Compound

CHEBI:18019

An essential amino acid. It is often added to animal feed.

Definition from MeSH (D008239), National Library of Medicine, read 2026-09-23. NLM revises MeSH; this copy may not reflect its current record.

CHEBI:18019ChEBI

Open in the graph

What it touches on the way

Mechanistic reach

16 entities

16 entities reached.

0 reported hops16 assembled from the scaffold

Show the remaining 4

What the reference databases state

Statements

100 statements

100 statements · 1 reference database · Subject: CHEBI:18019 · Sources: Human-GEM

Order

CHEBI:18019 is converted to 6-amino-2-oxohexanoateCompoundHuman-GEM MAR08017Inferred only
CHEBI:18019 is converted to L-saccharopineCompoundHuman-GEM MAR04288Inferred only
CHEBI:18019 is a substrate of AASSProteinHuman-GEM MAR04288Inferred only
CHEBI:18019 is a substrate of CELProteinHuman-GEM MAR06405Inferred only
CHEBI:18019 is a substrate of DHPSProteinHuman-GEM MAR06967Inferred only
CHEBI:18019 is a substrate of KARS1ProteinHuman-GEM MAR05142Inferred only
CHEBI:18019 is a substrate of LIPAProteinHuman-GEM MAR06405Inferred only
CHEBI:18019 is transported by SLC22A5ProteinHuman-GEM MAR08917Inferred only
CHEBI:18019 is transported by SLC25A15ProteinHuman-GEM MAR06321Inferred only
CHEBI:18019 is transported by SLC25A15ProteinHuman-GEM MAR06302Inferred only
CHEBI:18019 is transported by SLC25A15ProteinHuman-GEM MAR06301Inferred only
CHEBI:18019 is transported by SLC25A2ProteinHuman-GEM MAR06300Inferred only

Show the remaining 88

CHEBI:18019 is transported by SLC25A2ProteinHuman-GEM MAR06303Inferred only
CHEBI:18019 is transported by SLC25A2ProteinHuman-GEM MAR06302Inferred only
CHEBI:18019 is transported by SLC25A2ProteinHuman-GEM MAR06299Inferred only
CHEBI:18019 is transported by SLC25A2ProteinHuman-GEM MAR06301Inferred only
CHEBI:18019 is transported by SLC25A2ProteinHuman-GEM MAR06304Inferred only
CHEBI:18019 is transported by SLC25A2ProteinHuman-GEM MAR06321Inferred only
CHEBI:18019 is transported by SLC25A2ProteinHuman-GEM MAR06306Inferred only
CHEBI:18019 is transported by SLC25A2ProteinHuman-GEM MAR06305Inferred only
CHEBI:18019 is transported by SLC36A1ProteinHuman-GEM MAR05056Inferred only
CHEBI:18019 is transported by SLC3A1ProteinHuman-GEM MAR05908Inferred only
CHEBI:18019 is transported by SLC3A1ProteinHuman-GEM MAR05907Inferred only
CHEBI:18019 is transported by SLC3A1ProteinHuman-GEM MAR05922Inferred only
CHEBI:18019 is transported by SLC3A1ProteinHuman-GEM MAR05921Inferred only
CHEBI:18019 is transported by SLC3A1ProteinHuman-GEM MAR05920Inferred only
CHEBI:18019 is transported by SLC3A1ProteinHuman-GEM MAR05919Inferred only
CHEBI:18019 is transported by SLC3A1ProteinHuman-GEM MAR05918Inferred only
CHEBI:18019 is transported by SLC3A1ProteinHuman-GEM MAR05917Inferred only
CHEBI:18019 is transported by SLC3A1ProteinHuman-GEM MAR05842Inferred only
CHEBI:18019 is transported by SLC3A1ProteinHuman-GEM MAR05916Inferred only
CHEBI:18019 is transported by SLC3A1ProteinHuman-GEM MAR05915Inferred only
CHEBI:18019 is transported by SLC3A1ProteinHuman-GEM MAR05914Inferred only
CHEBI:18019 is transported by SLC3A1ProteinHuman-GEM MAR05913Inferred only
CHEBI:18019 is transported by SLC3A1ProteinHuman-GEM MAR05912Inferred only
CHEBI:18019 is transported by SLC3A1ProteinHuman-GEM MAR05911Inferred only
CHEBI:18019 is transported by SLC3A1ProteinHuman-GEM MAR05910Inferred only
CHEBI:18019 is transported by SLC3A1ProteinHuman-GEM MAR05909Inferred only
CHEBI:18019 is transported by SLC3A2ProteinHuman-GEM MAR05578Inferred only
CHEBI:18019 is transported by SLC6A14ProteinHuman-GEM MAR09596Inferred only
CHEBI:18019 is transported by SLC7A1ProteinHuman-GEM MAR05071Inferred only
CHEBI:18019 is transported by SLC7A2ProteinHuman-GEM MAR05071Inferred only
