Compound
glycocholate
The glycine conjugate of cholic acid. It acts as a detergent to solubilize fats for absorption and is itself absorbed.
Structure
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- Class
- Organic compound, anion
- Formula
- C26H42NO6
- Mass
- 464.623 g/mol
- Charge
- -1
- InChIKey
- RFDAIACWWDREDC-FRVQLJSFSA-M
- SMILES
- [H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]1([H])C[C@H](O)[C@@]3(C)[C@@]([H])(CC[C@]3([H])[C@H](C)CCC(=O)NCC(=O)[O-])[C@]1([H])[C@H](O)C2
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
12 entities
12 entities reached.
0 reported hops12 assembled from the scaffold
- ABCC3ProteinUNIPROT:O15438transported byInferred only66 paths30 endpoints
- SULT2A1ProteinUNIPROT:Q06520metabolized byInferred only24 paths24 endpoints
- ABCC4ProteinUNIPROT:O15439transported byInferred only20 paths10 endpoints
- SLC51BProteinUNIPROT:Q86UW2transported byInferred only18 paths9 endpoints
- SLCO1B3ProteinUNIPROT:Q9NPD5transported byInferred only15 paths2 endpoints
- SLC51AProteinUNIPROT:Q86UW1transported byInferred only10 paths5 endpoints
- SLC10A1ProteinUNIPROT:Q14973transported byInferred only8 paths2 endpoints
- ABCB11ProteinUNIPROT:O95342transported byInferred only8 paths3 endpoints
- SLC10A2ProteinUNIPROT:Q12908transported byInferred only6 paths2 endpoints
- SLCO3A1ProteinUNIPROT:Q9UIG8transported byInferred only3 paths3 endpoints
- SLCO1B1ProteinUNIPROT:Q9Y6L6transported byInferred only3 paths2 endpoints
- SLC46A3ProteinUNIPROT:Q7Z3Q1transported byInferred only1 path1 endpoint
What the reference databases state
Statements
36 statements
36 statements · 2 reference databases · Subject: glycocholate · Sources: Human-GEM, Rhea
- glycocholate is metabolised by SULT2A1ProteinHuman-GEM MAR12236Inferred only
- glycocholate is transported by ABCB11ProteinHuman-GEM MAR01868Inferred only
- glycocholate is transported by ABCB11ProteinRhea RHEA:50056Inferred only
- glycocholate is transported by ABCC11ProteinRhea RHEA:50056Inferred only
- glycocholate is transported by ABCC11ProteinHuman-GEM MAR01868Inferred only
- glycocholate is transported by ABCC3ProteinRhea RHEA:50056Inferred only
- glycocholate is transported by ABCC3ProteinHuman-GEM MAR01868Inferred only
- glycocholate is transported by ABCC4ProteinHuman-GEM MAR01868Inferred only
- glycocholate is transported by ABCC4ProteinRhea RHEA:66400Inferred only
- glycocholate is transported by SLC10A1ProteinHuman-GEM MAR01863Inferred only
- glycocholate is transported by SLC10A1ProteinRhea RHEA:71935Inferred only
- glycocholate is transported by SLC10A1ProteinHuman-GEM MAR01862Inferred only
Show the remaining 24
- glycocholate is transported by SLC10A1ProteinHuman-GEM MAR01852Inferred only
- glycocholate is transported by SLC10A2ProteinRhea RHEA:71935Inferred only
- glycocholate is transported by SLC10A2ProteinHuman-GEM MAR01862Inferred only
- glycocholate is transported by SLC10A2ProteinHuman-GEM MAR01863Inferred only
- glycocholate is transported by SLC22A24ProteinRhea RHEA:72351Inferred only
- glycocholate is transported by SLC46A3ProteinRhea RHEA:75503Inferred only
- glycocholate is transported by SLC51AProteinRhea RHEA:71851Inferred only
- glycocholate is transported by SLC51AProteinHuman-GEM MAR01868Inferred only
- glycocholate is transported by SLC51BProteinRhea RHEA:71851Inferred only
- glycocholate is transported by SLC51BProteinHuman-GEM MAR01868Inferred only
- glycocholate is transported by SLCO1A2ProteinHuman-GEM MAR01883Inferred only
- glycocholate is transported by SLCO1A2ProteinHuman-GEM MAR08879Inferred only
