Compound
3,3',5'-triiodo-L-thyronine
Zwitterionic form of 3,3',5'-triiodo-L-thyronine.
Definition from ChEBI (CHEBI:57261), read 2026-09-23. CC BY 4.0.
Structure
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- Class
- Organic compound
- Formula
- C15H12I3NO4
- Mass
- 650.976 g/mol
- Charge
- 0
- InChIKey
- HZCBWYNLGPIQRK-LBPRGKRZSA-N
- SMILES
- [NH3+][C@@H](Cc1ccc(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)[O-]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
12 entities
12 entities reached.
0 reported hops12 assembled from the scaffold
- DIO2ProteinUNIPROT:Q92813substrate ofInferred only18 paths18 endpoints
- SULT1A1ProteinUNIPROT:P50225metabolized byInferred only17 paths17 endpoints
- SULT1A3ProteinUNIPROT:P0DMM9metabolized byInferred only15 paths15 endpoints
- DIO3ProteinUNIPROT:P55073substrate ofInferred only9 paths9 endpoints
- SLC7A5ProteinUNIPROT:Q01650transported byInferred only8 paths8 endpoints
- SULT1A4ProteinUNIPROT:P0DMN0metabolized byInferred only8 paths8 endpoints
- DIO1ProteinUNIPROT:P49895substrate ofInferred only8 paths8 endpoints
- SULT1B1ProteinUNIPROT:O43704metabolized byInferred only6 paths6 endpoints
- SLCO4A1ProteinUNIPROT:Q96BD0transported byInferred only4 paths4 endpoints
- SLCO1B1ProteinUNIPROT:Q9Y6L6transported byInferred only3 paths2 endpoints
- SLCO1C1ProteinUNIPROT:Q9NYB5transported byInferred only2 paths2 endpoints
- SLC16A2ProteinUNIPROT:P36021transported byInferred only2 paths2 endpoints
What the reference databases state
Chemical structure
- 3,3',5'-triiodo-L-thyronine sulfate has the functional parent 3,3',5'-triiodo-L-thyronineCompoundChEBI CHEBI:176513Inferred only
Statements
14 statements
14 statements · 1 reference database · Subject: 3,3',5'-triiodo-L-thyronine · Sources: Rhea
- 3,3',5'-triiodo-L-thyronine is converted to 3,3',5'-triiodo-L-thyronine sulfateCompoundRhea RHEA:67888Inferred only
- 3,3',5'-triiodo-L-thyronine is metabolised by SULT1A1ProteinRhea RHEA:67888Inferred only
- 3,3',5'-triiodo-L-thyronine is metabolised by SULT1A3ProteinRhea RHEA:67888Inferred only
- 3,3',5'-triiodo-L-thyronine is metabolised by SULT1A4ProteinRhea RHEA:67888Inferred only
- 3,3',5'-triiodo-L-thyronine is metabolised by SULT1B1ProteinRhea RHEA:67888Inferred only
- 3,3',5'-triiodo-L-thyronine is a substrate of DIO1ProteinRhea RHEA:82575Inferred only
- 3,3',5'-triiodo-L-thyronine is a substrate of DIO2ProteinRhea RHEA:82575Inferred only
- 3,3',5'-triiodo-L-thyronine is a substrate of DIO3ProteinRhea RHEA:83775Inferred only
- 3,3',5'-triiodo-L-thyronine is transported by SLC16A2ProteinRhea RHEA:71815Inferred only
- 3,3',5'-triiodo-L-thyronine is transported by SLC7A5ProteinRhea RHEA:71815Inferred only
- 3,3',5'-triiodo-L-thyronine is transported by SLCO1A2ProteinRhea RHEA:71815Inferred only
- 3,3',5'-triiodo-L-thyronine is transported by SLCO1B1ProteinRhea RHEA:71815Inferred only
Show the remaining 2
- 3,3',5'-triiodo-L-thyronine is transported by SLCO1C1ProteinRhea RHEA:71815Inferred only
- 3,3',5'-triiodo-L-thyronine is transported by SLCO4A1ProteinRhea RHEA:71815Inferred only
Reactions
6 reactions
3,3',5'-triiodo-L-thyronine+iodide+A+hydronL-thyroxine+AH2
Reaction pageRight to leftBalanced
Rhea RHEA:18897CC BY 4.0Reference data
3,3',5'-triiodo-L-thyronine+3'-phosphoadenylyl sulfate3,3',5'-triiodo-L-thyronine sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT1B1 or SULT1A3 or SULT1A4 or SULT1A1
Reaction pageLeft to rightBalanced
Rhea RHEA:67888CC BY 4.0Reference data
3,3',5'-triiodo-L-thyronine+an aromatic L-alpha-amino acid3,3',5'-triiodo-L-thyronine+an aromatic L-alpha-amino acid
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:71431CC BY 4.0Reference data
3,3',5'-triiodo-L-thyronine3,3',5'-triiodo-L-thyronine
Transported by SLC16A2 or SLCO1A2 or SLC7A5 or SLCO4A1 or SLCO1C1 or SLCO1B1
Reaction pageLeft to rightBalanced
Rhea RHEA:71815CC BY 4.0Reference data
3,3'-diiodo-L-thyronine+iodide+A+hydron3,3',5'-triiodo-L-thyronine+AH2
Reaction pageRight to leftBalanced
Rhea RHEA:82575CC BY 4.0Reference data
3',5'-diiodo-L-thyronine+iodide+A+hydron3,3',5'-triiodo-L-thyronine+AH2
Catalysed by DIO3
Reaction pageRight to leftBalanced
Rhea RHEA:83775CC BY 4.0Reference data
Where it reaches
5 systems, 9 regions, 15 tissues, 15 transporter routes — routes, not measurements: transporters known to carry 3,3',5'-triiodo-L-thyronine are expressed there, and no source reports it arriving.
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Other names
1 name
Resolves to: 3,3',5'-triiodo-L-thyronine
- Systematic name
- (2S)-2-azaniumyl-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]propanoate