Compound
CHEBI:28666
One of the biologically active principles of srs-a. It is generated from leukotriene C4 after partial hydrolysis of the peptide chain, i.e., cleavage of the gamma-glutamyl portion. Its biological actions include stimulation of vascular and nonvascular smooth muscle, and increases in vascular permeability. (From Dictionary of Prostaglandins and Related Compounds, 1990)
What it touches on the way
Mechanistic reach
8 entities
8 entities reached.
0 reported hops8 assembled from the scaffold
- GGT1ProteinUNIPROT:P19440substrate ofInferred only34 paths34 endpoints
- GGT5ProteinUNIPROT:P36269substrate ofInferred only23 paths23 endpoints
- DPEP1ProteinUNIPROT:P16444substrate ofInferred only22 paths22 endpoints
- DPEP2ProteinUNIPROT:Q9H4A9substrate ofInferred only16 paths16 endpoints
- SLCO2A1ProteinUNIPROT:Q92959transported byInferred only14 paths13 endpoints
- GGT6ProteinUNIPROT:Q6P531substrate ofInferred only9 paths9 endpoints
- GGT7ProteinUNIPROT:Q9UJ14substrate ofInferred only9 paths9 endpoints
- SLCO1B1ProteinUNIPROT:Q9Y6L6transported byInferred only9 paths2 endpoints
What the reference databases state
Statements
16 statements
16 statements · 1 reference database · Subject: CHEBI:28666 · Sources: Human-GEM
- CHEBI:28666 is converted to leukotriene C4CompoundHuman-GEM MAR08548Inferred only
- leukotriene C4 is converted to CHEBI:28666CompoundHuman-GEM MAR01084Inferred only
- leukotriene C4 is converted to CHEBI:28666CompoundHuman-GEM MAR04796Inferred only
- leukotriene C4 is converted to CHEBI:28666CompoundHuman-GEM MAR08548Inferred only
- CHEBI:28666 is a substrate of DPEP1ProteinHuman-GEM MAR01085Inferred only
- CHEBI:28666 is a substrate of DPEP2ProteinHuman-GEM MAR01085Inferred only
- CHEBI:28666 is a substrate of GGT1ProteinHuman-GEM MAR08548Inferred only
- CHEBI:28666 is a substrate of GGT5ProteinHuman-GEM MAR08548Inferred only
- CHEBI:28666 is a substrate of GGT6ProteinHuman-GEM MAR08548Inferred only
- CHEBI:28666 is a substrate of GGT7ProteinHuman-GEM MAR08548Inferred only
- CHEBI:28666 is a substrate of GGTLC1ProteinHuman-GEM MAR08548Inferred only
- CHEBI:28666 is a substrate of GGTLC2ProteinHuman-GEM MAR08548Inferred only
Show the remaining 4
- CHEBI:28666 is transported by SLCO1B1ProteinHuman-GEM MAR06139Inferred only
- CHEBI:28666 is transported by SLCO1B1ProteinHuman-GEM MAR06140Inferred only
- CHEBI:28666 is transported by SLCO1B1ProteinHuman-GEM MAR06141Inferred only
- CHEBI:28666 is transported by SLCO2A1ProteinHuman-GEM MAR06219Inferred only
Reactions
12 reactions
proton+leukotriene C4MAM01111e+CHEBI:28666
Catalysed by GGT5 or GGT1 or GGTLC2 or GGT7 or GGTLC1 or GGT6
Reaction pageLeft to rightBalancedEC 2.3.2.2GO:0005615
Human-GEM MAR01084CC BY 4.0Reference data
water+CHEBI:28666glycine+CHEBI:15650
Reaction pageLeft to rightBalancedEC 3.4.13.19GO:0005615
Human-GEM MAR01085CC BY 4.0Reference data
water+leukotriene C4L-glutamate(1-)+CHEBI:28666
Catalysed by GGT5 or GGT1 or GGTLC2 or GGT7 or GGT6 or GGTLC3
Reaction pageLeft to rightBalancedEC 2.3.2.2GO:0005829
Human-GEM MAR04796CC BY 4.0Reference data
MAM01980c+hydrogencarbonate+CHEBI:28666MAM01980e+hydrogencarbonate+CHEBI:28666
Transported by SLCO1B1
Reaction pageReversibleBalance undeterminableGO:0005829, GO:0005615
Human-GEM MAR06139CC BY 4.0Reference data
hydrogencarbonate+CHEBI:28666+2,4-dinitrophenyl-S-glutathionehydrogencarbonate+CHEBI:28666+2,4-dinitrophenyl-S-glutathione
Transported by SLCO1B1
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR06140CC BY 4.0Reference data
hydrogencarbonate+CHEBI:28666+MAM02901chydrogencarbonate+CHEBI:28666+MAM02901e
Transported by SLCO1B1
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR06141CC BY 4.0Reference data
CHEBI:16856+hydrogencarbonate+CHEBI:28666CHEBI:16856+hydrogencarbonate+CHEBI:28666
Transported by SLCO2A1
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR06219CC BY 4.0Reference data
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR06251CC BY 4.0Reference data
water+leukotriene C4L-glutamate(1-)+CHEBI:28666
Catalysed by GGT5 or GGT1 or GGTLC2 or GGT7 or GGTLC1 or GGT6
Reaction pageReversibleBalancedEC 2.3.2.2GO:0005783
Human-GEM MAR08548CC BY 4.0Reference data
water+CHEBI:28666glycine+CHEBI:15650
Reaction pageReversibleBalancedGO:0005829
Human-GEM MAR08552CC BY 4.0Reference data
Reaction pageReversibleBalancedGO:0005829, GO:0005783
Human-GEM MAR08553CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableGO:0005615
Human-GEM MAR09367CC BY 4.0Reference data
Where it reaches
5 systems, 8 regions, 15 tissues, 15 transporter routes — routes, not measurements: transporters known to carry CHEBI:28666 are expressed there, and no source reports it arriving.
Loading the model…
Other names
5 names
Resolves to: CHEBI:28666
- Also called
- (R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-Carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-L-cysteinyl)glycine5S-hydroxy-6R-(S-cysteinylglycinyl)-7E,9E,11E,14Z-eicosatetraenoic acidLeukotriene D4LTD4
- Systematic name
- S-{(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]pentadeca-2,4,6,9-tetraen-1-yl}-L-cysteinylglycine