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Proteins/UNIPROT:P26358
DNA methyltransferase that methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing..
Function from UniProtKB (P26358), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · inhibits
1 compound
1 compound.
0 reported routes1 assembled route
2 rows
334 statements
334 statements · 6 reference databases · Subject: DNMT1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Reactome, WikiPathways · Rows fetched: 300
4 reactions
MAM01721c+S-adenosyl-L-methionineMAM01722c+proton+CHEBI:16680
Catalysed by DNMT1 & DNMT3B or TRDMT1 or DNMT3A or DNMT3L
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.37cytosol
Human-GEM MAR04072CC BY 4.0Reference data
MAM01721n+MAM02882nMAM01722n+proton+MAM02881n
1 paper
9 names
Resolves to: DNMT1
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.37nucleus
Human-GEM MAR08640CC BY 4.0Reference data
MAM01721n+S-adenosyl-L-methionineMAM01722n+proton+CHEBI:16680
Catalysed by DNMT1 & DNMT3B or TRDMT1 or DNMT3A or DNMT3L
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.37nucleus
Human-GEM MAR08641CC BY 4.0Reference data
a 2'-deoxycytidine in DNA+S-adenosyl-L-methioninea 5-methyl-2'-deoxycytidine in DNA+S-adenosyl-L-homocysteine+hydron
Catalysed by DNMT1 or DNMT3B or DNMT3A
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:13681CC BY 4.0Reference data