_stated)
After an imposed conventional sleep period (from 24:00 to 08:00), subjects taking melatonin reported being less sleepy and fatigued than they did while taking placebo.
PMID:11211063 · one of two readings recorded this
self-reported sleepiness and fatigue after an imposed sleep period
decreases, less sleepy and fatigued on melatonin than on placebo, n = 20
After an imposed conventional sleep period (from 24:00 to 08:00), subjects taking melatonin reported being less sleepy and fatigued than they did while taking placebo.
PMID:11211063 · one of two readings recorded this
sleep onset latency, by polysomnography
decreases, n = 20
In the 20 patients who completed the study, sleep onset latency was significantly reduced while subjects were taking melatonin as compared with both placebo and baseline.
PMID:11211063 · one of two readings recorded this
sleep onset latency, polysomnography
decreases, n = 20
In the 20 patients who completed the study, sleep onset latency was significantly reduced while subjects were taking melatonin as compared with both placebo and baseline.
PMID:11211063 · one of two readings recorded this
subjective sleepiness and fatigue after an imposed 24:00-08:00 sleep period, no named validated instrument stated
decreases, n = 20
Not recorded as a finding: self-report of sleepiness/fatigue vs placebo but no named validated fatigue instrument, so CAT:outcome/subjective-fatigue cannot be matched
After an imposed conventional sleep period (from 24:00 to 08:00), subjects taking melatonin reported being less sleepy and fatigued than they did while taking placebo.
PMID:11211063 · one of two readings recorded this
subjective sleepiness and fatigue after an imposed 24:00-08:00 sleep period
decreases, n = 20
After an imposed conventional sleep period (from 24:00 to 08:00), subjects taking melatonin reported being less sleepy and fatigued than they did while taking placebo.
PMID:11211063 · one of two readings recorded this
subjective sleepiness, fatigue and alertness, no named validated instrument stated
no effect, n = 20
Not recorded as a finding: the CAT:outcome/subjective-fatigue node requires a named validated instrument and this sentence names none
Melatonin did not result in altered scores on subjective measures of sleepiness, fatigue, and alertness, which were administered at different times of the day.
PMID:11211063 · one of two readings recorded this
subjective sleepiness, fatigue, and alertness, unnamed self-report measures
no effect, n = 20
Not recorded as a finding: instrument not named (instrument_not_stated); also bundles three constructs in one contrast
Melatonin did not result in altered scores on subjective measures of sleepiness, fatigue, and alertness, which were administered at different times of the day.
PMID:11211063 · one of two readings recorded this
subjective sleepiness, fatigue and alertness
no effect, n = 20
Melatonin did not result in altered scores on subjective measures of sleepiness, fatigue, and alertness, which were administered at different times of the day.
PMID:11211063 · one of two readings recorded this
total sleep time, by baseline comparison for each arm
no effect, no evidence that melatonin altered total sleep time (as compared with baseline total sleep time), but there was a significant decrease in total sleep time while patients were taking placebo, n = 20
Not recorded as a finding: no direct between-arm test of total sleep time at endpoint is stated; only separate within-arm comparisons to baseline are given for melatonin and placebo
There was no evidence that melatonin altered total sleep time (as compared with baseline total sleep time), but there was a significant decrease in total sleep time while patients were taking placebo.
PMID:11211063 · one of two readings recorded this
total sleep time, polysomnography
Not recorded as a finding: only within-arm comparisons to baseline are stated (melatonin unchanged vs baseline; placebo significantly decreased vs baseline); no direct between-arm contrast sentence exists (within_arm_only)
There was no evidence that melatonin altered total sleep time (as compared with baseline total sleep time), but there was a significant decrease in total sleep time while patients were taking placebo.
PMID:11211063 · one of two readings recorded this
headache adverse event
occurred in 2 children during the first 2 days of melatonin treatment
Mild headache occurred in 2 children during the first 2 days of the melatonin treatment.
PMID:11292231 · one of two readings recorded this
lights-off time, diary and actigraphic sleep onset, melatonin onset and total sleep time, by diary, actigraphy and salivary melatonin assay
increases, lights-off time advanced 34 (6-63) minutes, diary sleep onset 63 (32-94) minutes, actigraphic sleep onset 75 (36-114) minutes, and melatonin onset 57 (24 to 89) minutes; total sleep time increased 41 (19-62) minutes, n = 40
Not recorded as a finding: the result compares a group with itself, not with a control
In the melatonin group, mean (95% CI) lights-off time advanced 34 (6-63) minutes, diary sleep onset 63 (32-94) minutes, actigraphic sleep onset 75 (36-114) minutes, and melatonin onset 57 (24 to 89) minutes; total sleep time increased 41 (19-62) minutes.
PMID:11292231 · one of two readings recorded this
lights-off time, diary and actigraphic sleep onset, melatonin onset and total sleep time
increases, lights-off time advanced 34 (6-63) minutes, diary sleep onset 63 (32-94) minutes, actigraphic sleep onset 75 (36-114) minutes, and melatonin onset 57 (24 to 89) minutes; total sleep time increased 41 (19-62) minutes, n = 40
In the melatonin group, mean (95% CI) lights-off time advanced 34 (6-63) minutes, diary sleep onset 63 (32-94) minutes, actigraphic sleep onset 75 (36-114) minutes, and melatonin onset 57 (24 to 89) minutes; total sleep time increased 41 (19-62) minutes.
PMID:11292231 · one of two readings recorded this
lights-off time, diary and actigraphic sleep onset, melatonin onset (DLMO), and total sleep time
increases, lights-off advanced 34 (6-63) min; diary sleep onset advanced 63 (32-94) min; actigraphic sleep onset advanced 75 (36-114) min; melatonin onset advanced 57 (24-89) min; total sleep time increased 41 (19-62) min, n = 33
In the melatonin group, mean (95% CI) lights-off time advanced 34 (6-63) minutes, diary sleep onset 63 (32-94) minutes, actigraphic sleep onset 75 (36-114) minutes, and melatonin onset 57 (24 to 89) minutes; total sleep time increased 41 (19-62) minutes.
PMID:11292231 · one of two readings recorded this
lights-off time, diary and actigraphic sleep onset time, and dim-light melatonin onset (DLMO), diary/actigraphy/saliva
lights-off advanced 34 (6-63) min; diary sleep onset advanced 63 (32-94) min; actigraphic sleep onset advanced 75 (36-114) min; melatonin onset advanced 57 (24-89) min
Not recorded as a finding: no outcome node exists for these clock-time or onset-shift measures; the node list only has sleep-onset-latency (duration) and total-sleep-time
In the melatonin group, mean (95% CI) lights-off time advanced 34 (6-63) minutes, diary sleep onset 63 (32-94) minutes, actigraphic sleep onset 75 (36-114) minutes, and melatonin onset 57 (24 to 89) minutes; total sleep time increased 41 (19-62) minutes.
PMID:11292231 · one of two readings recorded this
sleep latency, wake-up time and sustained attention reaction time (Bourdon-Vos test)
no effect, n = 40
There were no significant differences between the treatment groups in the change of sleep latency, wake-up time, and sustained attention reaction times.
PMID:11292231 · one of two readings recorded this
sleep latency, wake-up time, sustained attention reaction times (Bourdon-Vos test, n=36)
no effect, n = 36
There were no significant differences between the treatment groups in the change of sleep latency, wake-up time, and sustained attention reaction times.
PMID:11292231 · one of two readings recorded this
wake-up time, diary
no effect
Not recorded as a finding: no outcome node exists for wake-up time
There were no significant differences between the treatment groups in the change of sleep latency, wake-up time, and sustained attention reaction times.
PMID:11292231 · one of two readings recorded this
core body temperature (hypothermia), 3.0 mg dose, site not stated
decreases
The pharmacologic dose (3.0 mg), like the lowest dose (0.1 mg), also improved sleep; however, it induced hypothermia and caused plasma melatonin to remain elevated into the daylight hours.
PMID:11600532 · one of two readings recorded this
sleep, 3.0 mg and 0.1 mg doses
increases
The pharmacologic dose (3.0 mg), like the lowest dose (0.1 mg), also improved sleep; however, it induced hypothermia and caused plasma melatonin to remain elevated into the daylight hours.
PMID:11600532 · one of two readings recorded this
sleep and core body temperature (hypothermia), pharmacologic 3.0 mg dose
decreases, induced hypothermia and caused plasma melatonin to remain elevated into the daylight hours
The pharmacologic dose (3.0 mg), like the lowest dose (0.1 mg), also improved sleep; however, it induced hypothermia and caused plasma melatonin to remain elevated into the daylight hours.
PMID:11600532 · one of two readings recorded this
sleep efficiency, by polysomnography, physiologic 0.3 mg dose
increases, restored sleep efficiency (P < 0.0001), acting principally in the midthird of the night; also elevated plasma melatonin levels (P < 0.0008) to normal
The physiologic melatonin dose (0.3 mg) restored sleep efficiency (P < 0.0001), acting principally in the midthird of the night; it also elevated plasma melatonin levels (P < 0.0008) to normal.
PMID:11600532 · one of two readings recorded this
sleep efficiency, by polysomnography
increases
Not recorded as a finding: this platform holds no node for the endpoint
The physiologic melatonin dose (0.3 mg) restored sleep efficiency (P < 0.0001), acting principally in the midthird of the night; it also elevated plasma melatonin levels (P < 0.0008) to normal.
