fucoxanthin

bioaccessibility and physicochemical stability of fucoxanthin achieved via nano/micro-encapsulation delivery systems for oral food/nutraceutical use, no clinical or physiological outcome measured

increases, these formulated nano/micro-capsules have proven to be effective in stabilizing and enhancing the bioaccessibility of fucoxanthin, no quantitative figure given

Not recorded as a finding: this platform holds no node for the endpoint

These formulated nano/micro-capsules have proven to be effective in stabilizing and enhancing the bioaccessibility of fucoxanthin.

PMID:33151231 · one of two readings recorded this

bioaccessibility and physicochemical stability of fucoxanthin after encapsulation

increases

These formulated nano/micro-capsules have proven to be effective in stabilizing and enhancing the bioaccessibility of fucoxanthin.

PMID:33151231 · one of two readings recorded this

bioaccessibility and stability of fucoxanthin encapsulated in nano/micro-delivery systems

increases

These formulated nano/micro-capsules have proven to be effective in stabilizing and enhancing the bioaccessibility of fucoxanthin.

PMID:33151231 · one of two readings recorded this

FoxO transcriptional activity, autophagy, mitochondrial function, apoptosis

decreases

Through activating SIRT1, fucoxanthin inhibits forkhead box O (FoxO) transcriptional activity to reduce protein degradation, induces autophagy to enhance degraded protein clearance, promotes mitochondrial function and diminishes apoptosis.

PMID:33865017 · one of two readings recorded this

muscle atrophy F-box (Atrogin-1) and muscle ring finger 1 (MuRF1) expression

decreases

Fucoxanthin alleviates dexamethasone-induced muscle atrophy in C2C12 myotubes, indicated by increased myotubes diameter and expression of myosin heavy chain (MyHC), decreased expression of muscle atrophy F-box (Atrogin-1) and muscle ring finger 1 (MuRF1).

PMID:33865017 · one of two readings recorded this

myotube diameter and myosin heavy chain (MyHC) expression

increases

Fucoxanthin alleviates dexamethasone-induced muscle atrophy in C2C12 myotubes, indicated by increased myotubes diameter and expression of myosin heavy chain (MyHC), decreased expression of muscle atrophy F-box (Atrogin-1) and muscle ring finger 1 (MuRF1).

PMID:33865017 · one of two readings recorded this

myotube diameter and myosin heavy chain (MyHC) expression in dexamethasone-treated C2C12 cells

increases

Not recorded as a finding: no CAT:outcome node for in vitro myotube diameter/MyHC expression (the lean-mass and 1rm-strength nodes require in vivo or human measurement)

Fucoxanthin alleviates dexamethasone-induced muscle atrophy in C2C12 myotubes, indicated by increased myotubes diameter and expression of myosin heavy chain (MyHC), decreased expression of muscle atrophy F-box (Atrogin-1) and muscle ring finger 1 (MuRF1).

PMID:33865017 · one of two readings recorded this

myotube diameter; MyHC, Atrogin-1, MuRF1 expression

increases

Fucoxanthin alleviates dexamethasone-induced muscle atrophy in C2C12 myotubes, indicated by increased myotubes diameter and expression of MyHC, decreased expression of muscle atrophy F-box (Atrogin-1) and muscle ring finger 1 (MuRF1).

PMID:33865017 · one of two readings recorded this

acute and repeat-dose oral toxicity, mutagenicity and genotoxicity of fucoxanthin in mice and rats

no effect

Both studies showed no mortalities and abnormalities in the histological observation of different organs; however, total plasma cholesterol was elevated, possibly due to the interference of fucoxanthinol of the fucoxanthin metabolite or species variance that warrants further elucidation.

PMID:35621930 · one of two readings recorded this

antibacterial activity against Gram-positive bacterial species by agar disc-diffusion and micro-dilution assay

increases

It was observed that fucoxanthin was active against Streptococcus agalactiae, Staphylococcus epidermidis, and Staphylococcus aureus in the agar disc diffusion method, and Streptococcus agalactiae for the microdilution method.

PMID:35621930 · one of two readings recorded this

body weight, BMI, and fat area and mass in a double-blind placebo-controlled clinical trial (Hitoe et al.), as narrated by this unpooled systematic review

decreases

Not recorded as a finding: a review that discusses its trials without pooling them

In a double-blind placebo-controlled study conducted by Hitoe et al., capsules containing 1 and 3 mg fucoxanthin were administered to mildly obese males and females for 4 weeks, resulting in reduced body weight, BMI, and fat area and mass.

