Compound
CHEBI:16497
A purine 2'-deoxyribonucleoside 5'-triphosphate having guanine as the nucleobase.
Definition from ChEBI (CHEBI:16497), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
33 entities
33 entities reached.
0 reported hops33 assembled from the scaffold
- NME1ProteinUNIPROT:P15531substrate ofInferred only93 paths31 endpoints
- RFC5ProteinUNIPROT:P40937substrate ofInferred only87 paths87 endpoints
- NME2ProteinUNIPROT:P22392substrate ofInferred only78 paths26 endpoints
- POLD2ProteinUNIPROT:P49005substrate ofInferred only73 paths73 endpoints
- POLD1ProteinUNIPROT:P28340substrate ofInferred only70 paths70 endpoints
- POLD3ProteinUNIPROT:Q15054substrate ofInferred only60 paths60 endpoints
- POLEProteinUNIPROT:Q07864substrate ofInferred only52 paths52 endpoints
- POLA1ProteinUNIPROT:P09884substrate ofInferred only49 paths49 endpoints
- POLD4ProteinUNIPROT:Q9HCU8substrate ofInferred only49 paths49 endpoints
- POLE2ProteinUNIPROT:P56282substrate ofInferred only45 paths45 endpoints
- POLA2ProteinUNIPROT:Q14181substrate ofInferred only44 paths44 endpoints
- SLC25A36ProteinUNIPROT:Q96CQ1transported byInferred only39 paths39 endpoints
Show the remaining 21
- POLE4ProteinUNIPROT:Q9NR33substrate ofInferred only39 paths39 endpoints
- POLE3ProteinUNIPROT:Q9NRF9substrate ofInferred only38 paths38 endpoints
- POLBProteinUNIPROT:P06746substrate ofInferred only31 paths31 endpoints
- POLKProteinUNIPROT:Q9UBT6substrate ofInferred only31 paths31 endpoints
- POLHProteinUNIPROT:Q9Y253substrate ofInferred only27 paths27 endpoints
- NME7ProteinUNIPROT:Q9Y5B8substrate ofInferred only24 paths12 endpoints
- NME4ProteinUNIPROT:O00746substrate ofInferred only20 paths10 endpoints
- REV3LProteinUNIPROT:O60673substrate ofInferred only20 paths20 endpoints
- CMPK1ProteinUNIPROT:P30085substrate ofInferred only20 paths4 endpoints
- NME3ProteinUNIPROT:Q13232substrate ofInferred only16 paths8 endpoints
- POLIProteinUNIPROT:Q9UNA4substrate ofInferred only16 paths16 endpoints
- NME6ProteinUNIPROT:O75414substrate ofInferred only12 paths6 endpoints
- POLGProteinUNIPROT:P54098substrate ofInferred only9 paths9 endpoints
- ITPAProteinUNIPROT:Q9BY32substrate ofInferred only9 paths9 endpoints
- POLLProteinUNIPROT:Q9UGP5substrate ofInferred only8 paths8 endpoints
- TK2ProteinUNIPROT:O00142substrate ofInferred only7 paths7 endpoints
- TENT4AProteinUNIPROT:Q5XG87substrate ofInferred only7 paths7 endpoints
- POLG2ProteinUNIPROT:Q9UHN1substrate ofInferred only6 paths6 endpoints
- POLMProteinUNIPROT:Q9NP87substrate ofInferred only5 paths5 endpoints
- POLNProteinUNIPROT:Q7Z5Q5substrate ofInferred only4 paths4 endpoints
- POLQProteinUNIPROT:O75417substrate ofInferred only4 paths4 endpoints
What the reference databases state
Statements
60 statements
60 statements · 1 reference database · Subject: CHEBI:16497 · Sources: Human-GEM
- CHEBI:28862 is converted to CHEBI:16497CompoundHuman-GEM MAR08449Inferred only
- CHEBI:16497 is converted to CHEBI:28862CompoundHuman-GEM MAR07874Inferred only
- CHEBI:16497 is converted to CHEBI:28862CompoundHuman-GEM MAR04570Inferred only
- CHEBI:16497 is converted to CHEBI:28862CompoundHuman-GEM MAR07873Inferred only
- CHEBI:16497 is converted to CHEBI:28862CompoundHuman-GEM MAR07888Inferred only
- CHEBI:16497 is converted to CHEBI:28862CompoundHuman-GEM MAR08448Inferred only
- CHEBI:16497 is converted to CHEBI:28862CompoundHuman-GEM MAR08449Inferred only
- CHEBI:16497 is converted to CHEBI:28862CompoundHuman-GEM MAR04572Inferred only
- CHEBI:28862 is converted to CHEBI:16497CompoundHuman-GEM MAR04570Inferred only
- CHEBI:28862 is converted to CHEBI:16497CompoundHuman-GEM MAR07873Inferred only
