Compound
dopamine
One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action.
Structure
Loading the model…
- Class
- Organic compound, cation
- Formula
- C8H12NO2
- Mass
- 154.189 g/mol
- Charge
- +1
- InChIKey
- VYFYYTLLBUKUHU-UHFFFAOYSA-O
- SMILES
- [NH3+]CCc1ccc(O)c(O)c1
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
28 entities
28 entities reached.
0 reported hops28 assembled from the scaffold
- VDAC1ProteinUNIPROT:P21796transported byInferred only228 paths199 endpoints
- MAOAProteinUNIPROT:P21397metabolized byInferred only72 paths36 endpoints
- SULT1A1ProteinUNIPROT:P50225metabolized byInferred only68 paths17 endpoints
- SULT1A3ProteinUNIPROT:P0DMM9metabolized byInferred only60 paths15 endpoints
- SLC6A3ProteinUNIPROT:Q01959transported byInferred only36 paths9 endpoints
- COMTProteinUNIPROT:P21964metabolized byInferred only35 paths35 endpoints
- TGM2ProteinUNIPROT:P21980substrate ofInferred only28 paths24 endpoints
- MAOBProteinUNIPROT:P27338metabolized byInferred only26 paths13 endpoints
- SULT1A4ProteinUNIPROT:P0DMN0metabolized byInferred only24 paths8 endpoints
- DBHProteinUNIPROT:P09172substrate ofInferred only22 paths11 endpoints
- SLC18A2ProteinUNIPROT:Q05940transported byInferred only21 paths7 endpoints
- DDCProteinUNIPROT:P20711substrate ofInferred only19 paths19 endpoints
Show the remaining 16
- SLC6A2ProteinUNIPROT:P23975transported byInferred only18 paths6 endpoints
- SLC18A1ProteinUNIPROT:P54219transported byInferred only18 paths6 endpoints
- MPOProteinUNIPROT:P05164substrate ofInferred only13 paths13 endpoints
- SLCO1B3ProteinUNIPROT:Q9NPD5transported byInferred only12 paths2 endpoints
- SULT1B1ProteinUNIPROT:O43704metabolized byInferred only12 paths6 endpoints
- AOC1ProteinUNIPROT:P19801substrate ofInferred only12 paths12 endpoints
- TYRProteinUNIPROT:P14679substrate ofInferred only11 paths11 endpoints
- SLC22A2ProteinUNIPROT:O15244transported byInferred only10 paths5 endpoints
- SLC22A3ProteinUNIPROT:O75751transported byInferred only8 paths4 endpoints
- SULT1A2ProteinUNIPROT:P50226metabolized byInferred only8 paths8 endpoints
- SLC22A1ProteinUNIPROT:O15245transported byInferred only6 paths3 endpoints
- AOC3ProteinUNIPROT:Q16853substrate ofInferred only5 paths5 endpoints
- SLC29A4ProteinUNIPROT:Q7RTT9transported byInferred only5 paths1 endpoint
- LPOProteinUNIPROT:P22079substrate ofInferred only5 paths5 endpoints
- AOC2ProteinUNIPROT:O75106substrate ofInferred only3 paths3 endpoints
- EPXProteinUNIPROT:P11678substrate ofInferred only3 paths3 endpoints
What the reference databases state
Statements
82 statements
82 statements · 2 reference databases · Subject: dopamine · Sources: Human-GEM, Rhea
- dopamine is converted to 3,4-dihydroxyphenylacetaldehydeCompoundHuman-GEM MAR06758Inferred only
- dopamine is converted to 3,4-dihydroxyphenylacetaldehydeCompoundRhea RHEA:27946Inferred only
- 3,4-dihydroxyphenylacetaldehyde is converted to dopamineCompoundRhea RHEA:27946Inferred only
- CHEBI:15765 is converted to dopamineCompoundHuman-GEM MAR06731Inferred only
- dopamine is converted to CHEBI:37946CompoundHuman-GEM MAR07689Inferred only
- dopamine is converted to CHEBI:742324CompoundHuman-GEM MAR06763Inferred only
- dopamine is converted to dopamine 3-O-sulfateCompoundRhea RHEA:67880Inferred only
- dopamine is converted to dopamine 4-O-sulfateCompoundHuman-GEM MAR12001Inferred only
- dopamine is converted to dopamine 4-O-sulfateCompoundRhea RHEA:67884Inferred only
- dopamine quinone is converted to dopamineCompoundRhea RHEA:66600Inferred only
- dopamine is converted to dopamine quinoneCompoundHuman-GEM MAR12004Inferred only
- dopamine is converted to dopamine quinoneCompoundRhea RHEA:66600Inferred only
Show the remaining 70
- dopamine is converted to dopamine quinoneCompoundHuman-GEM MAR06808Inferred only