PMID:35621930 · one of two readings recorded this

body weight, BMI, and fat area/mass in mildly obese adults (Hitoe et al. RCT, narrated)

decreases

In a double-blind placebo-controlled study conducted by Hitoe et al., capsules containing 1 and 3 mg fucoxanthin were administered to mildly obese males and females for 4 weeks, resulting in reduced body weight, BMI, and fat area and mass.

PMID:35621930 · one of two readings recorded this

body weight, BMI, fat area and fat mass in mildly obese human subjects (clinical trial narrated by the review)

decreases

In a double-blind placebo-controlled study conducted by Hitoe et al., capsules containing 1 and 3 mg fucoxanthin were administered to mildly obese males and females for 4 weeks, resulting in reduced body weight, BMI, and fat area and mass.

PMID:35621930 · one of two readings recorded this

bone turnover markers, osteoclast differentiation and bone resorption in ovariectomised rats and RAW264.7 osteoclast-like cells

decreases

Guo et al. reported that treatment with fucoxanthin in ovariectomized (OVX) rats significantly decreased the body weight gain, uterine index, bone turnover markers, such as Ca, P and OC, and inflammatory markers such as TNF-alpha, IL-6, and IL-1beta.

PMID:35621930 · one of two readings recorded this

cardiac injury and ventricular/muscular function markers in aging mice and doxorubicin- or isoprenaline-injured cardiac models

decreases

In another study of the doxorubicin-injected ICR mice model, fucoxanthin prevented cardiotoxicity.

PMID:35621930 · one of two readings recorded this

cognitive performance and neuronal injury markers in scopolamine-, streptozotocin-, amyloid-beta-, and ischaemia/reperfusion-induced rodent and cell models

increases

Fucoxanthin was shown to recover cognitive deficits induced by scopolamine in mice, possibly involving different mechanisms that include the inhibition of acetylcholinesterase and the attenuation of oxidative stress.

PMID:35621930 · one of two readings recorded this

corneal Nrf2 expression and neural markers after UVB-induced corneal denervation in rats

increases

UVB-induced corneal denervation and trigeminal pain in the rat model were performed, where fucoxanthin increased Nrf2 expression in the cornea and decreased p38 MAP kinase, GFAP-positive neural cells, TRPV1 expression in the trigeminal ganglia neurons, and eye-opening and wipe behavior.

PMID:35621930 · one of two readings recorded this

DPPH radical scavenging, iron-chelating activity, reducing power, and antioxidant enzyme activity (SOD, CAT, GSH-Px, T-AOC) in vitro and in vivo

increases

An in vitro cell-free assay resulted in antioxidant activities of fucoxanthin extracted from brown algae, with an increased level of DPPH radical scavenging activity and iron-chelating activity and decreased reducing power in the in vitro cell-free assay.

PMID:35621930 · one of two readings recorded this

high-fat-diet-induced obesity, hyperglycaemia, hyperlipidaemia and insulin resistance markers in mice

decreases

The dietary supplementation of fucoxanthin in HFD-induced obese mice improved obesity, hyperglycemia and hyperlipidemia, and alleviated insulin resistance, possibly through the regulation of IRS-1/PI3 K/Akt and PPARgamma/SREBP-1/FAS signaling pathways.

PMID:35621930 · one of two readings recorded this

incidence and multiplicity of colonic adenocarcinoma in AOM/DSS-induced colorectal cancer mice (Terasaki et al., narrated)

decreases

Another study by Terasaki et al. found that the oral administration of fucoxanthin in azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colorectal cancer mice reduced the incidence and the multiplicity of colonic adenocarcinoma, by downregulating the integrin signaling pathway.

PMID:35621930 · one of two readings recorded this

plasma AUC of fucoxanthin versus its metabolite fucoxanthinol after intravenous injection in rats (narrated)

increases, AUC of fucoxanthin was 2.5 times higher when compared with fucoxanthinol

The metabolism of fucoxanthin (2 mg/kg) to fucoxanthinol was reported to be quicker and found after 5 min post-injection; area under the curve (AUC) of fucoxanthin was 2.5 times higher when compared with fucoxanthinol.