PMID:11600532 · one of two readings recorded this
sleep efficiency, polysomnography, 0.3 mg dose
increases, restored sleep efficiency
The physiologic melatonin dose (0.3 mg) restored sleep efficiency (P < 0.0001), acting principally in the midthird of the night; it also elevated plasma melatonin levels (P < 0.0008) to normal.
PMID:11600532 · one of two readings recorded this
sleep efficiency, restored by the physiologic (0.3 mg) melatonin dose, polysomnography
increases, restored sleep efficiency
Not recorded as a finding: this platform holds no node for the endpoint
The physiologic melatonin dose (0.3 mg) restored sleep efficiency (P < 0.0001), acting principally in the midthird of the night; it also elevated plasma melatonin levels (P < 0.0008) to normal.
PMID:11600532 · one of two readings recorded this
sleep, in normally-sleeping control subjects
no effect, n = 15
Although control subjects, like insomniacs, had low melatonin levels, their sleep was unaffected by any melatonin dose.
PMID:11600532 · one of two readings recorded this
sleep, normal-sleeping (control) subjects
no effect, n = 15
Although control subjects, like insomniacs, had low melatonin levels, their sleep was unaffected by any melatonin dose.
PMID:11600532 · one of two readings recorded this
sleep efficiency, total sleep time and wake time during sleep
increases, improved in 3 studies
In 3 studies other measures of sleep quality (sleep efficiency, total sleep time and wake time during sleep) improved.
PMID:11828891 · one of two readings recorded this
sleep latency and other sleep quality measures (sleep efficiency, total sleep time, wake time during sleep) in elderly insomniacs, reviewed narratively across 6 double-blind randomised crossover trials (n=95)
decreases, sleep latency decreased significantly in 4 of 6 studies
Not recorded as a finding: a review that discusses its trials without pooling them
Sleep latency decreased significantly in 4 studies.
PMID:11828891 · one of two readings recorded this
sleep latency
decreases, decreased significantly in 4 studies
Sleep latency decreased significantly in 4 studies.
PMID:11828891 · one of two readings recorded this
sleep onset latency, narrated across six double-blind randomised crossover trials (n = 95) by wrist actigraphy and polysomnography
decreases, sleep latency decreased significantly in 4 of the studies
Not recorded as a finding: a review that discusses its trials without pooling them
Sleep latency decreased significantly in 4 studies.
PMID:11828891 · one of two readings recorded this
sleep onset latency (wrist actigraphy, polysomnography)
decreases, sleep latency decreased significantly in 4 of the studies
Sleep latency decreased significantly in 4 studies.
PMID:11828891 · one of two readings recorded this
sleep quality (sleep efficiency, total sleep time, wake time during sleep)
increases, other measures of sleep quality improved in 3 studies
In 3 studies other measures of sleep quality (sleep efficiency, total sleep time and wake time during sleep) improved.
PMID:11828891 · one of two readings recorded this
subjective sleep quality
no effect, did not improve
Subjective sleep quality did not improve.
PMID:11828891 · both readings recorded this
jet-lag severity, pooled subjective rating and number-needed-to-treat across 9 of 10 randomised trials of oral melatonin taken near destination bedtime
decreases, NNT = 2; melatonin decreased jet-lag in 9 of 10 trials
Not recorded as a finding: this platform holds no node for the endpoint
Nine of the ten trials found that melatonin, taken close to the target bedtime at the destination (10pm to midnight), decreased jet-lag from flights crossing five or more time zones.
PMID:12076414 · one of two readings recorded this
jet-lag severity (subjective rating)
decreases, NNT = 2; melatonin decreased jet-lag in 9 of 10 trials
Nine of the ten trials found that melatonin, taken close to the target bedtime at the destination (10pm to midnight), decreased jet-lag from flights crossing five or more time zones.
PMID:12076414 · one of two readings recorded this
jet lag symptom severity after transmeridian flight, pooled across 9 randomised trials as a number needed to treat
decreases, NNT = 2
Not recorded as a finding: this platform holds no node for the endpoint
Nine of the ten trials found that melatonin, taken close to the target bedtime at the destination (10pm to midnight), decreased jet-lag from flights crossing five or more time zones.
PMID:12076414 · one of two readings recorded this
jet-lag symptom severity after transmeridian flight
decreases, NNT = 2
Nine of the ten trials found that melatonin, taken close to the target bedtime at the destination (10pm to midnight), decreased jet-lag from flights crossing five or more time zones.
PMID:12076414 · one of two readings recorded this
sleep onset and sleep quality after flight
increases, people fall asleep faster and sleep better after 5mg than 0.5mg
Daily doses of melatonin between 0.5 and 5mg are similarly effective, except that people fall asleep faster and sleep better after 5mg than 0.5mg.
PMID:12076414 · one of two readings recorded this
sleep onset and sleep quality at different melatonin doses
unclear, 0.5mg and 5mg similarly effective overall, but faster onset and better sleep after 5mg than 0.5mg
Daily doses of melatonin between 0.5 and 5mg are similarly effective, except that people fall asleep faster and sleep better after 5mg than 0.5mg.
PMID:12076414 · one of two readings recorded this
sleep EEG, amount and subjective quality of sleep, and side effects (combined statement), by EEG, sleep logs and analogue-visual scales
no effect, n = 10
Not recorded as a finding: a node exists but the paper states a different instrument or population
There were no significant differences in sleep EEG, the amount or subjective quality of sleep or side effects between the placebo, 0.3-mg melatonin or 1.0-mg melatonin treatments.
PMID:12790159 · one of two readings recorded this
sleep EEG, amount and subjective quality of sleep, and side effects, compared between placebo, 0.3 mg and 1.0 mg melatonin; sleep logs and analogue-visual scales
no effect, n = 10
Not recorded as a finding: this platform holds no node for the endpoint
There were no significant differences in sleep EEG, the amount or subjective quality of sleep or side effects between the placebo, 0.3-mg melatonin or 1.0-mg melatonin treatments.
PMID:12790159 · one of two readings recorded this
sleep EEG, amount and subjective quality of sleep, and side effects
no effect, n = 10
There were no significant differences in sleep EEG, the amount or subjective quality of sleep or side effects between the placebo, 0.3-mg melatonin or 1.0-mg melatonin treatments.
PMID:12790159 · one of two readings recorded this
sleep EEG, subjective amount and quality of sleep, side effects
no effect, n = 10
There were no significant differences in sleep EEG, the amount or subjective quality of sleep or side effects between the placebo, 0.3-mg melatonin or 1.0-mg melatonin treatments.
PMID:12790159 · one of two readings recorded this
health status, RAND General Health Rating Index (RAND-GHRI) and Functional Status II (FS-II) questionnaires
increases, standardized response means for the RAND-GHRI of 0.69 versus 0.07 and for the FS-II of 1.61 versus 0.64, n = 62
Not recorded as a finding: this platform holds no node for the endpoint
The total scores of the RAND-GHRI and FS-II improved significantly more during melatonin treatment compared to placebo.
PMID:14566165 · one of two readings recorded this
health status, RAND-GHRI and FS-II questionnaires
increases
The total scores of the RAND-GHRI and FS-II improved significantly more during melatonin treatment compared to placebo.
PMID:14566165 · both readings recorded this
lights-off time and total sleep time, diary
no effect
Lights-off time and total sleep time did not change.
PMID:14566165 · one of two readings recorded this
lights-off time and total sleep time
no effect, n = 62
Lights-off time and total sleep time did not change.
PMID:14566165 · one of two readings recorded this
sleep onset, sleep offset, melatonin onset, and sleep latency, diary/saliva
decreases, sleep onset advanced 57 min; sleep offset advanced 9 min; melatonin onset advanced 82 min; sleep latency decreased 17 min
Melatonin treatment also significantly advanced sleep onset by 57 minutes, sleep offset by 9 minutes, and melatonin onset by 82 minutes, and decreased sleep latency by 17 minutes.
PMID:14566165 · one of two readings recorded this
sleep onset time, sleep offset time, and dim-light melatonin onset (DLMO), diary and saliva
advanced sleep onset 57 min, sleep offset 9 min, melatonin onset 82 min
Not recorded as a finding: no outcome node exists for clock-time sleep onset, sleep offset, or DLMO shift; the node list only has sleep-onset-latency (duration) and total-sleep-time
Melatonin treatment also significantly advanced sleep onset by 57 minutes, sleep offset by 9 minutes, and melatonin onset by 82 minutes, and decreased sleep latency by 17 minutes.
PMID:14566165 · one of two readings recorded this
sleep onset timing, sleep offset timing, melatonin onset timing and sleep latency
decreases, advanced sleep onset by 57 minutes, sleep offset by 9 minutes, and melatonin onset by 82 minutes, and decreased sleep latency by 17 minutes, n = 62
Melatonin treatment also significantly advanced sleep onset by 57 minutes, sleep offset by 9 minutes, and melatonin onset by 82 minutes, and decreased sleep latency by 17 minutes.
PMID:14566165 · one of two readings recorded this
total sleep time and lights-off time, diary
no effect
Not recorded as a finding: the only sentence carrying this result is agentless and does not name melatonin; not self-supporting per the rule preferring a sentence that names the compound
Lights-off time and total sleep time did not change.