- dopamine is converted to dopamine quinoneCompoundHuman-GEM MAR03392Inferred only
- dopamine is converted to dopamine quinoneCompoundHuman-GEM MAR03391Inferred only
- dopamine is converted to L-dopaCompoundRhea RHEA:12272Inferred only
- L-dopa is converted to dopamineCompoundRhea RHEA:12272Inferred only
- dopamine is metabolised by COMTProteinHuman-GEM MAR06763Inferred only
- dopamine is metabolised by MAOAProteinHuman-GEM MAR06758Inferred only
- dopamine is metabolised by MAOAProteinRhea RHEA:27946Inferred only
- dopamine is metabolised by MAOBProteinRhea RHEA:27946Inferred only
- dopamine is metabolised by MAOBProteinHuman-GEM MAR06758Inferred only
- dopamine is metabolised by SULT1A1ProteinHuman-GEM MAR12001Inferred only
- dopamine is metabolised by SULT1A1ProteinHuman-GEM MAR07689Inferred only
- dopamine is metabolised by SULT1A1ProteinRhea RHEA:67880Inferred only
- dopamine is metabolised by SULT1A1ProteinRhea RHEA:67884Inferred only
- dopamine is metabolised by SULT1A2ProteinHuman-GEM MAR07689Inferred only
- dopamine is metabolised by SULT1A3ProteinHuman-GEM MAR07689Inferred only
- dopamine is metabolised by SULT1A3ProteinRhea RHEA:67880Inferred only
- dopamine is metabolised by SULT1A3ProteinHuman-GEM MAR12001Inferred only
- dopamine is metabolised by SULT1A3ProteinRhea RHEA:67884Inferred only
- dopamine is metabolised by SULT1A4ProteinHuman-GEM MAR07689Inferred only
- dopamine is metabolised by SULT1A4ProteinRhea RHEA:67884Inferred only
- dopamine is metabolised by SULT1A4ProteinRhea RHEA:67880Inferred only
- dopamine is metabolised by SULT1B1ProteinRhea RHEA:67884Inferred only
- dopamine is metabolised by SULT1B1ProteinRhea RHEA:67880Inferred only
- dopamine is a substrate of AOC1ProteinHuman-GEM MAR06758Inferred only
- dopamine is a substrate of AOC2ProteinHuman-GEM MAR06758Inferred only
- dopamine is a substrate of AOC3ProteinHuman-GEM MAR06758Inferred only
- dopamine is a substrate of DBHProteinHuman-GEM MAR06741Inferred only
- dopamine is a substrate of DBHProteinRhea RHEA:19117Inferred only
- dopamine is a substrate of DDCProteinRhea RHEA:12272Inferred only
- dopamine is a substrate of EPXProteinHuman-GEM MAR06808Inferred only
- dopamine is a substrate of LPOProteinHuman-GEM MAR06808Inferred only
- dopamine is a substrate of LRTOMTProteinHuman-GEM MAR06763Inferred only
- dopamine is a substrate of MPOProteinHuman-GEM MAR03391Inferred only
- dopamine is a substrate of TGM2ProteinRhea RHEA:66556Inferred only
- dopamine is a substrate of TYRProteinHuman-GEM MAR12004Inferred only
- dopamine is transported by SLC18A1ProteinHuman-GEM MAR00334Inferred only
- dopamine is transported by SLC18A1ProteinHuman-GEM MAR07636Inferred only
- dopamine is transported by SLC18A1ProteinRhea RHEA:73739Inferred only
- dopamine is transported by SLC18A2ProteinHuman-GEM MAR07636Inferred only
- dopamine is transported by SLC18A2ProteinRhea RHEA:73739Inferred only
- dopamine is transported by SLC18A2ProteinHuman-GEM MAR00334Inferred only
- dopamine is transported by SLC22A1ProteinRhea RHEA:73863Inferred only
- dopamine is transported by SLC22A1ProteinHuman-GEM MAR06732Inferred only
- dopamine is transported by SLC22A2ProteinHuman-GEM MAR06732Inferred only
- dopamine is transported by SLC22A2ProteinRhea RHEA:73863Inferred only
- dopamine is transported by SLC22A3ProteinHuman-GEM MAR06732Inferred only
- dopamine is transported by SLC22A3ProteinRhea RHEA:73863Inferred only
- dopamine is transported by SLC29A3ProteinRhea RHEA:73863Inferred only
- dopamine is transported by SLC29A4ProteinHuman-GEM MAR07760Inferred only
- dopamine is transported by SLC29A4ProteinRhea RHEA:73863Inferred only
- dopamine is transported by SLC29A4ProteinHuman-GEM MAR06732Inferred only