PMID:35621930 · one of two readings recorded this

pro-inflammatory cytokine expression (TNF-alpha, IL-1beta, IL-6, COX-2, iNOS) in LPS- or particulate-matter-induced cell and animal models

decreases

Fucoxanthin treatment in LPS-generated inflammation in RAW 264.7 macrophage resulted in the lower expression of Tnfalpha, Il1b, and Il6 mRNA and TNFalpha, due to abated Nrf2 nuclear translocation via PI3K/AKT signaling pathway.

PMID:35621930 · one of two readings recorded this

renal fibrosis, oxidative stress and calculi deposition in diabetic-nephropathy and ethylene-glycol renal-stone rodent models

decreases

In another study of ethylene glycol-treated albino rats, fucoxanthin normalized the elevated renal stone and biochemical markers.

PMID:35621930 · one of two readings recorded this

renal function, retinopathy and diabetic complication markers in streptozotocin-induced diabetic rats and db/db mice

decreases

In streptozotocin-induced diabetic rats, fucoxanthin effectively improved renal fibrosis by activating Sirt1/Nrf2 signaling to reduce oxidative stress.

PMID:35621930 · one of two readings recorded this

tumour cell viability, proliferation, apoptosis and tumorigenesis across multiple cancer cell lines and xenograft/carcinogen-induced mouse models

decreases

The cell tumorgenicity and sphere formation observed in human colorectal cancer cells and mice with tumors were attenuated when fucoxanthinol, a metabolite of fucoxanthin, was added to the culture.

PMID:35621930 · one of two readings recorded this

fucoxanthin content (accumulation) in Phaeodactylum tricornutum cells under exogenous arachidonic acid treatment

increases, 1.1 mg/g dry weight (DW), 36.6% higher than untreated cells

Not recorded as a finding: the compound is what was measured, not what was given

Our results demonstrated that even low concentration of AA at 0.1 mg/L strongly induced fucoxanthin accumulation in algal cells to a maximum of 1.1 mg/g dry weight (DW), which was 36.6% higher than that in the untreated ones.

PMID:36286467 · one of two readings recorded this

fucoxanthin content in Phaeodactylum tricornutum cells induced by exogenous arachidonic acid, mg/g dry weight

increases, 1.1 mg/g dry weight, 36.6% higher than untreated

Not recorded as a finding: the compound is what was measured, not what was given

Our results demonstrated that even low concentration of AA at 0.1 mg/L strongly induced fucoxanthin accumulation in algal cells to a maximum of 1.1 mg/g dry weight (DW), which was 36.6% higher than that in the untreated ones.

PMID:36286467 · one of two readings recorded this

immune activation response to LPS primary stimulation and immunosuppression to LPS restimulation

decreases

Our results showed that FX could not only suppress the immune activation responses caused by LPS primary stimulation, but also antagonize LPS restimulation-induced immunosuppression in macrophages.

PMID:37340299 · one of two readings recorded this

immune activation response to primary LPS stimulation and immunosuppression response to LPS restimulation, inflammatory mediator production

Our results showed that FX could not only suppress the immune activation responses caused by LPS primary stimulation, but also antagonize LPS restimulation-induced immunosuppression in macrophages.

PMID:37340299 · one of two readings recorded this

GBM cell survival / ferroptotic cell death

decreases

Here, we show that fucoxanthin inhibits the survival of GBM cells by triggering ferroptosis, a ferric ion and reactive oxygen species (ROS) dependent cell death and ferrostatin-1 could block it.

PMID:37421513 · one of two readings recorded this

GBM cell survival via ferroptosis

decreases

Here, we show that fucoxanthin inhibits the survival of GBM cells by triggering ferroptosis, a ferric ion and reactive oxygen species (ROS) dependent cell death and ferrostatin-1 could block it.

PMID:37421513 · one of two readings recorded this

GBM xenograft tumor growth in vivo

decreases

Not recorded as a finding: no CAT:outcome node for tumor xenograft growth

Fucoxanthin is able to block degradation and maintain high levels of TFRC, and similarly inhibits the growth of GBM xenografts in vivo, downregulates the expression of proliferating cell nuclear antigen (PCNA) and upregulates the levels of TFRC in tumor tissues.