- CHEBI:28862 is converted to CHEBI:16497CompoundHuman-GEM MAR07874Inferred only
- CHEBI:28862 is converted to CHEBI:16497CompoundHuman-GEM MAR07888Inferred only
Show the remaining 48
- CHEBI:28862 is converted to CHEBI:16497CompoundHuman-GEM MAR08448Inferred only
- CHEBI:16497 is converted to dGMPCompoundHuman-GEM MAR02120Inferred only
- CHEBI:16497 is a substrate of CMPK1ProteinHuman-GEM MAR07874Inferred only
- CHEBI:16497 is a substrate of CMPK1ProteinHuman-GEM MAR08451Inferred only
- CHEBI:16497 is a substrate of CMPK1ProteinHuman-GEM MAR08449Inferred only
- CHEBI:16497 is a substrate of CMPK1ProteinHuman-GEM MAR08448Inferred only
- CHEBI:16497 is a substrate of CMPK1ProteinHuman-GEM MAR07873Inferred only
- CHEBI:16497 is a substrate of ITPAProteinHuman-GEM MAR02120Inferred only
- CHEBI:16497 is a substrate of NME1ProteinHuman-GEM MAR04572Inferred only
- CHEBI:16497 is a substrate of NME1ProteinHuman-GEM MAR04570Inferred only
- CHEBI:16497 is a substrate of NME1ProteinHuman-GEM MAR07888Inferred only
- CHEBI:16497 is a substrate of NME2ProteinHuman-GEM MAR07888Inferred only
- CHEBI:16497 is a substrate of NME2ProteinHuman-GEM MAR04570Inferred only
- CHEBI:16497 is a substrate of NME2ProteinHuman-GEM MAR04572Inferred only
- CHEBI:16497 is a substrate of NME3ProteinHuman-GEM MAR04572Inferred only
- CHEBI:16497 is a substrate of NME3ProteinHuman-GEM MAR04570Inferred only
- CHEBI:16497 is a substrate of NME4ProteinHuman-GEM MAR04572Inferred only
- CHEBI:16497 is a substrate of NME4ProteinHuman-GEM MAR04570Inferred only
- CHEBI:16497 is a substrate of NME6ProteinHuman-GEM MAR04572Inferred only
- CHEBI:16497 is a substrate of NME6ProteinHuman-GEM MAR04570Inferred only
- CHEBI:16497 is a substrate of NME7ProteinHuman-GEM MAR04570Inferred only
- CHEBI:16497 is a substrate of NME7ProteinHuman-GEM MAR04572Inferred only
- CHEBI:16497 is a substrate of POLA1ProteinHuman-GEM MAR07160Inferred only
- CHEBI:16497 is a substrate of POLA2ProteinHuman-GEM MAR07160Inferred only
- CHEBI:16497 is a substrate of POLBProteinHuman-GEM MAR07160Inferred only
- CHEBI:16497 is a substrate of POLD1ProteinHuman-GEM MAR07160Inferred only
- CHEBI:16497 is a substrate of POLD2ProteinHuman-GEM MAR07160Inferred only
- CHEBI:16497 is a substrate of POLD3ProteinHuman-GEM MAR07160Inferred only
- CHEBI:16497 is a substrate of POLD4ProteinHuman-GEM MAR07160Inferred only
- CHEBI:16497 is a substrate of POLEProteinHuman-GEM MAR07160Inferred only
- CHEBI:16497 is a substrate of POLE2ProteinHuman-GEM MAR07160Inferred only
- CHEBI:16497 is a substrate of POLE3ProteinHuman-GEM MAR07160Inferred only
- CHEBI:16497 is a substrate of POLE4ProteinHuman-GEM MAR07160Inferred only
- CHEBI:16497 is a substrate of POLGProteinHuman-GEM MAR07160Inferred only
- CHEBI:16497 is a substrate of POLG2ProteinHuman-GEM MAR07160Inferred only
- CHEBI:16497 is a substrate of POLHProteinHuman-GEM MAR07160Inferred only
- CHEBI:16497 is a substrate of POLIProteinHuman-GEM MAR07160Inferred only
- CHEBI:16497 is a substrate of POLKProteinHuman-GEM MAR07160Inferred only
- CHEBI:16497 is a substrate of POLLProteinHuman-GEM MAR07160Inferred only
- CHEBI:16497 is a substrate of POLMProteinHuman-GEM MAR07160Inferred only
- CHEBI:16497 is a substrate of POLNProteinHuman-GEM MAR07160Inferred only
- CHEBI:16497 is a substrate of POLQProteinHuman-GEM MAR07160Inferred only
- CHEBI:16497 is a substrate of REV3LProteinHuman-GEM MAR07160Inferred only
- CHEBI:16497 is a substrate of RFC5ProteinHuman-GEM MAR07160Inferred only
- CHEBI:16497 is a substrate of TENT4AProteinHuman-GEM MAR07160Inferred only
