Compound
glutarate
A dicarboxylic acid dianion obtained by deprotonation of both the carboxy groups of glutaric acid.
Definition from ChEBI (CHEBI:30921), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C5H6O4
- Mass
- 130.099 g/mol
- Charge
- -2
- InChIKey
- JFCQEDHGNNZCLN-UHFFFAOYSA-L
- SMILES
- O=C([O-])CCCC(=O)[O-]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
5 entities
5 entities reached.
0 reported hops5 assembled from the scaffold
- SLC22A8ProteinUNIPROT:Q8TCC7transported byInferred only9 paths1 endpoint
- SLC13A3ProteinUNIPROT:Q8WWT9transported byInferred only3 paths3 endpoints
- SLC22A11ProteinUNIPROT:Q9NSA0transported byInferred only2 paths2 endpoints
- SLC22A7ProteinUNIPROT:Q9Y694transported byInferred only2 paths2 endpoints
- SLC22A6ProteinUNIPROT:Q4U2R8transported byInferred only1 path1 endpoint
What the reference databases state
Chemical structure
- 3-hydroxy-3-methylglutarate has the functional parent glutarateCompoundChEBI CHEBI:17325Inferred only
Statements
32 statements
32 statements · 2 reference databases · Subject: glutarate · Sources: Human-GEM, Rhea
- (S)-2-hydroxyglutarate is converted to glutarateCompoundRhea RHEA:13821Inferred only
- glutarate is converted to (S)-2-hydroxyglutarateCompoundRhea RHEA:13821Inferred only
- 5-oxopentanoate is converted to glutarateCompoundRhea RHEA:57832Inferred only
- glutarate is converted to 5-oxopentanoateCompoundRhea RHEA:57832Inferred only
- glutarate is converted to glutaryl-CoACompoundRhea RHEA:14169Inferred only
- glutaryl-CoA is converted to glutarateCompoundRhea RHEA:40575Inferred only
- glutaryl-CoA is converted to glutarateCompoundRhea RHEA:14169Inferred only
- glutarate is a substrate of SUGCTProteinRhea RHEA:81711Inferred only
- glutarate is a substrate of SUGCTProteinRhea RHEA:81715Inferred only
- glutarate is a substrate of SUGCTProteinRhea RHEA:81723Inferred only
- glutarate is a substrate of SUGCTProteinRhea RHEA:67900Inferred only
- glutarate is transported by SLC13A3ProteinRhea RHEA:71955Inferred only
Show the remaining 20
- glutarate is transported by SLC22A11ProteinRhea RHEA:72151Inferred only
- glutarate is transported by SLC22A24ProteinRhea RHEA:72359Inferred only
- glutarate is transported by SLC22A24ProteinRhea RHEA:72175Inferred only
- glutarate is transported by SLC22A24ProteinRhea RHEA:72355Inferred only
- glutarate is transported by SLC22A24ProteinRhea RHEA:72351Inferred only
- glutarate is transported by SLC22A24ProteinRhea RHEA:72151Inferred only
- glutarate is transported by SLC22A24ProteinRhea RHEA:72155Inferred only
- glutarate is transported by SLC22A24ProteinRhea RHEA:72159Inferred only
- glutarate is transported by SLC22A6ProteinRhea RHEA:75999Inferred only
- glutarate is transported by SLC22A7ProteinRhea RHEA:76251Inferred only
- glutarate is transported by SLC22A8ProteinHuman-GEM MAR11734Inferred only
- glutarate is transported by SLC22A8ProteinRhea RHEA:71751Inferred only
- glutarate is transported by SLC22A8ProteinRhea RHEA:72151Inferred only
- glutarate is transported by SLC22A8ProteinRhea RHEA:72159Inferred only
- glutarate is transported by SLC22A8ProteinRhea RHEA:72355Inferred only
- glutarate is transported by SLC22A8ProteinRhea RHEA:72495Inferred only
- glutarate is transported by SLC22A8ProteinRhea RHEA:72503Inferred only
- glutarate is transported by SLC22A8ProteinRhea RHEA:72515Inferred only
- glutarate is transported by SLC22A8ProteinRhea RHEA:72551Inferred only
- glutarate is transported by SLC25A21ProteinRhea RHEA:71751Inferred only
Reactions
30 reactions
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR11392CC BY 4.0Reference data
2-oxoglutarate(2-)+glutarate2-oxoglutarate(2-)+glutarate
Transported by SLC22A8
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR11734CC BY 4.0Reference data
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR11735CC BY 4.0Reference data
glutarate+2-oxoglutarate(2-)+dioxygen(S)-2-hydroxyglutarate+succinate(2-)+carbon dioxide
Reaction pageDirection not assertedBalanced
Rhea RHEA:13821CC BY 4.0Reference data
glutarate+ATP(4-)+coenzyme A(4-)glutaryl-CoA+ADP(3-)+hydrogenphosphate
Reaction pageDirection not assertedBalanced
Rhea RHEA:14169CC BY 4.0Reference data
CHEBI:58693+waterCHEBI:58501+glutarate
Reaction pageDirection not assertedBalanced
Rhea RHEA:23508CC BY 4.0Reference data
glutaryl-CoA+waterglutarate+coenzyme A(4-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:40575CC BY 4.0Reference data
1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine+waterglutarate+1-hexadecanoyl-sn-glycero-3-phosphocholine+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:41159CC BY 4.0Reference data
1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine+water1-O-hexadecyl-sn-glycero-3-phosphocholine+glutarate+hydron
Catalysed by PAFAH2
Reaction pageLeft to rightBalanced
Rhea RHEA:41700CC BY 4.0Reference data
5-oxopentanoate+NADP(3-)+waterglutarate+NADPH(4-)+2hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:57832CC BY 4.0Reference data
glutarate+succinyl-CoAglutaryl-CoA+succinate(2-)
Catalysed by SUGCT
Reaction pageReversibleBalanced
Rhea RHEA:67900CC BY 4.0Reference data
glutarate+2-oxoglutarate(2-)glutarate+2-oxoglutarate(2-)
Transported by SLC22A8 or SLC25A21
Reaction pageDirection not assertedBalanced
Rhea RHEA:71751CC BY 4.0Reference data
Where it reaches
4 systems, 5 regions, 7 tissues, 8 transporter routes — routes, not measurements: transporters known to carry glutarate are expressed there, and no source reports it arriving.
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Other names
1 name
Resolves to: glutarate
- Systematic name
- pentanedioate