Compound
prostaglandin E2
The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C20H31O5
- Mass
- 351.463 g/mol
- Charge
- -1
- InChIKey
- XEYBRNLFEZDVAW-ARSRFYASSA-M
- SMILES
- CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=CCCCC(=O)[O-]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
21 entities
21 entities reached.
0 reported hops21 assembled from the scaffold
- SLCO2A1ProteinUNIPROT:Q92959transported byInferred only56 paths13 endpoints
- CBR1ProteinUNIPROT:P16152substrate ofInferred only44 paths22 endpoints
- PTGES3ProteinUNIPROT:Q15185substrate ofInferred only31 paths31 endpoints
- ABCC4ProteinUNIPROT:O15439transported byInferred only20 paths10 endpoints
- HPGDProteinUNIPROT:P15428substrate ofInferred only17 paths17 endpoints
- SLCO1B3ProteinUNIPROT:Q9NPD5transported byInferred only15 paths2 endpoints
- PTGESProteinUNIPROT:O14684substrate ofInferred only13 paths13 endpoints
- PTGES2ProteinUNIPROT:Q9H7Z7substrate ofInferred only11 paths11 endpoints
- SLC22A2ProteinUNIPROT:O15244transported byInferred only10 paths5 endpoints
- SLC51BProteinUNIPROT:Q86UW2transported byInferred only9 paths9 endpoints
- SLCO3A1ProteinUNIPROT:Q9UIG8transported byInferred only9 paths3 endpoints
- SLCO4A1ProteinUNIPROT:Q96BD0transported byInferred only8 paths4 endpoints
Show the remaining 9
- SLC22A1ProteinUNIPROT:O15245transported byInferred only6 paths3 endpoints
- SLC51AProteinUNIPROT:Q86UW1transported byInferred only5 paths5 endpoints
- SLC22A3ProteinUNIPROT:O75751transported byInferred only4 paths4 endpoints
- SLCO1B1ProteinUNIPROT:Q9Y6L6transported byInferred only3 paths2 endpoints
- SLC22A8ProteinUNIPROT:Q8TCC7transported byInferred only2 paths1 endpoint
- SLC22A11ProteinUNIPROT:Q9NSA0transported byInferred only2 paths2 endpoints
- SLC22A7ProteinUNIPROT:Q9Y694transported byInferred only2 paths2 endpoints
- SLCO2B1ProteinUNIPROT:O94956transported byInferred only2 paths2 endpoints
- SLC22A6ProteinUNIPROT:Q4U2R8transported byInferred only1 path1 endpoint
What the reference databases state
Statements
57 statements
57 statements · 2 reference databases · Subject: prostaglandin E2 · Sources: Human-GEM, Rhea
- prostaglandin E2 is converted to 15-oxoprostaglandin E2CompoundRhea RHEA:63476Inferred only
- prostaglandin E2 is converted to 15-oxoprostaglandin E2CompoundRhea RHEA:11876Inferred only
- prostaglandin E2 is converted to prostaglandin A2CompoundHuman-GEM MAR03016Inferred only
- prostaglandin E2 is converted to prostaglandin A2CompoundRhea RHEA:50536Inferred only
- prostaglandin E2 is converted to prostaglandin A2CompoundHuman-GEM MAR01321Inferred only
- prostaglandin A2 is converted to prostaglandin E2CompoundHuman-GEM MAR01321Inferred only
- prostaglandin A2 is converted to prostaglandin E2CompoundHuman-GEM MAR03016Inferred only
- prostaglandin A2 is converted to prostaglandin E2CompoundRhea RHEA:50536Inferred only
- prostaglandin E2 is converted to prostaglandin F2alphaCompoundRhea RHEA:24508Inferred only
- prostaglandin F2alpha is converted to prostaglandin E2CompoundHuman-GEM MAR01327Inferred only
- prostaglandin H2 is converted to prostaglandin E2CompoundHuman-GEM MAR01312Inferred only
- prostaglandin H2 is converted to prostaglandin E2CompoundHuman-GEM MAR08560Inferred only
Show the remaining 45
- prostaglandin H2 is converted to prostaglandin E2CompoundRhea RHEA:12893Inferred only
- prostaglandin E2 is converted to prostaglandin H2CompoundHuman-GEM MAR08560Inferred only
- prostaglandin E2 is a substrate of CBR1ProteinRhea RHEA:63476Inferred only
- prostaglandin E2 is a substrate of CBR1ProteinRhea RHEA:24508Inferred only
- prostaglandin E2 is a substrate of HPGDProteinRhea RHEA:11876Inferred only
- prostaglandin E2 is a substrate of PTGESProteinHuman-GEM MAR08560Inferred only
- prostaglandin E2 is a substrate of PTGES2ProteinHuman-GEM MAR08560Inferred only
- prostaglandin E2 is a substrate of PTGES3ProteinHuman-GEM MAR08560Inferred only