PMID:37421513 · one of two readings recorded this

GBM xenograft tumor growth; PCNA and TFRC expression in tumor tissue

decreases

Fucoxanthin is able to block degradation and maintain high levels of TFRC, and similarly inhibits the growth of GBM xenografts in vivo, downregulates the expression of proliferating cell nuclear antigen (PCNA) and upregulates the levels of TFRC in tumor tissues.

PMID:37421513 · one of two readings recorded this

GBM xenograft tumor growth, PCNA and TFRC levels in tumor tissue

decreases

Fucoxanthin is able to block degradation and maintain high levels of TFRC, and similarly inhibits the growth of GBM xenografts in vivo, downregulates the expression of proliferating cell nuclear antigen (PCNA) and upregulates the levels of TFRC in tumor tissues.

PMID:37421513 · one of two readings recorded this

cardiomyocyte cell death after hypoxia and reperfusion

decreases

In the in vitro study, calcein AM/PI staining and TUNEL staining showed that FX reduced cell death caused by hypoxia and reperfusion treatment.

PMID:37861458 · one of two readings recorded this

cardiomyocyte cell death (calcein AM/PI, TUNEL staining)

decreases

In the in vitro study, calcein AM/PI staining and TUNEL staining showed that FX reduced cell death caused by hypoxia and reperfusion treatment.

PMID:37861458 · one of two readings recorded this

cellular and mitochondrial reactive oxygen species (DCFH-DA, MitoSOX)

decreases

DCFH-DA and MitoSOX probes indicated that FX inhibited cellular and mitochondrial reactive oxygen species (ROS).

PMID:37861458 · one of two readings recorded this

cellular and mitochondrial reactive oxygen species (ROS)

decreases

DCFH-DA and MitoSOX probes indicated that FX inhibited cellular and mitochondrial reactive oxygen species (ROS).

PMID:37861458 · one of two readings recorded this

ferroptosis (lipid ROS, Fe2+ release, FTH/TFRC/GPX4 expression)

decreases

The results revealed that FX ameliorated ferroptosis in vitro and in vivo, as indicated by inhibiting lipid ROS and Fe2+ release, as well as by modulating ferroptosis hallmark FTH, TFRC, and GPX4 expression.

PMID:37861458 · one of two readings recorded this

left ventricular ejection fraction (LVEF) and fractional shortening (LVFS), echocardiography, mice with myocardial ischemia-reperfusion injury

increases

Not recorded as a finding: no outcome node for cardiac ejection fraction/fractional shortening in the closed outcome vocabulary

Furthermore, FX improved LVEF and LVFS and inhibited myocardial hypertrophy and fibrosis after 4 weeks in mice with MIRI.

PMID:37861458 · one of two readings recorded this

left ventricular ejection fraction (LVEF), fractional shortening (LVFS), myocardial hypertrophy and fibrosis

increases

Furthermore, FX improved LVEF and LVFS and inhibited myocardial hypertrophy and fibrosis after 4 weeks in mice with MIRI.

PMID:37861458 · one of two readings recorded this

left ventricular ejection fraction (LVEF), left ventricular fractional shortening (LVFS), myocardial hypertrophy and fibrosis

increases

Furthermore, FX improved LVEF and LVFS and inhibited myocardial hypertrophy and fibrosis after 4 weeks in mice with MIRI.

PMID:37861458 · one of two readings recorded this

myocardial infarct size after ischemia-reperfusion in mice

decreases

Not recorded as a finding: no CAT:outcome node for infarct size in an ischemia-reperfusion animal model

TTC-Evans blue staining showed that FX reduced the infarction size induced by MIRI.

PMID:37861458 · one of two readings recorded this

myocardial infarction size

decreases

TTC-Evans blue staining showed that FX reduced the infarction size induced by MIRI.

PMID:37861458 · one of two readings recorded this

myocardial infarction size (TTC-Evans blue staining)

decreases

TTC-Evans blue staining showed that FX reduced the infarction size induced by MIRI.

PMID:37861458 · one of two readings recorded this

myofibril loss and mitochondrion shrinkage (electron microscopy)

decreases

Transmission electron microscopy showed that FX ameliorated the MIRI-induced myofibril loss and mitochondrion shrinkage.