CHEBI:18019 is transported by SLC7A3ProteinHuman-GEM MAR05071Inferred only
CHEBI:18019 is transported by SLC7A5ProteinHuman-GEM MAR05578Inferred only
CHEBI:18019 is transported by SLC7A5ProteinHuman-GEM MAR05581Inferred only
CHEBI:18019 is transported by SLC7A5ProteinHuman-GEM MAR05579Inferred only
CHEBI:18019 is transported by SLC7A5ProteinHuman-GEM MAR05580Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05882Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05910Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05877Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05911Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05872Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05912Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05867Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05913Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05857Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05897Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05907Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05892Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05908Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05887Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05909Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05852Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05914Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05847Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05915Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05916Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05842Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05917Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05837Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05918Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05832Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05919Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05827Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05920Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05921Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05581Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05922Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05580Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05579Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05578Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05862Inferred only
CHEBI:18019 is transported by SLC7A6ProteinHuman-GEM MAR05902Inferred only
CHEBI:18019 is transported by SLC7A7ProteinHuman-GEM MAR05842Inferred only
CHEBI:18019 is transported by SLC7A9ProteinHuman-GEM MAR05913Inferred only
CHEBI:18019 is transported by SLC7A9ProteinHuman-GEM MAR05914Inferred only
CHEBI:18019 is transported by SLC7A9ProteinHuman-GEM MAR05922Inferred only
CHEBI:18019 is transported by SLC7A9ProteinHuman-GEM MAR05907Inferred only
CHEBI:18019 is transported by SLC7A9ProteinHuman-GEM MAR05918Inferred only
CHEBI:18019 is transported by SLC7A9ProteinHuman-GEM MAR05910Inferred only
CHEBI:18019 is transported by SLC7A9ProteinHuman-GEM MAR05919Inferred only
CHEBI:18019 is transported by SLC7A9ProteinHuman-GEM MAR05909Inferred only
CHEBI:18019 is transported by SLC7A9ProteinHuman-GEM MAR05920Inferred only
CHEBI:18019 is transported by SLC7A9ProteinHuman-GEM MAR05908Inferred only
CHEBI:18019 is transported by SLC7A9ProteinHuman-GEM MAR05921Inferred only
CHEBI:18019 is transported by SLC7A9ProteinHuman-GEM MAR05915Inferred only
CHEBI:18019 is transported by SLC7A9ProteinHuman-GEM MAR05912Inferred only
CHEBI:18019 is transported by SLC7A9ProteinHuman-GEM MAR05916Inferred only
CHEBI:18019 is transported by SLC7A9ProteinHuman-GEM MAR05917Inferred only
CHEBI:18019 is transported by SLC7A9ProteinHuman-GEM MAR05911Inferred only

