Compound
phosphoenolpyruvic acid
A monocarboxylic acid anion derived from selective deprotonation of the carboxy group of phosphoenolpyruvic acid. It is a metabolic intermediate in glycolysis; gluconeogenesis; and other pathways.
What it touches on the way
Mechanistic reach
7 entities
7 entities reached.
0 reported hops7 assembled from the scaffold
- PKMProteinUNIPROT:P14618substrate ofInferred only462 paths65 endpoints
- SLC25A1ProteinUNIPROT:P53007transported byInferred only84 paths28 endpoints
- PKLRProteinUNIPROT:P30613substrate ofInferred only77 paths11 endpoints
- ENO1ProteinUNIPROT:P06733substrate ofInferred only75 paths75 endpoints
- ENO2ProteinUNIPROT:P09104substrate ofInferred only35 paths35 endpoints
- ENO3ProteinUNIPROT:P13929substrate ofInferred only17 paths17 endpoints
- NANSProteinUNIPROT:Q9NR45substrate ofInferred only12 paths6 endpoints
What the reference databases state
Statements
30 statements
30 statements · 1 reference database · Subject: phosphoenolpyruvic acid · Sources: Human-GEM
- (2R)-2-phosphoglycerate is converted to phosphoenolpyruvic acidCompoundHuman-GEM MAR04363Inferred only
- phosphoenolpyruvic acid is converted to (2R)-2-phosphoglycerateCompoundHuman-GEM MAR04363Inferred only
- oxaloacetate is converted to phosphoenolpyruvic acidCompoundHuman-GEM MAR04101Inferred only
- oxaloacetate is converted to phosphoenolpyruvic acidCompoundHuman-GEM MAR04103Inferred only
- phosphoenolpyruvic acid is converted to pyruvateCompoundHuman-GEM MAR04358Inferred only
- phosphoenolpyruvic acid is converted to pyruvateCompoundHuman-GEM MAR04210Inferred only
- phosphoenolpyruvic acid is converted to pyruvateCompoundHuman-GEM MAR04193Inferred only
- phosphoenolpyruvic acid is converted to pyruvateCompoundHuman-GEM MAR04171Inferred only
- phosphoenolpyruvic acid is a substrate of ENO1ProteinHuman-GEM MAR04363Inferred only
- phosphoenolpyruvic acid is a substrate of ENO2ProteinHuman-GEM MAR04363Inferred only
- phosphoenolpyruvic acid is a substrate of ENO3ProteinHuman-GEM MAR04363Inferred only
- phosphoenolpyruvic acid is a substrate of NANSProteinHuman-GEM MAR08371Inferred only
Show the remaining 18
- phosphoenolpyruvic acid is a substrate of NANSProteinHuman-GEM MAR04529Inferred only
- phosphoenolpyruvic acid is a substrate of PKLRProteinHuman-GEM MAR04573Inferred only
- phosphoenolpyruvic acid is a substrate of PKLRProteinHuman-GEM MAR04171Inferred only
- phosphoenolpyruvic acid is a substrate of PKLRProteinHuman-GEM MAR04358Inferred only
- phosphoenolpyruvic acid is a substrate of PKLRProteinHuman-GEM MAR04193Inferred only
- phosphoenolpyruvic acid is a substrate of PKLRProteinHuman-GEM MAR06627Inferred only
- phosphoenolpyruvic acid is a substrate of PKLRProteinHuman-GEM MAR04421Inferred only
- phosphoenolpyruvic acid is a substrate of PKLRProteinHuman-GEM MAR04210Inferred only
- phosphoenolpyruvic acid is a substrate of PKMProteinHuman-GEM MAR04171Inferred only
- phosphoenolpyruvic acid is a substrate of PKMProteinHuman-GEM MAR04210Inferred only
- phosphoenolpyruvic acid is a substrate of PKMProteinHuman-GEM MAR04358Inferred only