PMID:14566165 · one of two readings recorded this
blood pressure, single acute dose
no effect, n = 16
A single dose of melatonin had no effect on blood pressure.
PMID:14732734 · both readings recorded this
day-night amplitude of systolic and diastolic blood pressure rhythm
increases, increased by 15% and 25% respectively, n = 16
The day-night amplitudes of the rhythms in systolic and diastolic blood pressures were increased by 15% and 25%, respectively.
PMID:14732734 · one of two readings recorded this
day-night amplitude of systolic and diastolic blood pressure rhythms
increases, increased by 15% and 25%, respectively, n = 16
The day-night amplitudes of the rhythms in systolic and diastolic blood pressures were increased by 15% and 25%, respectively.
PMID:14732734 · one of two readings recorded this
heart rate
no effect, n = 16
The treatment did not affect heart rate.
PMID:14732734 · one of two readings recorded this
sleep, repeated vs acute dosing
increases, n = 16
Repeated (but not acute) melatonin also improved sleep.
PMID:14732734 · one of two readings recorded this
systolic and diastolic blood pressure during sleep, by 24-hour ambulatory blood pressure monitoring
decreases, reduced systolic and diastolic blood pressure during sleep by 6 and 4 mm Hg, respectively, n = 16
Not recorded as a finding: the comparison was against another active treatment
Repeated melatonin intake reduced systolic and diastolic blood pressure during sleep by 6 and 4 mm Hg, respectively.
PMID:14732734 · one of two readings recorded this
systolic and diastolic blood pressure during sleep (nocturnal segment), 24-hour ambulatory blood pressure monitoring
decreases, reduced by 6 mm Hg systolic and 4 mm Hg diastolic during sleep, n = 16
Not recorded as a finding: a node exists but the paper states a different instrument or population
Repeated melatonin intake reduced systolic and diastolic blood pressure during sleep by 6 and 4 mm Hg, respectively.
PMID:14732734 · one of two readings recorded this
systolic and diastolic blood pressure during sleep, repeated dosing
decreases, reduced by 6 mm Hg systolic and 4 mm Hg diastolic, n = 16
Repeated melatonin intake reduced systolic and diastolic blood pressure during sleep by 6 and 4 mm Hg, respectively.
PMID:14732734 · one of two readings recorded this
systolic and diastolic blood pressure during sleep, repeated vs single dosing
decreases, reduced systolic and diastolic blood pressure during sleep by 6 and 4 mm Hg, respectively, n = 16
Repeated melatonin intake reduced systolic and diastolic blood pressure during sleep by 6 and 4 mm Hg, respectively.
PMID:14732734 · one of two readings recorded this
diastolic blood pressure decline during sleep, in healthy controls
no effect, n = 10
No significant drug effect was present in the controls.
PMID:15043687 · one of two readings recorded this
diastolic blood pressure decline during sleep, in type 1 diabetes patients
decreases, 17.8+/-4.4 mmHg on melatonin vs 16.0+/-3.0 mmHg on placebo, n = 11
In the patients with type 1 diabetes, the decline in diastolic blood pressure during sleep was significantly greater on melatonin (17.8 +/- 4.4 mmHg) than on placebo (16.0 +/- 3.0 mmHg, p < 0.01).
PMID:15043687 · one of two readings recorded this
diastolic blood pressure decline during sleep (nocturnal segment) in type 1 diabetes patients, 24-hour ambulatory blood pressure monitoring
decreases, diastolic decline during sleep 17.8+/-4.4 mmHg on melatonin vs 16.0+/-3.0 mmHg on placebo, n = 11
Not recorded as a finding: a node exists but the paper states a different instrument or population
In the patients with type 1 diabetes, the decline in diastolic blood pressure during sleep was significantly greater on melatonin (17.8 +/- 4.4 mmHg) than on placebo (16.0 +/- 3.0 mmHg, p < 0.01).
PMID:15043687 · one of two readings recorded this
nocturnal decline in diastolic blood pressure (dipping magnitude), by 24-hour ambulatory blood pressure monitoring
increases, greater on melatonin (17.8 +/- 4.4 mmHg) than on placebo (16.0 +/- 3.0 mmHg, p < 0.01), n = 11
Not recorded as a finding: this platform holds no node for the endpoint
In the patients with type 1 diabetes, the decline in diastolic blood pressure during sleep was significantly greater on melatonin (17.8 +/- 4.4 mmHg) than on placebo (16.0 +/- 3.0 mmHg, p < 0.01).
PMID:15043687 · one of two readings recorded this
nocturnal decline in diastolic blood pressure (dipping magnitude), diabetes group
increases, greater on melatonin (17.8 +/- 4.4 mmHg) than on placebo (16.0 +/- 3.0 mmHg, p < 0.01), n = 11
In the patients with type 1 diabetes, the decline in diastolic blood pressure during sleep was significantly greater on melatonin (17.8 +/- 4.4 mmHg) than on placebo (16.0 +/- 3.0 mmHg, p < 0.01).
PMID:15043687 · one of two readings recorded this
nocturnal decline in diastolic blood pressure, healthy control group
no effect, n = 10
No significant drug effect was present in the controls.
PMID:15043687 · one of two readings recorded this
seizure frequency
unclear
Overall, MLT appeared to influence the seizure frequency poorly, though there may be occasional seizure worsening or improving.
PMID:15275698 · one of two readings recorded this
seizure frequency
unclear, seizure frequency influenced poorly; occasional worsening or improving
Overall, MLT appeared to influence the seizure frequency poorly, though there may be occasional seizure worsening or improving.
PMID:15275698 · one of two readings recorded this
sleep latency, by sleep logs
p = 0.019
The analysis of all the sleep logs disclosed a significant treatment effect of melatonin on sleep latency (P = 0.019).
PMID:15275698 · one of two readings recorded this
sleep latency (time to fall asleep), by sleep logs
p = 0.019
Not recorded as a finding: the direction is carried only as a signed number
The analysis of all the sleep logs disclosed a significant treatment effect of melatonin on sleep latency (P = 0.019).
PMID:15275698 · one of two readings recorded this
sleep latency (time to fall asleep), from sleep logs
p = 0.019
Not recorded as a finding: the direction is carried only as a signed number
The analysis of all the sleep logs disclosed a significant treatment effect of melatonin on sleep latency (P = 0.019).
PMID:15275698 · one of two readings recorded this
sleep latency (time to fall asleep), sleep logs
p = 0.019
The analysis of all the sleep logs disclosed a significant treatment effect of melatonin on sleep latency (P = 0.019).
PMID:15275698 · one of two readings recorded this
dim light melatonin onset (DLMO), phase advance
increases, +1:12 h advance with melatonin as compared with placebo
Not recorded as a finding: no outcome node in the list for dim light melatonin onset
Melatonin advanced DLMO with +1:12 h (P < 0.001), SO with +0:42 h (P = 0.004), SL decreased with 25 min (P = 0.019), and TSD did not change significantly, as compared with placebo.
PMID:15910516 · one of two readings recorded this
dim light melatonin onset (DLMO), phase timing
increases, advanced by +1:12 h with melatonin vs placebo
Not recorded as a finding: circadian phase marker DLMO has no matching outcome node in the list
Melatonin advanced DLMO with +1:12 h (P < 0.001), SO with +0:42 h (P = 0.004), SL decreased with 25 min (P = 0.019), and TSD did not change significantly, as compared with placebo.
PMID:15910516 · one of two readings recorded this
dim light melatonin onset (DLMO), sleep onset (SO), sleep latency (SL), total sleep duration (TSD)
Melatonin advanced DLMO with +1:12 h (P < 0.001), SO with +0:42 h (P = 0.004), SL decreased with 25 min (P = 0.019), and TSD did not change significantly, as compared with placebo.
PMID:15910516 · one of two readings recorded this
pretreatment DLMO as predictor of treatment response
pretreatment DLMO significantly related to DeltaDLMO and DeltaSO in the melatonin-treated group, p = 0.012
In the melatonin-treated group, but not in the placebo-treated group, pretreatment DLMO was significantly related to DeltaDLMO [F(1, 29) = 7.28, P = 0.012] and DeltaSO [F(1, 25) = 7.72, P = 0.010].
PMID:15910516 · one of two readings recorded this
relationship between pretreatment DLMO and treatment response (DeltaDLMO, DeltaSO)
increases, p = 0.012
In the melatonin-treated group, but not in the placebo-treated group, pretreatment DLMO was significantly related to DeltaDLMO [F(1, 29) = 7.28, P = 0.012] and DeltaSO [F(1, 25) = 7.72, P = 0.010].
PMID:15910516 · one of two readings recorded this
sleep latency (SL)
decreases, decreased by 25 min with melatonin vs placebo, p = 0.019
Melatonin advanced DLMO with +1:12 h (P < 0.001), SO with +0:42 h (P = 0.004), SL decreased with 25 min (P = 0.019), and TSD did not change significantly, as compared with placebo.
PMID:15910516 · one of two readings recorded this
sleep onset (SO), circadian phase timing
increases, advanced by +0:42 h with melatonin vs placebo, p = 0.004
Not recorded as a finding: phase-advance timing (SO) is distinct from the sleep-onset-latency duration node; no matching outcome node for a phase marker
Melatonin advanced DLMO with +1:12 h (P < 0.001), SO with +0:42 h (P = 0.004), SL decreased with 25 min (P = 0.019), and TSD did not change significantly, as compared with placebo.