- CHEBI:16497 is a substrate of TK2ProteinHuman-GEM MAR06624Inferred only
- CHEBI:16497 is transported by SLC25A33ProteinHuman-GEM MAR20157Inferred only
- CHEBI:16497 is transported by SLC25A36ProteinHuman-GEM MAR20140Inferred only
Reactions
21 reactions
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR01918CC BY 4.0Reference data
CHEBI:16497+waterdGMP+proton+diphosphate(3-)
Catalysed by ITPA
Reaction pageLeft to rightBalancedEC 3.6.1.9extracellular space
Human-GEM MAR02120CC BY 4.0Reference data
0.505626L-alanine+0.35926L-arginine+0.279425L-asparagine+0.352607L-aspartate+20.704451ATP+0.020401CHEBI:1307929+0.011658a cardiolipin+0.039036CHEBI:17677+0.046571L-cysteine+0.013183CHEBI:16284+0.009442dCTP+0.009898CHEBI:16497+0.013091dTTP+0.275194D-glucopyranose 6-phosphate+0.385872L-glutamate(1-)+0.325996L-glutamine+0.538891glycine+0.036117GTP+20.650823water+0.126406CHEBI:15971+0.286078L-isoleucine+0.545544L-leucine+0.592114CHEBI:18019+0.153018L-methionine+0.1544631,2-diacyl-sn-glycero-3-phosphocholine(1+)+0.055374phosphatidylethanolamine+0.002914MAM02715c+0.259466L-phenylalanine+0.0233151-phosphatidyl-1D-myo-inositol+0.412484CHEBI:17203+0.005829phosphatidyl-L-serine+0.392525L-seryl residue+0.017486a sphingomyelin+0.31269CHEBI:16857+0.013306L-tryptophan+0.159671CHEBI:17895+0.053446UTP+0.352607L-valine20.650823ADP+20.650823proton+20.650823phosphate(3-)+MAM03970c
Reaction pageBlockedBalance undeterminablecytosol, nucleus
Human-GEM MAR04413CC BY 4.0Reference data
ADP+CHEBI:16497ATP+CHEBI:28862
Catalysed by NME3 or NME4 or NME7 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6cytosol
Human-GEM MAR04570CC BY 4.0Reference data
ADP+CHEBI:16497ATP+CHEBI:28862
Catalysed by NME3 or NME4 or NME7 or NME6 or NME1 or NME2
Reaction pageLeft to rightBalancedEC 2.7.4.6mitochondrial matrix
Human-GEM MAR04572CC BY 4.0Reference data
CHEBI:28862+proton+phosphoenolpyruvic acidCHEBI:16497+pyruvate
Reaction pageLeft to rightBalancedEC 2.7.1.40cytosol
Human-GEM MAR04573CC BY 4.0Reference data
GTP+thioredoxin dithiolCHEBI:16497+water+thioredoxin disulfide
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1cytosol
Human-GEM MAR04614CC BY 4.0Reference data
2'-deoxyuridine+CHEBI:16497CHEBI:28862+dUMP+proton
Reaction pageLeft to rightBalancedEC 2.7.1.21cytosol
Human-GEM MAR06623CC BY 4.0Reference data
2'-deoxyuridine+CHEBI:16497CHEBI:28862+dUMP+proton
Catalysed by TK2
Reaction pageLeft to rightBalancedEC 2.7.1.21mitochondrial matrix
Human-GEM MAR06624CC BY 4.0Reference data
0.3CHEBI:16284+0.2dCTP+0.2CHEBI:16497+0.3dTTPMAM01721n+diphosphate(3-)
Catalysed by POLE4 & POLE3 or POLD1 & POLD2 & POLD3 & POLD4 or POLA1 & POLA2 or POLA1 & POLD1 & POLD2 & POLE2 & POLE & POLA2 & POLD3 & POLD4 & POLE4 & POLE3 or REV3L or POLQ or POLB or POLI or RFC5 or TENT4A or POLK or POLM and 5 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.7.7.7nucleus
Human-GEM MAR07160CC BY 4.0Reference data
adenosine+CHEBI:16497AMP+CHEBI:28862+proton
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR07803CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, nucleus
Human-GEM MAR07862CC BY 4.0Reference data
Where it reaches
7 systems, 13 regions, 39 tissues, 39 transporter routes — routes, not measurements: transporters known to carry CHEBI:16497 are expressed there, and no source reports it arriving.
Loading the model…
Other names
8 names
Resolves to: CHEBI:16497
- Also called
- 2'-deoxy-GTP2'-deoxyguanosine 5'-triphosphate2'-deoxyguanosine triphosphatedeoxy-GTPdeoxyguanosine 5'-triphosphatedeoxyguanosine triphosphatedGTP
- Systematic name
- 2'-deoxyguanosine 5'-(tetrahydrogen triphosphate)