- phosphoenolpyruvic acid is a substrate of PKMProteinHuman-GEM MAR06627Inferred only
- phosphoenolpyruvic acid is a substrate of PKMProteinHuman-GEM MAR04421Inferred only
- phosphoenolpyruvic acid is a substrate of PKMProteinHuman-GEM MAR04573Inferred only
- phosphoenolpyruvic acid is a substrate of PKMProteinHuman-GEM MAR04193Inferred only
- phosphoenolpyruvic acid is transported by SLC25A1ProteinHuman-GEM MAR06297Inferred only
- phosphoenolpyruvic acid is transported by SLC25A1ProteinHuman-GEM MAR06298Inferred only
- phosphoenolpyruvic acid is transported by SLC25A1ProteinHuman-GEM MAR04971Inferred only
Reactions
17 reactions
GTP+oxaloacetatecarbon dioxide+GDP+phosphoenolpyruvic acid
Catalysed by PCK1
Reaction pageLeft to rightBalancedEC 4.1.1.32cytosol
Human-GEM MAR04101CC BY 4.0Reference data
GTP+oxaloacetatecarbon dioxide+GDP+phosphoenolpyruvic acid
Catalysed by PCK2
Reaction pageLeft to rightBalancedEC 4.1.1.32mitochondrial matrix
Human-GEM MAR04103CC BY 4.0Reference data
GDP+proton+phosphoenolpyruvic acidGTP+pyruvate
Reaction pageLeft to rightBalancedEC 2.7.1.40cytosol
Human-GEM MAR04171CC BY 4.0Reference data
CHEBI:17239+proton+phosphoenolpyruvic acidCHEBI:17677+pyruvate
Reaction pageLeft to rightBalancedEC 2.7.1.40cytosol
Human-GEM MAR04193CC BY 4.0Reference data
proton+phosphoenolpyruvic acid+UDPpyruvate+UTP
Reaction pageLeft to rightBalancedEC 2.7.1.40cytosol
Human-GEM MAR04210CC BY 4.0Reference data
ADP+proton+phosphoenolpyruvic acidATP+pyruvate
Reaction pageLeft to rightBalancedEC 2.7.1.40cytosol
Human-GEM MAR04358CC BY 4.0Reference data
(2R)-2-phosphoglyceratewater+phosphoenolpyruvic acid
Catalysed by ENO1 or ENO3 or ENO2
Reaction pageReversibleBalancedEC 4.2.1.11cytosol
Human-GEM MAR04363CC BY 4.0Reference data
CHEBI:16174+proton+phosphoenolpyruvic acidCHEBI:16284+pyruvate
Reaction pageLeft to rightBalancedEC 2.7.1.40cytosol
Human-GEM MAR04421CC BY 4.0Reference data
water+aldehydo-N-acetyl-D-mannosamine 6-phosphate+phosphoenolpyruvic acidN-acetylneuraminate 9-phosphate+phosphate(3-)
Catalysed by NANS
Reaction pageLeft to rightBalancedEC 2.5.1.56, 2.5.1.57cytosol
Human-GEM MAR04529CC BY 4.0Reference data
CHEBI:28862+proton+phosphoenolpyruvic acidCHEBI:16497+pyruvate
Reaction pageLeft to rightBalancedEC 2.7.1.40cytosol
Human-GEM MAR04573CC BY 4.0Reference data
citric acid+phosphoenolpyruvic acidcitric acid+phosphoenolpyruvic acid
Transported by SLC25A1
Reaction pageReversibleBalancedmitochondrial matrix, cytosol
Human-GEM MAR04971CC BY 4.0Reference data
isocitric acid+phosphoenolpyruvic acidisocitric acid+phosphoenolpyruvic acid
Transported by SLC25A1
Reaction pageReversibleBalancedmitochondrial matrix, cytosol
Human-GEM MAR06297CC BY 4.0Reference data
Where it reaches
7 systems, 11 regions, 24 tissues, 24 transporter routes — routes, not measurements: transporters known to carry phosphoenolpyruvic acid are expressed there, and no source reports it arriving.
Loading the model…
Other names
5 names
Resolves to: phosphoenolpyruvic acid
- Also called
- 2-(phosphonooxy)-2-propenoic acid2-PHOSPHOENOLPYRUVIC ACIDPEPPHOSPHOENOLPYRUVATE
- Systematic name
- 2-(phosphonooxy)prop-2-enoic acid