PMID:15910516 · one of two readings recorded this
sleep onset (SO), clock-time phase advance
increases, +0:42 h advance with melatonin as compared with placebo
Not recorded as a finding: no outcome node in the list for the clock-time sleep-onset phase marker, distinct from sleep-onset latency
Melatonin advanced DLMO with +1:12 h (P < 0.001), SO with +0:42 h (P = 0.004), SL decreased with 25 min (P = 0.019), and TSD did not change significantly, as compared with placebo.
PMID:15910516 · one of two readings recorded this
sleep onset (SO), phase timing
increases, advanced by +0:42 h with melatonin vs placebo, p = 0.004
Melatonin advanced DLMO with +1:12 h (P < 0.001), SO with +0:42 h (P = 0.004), SL decreased with 25 min (P = 0.019), and TSD did not change significantly, as compared with placebo.
PMID:15910516 · one of two readings recorded this
total sleep duration (TSD)
no effect
Melatonin advanced DLMO with +1:12 h (P < 0.001), SO with +0:42 h (P = 0.004), SL decreased with 25 min (P = 0.019), and TSD did not change significantly, as compared with placebo.
PMID:15910516 · one of two readings recorded this
circadian phase advance, dim-light melatonin onset (DLMO) timing, by salivary melatonin assay
increases, correlated strongly with the time of melatonin administration, with earlier times being more effective (r2 = 0.94, P < .0001), n = 13
Not recorded as a finding: this platform holds no node for the endpoint
The magnitude of phase advance in dim-light melatonin onset correlated strongly with the time of melatonin administration, with earlier times being more effective (r2 = 0.94, P < .0001).
PMID:16295212 · one of two readings recorded this
circadian phase advance, dim-light melatonin onset (DLMO) timing, correlated with administration timing
increases, correlated strongly with the time of melatonin administration, with earlier times being more effective (r2 = 0.94, P < .0001), n = 13
The magnitude of phase advance in dim-light melatonin onset correlated strongly with the time of melatonin administration, with earlier times being more effective (r2 = 0.94, P < .0001).
PMID:16295212 · one of two readings recorded this
circadian phase advance of endogenous melatonin (dim light melatonin onset, DLMO) and correlation with administration timing
increases, n = 13
Not recorded as a finding: this platform holds no node for the endpoint
Both doses of melatonin advanced the circadian phase of endogenous melatonin.
PMID:16295212 · one of two readings recorded this
circadian phase advance of endogenous melatonin (DLMO)
increases, n = 13
Both doses of melatonin advanced the circadian phase of endogenous melatonin.
PMID:16295212 · one of two readings recorded this
correlation between DLMO phase advance and time of melatonin administration
r2 = 0.94
The magnitude of phase advance in dim-light melatonin onset correlated strongly with the time of melatonin administration, with earlier times being more effective (r2 = 0.94, P < .0001).
PMID:16295212 · one of two readings recorded this
sleep time change, correlation with administration timing
Similar, though weaker, relationships were obtained between the timing of melatonin administration and changes in sleep time.
PMID:16295212 · one of two readings recorded this
activities of daily living, affect, behaviour (remainder)
no effect
The remainder of the treatment effects for affect, behaviour and activities of daily living were non-significant.
PMID:16437462 · one of two readings recorded this
activities of daily living (change scores)
no effect
Not recorded as a finding: reported only as a qualitative 'non-significant' remainder statement, unclear whether pooled or narrative, so node CAT:outcome/activities-of-daily-living-score requirement for a stated estimate is not met
The remainder of the treatment effects for affect, behaviour and activities of daily living were non-significant.
PMID:16437462 · one of two readings recorded this
MMSE cognitive and ADAS-cognitive change scores
no effect
This review revealed non-significant effects from the pooled estimates of MMSE cognitive, and ADAS-cognitive change scores.
PMID:16437462 · one of two readings recorded this
adverse effects, short-term use
no effect, n = 651
17 randomised controlled trials with 651 participants showed no evidence of adverse effects of melatonin with short term use (three months or less).
PMID:16473858 · one of two readings recorded this
sleep onset latency, secondary sleep disorders
no effect, WMD -13.2 (95% CI -27.3 to 0.9) min, n = 97
Six randomised controlled trials with 97 participants showed no evidence that melatonin had an effect on sleep onset latency in people with secondary sleep disorders (weighted mean difference -13.2 (95% confidence interval -27.3 to 0.9) min).
PMID:16473858 · one of two readings recorded this
sleep onset latency, sleep disorders accompanying sleep restriction
no effect, -1.0 (-2.3 to 0.3) min, n = 427
Nine randomised controlled trials with 427 participants showed no evidence that melatonin had an effect on sleep onset latency in people who had sleep disorders accompanying sleep restriction (-1.0 (-2.3 to 0.3) min).
PMID:16473858 · one of two readings recorded this
ADHD symptoms
no effect
Improved sleep had no demonstrable effect on ADHD symptoms.
PMID:16670647 · both readings recorded this
initial insomnia, combined sleep hygiene + melatonin, baseline to 90 days
decreases, effect size 1.7, mean decrease of 60 minutes
The effect size of the combined sleep hygiene and melatonin intervention from baseline to 90 days' posttrial was 1.7, with a mean decrease in initial insomnia of 60 minutes.
PMID:16670647 · one of two readings recorded this
initial insomnia (time to fall asleep), instrument not named
decreases, 16-minute reduction with melatonin relative to placebo, effect size 0.6
Analysis of the trial data able to be evaluated showed a significant reduction in initial insomnia of 16 minutes with melatonin relative to placebo, with an effect size of 0.6.
PMID:16670647 · one of two readings recorded this
initial insomnia (time to fall asleep, minutes)
decreases, reduction of 16 minutes with melatonin relative to placebo, effect size 0.6
Not recorded as a finding: the paper never states the instrument the node requires
Analysis of the trial data able to be evaluated showed a significant reduction in initial insomnia of 16 minutes with melatonin relative to placebo, with an effect size of 0.6.
PMID:16670647 · one of two readings recorded this
initial insomnia (time to fall asleep, threshold >60 minutes), instrument not named
decreases, 16-minute reduction in initial insomnia with melatonin relative to placebo, effect size 0.6
Not recorded as a finding: the paper never states the instrument the node requires
Analysis of the trial data able to be evaluated showed a significant reduction in initial insomnia of 16 minutes with melatonin relative to placebo, with an effect size of 0.6.
PMID:16670647 · one of two readings recorded this
initial insomnia (time to fall asleep)
decreases, reduction of 16 minutes with melatonin relative to placebo, effect size 0.6
Analysis of the trial data able to be evaluated showed a significant reduction in initial insomnia of 16 minutes with melatonin relative to placebo, with an effect size of 0.6.
PMID:16670647 · one of two readings recorded this
sleep hygiene effect on initial insomnia (pre-randomization)
decreases, reduced initial insomnia to <60 minutes in 5 cases, overall effect size 0.67
Sleep hygiene reduced initial insomnia to <60 minutes in 5 cases, with an overall effect size in the group as a whole of 0.67.
PMID:16670647 · one of two readings recorded this
sleep hygiene intervention alone, initial insomnia
decreases, reduced initial insomnia to <60 minutes in 5 cases, effect size 0.67
Sleep hygiene reduced initial insomnia to <60 minutes in 5 cases, with an overall effect size in the group as a whole of 0.67.
PMID:16670647 · one of two readings recorded this
alertness acrophase, ratings every 2 h while awake
no effect
Alertness acrophase calculated from the subjects' ratings of alertness made every 2 h while awake was unaltered.
PMID:1674014 · one of two readings recorded this
alertness acrophase, subject ratings of alertness every 2 h while awake
no effect
Not recorded as a finding: no outcome node for alertness acrophase / circadian timing of alertness
Alertness acrophase calculated from the subjects' ratings of alertness made every 2 h while awake was unaltered.
PMID:1674014 · one of two readings recorded this
alertness acrophase (timing of peak subjective alertness)
no effect, n = 8
Not recorded as a finding: No outcome node exists for circadian timing of subjective alertness.
Alertness acrophase calculated from the subjects' ratings of alertness made every 2 h while awake was unaltered.
PMID:1674014 · one of two readings recorded this
sleep onset time and wake time (clock-time circadian phase advance)
decreases, mean advance 82 min (range 19-124) for sleep onset time; 117 min (range 10-187) for wake time, n = 8
Not recorded as a finding: No outcome node matches circadian phase-shift timing; sleep-onset-latency requires the interval from lights-out to sleep onset, a different construct from a phase advance in clock time.
In all 8 subjects sleep onset time (mean advance 82 [range 19-124] min; p less than 0.01) and wake time (117 [10-187] min; p less than 0.01) were significantly earlier during melatonin treatment than during placebo.
PMID:1674014 · one of two readings recorded this
sleep onset time (clock-time circadian phase)
decreases, mean advance 82 min (range 19-124), p less than 0.01, n = 8
In all 8 subjects sleep onset time (mean advance 82 [range 19-124] min; p less than 0.01) and wake time (117 [10-187] min; p less than 0.01) were significantly earlier during melatonin treatment than during placebo.
