Compound
glycodeoxycholate
A bile salt formed in the liver by conjugation of deoxycholate with glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and choleretic.
Structure
- Class
- Organic compound, anion
- Formula
- C26H42NO5
- Mass
- 448.624 g/mol
- Charge
- -1
- InChIKey
- WVULKSPCQVQLCU-BUXLTGKBSA-M
- SMILES
- [H][C@]12CC[C@]3([H])[C@]([H])(C[C@H](O)[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC(=O)NCC(=O)[O-])[C@@]1(C)CC[C@@H](O)C2
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
4 entities
4 entities reached.
0 reported hops4 assembled from the scaffold
What the reference databases state
Statements
7 statements
7 statements · 2 reference databases · Subject: glycodeoxycholate · Sources: Human-GEM, Rhea
- glycodeoxycholate is converted to glycodeoxycholate 3-sulfateCompoundRhea RHEA:77207Inferred only
- glycodeoxycholate is metabolised by SULT2A1ProteinHuman-GEM MAR12242Inferred only
- glycodeoxycholate is metabolised by SULT2A1ProteinRhea RHEA:77207Inferred only
- glycodeoxycholate is transported by ABCC4ProteinRhea RHEA:66380Inferred only
- glycodeoxycholate is transported by SLC51AProteinRhea RHEA:71867Inferred only
- glycodeoxycholate is transported by SLC51BProteinRhea RHEA:71867Inferred only
- glycodeoxycholate is transported by SLCO1A2ProteinRhea RHEA:71867Inferred only
Reactions
10 reactions
deoxycholate+glycine+protonglycodeoxycholate+water
Reaction pageReversibleBalancedEC 3.5.1.24cytosol
Human-GEM MAR01834CC BY 4.0Reference data
glycodeoxycholateglycodeoxycholate
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR09189CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR09463CC BY 4.0Reference data
deoxycholoyl-CoA+glycineCHEBI:1146900+glycodeoxycholate
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR10069CC BY 4.0Reference data
glycodeoxycholate+3'-phospho-5'-adenylyl sulfateproton+adenosine 3',5'-bismonophosphate+MAM03589c
Catalysed by SULT2A1
Reaction pageLeft to rightBalancedEC 2.8.2.14cytosol
Human-GEM MAR12242CC BY 4.0Reference data
glycodeoxycholate+waterdeoxycholate+glycine
Reaction pageDirection not assertedBalanced
Rhea RHEA:47552CC BY 4.0Reference data
glycodeoxycholate+glutathione+ATP(4-)+waterglycodeoxycholate+glutathione+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCC4
Reaction pageLeft to rightBalanced
Rhea RHEA:66380CC BY 4.0Reference data
glycodeoxycholateglycodeoxycholate
Transported by SLCO1A2 or SLC51A or SLC51B
Reaction pageDirection not assertedBalanced
Rhea RHEA:71867CC BY 4.0Reference data
glycodeoxycholate+2sodium(1+)glycodeoxycholate+2sodium(1+)
Reaction pageDirection not assertedBalanced
Rhea RHEA:72055CC BY 4.0Reference data
glycodeoxycholate+3'-phosphoadenylyl sulfateglycodeoxycholate 3-sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT2A1
Reaction pageLeft to rightBalanced
Rhea RHEA:77207CC BY 4.0Reference data
Where it reaches
3 systems, 9 regions, 18 tissues, 23 transporter routes — routes, not measurements: transporters known to carry glycodeoxycholate are expressed there, and no source reports it arriving.
Loading the model…
Other names
2 names
Resolves to: glycodeoxycholate
- Systematic name
- {[(3alpha,5beta,12alpha)-3,12-dihydroxy-24-oxocholan-24-yl]amino}acetate{[(3α,5β,12α)-3,12-dihydroxy-24-oxocholan-24-yl]amino}acetate