- dopamine is transported by SLC29A4ProteinHuman-GEM MAR09878Inferred only
- dopamine is transported by SLC29A4ProteinHuman-GEM MAR07761Inferred only
- dopamine is transported by SLC6A2ProteinHuman-GEM MAR06733Inferred only
- dopamine is transported by SLC6A2ProteinRhea RHEA:70919Inferred only
- dopamine is transported by SLC6A2ProteinRhea RHEA:70931Inferred only
- dopamine is transported by SLC6A3ProteinHuman-GEM MAR06733Inferred only
- dopamine is transported by SLC6A3ProteinRhea RHEA:70931Inferred only
- dopamine is transported by SLC6A3ProteinRhea RHEA:70919Inferred only
- dopamine is transported by SLC6A3ProteinHuman-GEM MAR09614Inferred only
- dopamine is transported by SLCO1A2ProteinHuman-GEM MAR01909Inferred only
- dopamine is transported by SLCO1A2ProteinHuman-GEM MAR06217Inferred only
- dopamine is transported by SLCO1A2ProteinHuman-GEM MAR01908Inferred only
- dopamine is transported by SLCO1A2ProteinHuman-GEM MAR01907Inferred only
- dopamine is transported by SLCO1B3ProteinHuman-GEM MAR01909Inferred only
- dopamine is transported by SLCO1B3ProteinHuman-GEM MAR01907Inferred only
- dopamine is transported by SLCO1B3ProteinHuman-GEM MAR06217Inferred only
- dopamine is transported by SLCO1B3ProteinHuman-GEM MAR01908Inferred only
- dopamine is transported by VDAC1ProteinRhea RHEA:73863Inferred only
Reactions
60 reactions
ATP+dopamine+waterADP+dopamine+proton+phosphate(3-)
Transported by SLC18A1 or SLC18A2
Reaction pageLeft to rightBalancedEC 2.1.1.6cytosol, extracellular space
Human-GEM MAR00334CC BY 4.0Reference data
dopamine+MAM01980c+hydrogencarbonatedopamine+MAM01980e+hydrogencarbonate
Transported by SLCO1A2 or SLCO1B3
Reaction pageReversibleBalance undeterminableextracellular space, cytosol
Human-GEM MAR01907CC BY 4.0Reference data
dopamine+hydrogencarbonate+2,4-dinitrophenyl-S-glutathionedopamine+hydrogencarbonate+2,4-dinitrophenyl-S-glutathione
Transported by SLCO1A2 or SLCO1B3
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR01908CC BY 4.0Reference data
dopamine+hydrogencarbonate+MAM02901cdopamine+hydrogencarbonate+MAM02901e
Transported by SLCO1A2 or SLCO1B3
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR01909CC BY 4.0Reference data
dopamine+hydrogen peroxidedopamine quinone+2water
Catalysed by MPO
Reaction pageLeft to rightBalancedEC 1.11.1.7lysosome
Human-GEM MAR03391CC BY 4.0Reference data
dopamine+hydrogen peroxidedopamine quinone+2water
Reaction pageLeft to rightBalancedEC 1.11.1.7peroxisome
Human-GEM MAR03392CC BY 4.0Reference data
dopamine+CHEBI:16856+hydrogencarbonatedopamine+CHEBI:16856+hydrogencarbonate
Transported by SLCO1A2 & SLCO1B3
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR06217CC BY 4.0Reference data
proton+CHEBI:15765carbon dioxide+dopamine
Catalysed by DDC
Reaction pageLeft to rightBalancedEC 4.1.1.28cytosol
Human-GEM MAR06731CC BY 4.0Reference data
Transported by SLC22A2 or SLC22A3 or SLC29A4 or SLC22A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06732CC BY 4.0Reference data
dopamine+2sodium(1+)dopamine+2sodium(1+)
Transported by SLC6A2 or SLC6A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06733CC BY 4.0Reference data
water+MAM02875cacetaldehyde+dopamine
Reaction pageReversibleBalancedcytosol
Human-GEM MAR06734CC BY 4.0Reference data
water+MAM02876cdopamine+pyruvate
Reaction pageReversibleBalancedcytosol
Human-GEM MAR06738CC BY 4.0Reference data
Where it reaches
10 systems, 28 regions, 187 tissues, 210 transporter routes — routes, not measurements: transporters known to carry dopamine are expressed there, and no source reports it arriving.
Loading the model…
Other names
3 names
Resolves to: dopamine
- Also called
- 2-(3,4-dihydroxyphenyl)ethan-1-aminiumdopaminium cation
- Systematic name
- 2-(3,4-dihydroxyphenyl)ethanaminium