PMID:1674014 · one of two readings recorded this
sleep onset time (phase advance), pretrial sleep logs
decreases, mean advance 82 min (range 19-124 min), n = 8
Not recorded as a finding: no outcome node for circadian phase-shift/timing of sleep onset — a different construct from sleep-onset-latency, which the node defines as the interval from lights-out to sleep onset rather than a shift in clock time
In all 8 subjects sleep onset time (mean advance 82 [range 19-124] min; p less than 0.01) and wake time (117 [10-187] min; p less than 0.01) were significantly earlier during melatonin treatment than during placebo.
PMID:1674014 · one of two readings recorded this
wake time (clock-time circadian phase)
decreases, 117 min (range 10-187), p less than 0.01, n = 8
In all 8 subjects sleep onset time (mean advance 82 [range 19-124] min; p less than 0.01) and wake time (117 [10-187] min; p less than 0.01) were significantly earlier during melatonin treatment than during placebo.
PMID:1674014 · one of two readings recorded this
wake time (phase advance), pretrial sleep logs
decreases, mean advance 117 min (range 10-187 min), n = 8
Not recorded as a finding: no outcome node for circadian phase-shift/timing of wake time
In all 8 subjects sleep onset time (mean advance 82 [range 19-124] min; p less than 0.01) and wake time (117 [10-187] min; p less than 0.01) were significantly earlier during melatonin treatment than during placebo.
PMID:1674014 · one of two readings recorded this
between-group reduction in nocturnal systolic BP, most prominent 2:00-5:00 AM
decreases, p = 0.01
The reduction in nocturnal systolic BP was significantly greater with melatonin than with placebo (P=.01), and was most prominent between 2:00 AM and 5:00 AM (P=.002).
PMID:17000226 · one of two readings recorded this
nocturnal (night-time) systolic blood pressure, by 24-hour ambulatory blood pressure monitoring
decreases, significantly greater with melatonin than with placebo (P=.01), and was most prominent between 2:00 AM and 5:00 AM (P=.002), n = 38
Not recorded as a finding: a node exists but the paper states a different instrument or population
The reduction in nocturnal systolic BP was significantly greater with melatonin than with placebo (P=.01), and was most prominent between 2:00 AM and 5:00 AM (P=.002).
PMID:17000226 · one of two readings recorded this
nocturnal (sleep-period) systolic and diastolic blood pressure, 24-hour ambulatory blood pressure monitoring
decreases, nocturnal systolic BP from 136+/-9 to 130+/-10 mm Hg (P=.011); diastolic from 72+/-11 to 69+/-9 mm Hg (P=.002), p = 0.011, n = 38
Not recorded as a finding: a node exists but the paper states a different instrument or population
Melatonin treatment reduced nocturnal systolic BP significantly from 136+/-9 to 130+/-10 mm Hg (P=.011), and diastolic BP from 72+/-11 to 69+/-9 mm Hg (P=.002), whereas placebo had no effect on nocturnal BP.
PMID:17000226 · one of two readings recorded this
nocturnal systolic and diastolic blood pressure, 24-hour ABPM
decreases, systolic 136+/-9 to 130+/-10 mm Hg (P=.011); diastolic 72+/-11 to 69+/-9 mm Hg (P=.002), p = 0.011, n = 38
Melatonin treatment reduced nocturnal systolic BP significantly from 136+/-9 to 130+/-10 mm Hg (P=.011), and diastolic BP from 72+/-11 to 69+/-9 mm Hg (P=.002), whereas placebo had no effect on nocturnal BP.
PMID:17000226 · one of two readings recorded this
nocturnal systolic and diastolic blood pressure, by 24-hour ambulatory monitoring
decreases, reduced nocturnal systolic BP significantly from 136+/-9 to 130+/-10 mm Hg (P=.011), and diastolic BP from 72+/-11 to 69+/-9 mm Hg (P=.002), whereas placebo had no effect on nocturnal BP, n = 38
Melatonin treatment reduced nocturnal systolic BP significantly from 136+/-9 to 130+/-10 mm Hg (P=.011), and diastolic BP from 72+/-11 to 69+/-9 mm Hg (P=.002), whereas placebo had no effect on nocturnal BP.
PMID:17000226 · one of two readings recorded this
reduction in nocturnal systolic blood pressure versus placebo
decreases, significantly greater with melatonin than with placebo (P=.01), and was most prominent between 2:00 AM and 5:00 AM (P=.002), n = 38
The reduction in nocturnal systolic BP was significantly greater with melatonin than with placebo (P=.01), and was most prominent between 2:00 AM and 5:00 AM (P=.002).
PMID:17000226 · one of two readings recorded this
actigraphy-derived sleep onset (circadian phase timing)
increases, advanced by 26.9 +/- 47.8 minutes with melatonin vs delayed by 10.5 +/- 37.4 minutes with placebo
Not recorded as a finding: phase-advance timing of sleep onset has no matching outcome node distinct from sleep-onset-latency duration
Sleep onset advanced by 26.9 +/- 47.8 minutes with melatonin and delayed by 10.5 +/- 37.4 minutes with placebo (p < .0001).
PMID:17242627 · one of two readings recorded this
behavior, cognition and quality of life composite
no effect
Not recorded as a finding: no matching outcome node for this composite; sentence bundles three distinct constructs under one non-effect statement
There was no significant effect on behavior, cognition, and quality of life, and significant adverse events did not occur.
PMID:17242627 · one of two readings recorded this
behavior, cognition, and quality of life in children with ADHD, instrument not named
no effect
Not recorded as a finding: no matching outcome node for behavior/cognition/quality-of-life as stated, and no instrument is named for these constructs in the abstract
There was no significant effect on behavior, cognition, and quality of life, and significant adverse events did not occur.
PMID:17242627 · one of two readings recorded this
behavior, cognition and quality of life
no effect
There was no significant effect on behavior, cognition, and quality of life, and significant adverse events did not occur.
PMID:17242627 · both readings recorded this
salivary dim light melatonin onset, clock-time advance
increases, advance of 44.4 +/- 67.9 minutes in melatonin, delay of 12.8 +/- 60.0 minutes in placebo, p = 0.0001
There was an advance in dim light melatonin onset of 44.4 +/- 67.9 minutes in melatonin and a delay of 12.8 +/- 60.0 minutes in placebo (p < .0001).
PMID:17242627 · one of two readings recorded this
salivary dim light melatonin onset (DLMO)
increases, advance of 44.4 +/- 67.9 minutes with melatonin vs delay of 12.8 +/- 60.0 minutes with placebo
Not recorded as a finding: circadian phase marker DLMO has no matching outcome node in the list
There was an advance in dim light melatonin onset of 44.4 +/- 67.9 minutes in melatonin and a delay of 12.8 +/- 60.0 minutes in placebo (p < .0001).
PMID:17242627 · one of two readings recorded this
sleep onset (actigraphy-derived), clock-time advance
increases, sleep onset advanced by 26.9 +/- 47.8 minutes with melatonin and delayed by 10.5 +/- 37.4 minutes with placebo, p = 0.0001
Sleep onset advanced by 26.9 +/- 47.8 minutes with melatonin and delayed by 10.5 +/- 37.4 minutes with placebo (p < .0001).
PMID:17242627 · one of two readings recorded this
total time asleep (actigraphy-derived)
increases, 19.8 +/- 61.9 minutes increase with melatonin as compared with -13.6 +/- 50.6 minutes with placebo, p = 0.01
Total time asleep increased with melatonin (19.8 +/- 61.9 minutes) as compared to placebo (-13.6 +/- 50.6 minutes; p = .01).
PMID:17242627 · one of two readings recorded this
quality of life, WHO-5 well-being index (per Methods)
increases, p = 0.034
Not recorded as a finding: the results sentence reporting the finding does not itself name the instrument, so it does not self-support the health-related-quality-of-life node's instrument requirement
Quality of life also improved significantly (p = 0.034).
PMID:17875243 · one of two readings recorded this
quality of life, WHO-5 well-being index
increases, improved significantly, p = 0.034, p = 0.034
Not recorded as a finding: WHO-5 not among health-related-quality-of-life node's named multi-domain instruments
Quality of life also improved significantly (p = 0.034).
PMID:17875243 · one of two readings recorded this
quality of life, WHO-5
increases, p=0.034, p = 0.034
Quality of life also improved significantly (p = 0.034).
PMID:17875243 · both readings recorded this
sleep latency (LSEQ)
decreases, -24.3 vs -12.9 minutes, p = 0.028
A significant and clinically relevant shortening of sleep latency to the same extent as most frequently used sleep medications was also found (-24.3 vs.-12.9 minutes; p = 0.028).
PMID:17875243 · one of two readings recorded this
behaviour following wakening (BFW), morning alertness, Leeds Sleep Evaluation Questionnaire
increases, -15.7 vs -6.8 mm, P=0.002, p = 0.002
PR-melatonin significantly improved QOS (-22.5 versus -16.5 mm, P = 0.047), QON (0.89 versus 0.46 units; P = 0.003) and BFW (-15.7 versus -6.8 mm; P = 0.002) compared with placebo.
