Compound
estrone 3-O-(beta-D-glucuronate)
A steroid glucuronide anion that is the conjugate base of estrone 3-O-(β-D-glucuronide) arising from deprotonation of the carboxylic acid function; major species at pH 7.3.
Definition from ChEBI (CHEBI:136634), read 2026-09-23. CC BY 4.0.
Structure
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- Class
- Organic compound, anion
- Formula
- C24H29O8
- Mass
- 445.488 g/mol
- Charge
- -1
- InChIKey
- FJAZVHYPASAQKM-JBAURARKSA-M
- SMILES
- [H][C@@]12CCC(=O)[C@@]1(C)CC[C@]1([H])c3ccc(O[C@@H]4O[C@H](C(=O)[O-])[C@@H](O)[C@H](O)[C@H]4O)cc3CC[C@@]21[H]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
3 entities
3 entities reached.
What the reference databases state
Statements
6 statements
6 statements · 2 reference databases · Subject: estrone 3-O-(beta-D-glucuronate) · Sources: Human-GEM, Rhea
- estrone is converted to estrone 3-O-(beta-D-glucuronate)CompoundHuman-GEM MAR07962Inferred only
- estrone is converted to estrone 3-O-(beta-D-glucuronate)CompoundRhea RHEA:52476Inferred only
- estrone 3-O-(beta-D-glucuronate) is converted to estrone 3-O-(3-sulfo-beta-D-glucuronate)CompoundRhea RHEA:68676Inferred only
- estrone 3-O-(beta-D-glucuronate) is a substrate of CHST10ProteinRhea RHEA:68676Inferred only
- estrone 3-O-(beta-D-glucuronate) is transported by ABCC2ProteinRhea RHEA:86851Inferred only
- estrone 3-O-(beta-D-glucuronate) is transported by ABCC3ProteinHuman-GEM MAR07964Inferred only
Reactions
7 reactions
estrone+UDP-alpha-D-glucuronateestrone 3-O-(beta-D-glucuronate)+UDP
Catalysed by UGT1A1 or UGT1A8 or UGT1A10
Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum
Human-GEM MAR07962CC BY 4.0Reference data
estrone 3-O-(beta-D-glucuronate)estrone 3-O-(beta-D-glucuronate)
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR07963CC BY 4.0Reference data
ATP+estrone 3-O-(beta-D-glucuronate)+waterADP+estrone 3-O-(beta-D-glucuronate)+proton+phosphate(3-)
Transported by ABCC3
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07964CC BY 4.0Reference data
estrone 3-O-(beta-D-glucuronate)
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR09316CC BY 4.0Reference data
estrone+UDP-alpha-D-glucuronateestrone 3-O-(beta-D-glucuronate)+UDP+hydron
Catalysed by UGT1A3 or UGT1A10 or UGT1A8
Reaction pageLeft to rightBalanced
Rhea RHEA:52476CC BY 4.0Reference data
estrone 3-O-(beta-D-glucuronate)+3'-phosphoadenylyl sulfateestrone 3-O-(3-sulfo-beta-D-glucuronate)+adenosine 3',5'-bisphosphate+hydron
Catalysed by CHST10
Reaction pageLeft to rightBalanced
Rhea RHEA:68676CC BY 4.0Reference data
estrone 3-O-(beta-D-glucuronate)+ATP(4-)+waterestrone 3-O-(beta-D-glucuronate)+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCC2
Reaction pageLeft to rightBalanced
Rhea RHEA:86851CC BY 4.0Reference data
Where it reaches
7 systems, 15 regions, 31 tissues, 36 transporter routes — routes, not measurements: transporters known to carry estrone 3-O-(beta-D-glucuronate) are expressed there, and no source reports it arriving.
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Other names
2 names
Resolves to: estrone 3-O-(beta-D-glucuronate)
- Systematic name
- 17-oxoestra-1,3,5(10)-trien-3-yl beta-D-glucopyranosiduronate17-oxoestra-1,3,5(10)-trien-3-yl β-D-glucopyranosiduronate