PMID:37861458 · one of two readings recorded this

hepatic oxidative stress gene and protein expression, RT-PCR/Western blot/immunohistochemistry

decreases

Not recorded as a finding: expression-level readout of unnamed oxidative-stress genes/proteins; no specific antioxidant enzyme is named and no outcome node (e.g. SOD/catalase/GPx activity) covers a generic gene-expression panel

For the hepatic inflammation and PAC-toxicity-induced oxidative stress genes and proteins, FUC-treated rats (100, 200, and 500 mg/kg) showed a reduction in the expression of oxidative stress genes.

PMID:37999416 · one of two readings recorded this

serum ALT, AST and ALP levels in paracetamol-induced hepatotoxic rats

decreases

Not recorded as a finding: the paper never states the instrument the node requires

The serum levels of liver biomarkers (ALT, AST, and ALP) increased after PAC-induced liver toxicity; FUC-treated rats showed lower levels compared to the positive control.

PMID:37999416 · one of two readings recorded this

intestinal epithelial cell apoptosis; tight junction proteins claudin-1, occludin, zonula occludens-1

decreases

Fx also significantly mitigated LPS-induced excessive apoptosis of intestinal epithelial cells (IECs) and curbed the decrease of tight junction proteins including claudin-1, occludin, and zonula occludens-1 in the ileum and colon.

PMID:38787699 · one of two readings recorded this

intestinal epithelial cell apoptosis, tight junction proteins (claudin-1, occludin, zonula occludens-1) in ileum and colon

decreases

Fx also significantly mitigated LPS-induced excessive apoptosis of intestinal epithelial cells (IECs) and curbed the decrease of tight junction proteins including claudin-1, occludin, and zonula occludens-1 in the ileum and colon.

PMID:38787699 · one of two readings recorded this

intestinal reactive oxygen species, malondialdehyde and protein carbonylation

decreases

Moreover, Fx also notably restrained intestinal reactive oxygen species (ROS), malondialdehyde and protein carbonylation levels in LPS-treated mice, and it might be mediated by activating the nuclear factor-erythroid 2 related factor 2 (Nrf2) signaling pathway.

PMID:38787699 · one of two readings recorded this

intestinal reactive oxygen species, malondialdehyde, protein carbonylation

decreases

Moreover, Fx also notably restrained intestinal reactive oxygen species (ROS), malondialdehyde and protein carbonylation levels in LPS-treated mice, and it might be mediated by activating the nuclear factor-erythroid 2 related factor 2 (Nrf2) signaling pathway.

PMID:38787699 · one of two readings recorded this

macrophage/neutrophil infiltration; TNF-α, IL-1β, IL-6 overproduction; GSDMD-mediated pyroptosis

decreases

Additionally, Fx effectively alleviated LPS-induced extensive infiltration of macrophages and neutrophils into the intestinal mucosa, the overproduction of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin 1beta (IL-1β) and IL-6, and gasdermin D (GSDMD)-mediated pyroptosis of IECs.

PMID:38787699 · one of two readings recorded this

frequency of CD19+ B cells, memory B cells and activated follicular helper CD4+ T (Tfh) cells in PBMC cultures

decreases

Not recorded as a finding: assay instrument (presumably flow cytometry) is not named in the abstract; the lymphocyte-subpopulation-proportions node requires the assay to be stated

Importantly, fucoxanthin demonstrated significant immunomodulatory effects by reducing the frequency of key immune cell populations, including CD19+ B cells, memory B cells, and activated follicular helper CD4+ T (Tfh) cells in cultures of peripheral blood mononuclear cells in vitro.

PMID:39953920 · both readings recorded this

dysfunctional cell proliferation and G0/G1 cell cycle arrest

decreases

Additionally, fucoxanthin decreased dysfunctional cell proliferation and reversed the cell cycle arrest in the G0/G1 phase.

PMID:40336366 · one of two readings recorded this

dysfunctional keratinocyte proliferation and G0/G1 cell-cycle arrest

decreases

Additionally, fucoxanthin decreased dysfunctional cell proliferation and reversed the cell cycle arrest in the G0/G1 phase.

PMID:40336366 · one of two readings recorded this

keratinocyte cell proliferation / cell-cycle arrest, HaCaT cells

decreases

Not recorded as a finding: no outcome node for cell-culture proliferation/cell-cycle assays in the closed outcome vocabulary

Additionally, fucoxanthin decreased dysfunctional cell proliferation and reversed the cell cycle arrest in the G0/G1 phase.