PMID:18036082 · one of two readings recorded this
morning alertness (BFW), Leeds Sleep Evaluation Questionnaire
increases, -15.7 vs -6.8 mm, p = 0.002
PR-melatonin significantly improved QOS (-22.5 versus -16.5 mm, P = 0.047), QON (0.89 versus 0.46 units; P = 0.003) and BFW (-15.7 versus -6.8 mm; P = 0.002) compared with placebo.
PMID:18036082 · one of two readings recorded this
quality of night (QON), 5-category scale
increases, 0.89 vs 0.46 units, p = 0.003
PR-melatonin significantly improved QOS (-22.5 versus -16.5 mm, P = 0.047), QON (0.89 versus 0.46 units; P = 0.003) and BFW (-15.7 versus -6.8 mm; P = 0.002) compared with placebo.
PMID:18036082 · one of two readings recorded this
quality of night (QON), five categorical unit scale
increases, 0.89 vs 0.46 units, P=0.003, p = 0.003
PR-melatonin significantly improved QOS (-22.5 versus -16.5 mm, P = 0.047), QON (0.89 versus 0.46 units; P = 0.003) and BFW (-15.7 versus -6.8 mm; P = 0.002) compared with placebo.
PMID:18036082 · one of two readings recorded this
quality of sleep (QOS), Leeds Sleep Evaluation Questionnaire visual analogue scale
increases, -22.5 versus -16.5 mm, P = 0.047, p = 0.047
Not recorded as a finding: this platform holds no node for the endpoint
PR-melatonin significantly improved QOS (-22.5 versus -16.5 mm, P = 0.047), QON (0.89 versus 0.46 units; P = 0.003) and BFW (-15.7 versus -6.8 mm; P = 0.002) compared with placebo.
PMID:18036082 · one of two readings recorded this
quality of sleep (QOS), Leeds Sleep Evaluation Questionnaire
increases, -22.5 vs -16.5 mm, P=0.047, p = 0.047
PR-melatonin significantly improved QOS (-22.5 versus -16.5 mm, P = 0.047), QON (0.89 versus 0.46 units; P = 0.003) and BFW (-15.7 versus -6.8 mm; P = 0.002) compared with placebo.
PMID:18036082 · both readings recorded this
quality of sleep (QOS), quality of night (QON), and morning alertness (BFW) via Leeds Sleep Evaluation Questionnaire
increases, QOS -22.5 vs -16.5 mm P=0.047; QON 0.89 vs 0.46 units P=0.003; BFW -15.7 vs -6.8 mm P=0.002
Not recorded as a finding: this platform holds no node for the endpoint
PR-melatonin significantly improved QOS (-22.5 versus -16.5 mm, P = 0.047), QON (0.89 versus 0.46 units; P = 0.003) and BFW (-15.7 versus -6.8 mm; P = 0.002) compared with placebo.
PMID:18036082 · one of two readings recorded this
rebound insomnia / withdrawal effects
no effect
There was no evidence of rebound insomnia or withdrawal effects following treatment discontinuation.
PMID:18036082 · one of two readings recorded this
evidence-graded recommendation for treatment of circadian rhythm sleep disorders
Timed melatonin administration is indicated for JLD (Standard); SWD, DSPD, and FRD in unsighted persons (Guideline); and for ASPD, FRD in sighted individuals, and for ISWR in children with moderate to severe psychomotor retardation (Option).
PMID:18041479 · one of two readings recorded this
clinician and parent global ratings
increases, significant improvement
Similarly, significant improvement was observed in clinician and parent ratings.
PMID:18078449 · one of two readings recorded this
clinician and parent ratings of sleep disorder severity and global functioning
increases
Similarly, significant improvement was observed in clinician and parent ratings.
PMID:18078449 · one of two readings recorded this
sleep efficiency and longest sleep episode, open-label phase
increases
There was additional improvement in the open-label somnolog measures of sleep efficiency and the longest sleep episode in the open-label phase.
PMID:18078449 · both readings recorded this
total night-time sleep and sleep latency, by caregiver-completed somnologs and wrist actigraphs
increases, approximately 30 minutes improvement
Not recorded as a finding: the supporting sentence never names the compound
Recordings of total night-time sleep and sleep latency showed significant improvement of approximately 30 min.
PMID:18078449 · one of two readings recorded this
total night-time sleep and sleep latency, by caregiver somnologs and wrist actigraphs
increases, approximately 30 minutes improvement
Recordings of total night-time sleep and sleep latency showed significant improvement of approximately 30 min.
PMID:18078449 · one of two readings recorded this
total night-time sleep and sleep latency, caregiver-completed somnologs and wrist actigraphs
increases, significant improvement of approximately 30 min, combined across total night-time sleep and sleep latency with no separate per-endpoint figure given
Not recorded as a finding: another reason, stated per paper
Recordings of total night-time sleep and sleep latency showed significant improvement of approximately 30 min.
PMID:18078449 · one of two readings recorded this
total night-time sleep and sleep latency (caregiver somnologs, wrist actigraphs)
increases, significant improvement of approximately 30 min, combined across both endpoints
Recordings of total night-time sleep and sleep latency showed significant improvement of approximately 30 min.
PMID:18078449 · one of two readings recorded this
anxiety, Goldberg Anxiety Scale (GAS)
decreases, p=0.009, p = 0.009, n = 22
Depression measured by GDS and anxiety measured by GAS also improved significantly after melatonin administration (p=0.043 and p=0.009, respectively).
PMID:19225268 · one of two readings recorded this
depression (Yesavage GDS) and anxiety (Goldberg GAS)
decreases, p=0.043 (GDS), p=0.009 (GAS), n = 22
Depression measured by GDS and anxiety measured by GAS also improved significantly after melatonin administration (p=0.043 and p=0.009, respectively).
PMID:19225268 · one of two readings recorded this
depression, Yesavage Geriatric Depression Scale (GDS)
decreases, p=0.043, p = 0.043, n = 22
Depression measured by GDS and anxiety measured by GAS also improved significantly after melatonin administration (p=0.043 and p=0.009, respectively).
PMID:19225268 · one of two readings recorded this
hypnotic drug discontinuation rate
increases, 9 of 14 discontinued during melatonin but not during placebo, n = 14
Nine out of 14 subjects receiving hypnotic drugs were able to discontinue this treatment during melatonin but not placebo administration; one discontinued hypnotic drugs during both melatonin and placebo administration, and four were unable to discontinue hypnotic therapy.
PMID:19225268 · one of two readings recorded this
hypnotic drug discontinuation rate
increases, 9 of 14 discontinued during melatonin vs 1 during both arms; 4 unable, n = 14
Nine out of 14 subjects receiving hypnotic drugs were able to discontinue this treatment during melatonin but not placebo administration; one discontinued hypnotic drugs during both melatonin and placebo administration, and four were unable to discontinue hypnotic therapy.
PMID:19225268 · one of two readings recorded this
sleep quality, NHSMI test
decreases, 1.78+/-0.40 vs 3.44+/-0.56 placebo, p = 0.025, n = 22
Melatonin treatment for two months significantly improved sleep quality scores measured by the NHSMI test (1.78+/-0.40) when compared with both basal (3.72+/-0.45; p=0.001) and placebo (3.44+/-0.56; p=0.025) groups.
PMID:19225268 · both readings recorded this
sleep quality, Northside Hospital Sleep Medicine Institute (NHSMI) test score
decreases, 1.78+/-0.40 vs 3.72+/-0.45 (basal, p=0.001) and vs 3.44+/-0.56 (placebo, p=0.025), p = 0.025, n = 22
Not recorded as a finding: this platform holds no node for the endpoint
Melatonin treatment for two months significantly improved sleep quality scores measured by the NHSMI test (1.78+/-0.40) when compared with both basal (3.72+/-0.45; p=0.001) and placebo (3.44+/-0.56; p=0.025) groups.
PMID:19225268 · one of two readings recorded this
sleep quality score, Northside Hospital Sleep Medicine Institute (NHSMI) test
decreases, 1.78+/-0.40 vs 3.44+/-0.56 placebo; p=0.025, p = 0.025, n = 22
Not recorded as a finding: this platform holds no node for the endpoint
Melatonin treatment for two months significantly improved sleep quality scores measured by the NHSMI test (1.78+/-0.40) when compared with both basal (3.72+/-0.45; p=0.001) and placebo (3.44+/-0.56; p=0.025) groups.
PMID:19225268 · one of two readings recorded this
rebound effects during withdrawal
no effect
No rebound effects were observed during withdrawal.
PMID:19584739 · one of two readings recorded this
self-reported home sleep-quality improvement
increases, 50% vs 15%, p = 0.018
Half of the patients reported substantial improvement in sleep quality at home with PRM compared with 15% with placebo (P = 0.018).
PMID:19584739 · one of two readings recorded this
self-reported sleep quality improvement (proportion 'substantially improved'), no validated instrument named
increases, 50% PRM vs 15% placebo reporting substantial improvement, p = 0.018
Not recorded as a finding: no outcome node for an unnamed self-rated sleep-quality responder proportion
Half of the patients reported substantial improvement in sleep quality at home with PRM compared with 15% with placebo (P = 0.018).
PMID:19584739 · one of two readings recorded this
substantial improvement in perceived sleep quality at home, patient-reported
increases, 50% vs 15%; P = 0.018, p = 0.018
Not recorded as a finding: no outcome node for this binary self-report responder measure
Half of the patients reported substantial improvement in sleep quality at home with PRM compared with 15% with placebo (P = 0.018).