- prostaglandin E2 is a substrate of SCARF2ProteinHuman-GEM MAR01321Inferred only
- prostaglandin E2 is transported by ABCC4ProteinRhea RHEA:66388Inferred only
- prostaglandin E2 is transported by ABCC4ProteinHuman-GEM MAR08935Inferred only
- prostaglandin E2 is transported by SLC22A1ProteinHuman-GEM MAR06246Inferred only
- prostaglandin E2 is transported by SLC22A1ProteinRhea RHEA:50984Inferred only
- prostaglandin E2 is transported by SLC22A11ProteinRhea RHEA:50984Inferred only
- prostaglandin E2 is transported by SLC22A2ProteinHuman-GEM MAR06246Inferred only
- prostaglandin E2 is transported by SLC22A2ProteinRhea RHEA:50984Inferred only
- prostaglandin E2 is transported by SLC22A3ProteinHuman-GEM MAR06246Inferred only
- prostaglandin E2 is transported by SLC22A6ProteinRhea RHEA:76123Inferred only
- prostaglandin E2 is transported by SLC22A7ProteinRhea RHEA:50984Inferred only
- prostaglandin E2 is transported by SLC22A8ProteinRhea RHEA:72495Inferred only
- prostaglandin E2 is transported by SLC22A8ProteinRhea RHEA:72499Inferred only
- prostaglandin E2 is transported by SLC51AProteinRhea RHEA:50984Inferred only
- prostaglandin E2 is transported by SLC51BProteinRhea RHEA:50984Inferred only
- prostaglandin E2 is transported by SLCO1A2ProteinHuman-GEM MAR06101Inferred only
- prostaglandin E2 is transported by SLCO1A2ProteinHuman-GEM MAR06121Inferred only
- prostaglandin E2 is transported by SLCO1A2ProteinHuman-GEM MAR06120Inferred only
- prostaglandin E2 is transported by SLCO1A2ProteinHuman-GEM MAR06102Inferred only
- prostaglandin E2 is transported by SLCO1A2ProteinRhea RHEA:50984Inferred only
- prostaglandin E2 is transported by SLCO1A2ProteinHuman-GEM MAR06122Inferred only
- prostaglandin E2 is transported by SLCO1B1ProteinRhea RHEA:50984Inferred only
- prostaglandin E2 is transported by SLCO1B3ProteinHuman-GEM MAR06122Inferred only
- prostaglandin E2 is transported by SLCO1B3ProteinHuman-GEM MAR06102Inferred only
- prostaglandin E2 is transported by SLCO1B3ProteinHuman-GEM MAR06120Inferred only
- prostaglandin E2 is transported by SLCO1B3ProteinHuman-GEM MAR06121Inferred only
- prostaglandin E2 is transported by SLCO1B3ProteinRhea RHEA:50984Inferred only
- prostaglandin E2 is transported by SLCO2A1ProteinRhea RHEA:50984Inferred only
- prostaglandin E2 is transported by SLCO2A1ProteinHuman-GEM MAR06246Inferred only
- prostaglandin E2 is transported by SLCO2A1ProteinRhea RHEA:74383Inferred only
- prostaglandin E2 is transported by SLCO2A1ProteinHuman-GEM MAR06101Inferred only
- prostaglandin E2 is transported by SLCO2B1ProteinRhea RHEA:50984Inferred only
- prostaglandin E2 is transported by SLCO3A1ProteinHuman-GEM MAR06246Inferred only
- prostaglandin E2 is transported by SLCO3A1ProteinHuman-GEM MAR06101Inferred only
- prostaglandin E2 is transported by SLCO3A1ProteinRhea RHEA:50984Inferred only
- prostaglandin E2 is transported by SLCO4A1ProteinHuman-GEM MAR06101Inferred only
- prostaglandin E2 is transported by SLCO4A1ProteinRhea RHEA:50984Inferred only
Reactions
35 reactions
11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate+15-oxoprostaglandin E1+MAM00014x+(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate+MAM00254c+MAM00254m+MAM00254x+20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM00274c+MAM00274r+MAM00276c+MAM00277c+MAM00278c+MAM00280c+MAM00282c+11beta-hydroxyandrost-4-ene-3,17-dione+11beta-hydroxyandrost-4-ene-3,17-dione+11beta-hydroxyandrost-4-ene-3,17-dione+MAM00293c+MAM00297c+MAM00298c+MAM00304c+MAM00306c+MAM00308c+MAM00318c+MAM00318r+MAM00319c+MAM00320c+MAM00321c+MAM00322c+MAM00323c+MAM00323r+MAM00324r+MAM00327c+MAM00327r+MAM00328c+MAM00328r+MAM00333r+12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate+(13S)-hydroxy-(9Z,11E)-octadecadienoate+MAM00338c+MAM00340c+MAM00352r+13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM00364c+14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate+(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate+MAM00378c+MAM00382c+15-deoxy-Delta(12,14)-prostaglandin