PMID:40336366 · one of two readings recorded this

lipid peroxidation, DNA damage, mitochondrial membrane potential depolarization

decreases

Fucoxanthin decreased PM2.5-induced production of reactive oxygen species and mitigated lipid peroxidation, DNA damage, and depolarization of the mitochondrial membrane potential.

PMID:40336366 · one of two readings recorded this

NF-κB and NLRP3 inflammasome activation, IL-1/IL-6/COX-2 release

decreases

Fucoxanthin inhibited PM2.5-mediated activation of nuclear factor κB and Nod-like receptor family protein 3 inflammasome and the release of proinflammatory cytokines such as interleukin (IL)-1, IL-6, and cyclooxygenase-2.

PMID:40336366 · both readings recorded this

reactive oxygen species production

decreases

Fucoxanthin decreased PM2.5-induced production of reactive oxygen species and mitigated lipid peroxidation, DNA damage, and depolarization of the mitochondrial membrane potential.

PMID:40336366 · one of two readings recorded this

reactive oxygen species production, lipid peroxidation, DNA damage and mitochondrial membrane depolarization in PM2.5-exposed HaCaT keratinocytes

decreases

Not recorded as a finding: no CAT:outcome node exists for these cellular oxidative-damage endpoints

Fucoxanthin decreased PM2.5-induced production of reactive oxygen species and mitigated lipid peroxidation, DNA damage, and depolarization of the mitochondrial membrane potential.

PMID:40336366 · one of two readings recorded this

reactive oxygen species production, lipid peroxidation, DNA damage, mitochondrial membrane depolarization

decreases

Fucoxanthin decreased PM2.5-induced production of reactive oxygen species and mitigated lipid peroxidation, DNA damage, and depolarization of the mitochondrial membrane potential.

PMID:40336366 · one of two readings recorded this

senescence-associated β-galactosidase and matrix metalloproteinase expression

decreases

Senescence-associated β-galactosidase and matrix metalloproteinases were downregulated by fucoxanthin following exposure to PM2.5.

PMID:40336366 · both readings recorded this

retinal ganglion cell (RGC) survival, FluoroGold labelling

increases

Not recorded as a finding: this platform holds no node for the endpoint

Fucoxanthin intravitreal administration enhanced RGC survival and Bcl-2 expression while reducing Bax and glial fibrillar acidic protein levels.

PMID:40841125 · both readings recorded this

Akt and GSK-3β activation state in SweAPP N2a cells

increases

Not recorded as a finding: the only sentence reporting this refers to fucoxanthin solely by the pronoun 'it', not by name, so it does not self-support without the preceding sentence; two sentences cannot be combined outside the arm-label exception

Mechanistically, it activated Akt and inactivated GSK-3β, effects reversed by PI3K inhibition.

PMID:41195529 · one of two readings recorded this

BACE1 and glutaminyl cyclase (QC) protein/mRNA expression in SweAPP N2a cells

decreases

Not recorded as a finding: an expression readout, not a measurement of enzyme activity; mechanism_claims requires activity for the inhibits predicate, so this is not used, though the same paper's hippocampal-tissue sentence explicitly stating 'inhibition' was extractable

In SweAPP N2a cells, fucoxanthin (0.1-5 μM) significantly decreased BACE1 and QC expression, accompanied by reduced levels of Aβ1-42 and pE3-Aβ.

PMID:41195529 · one of two readings recorded this

BACE1 and QC expression, amyloid-β1-42 and pyroglutamate-3-Aβ (pE3-Aβ) levels in SweAPP N2a cells

decreases

Not recorded as a finding: this platform holds no node for the endpoint

In SweAPP N2a cells, fucoxanthin (0.1-5 μM) significantly decreased BACE1 and QC expression, accompanied by reduced levels of Aβ1-42 and pE3-Aβ.

PMID:41195529 · one of two readings recorded this

memory performance in an Aβ1-42-injected mouse model, compared to donepezil

increases

Not recorded as a finding: no validated memory instrument is named, and the working-memory outcome node requires the instrument to be recorded

In an Aβ1-42-injected mouse model, used for rapid induction of early amyloid pathology, oral administration of fucoxanthin (100 or 200 mg kg-1) improved memory performance, producing effects comparable to donepezil.

PMID:41195529 · one of two readings recorded this