PMID:19584739 · one of two readings recorded this
substantial improvement in sleep quality at home, patient-reported
increases, 50% vs 15%, P=0.018, p = 0.018
Half of the patients reported substantial improvement in sleep quality at home with PRM compared with 15% with placebo (P = 0.018).
PMID:19584739 · one of two readings recorded this
blood pressure circadian (dipping) pattern normalization
35% melatonin vs 15% controls (P=0.609), p = 0.609, n = 60
Inclusion of melatonin led to BP pattern normalization in 35% of patients in the melatonin group and in 15% of controls (P=0.609).
PMID:19876062 · one of two readings recorded this
blood pressure circadian pattern (dipper status) normalization, proportion of patients converting to a dipper pattern on 24-h ambulatory blood pressure monitoring
BP pattern normalization in 35% of patients in the melatonin group and in 15% of controls (P=0.609), p = 0.609, n = 60
Not recorded as a finding: this platform holds no node for the endpoint
Inclusion of melatonin led to BP pattern normalization in 35% of patients in the melatonin group and in 15% of controls (P=0.609).
PMID:19876062 · one of two readings recorded this
blood pressure circadian pattern (dipper status) normalization
BP pattern normalization in 35% of patients in the melatonin group and in 15% of controls (P=0.609), p = 0.609, n = 60
Inclusion of melatonin led to BP pattern normalization in 35% of patients in the melatonin group and in 15% of controls (P=0.609).
PMID:19876062 · one of two readings recorded this
circadian blood pressure dipping-pattern normalization (nondipper to dipper conversion) and heart-rate variability, 24-hour ABPM and 24-hour ECG
BP pattern normalization in 35% of melatonin group vs 15% of controls, p = 0.609, n = 60
Not recorded as a finding: this platform holds no node for the endpoint
Inclusion of melatonin led to BP pattern normalization in 35% of patients in the melatonin group and in 15% of controls (P=0.609).
PMID:19876062 · one of two readings recorded this
heart rate variability (SDNN) in dipper-conversion responders
increases
In patients with conversion from nondippers to dippers (responders), an increase in standard deviation of normal-to-normal intervals between initial and final HRV analyses was observed.
PMID:19876062 · one of two readings recorded this
mean circadian heart rate, in nonresponders
increases
Nonresponders represented an increase in the mean circadian heart rate.
PMID:19876062 · one of two readings recorded this
standard deviation of normal-to-normal RR intervals (SDNN), heart-rate variability, in responders (nondipper-to-dipper converters)
increases
In patients with conversion from nondippers to dippers (responders), an increase in standard deviation of normal-to-normal intervals between initial and final HRV analyses was observed.
PMID:19876062 · one of two readings recorded this
clinical global impression (CGI) score
decreases, 6.1 vs 4.6, P=0.024, p = 0.024, n = 8
Compared to baseline, melatonin significantly reduced the number of 30-s REM sleep epochs without muscle atonia (39% versus 27%; P = 0.012), and led to a significant improvement in clinical global impression (CGI: 6.1 versus 4.6; P = 0.024).
PMID:20561180 · both readings recorded this
REM sleep epochs without muscle atonia (carryover, Part II placebo after Part I melatonin)
decreases, -16% vs baseline, P=0.043, p = 0.043
Interestingly, the number of REM sleep epochs without muscle atonia remained lower in patients who took placebo during Part II after having received melatonin in Part I (-16% compared to baseline; P = 0.043).
PMID:20561180 · one of two readings recorded this
REM sleep epochs without muscle atonia, percentage by polysomnography; clinical global impression (CGI) score
decreases, 39% versus 27%; P = 0.012, p = 0.012, n = 8
Not recorded as a finding: this platform holds no node for the endpoint
Compared to baseline, melatonin significantly reduced the number of 30-s REM sleep epochs without muscle atonia (39% versus 27%; P = 0.012), and led to a significant improvement in clinical global impression (CGI: 6.1 versus 4.6; P = 0.024).
PMID:20561180 · one of two readings recorded this
REM sleep epochs without muscle atonia, percentage, polysomnography
decreases, 39% vs 27%, P=0.012, p = 0.012, n = 8
Compared to baseline, melatonin significantly reduced the number of 30-s REM sleep epochs without muscle atonia (39% versus 27%; P = 0.012), and led to a significant improvement in clinical global impression (CGI: 6.1 versus 4.6; P = 0.024).
PMID:20561180 · one of two readings recorded this
REM sleep epochs without muscle atonia (%), polysomnography
decreases, 39% vs 27% (melatonin vs baseline), p = 0.012, n = 8
Compared to baseline, melatonin significantly reduced the number of 30-s REM sleep epochs without muscle atonia (39% versus 27%; P = 0.012), and led to a significant improvement in clinical global impression (CGI: 6.1 versus 4.6; P = 0.024).
PMID:20561180 · one of two readings recorded this
REM sleep without muscle atonia, percentage of 30-s REM epochs, polysomnography
decreases, 39% versus 27%; P = 0.012, p = 0.012, n = 8
Not recorded as a finding: this platform holds no node for the endpoint
Compared to baseline, melatonin significantly reduced the number of 30-s REM sleep epochs without muscle atonia (39% versus 27%; P = 0.012), and led to a significant improvement in clinical global impression (CGI: 6.1 versus 4.6; P = 0.024).
PMID:20561180 · one of two readings recorded this
dim light melatonin onset (DLMO) shift, salivary melatonin threshold (4 pg/ml)
increases
Not recorded as a finding: no outcome node exists for DLMO phase-shift, a distinct construct from sleep onset latency
The DLMO advance in the 0.1 and 0.15 mg/kg treatment group was significantly (p < 0.001) different from placebo; the 0.05 mg/kg group did not reach significance (p = 0.053).
PMID:20668840 · both readings recorded this
dim light melatonin onset (DLMO) shift, salivary threshold
increases
The DLMO advance in the 0.1 and 0.15 mg/kg treatment group was significantly (p < 0.001) different from placebo; the 0.05 mg/kg group did not reach significance (p = 0.053).
PMID:20668840 · one of two readings recorded this
dim light melatonin onset (DLMO) shift
increases, advanced 50-90 min in melatonin groups vs delayed 16 min placebo; significant for 0.1, 0.15 mg/kg (p<0.001), not 0.05 mg/kg (p=0.053)
The DLMO advance in the 0.1 and 0.15 mg/kg treatment group was significantly (p < 0.001) different from placebo; the 0.05 mg/kg group did not reach significance (p = 0.053).
PMID:20668840 · one of two readings recorded this
sleep onset latency (SOL), actigraphy-derived
decreases, 31-42 min greater reduction vs placebo
The difference between placebo treatment and melatonin treatment for SOL shift was 31–42 min, and the reduction of SOL differed significantly in all three treatment groups from placebo (p = 0.007, p = 0.001, and p < 0.001).
PMID:20668840 · one of two readings recorded this
sleep onset latency (SOL) shift
decreases, 31-42 min reduction vs placebo, significant in all groups (p=0.007, 0.001, <0.001)
The difference between placebo treatment and melatonin treatment for SOL shift was 31–42 min, and the reduction of SOL differed significantly in all three treatment groups from placebo (p = 0.007, p = 0.001, and p < 0.001).
PMID:20668840 · one of two readings recorded this
sleep onset (SO) shift, actigraphy-derived clock time
increases, 42-56 min shift vs placebo
Not recorded as a finding: no outcome node exists for the clock-time sleep-onset shift, distinct from sleep onset latency (duration)
SO advanced in all three melatonin groups compared to placebo; the SO shift difference between melatonin treatment and placebo treatment is 42–56 min, which is significant (p < 0.001) for all melatonin groups.
PMID:20668840 · one of two readings recorded this
sleep onset (SO) shift, actigraphy-derived
increases, 42-56 min shift difference vs placebo, significant in all melatonin groups (p<0.001)
Not recorded as a finding: no outcome node for sleep onset (SO) clock-time shift, distinct from sleep onset latency
SO advanced in all three melatonin groups compared to placebo; the SO shift difference between melatonin treatment and placebo treatment is 42–56 min, which is significant (p < 0.001) for all melatonin groups.
PMID:20668840 · one of two readings recorded this
sleep onset (SO) shift
increases, 42-56 min shift difference vs placebo, significant (p<0.001) in all groups
SO advanced in all three melatonin groups compared to placebo; the SO shift difference between melatonin treatment and placebo treatment is 42–56 min, which is significant (p < 0.001) for all melatonin groups.
PMID:20668840 · one of two readings recorded this
total sleep time and wake-up time
Wake-up time and total sleep time data are not analyzed since those data were found to be strongly influenced by fixed wake-up time.
PMID:20668840 · one of two readings recorded this
opioid consumption and postoperative pain scores
unclear, opioid-sparing effect or reduced pain scores in five studies, contradictory in three
An opioid-sparing effect or reduced pain scores were evident in five studies whereas three studies were contradictory.
PMID:20823763 · one of two readings recorded this
postoperative pain scores / opioid consumption
unclear, opioid-sparing effect or reduced pain scores in 5 studies, contradictory in 3 studies
An opioid-sparing effect or reduced pain scores were evident in five studies whereas three studies were contradictory.