- glycocholate is transported by SLCO1A2ProteinHuman-GEM MAR01884Inferred only
- glycocholate is transported by SLCO1A2ProteinHuman-GEM MAR01885Inferred only
- glycocholate is transported by SLCO1A2ProteinRhea RHEA:71851Inferred only
- glycocholate is transported by SLCO1A2ProteinHuman-GEM MAR01876Inferred only
- glycocholate is transported by SLCO1B1ProteinHuman-GEM MAR08879Inferred only
- glycocholate is transported by SLCO1B3ProteinHuman-GEM MAR08879Inferred only
- glycocholate is transported by SLCO1B3ProteinHuman-GEM MAR01876Inferred only
- glycocholate is transported by SLCO1B3ProteinHuman-GEM MAR01883Inferred only
- glycocholate is transported by SLCO1B3ProteinHuman-GEM MAR01885Inferred only
- glycocholate is transported by SLCO1B3ProteinHuman-GEM MAR01884Inferred only
- glycocholate is transported by SLCO3A1ProteinRhea RHEA:71851Inferred only
- glycocholate is transported by SLCO4C1ProteinRhea RHEA:71851Inferred only
Reactions
32 reactions
CHEBI:15519+glycineCHEBI:1146900+glycocholate
Catalysed by BAAT
Reaction pageLeft to rightBalancedEC 2.3.1.65peroxisome
Human-GEM MAR00083CC BY 4.0Reference data
Reaction pageReversibleBalancedEC 2.4.1.88extracellular space, cytosol
Human-GEM MAR01354CC BY 4.0Reference data
Reaction pageReversibleBalancedperoxisome, cytosol
Human-GEM MAR01368CC BY 4.0Reference data
CHEBI:15519+glycineCHEBI:1146900+glycocholate
Catalysed by BAAT
Reaction pageLeft to rightBalancedEC 2.3.1.65cytosol
Human-GEM MAR01670CC BY 4.0Reference data
glycocholate+MAM02357cglycocholate+MAM02357e
Transported by SLC10A1
Reaction pageReversibleBalance undeterminablecytosol, extracellular space
Human-GEM MAR01852CC BY 4.0Reference data
glycocholate+sodium(1+)glycocholate+sodium(1+)
Transported by SLC10A1 or SLC10A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR01862CC BY 4.0Reference data
glycocholate+2sodium(1+)glycocholate+2sodium(1+)
Transported by SLC10A1 or SLC10A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR01863CC BY 4.0Reference data
ATP+glycocholate+waterADP+glycocholate+proton+phosphate(3-)
Transported by ABCB11 or ABCC3 or ABCC4 or SLC51A or SLC51B or ABCC11
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR01868CC BY 4.0Reference data
glycocholate+CHEBI:16856+hydrogencarbonateglycocholate+CHEBI:16856+hydrogencarbonate
Transported by SLCO1A2 or SLCO1B3
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR01876CC BY 4.0Reference data
MAM01980c+glycocholate+hydrogencarbonateMAM01980e+glycocholate+hydrogencarbonate
Transported by SLCO1A2 or SLCO1B3
Reaction pageReversibleBalance undeterminablecytosol, extracellular space
Human-GEM MAR01883CC BY 4.0Reference data
glycocholate+hydrogencarbonate+2,4-dinitrophenyl-S-glutathioneglycocholate+hydrogencarbonate+2,4-dinitrophenyl-S-glutathione
Transported by SLCO1A2 or SLCO1B3
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR01884CC BY 4.0Reference data
glycocholate+hydrogencarbonate+MAM02901cglycocholate+hydrogencarbonate+MAM02901e
Transported by SLCO1A2 or SLCO1B3
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR01885CC BY 4.0Reference data
Where it reaches
8 systems, 17 regions, 39 tissues, 64 transporter routes — routes, not measurements: transporters known to carry glycocholate are expressed there, and no source reports it arriving.
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Other names
2 names
Resolves to: glycocholate
- Systematic name
- N-(3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oyl)glycinateN-(3α,7α,12α-trihydroxy-5β-cholan-24-oyl)glycinate