Reactions

159 reactions

L-alanine+L-arginine+L-asparagine+L-aspartate+CHEBI:1307929+a cholesterol ester+a cardiolipin+MAM01602c+L-cysteine+MAM01721n+MAM01722n+L-glutamate(1-)+L-glutamine+glycine+CHEBI:15971+L-isoleucine+L-leucine+MAM02392c+CHEBI:18019+L-methionine+L-phenylalanine+phosphatidic acid+1-phosphatidyl-1D-myo-inositol+CHEBI:17203+MAM02847c+L-seryl residue+a sphingomyelin+CHEBI:16857+L-tryptophan+CHEBI:17895+L-valine+MAM03161cMAM03970c
Reaction pageBlockedBalance undeterminablecytosol, endoplasmic reticulum, nucleus
Human-GEM MAR00021CC BY 4.0Reference data
MAM00185m+CHEBI:18019MAM01356m+proton+water
Reaction pageLeft to rightBalance undeterminablemitochondrial matrix
Human-GEM MAR00073CC BY 4.0Reference data
biocytin+waterbiotin+CHEBI:18019
Catalysed by BTD
Reaction pageLeft to rightBalancedEC 3.5.1.12mitochondrial matrix
Human-GEM MAR00091CC BY 4.0Reference data
2-oxoglutarate(2-)+proton+CHEBI:18019+NADPH(4-)water+NADP(3-)+L-saccharopine
Catalysed by AASS
Reaction pageLeft to rightBalancedEC 1.5.1.8mitochondrial matrix
Human-GEM MAR04288CC BY 4.0Reference data
0.505626L-alanine+0.35926L-arginine+0.279425L-asparagine+0.352607L-aspartate+20.704451ATP+0.020401CHEBI:1307929+0.011658a cardiolipin+0.039036CHEBI:17677+0.046571L-cysteine+0.013183CHEBI:16284+0.009442dCTP+0.009898CHEBI:16497+0.013091dTTP+0.275194D-glucopyranose 6-phosphate+0.385872L-glutamate(1-)+0.325996L-glutamine+0.538891glycine+0.036117GTP+20.650823water+0.126406CHEBI:15971+0.286078L-isoleucine+0.545544L-leucine+0.592114CHEBI:18019+0.153018L-methionine+0.1544631,2-diacyl-sn-glycero-3-phosphocholine(1+)+0.055374phosphatidylethanolamine+0.002914MAM02715c+0.259466L-phenylalanine+0.0233151-phosphatidyl-1D-myo-inositol+0.412484CHEBI:17203+0.005829phosphatidyl-L-serine+0.392525L-seryl residue+0.017486a sphingomyelin+0.31269CHEBI:16857+0.013306L-tryptophan+0.159671CHEBI:17895+0.053446UTP+0.352607L-valine20.650823ADP+20.650823proton+20.650823phosphate(3-)+MAM03970c
Reaction pageBlockedBalance undeterminablecytosol, nucleus
Human-GEM MAR04413CC BY 4.0Reference data
CHEBI:18019CHEBI:18019
Transported by SLC36A1
Reaction pageLeft to rightBalancedlysosome, cytosol
Human-GEM MAR05056CC BY 4.0Reference data
CHEBI:18019CHEBI:18019
Transported by SLC7A2 or SLC7A1 or SLC7A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05071CC BY 4.0Reference data
ATP+CHEBI:18019+MAM03074cAMP+MAM02405c+diphosphate(3-)
Catalysed by KARS1
Reaction pageLeft to rightBalance undeterminableEC 6.1.1.6cytosol
Human-GEM MAR05142CC BY 4.0Reference data
MAM01308c+608ATP+1216water608ADP+63L-alanine+27L-arginine+17L-asparagine+36L-aspartate+35L-cysteine+62L-glutamate(1-)+20L-glutamine+13glycine+619proton+16CHEBI:15971+9L-isoleucine+64L-leucine+60CHEBI:18019+7L-methionine+35L-phenylalanine+608phosphate(3-)+24CHEBI:17203+28L-seryl residue+29CHEBI:16857+2L-tryptophan+19CHEBI:17895+43L-valine
Catalysed by ALB
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR05258CC BY 4.0Reference data
MAM01308l+608ATP+1216water608ADP+63L-alanine+27L-arginine+17L-asparagine+36L-aspartate+35L-cysteine+62L-glutamate(1-)+20L-glutamine+13glycine+619proton+16CHEBI:15971+9L-isoleucine+64L-leucine+60CHEBI:18019+7L-methionine+35L-phenylalanine+608phosphate(3-)+24CHEBI:17203+28L-seryl residue+29CHEBI:16857+2L-tryptophan+19CHEBI:17895+43L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05259CC BY 4.0Reference data
MAM01343c+422ATP+844water422ADP+34L-alanine+16L-arginine+19L-asparagine+25L-aspartate+3L-cysteine+29L-glutamate(1-)+17L-glutamine+16glycine+434proton+9CHEBI:15971+20L-isoleucine+59L-leucine+26CHEBI:18019+14L-methionine+25L-phenylalanine+422phosphate(3-)+16CHEBI:17203+30L-seryl residue+29CHEBI:16857+3L-tryptophan+9CHEBI:17895+24L-valine
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR05260CC BY 4.0Reference data
MAM01343l+422ATP+844water422ADP+34L-alanine+16L-arginine+19L-asparagine+25L-aspartate+3L-cysteine+29L-glutamate(1-)+17L-glutamine+16glycine+434proton+9CHEBI:15971+20L-isoleucine+59L-leucine+26CHEBI:18019+14L-methionine+25L-phenylalanine+422phosphate(3-)+16CHEBI:17203+30L-seryl residue+29CHEBI:16857+3L-tryptophan+9CHEBI:17895+24L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05261CC BY 4.0Reference data

Show the remaining 147

Where it reaches

10 systems, 19 regions, 55 tissues, 70 transporter routes — routes, not measurements: transporters known to carry CHEBI:18019 are expressed there, and no source reports it arriving.

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Nervous

Endocrine

Respiratory

Cardiovascular

Digestive

Urinary

Reproductive

Blood and immune

Musculoskeletal

Skin and adipose

Other names

11 names

Resolves to: CHEBI:18019

Also called: (S)-2,6-diaminohexanoic acid(S)-alpha,epsilon-diaminocaproic acid(S)-lysine(S)-α,ε-diaminocaproic acid6-ammonio-L-norleucineL-2,6-Diaminocaproic acidLyslysineLysine acid
Systematic name: (2S)-2,6-diaminohexanoic acidL-lysine