PMID:20823763 · one of two readings recorded this
preoperative anxiety and postoperative pain/opioid consumption, reviewed narratively across 10 randomized trials of perioperative melatonin premedication
decreases, 9 of 10 studies showed statistically significant reduction of preoperative anxiety
Not recorded as a finding: a review that discusses its trials without pooling them
Nine of the 10 studies showed statistically significant reduction of preoperative anxiety with melatonin premedication compared with placebo.
PMID:20823763 · one of two readings recorded this
preoperative anxiety, narrated across 10 randomized trials of perioperative melatonin premedication
decreases, statistically significant reduction of preoperative anxiety in 9 of 10 studies
Not recorded as a finding: a review that discusses its trials without pooling them
Nine of the 10 studies showed statistically significant reduction of preoperative anxiety with melatonin premedication compared with placebo.
PMID:20823763 · one of two readings recorded this
preoperative anxiety
decreases, statistically significant reduction of preoperative anxiety in 9 of 10 studies
Nine of the 10 studies showed statistically significant reduction of preoperative anxiety with melatonin premedication compared with placebo.
PMID:20823763 · both readings recorded this
sleep quality and daytime functioning
unclear, inconclusive results
The results on sleep quality and daytime functioning were inconclusive.
PMID:21086534 · both readings recorded this
sundowning/agitated behaviour in dementia, narrated across four RCTs and five case series
increases, significant improvement on sundowning/agitated behaviour in two of the RCTs
Not recorded as a finding: a review that discusses its trials without pooling them
Two of the RCTs found a significant improvement on sundowning/agitated behaviour.
PMID:21086534 · one of two readings recorded this
sundowning/agitated behaviour, sleep quality and daytime functioning in dementia patients, scored narratively across 9 studies (4 RCTs, n=243; 5 case series, n=87)
increases, 2 of 4 RCTs found a significant improvement on sundowning/agitated behaviour
Not recorded as a finding: a review that discusses its trials without pooling them
Two of the RCTs found a significant improvement on sundowning/agitated behaviour.
PMID:21086534 · one of two readings recorded this
Sources cited
50 papers
- Subject
- melatonin
- Findings
- 77
- Papers
- 50
A Pilot Randomised Controlled Trial of Sublingual Melatonin for Sleep Onset Insomnia in Children With Foetal Alcohol Spectrum Disorder (FASD).record2026PMID:411228311 finding
Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.record2026PMID:422177426 findings
Effect of melatonin versus placebo for the prevention of delirium among medically hospitalised older patients: a double-blinded randomised controlled trial (project RESTORE).record2026PMID:415928262 findings
Evaluating the antioxidant and anti-inflammatory effect of melatonin in pediatric hemodialysis patients: a randomized, placebo-controlled trial.record2026PMID:415657871 finding
Melatonin effects on the left ventricular function in neonates with persistent pulmonary hypertension.record2026PMID:419547642 findings
Role of melatonin for prevention of necrotizing enterocolitis in preterm infants: a randomized controlled trial.record2026PMID:418479031 finding
Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose-Response Meta-Analysis.record2025PMID:415152497 findings
Effects of melatonin on advanced glycation end products, inflammation, and oxidative stress in peritoneal dialysis patients: a randomized controlled trial.record2025PMID:411256822 findings
Melatonin and delirium in the intensive care units: a systematic review and meta-analysis of randomized controlled trials.record2025PMID:410515612 findings
The effect of melatonin supplementation on glycemic control in patients with type 2 diabetes.record2025PMID:406982481 finding
Effect of melatonin supplementation on cardiometabolic risk factors, oxidative stress and hormonal profile in PCOS patients: a systematic review and meta-analysis of randomized clinical trials.record2024PMID:389655772 findings
Efficacy and safety of topical rosuvastatin & melatonin vs. placebo in patients with mild to moderate plaque psoriasis: A preliminary randomized double-blinded clinical trial.record2024PMID:385631311 finding
Is melatonin as an ergogenic hormone a myth? a systematic review and meta-analysis.record2024PMID:376582441 finding
Optimizing the Time and Dose of Melatonin as a Sleep-Promoting Drug: A Systematic Review of Randomized Controlled Trials and Dose-Response Meta-Analysis.record2024PMID:388880871 finding
Preventive Effects of Melatonin on Delirium in Intensive Care Unit Patients: A Meta-Analysis of Randomized Controlled Trials.record2024PMID:385181341 finding
A Randomized, Controlled, Parallel-Group, Trial on the Long-term Effects of Melatonin on Fatigue Associated With Breast Cancer and Its Adjuvant Treatments.record2023PMID:371397181 finding
Influence of Melatonin Treatment on Emotion, Sleep, and Life Quality in Perimenopausal Women: A Clinical Study.record2023PMID:378541691 finding
Melatonin supplementation reduces nighttime blood pressure but does not affect blood pressure reactivity in normotensive adults on a high-sodium diet.record2023PMID:376422811 finding
The clinical efficacy of melatonin in the treatment of patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials.record2023PMID:371813631 finding
Melatonergic agents influence the sleep-wake and circadian rhythms in healthy and psychiatric participants: a systematic review and meta-analysis of randomized controlled trials.record2022PMID:351156621 finding
Prophylactic melatonin for delirium in critically ill patients: A systematic review and meta-analysis with trial sequential analysis.record2022PMID:363168581 finding
The safety and efficacy of melatonin in the treatment of COVID-19: A systematic review and meta-analysis.record2022PMID:361810861 finding
Anti-inflammatory effects of melatonin: A systematic review and meta-analysis of clinical trials.record2021PMID:335812471 finding
Effects of daily administration of melatonin before bedtime on fasting insulin, glucose and insulin sensitivity in healthy adults and patients with metabolic diseases. A systematic review and meta-analysis.record2021PMID:343703381 finding
Effects of Melatonin Supplementation on Insulin Levels and Insulin Resistance: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.record2021PMID:344964121 finding
Neurocognitive effects of melatonin treatment in healthy adults and individuals with Alzheimer's disease and insomnia: A systematic review and meta-analysis of randomized controlled trials.record2021PMID:339571671 finding
The effects of melatonin therapy on the treatment of patients with Non-alcoholic steatohepatitis: A systematic review and Meta-analysis on clinical trial studies.record2021PMID:340582021 finding
Effect of melatonin supplementation on oxidative stress parameters: A systematic review and meta-analysis.record2020PMID:330074231 finding
Melatonin and its analogues for the prevention of postoperative delirium: A systematic review and meta-analysis.record2020PMID:321450981 finding
The effect of melatonin on delirium in hospitalised patients: A systematic review and meta-analyses with trial sequential analysis.record2020PMID:312792831 finding
The effect of melatonin supplementation on liver indices in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis of randomized clinical trials.record2020PMID:329516971 finding
The effect of melatonin supplementation on lipid profile and anthropometric indices: A systematic review and meta-analysis of clinical trials.record2019PMID:312351131 finding
Melatonin for the management of sleep problems in children with neurodevelopmental disorders: a systematic review and meta-analysis.record2018PMID:297204941 finding
Pharmacological and non-pharmacological interventions for non-respiratory sleep disturbance in children with neurodisabilities: a systematic review.record2018PMID:303829361 finding
The Effects of Melatonin Supplementation on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.record2018PMID:303962071 finding
The effects of melatonin supplementation on inflammatory markers among patients with metabolic syndrome or related disorders: a systematic review and meta-analysis of randomized controlled trials.record2018PMID:299079162 findings
Pharmacotherapies for sleep disturbances in dementia.record2016PMID:278518681 finding
Melatonin and Nighttime Blood Pressure in African Americans--24 mg Studyrecord2015NCT011143735 findings
Melatonin and Nighttime Blood Pressure in African Americans-8 mg Studyrecord2015NCT011143606 findings
A systematic review of peri-operative melatonin.record2014PMID:248355401 finding
Meta-analysis: melatonin for the treatment of primary sleep disorders.record2013PMID:236910951 finding
Melatonin as adjuvant cancer care with and without chemotherapy: a systematic review and meta-analysis of randomized trials.record2012PMID:220194901 finding
The use of exogenous melatonin in delayed sleep phase disorder: a meta-analysis.record2010PMID:211201221 finding
The effect of prolonged-release melatonin on sleep measures and psychomotor performance in elderly patients with insomnia.record2009PMID:195847391 finding
Effect of melatonin on sleep, behavior, and cognition in ADHD and chronic sleep-onset insomnia.record2007PMID:172426271 finding
Efficacy of prolonged release melatonin in insomnia patients aged 55-80 years: quality of sleep and next-day alertness outcomes.record2007PMID:178752431 finding
Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis.record2006PMID:164738582 findings
Effects of exogenous melatonin on sleep: a meta-analysis.record2005PMID:156497371 finding
Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta-analysis.record2005PMID:162072911 finding
A randomized, double-blind, placebo-controlled crossover study of the effect of exogenous melatonin on delayed sleep phase syndrome.record2001PMID:112110631 finding
Other names
4 names
Resolves to: melatonin
- Also called
- 5-methoxy-N-acetyltryptamineN-[2-(5-methoxyindol-3-yl)ethyl]acetamideN-Acetyl-5-methoxytryptamine
- Systematic name
- N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide