Studied for
5 endpoints, 5 findings, from 4 papers — 1 of them found no effect.
- CD4+ T cell countraisesGrade B, Likely. Human evidence, limited replication or design limits.
- Interleukin-6 concentrationlowersGrade B, Likely. Human evidence, limited replication or design limits.
- Maximal oxygen uptakeraisesGrade B, Likely. Human evidence, limited replication or design limits.
- Necrotising enterocolitis incidencelowersGrade B, Likely. Human evidence, limited replication or design limits.
- Tumour necrosis factor alpha concentrationno detected effectGrade B, Likely. Human evidence, limited replication or design limits.
Structure
Loading the model…
- Class
- Organic compound
- Formula
- C6H14N4O2
- Mass
- 174.204 g/mol
- Charge
- 0
- InChIKey
- ODKSFYDXXFIFQN-BYPYZUCNSA-N
- SMILES
- N=C(N)NCCC[C@H](N)C(=O)O
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence — none of it carries a grade.
What the evidence says
How to read these marks5 findings across 5 endpoints, from 4 papers, strongest first, 1 of them null.
What moved
4 findings
Decreases interleukin-6 concentration
LikelyGrade B, Likely. Human evidence, limited replication or design limits.Finding“Our analysis also showed that L-arginine had a noticeable impact on decreasing interleukin-6 (IL-6) levels (WMD = -7.72 pg/ml; 95% CI: -15.05, -0.39).”
Quoted verbatim from L-arginine impact on inflammatory and cardiac markers in patients undergoing coronary artery bypass graft: a systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Population
- adults undergoing coronary artery bypass grafting; overall pooled estimate
Increases CD4+ T cell count
LikelyGrade B, Likely. Human evidence, limited replication or design limits.Finding“With regards to cellular immunity, the arginine group exhibited a substantial increase in the CD4+ T cell count (SMD = 1.03, 95% CI: 0.67-1.38) compared to the control group.”
Quoted verbatim from Arginine on immune function and post-operative obstructions in colorectal cancer patients: a meta-analysis.. - Study
- meta-analysis
- Population
- colorectal cancer patients undergoing surgery; overall pooled estimate
Arginine on immune function and post-operative obstructions in colorectal cancer patients: a meta-analysis.2024PMID:39223466
Increases maximal oxygen uptake
LikelyGrade B, Likely. Human evidence, limited replication or design limits.Finding“This meta-analysis indicated that supplementation with L-arginine could increase VO2 max in healthy people.”
Quoted verbatim from The effect of L-arginine supplementation on maximal oxygen uptake: A systematic review and meta-analysis.. - Study
- meta-analysis
- Population
- healthy people; overall pooled estimate across 11 randomized clinical trials
The effect of L-arginine supplementation on maximal oxygen uptake: A systematic review and meta-analysis.2021PMID:33587327
Decreases necrotising enterocolitis incidence
LikelyGrade B, Likely. Human evidence, limited replication or design limits.Finding“L-arginine had a 59% reduction in the incidence of stage II and III NEC (RR 0.41, 95% CI 0.20 to 0.85, NNT = 9) compared with placebo (P = 0.02).”
Quoted verbatim from Arginine supplementation in prevention of necrotizing enterocolitis in the premature infant: an updated systematic review.. - Study
- meta-analysis
- Population
- preterm infants born at 34 weeks gestation or less with birth weight 1500 g or less; event definition is stage II and III NEC
Arginine supplementation in prevention of necrotizing enterocolitis in the premature infant: an updated systematic review.2014PMID:25205007
What did not
1 finding
Measured, and no effect detected. These are findings, not gaps — a trial that looked and found nothing is the most easily lost result in this field.
No detected effect on tumour necrosis factor alpha concentration
LikelyGrade B, Likely. Human evidence, limited replication or design limits.FindingNull result“However, we found no considerable impact of L-arginine treatment on creatine phosphokinase-MB (CPK-MB), tumor necrosis factor-alpha (TNF-α), and troponin I compared to the placebo groups.”
Quoted verbatim from L-arginine impact on inflammatory and cardiac markers in patients undergoing coronary artery bypass graft: a systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Population
- adults undergoing coronary artery bypass grafting; overall pooled estimate
What it touches on the way
A finding says L-arginine moved an endpoint. This is the biology in between: the proteins and reactions it runs through to get there. It is where to look for the two things a list of findings cannot answer — why a result might happen, and what else acts on the same machinery.
21 of these are proteins with a page of their own, and that is the door: a protein page says what else it carries, which is how one compound leads to the next.
Mechanistic reach
21 entities
21 entities reached, most connected first. Hub metabolites are excluded, so this is not a claim that the compound touches everything.
0 reported hop21 assembled from the scaffold
- SLC25A29ProteinUNIPROT:Q8N8R3transported byInferred only144 paths24 endpoints
- SLC7A9ProteinUNIPROT:P82251transported byInferred only36 paths6 endpoints
- NOS3ProteinUNIPROT:P29474substrate ofInferred only26 paths26 endpoints
- NOS2ProteinUNIPROT:P35228substrate ofInferred only18 paths18 endpoints
- SLC7A1ProteinUNIPROT:P30825transported byInferred only18 paths18 endpoints
- ACE2ProteinUNIPROT:Q9BYF1substrate ofInferred only15 paths15 endpoints
- SLC7A7ProteinUNIPROT:Q9UM01transported byInferred only14 paths14 endpoints
- SLC7A6ProteinUNIPROT:Q92536transported byInferred only12 paths2 endpoints
- GATMProteinUNIPROT:P50440substrate ofInferred only12 paths3 endpoints
- SLC7A2ProteinUNIPROT:P52569transported byInferred only12 paths12 endpoints
- ARG1ProteinUNIPROT:P05089substrate ofInferred only11 paths11 endpoints
- RARS1ProteinUNIPROT:P54136substrate ofInferred only10 paths10 endpoints
Show the remaining 9
- NOS1ProteinUNIPROT:P29475substrate ofInferred only9 paths9 endpoints
- ASLProteinUNIPROT:P04424substrate ofInferred only7 paths7 endpoints
- ARG2ProteinUNIPROT:P78540substrate ofInferred only5 paths5 endpoints
- IL4I1ProteinUNIPROT:Q96RQ9substrate ofInferred only4 paths4 endpoints
- AGMATProteinUNIPROT:Q9BSE5substrate ofInferred only4 paths4 endpoints
- RARS2ProteinUNIPROT:Q5T160substrate ofInferred only4 paths4 endpoints
- MTARC2ProteinUNIPROT:Q969Z3substrate ofInferred only3 paths3 endpoints
- MTARC1ProteinUNIPROT:Q5VT66substrate ofInferred only3 paths3 endpoints
- SLC6A14ProteinUNIPROT:Q9UN76transported byInferred only2 paths2 endpoints
Where it reaches
10 systems, 22 regions, 69 tissues, 78 transporter routes.
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