J2+MAM00384c+MAM00386c+MAM00386r+MAM00386x+MAM00387c+MAM00387r+MAM00387x+MAM00388c+MAM00388r+MAM00388x+MAM00389c+MAM00389r+MAM00389x+15-oxoprostaglandin F2alpha+MAM00395c+16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM00398x+17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM00424m+MAM00425x+MAM00426c+18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM00430c+MAM00590c+MAM00595c+MAM00595r+MAM00598c+MAM00598r+MAM00602c+MAM00687m+MAM00687x+MAM01038n+MAM01039x+MAM01041n+MAM01046c+MAM01047c+MAM01049c+MAM01050c+MAM01051c+5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate+MAM01055c+MAM01120c+MAM01120r+MAM01122c+MAM01122r+MAM01150c+MAM01150m+MAM01150x+MAM01153c+MAM01153m+MAM01153r+MAM01153x+MAM01167c+MAM01168r+MAM01171c+MAM01171m+MAM01171x+MAM01172c+MAM01172m+MAM01172x+7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM01202c+MAM01208c+8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate+MAM01210c+MAM01213c+MAM01239c+(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate+(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate+MAM02368c+MAM02395n+MAM02395r+MAM02395x+MAM02396r+MAM02396x+malonaldehyde+MAM02538c+MAM02538n+MAM02649m+MAM02649x+prostaglandin E2+prostaglandin E3+prostaglandin H1+prostaglandin J2+MAM02797c+MAM02798c+MAM02799c+MAM02851c+MAM02852c+MAM02862c+MAM02863c+MAM02864c+MAM03055c+MAM03055r+MAM03055x+MAM03056cMAM10003e
Reaction pageLeft to rightBalance undeterminablecytosol, peroxisome, mitochondrial matrix, endoplasmic reticulum, nucleus, extracellular space
Human-GEM MAR00036CC BY 4.0Reference data
prostaglandin H2prostaglandin E2
Catalysed by PTGES3 or PTGES2 or PTGES
Reaction pageLeft to rightBalancedEC 5.3.99.3cytosol
Human-GEM MAR01312CC BY 4.0Reference data
water+prostaglandin A2prostaglandin E2
Catalysed by SCARF2
Reaction pageReversibleBalancedEC 4.2.1.-cytosol
Human-GEM MAR01321CC BY 4.0Reference data
water+MAM02779cprostaglandin E2
Reaction pageReversibleBalancedcytosol
Human-GEM MAR01324CC BY 4.0Reference data
NADP(3-)+prostaglandin F2alphaproton+NADPH(4-)+prostaglandin E2
Catalysed by DHRS4 or CBR1 or CBR3 or AKR1C3
Reaction pageLeft to rightBalancedEC 1.1.1.184, 1.1.1.189cytosol
Human-GEM MAR01327CC BY 4.0Reference data
water+MAM02800cMAM01983c+proton+prostaglandin E2
Reaction pageReversibleBalancedEC 3.1.-.-cytosol
Human-GEM MAR01341CC BY 4.0Reference data
water+MAM02798cMAM01983c+proton+prostaglandin E2
Reaction pageReversibleBalancedEC 3.1.-.-cytosol
Human-GEM MAR01342CC BY 4.0Reference data
water+MAM02799cMAM01983c+proton+prostaglandin E2
Reaction pageReversibleBalancedEC 3.1.-.-cytosol
Human-GEM MAR01343CC BY 4.0Reference data
prostaglandin E2water+prostaglandin A2
Reaction pageReversibleBalancedmitochondrial matrix
Human-GEM MAR03016CC BY 4.0Reference data
hydrogencarbonate+prostaglandin E2hydrogencarbonate+prostaglandin E2
Transported by SLCO1A2 or SLCO4A1 or SLCO2A1 or SLCO3A1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR06101CC BY 4.0Reference data
CHEBI:16856+hydrogencarbonate+prostaglandin E2CHEBI:16856+hydrogencarbonate+prostaglandin E2
Transported by SLCO1A2 & SLCO1B3
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06102CC BY 4.0Reference data
MAM01980c+hydrogencarbonate+prostaglandin E2MAM01980e+hydrogencarbonate+prostaglandin E2
Transported by SLCO1A2 & SLCO1B3
Reaction pageReversibleBalance undeterminablecytosol, extracellular space
Human-GEM MAR06120CC BY 4.0Reference data
Where it reaches
7 systems, 13 regions, 35 tissues, 58 transporter routes — routes, not measurements: transporters known to carry prostaglandin E2 are expressed there, and no source reports it arriving.
Loading the model…
Other names
4 names
Resolves to: prostaglandin E2
- Also called
- PGE2prostaglandin E2 anion
- Systematic name
- (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dien-1-oate(5Z,13E,15S)-11α,15-dihydroxy-9-oxoprosta-5,13-dien-1-oate